• MeSH
• Information Services MeSH
• Medical Informatics MeSH
• Libraries, Medical trends   utilization   MeSH
• International Cooperation MeSH
• Telemedicine MeSH
• Publication type
• Abstracts MeSH
• Congress MeSH

• Conspectus
• Knihovnictví. Informatika
• NML Fields
• knihovnictví, informační věda a muzeologie
• lékařská informatika

Transplantace krvetvorby jsou již řadu let neodmyslitelnou a standardní součástí léčby zejména hematologických malignit. Základní metodologie odběrů krvetvorných buněk a jejich transplantací byly sice vypracovány již před 40 lety, ale dlouho bránilo masivnějšímu využití této léčebné modality především komplikované získávání transplantátů pomocí odběrů kostní dřeně. Za masivním rozšířením autologních transplantací v 90. letech minulého století tak stojí především využití mobilizace a sběru krvetvorných buněk (HSC, hematopoietic stem cells) z periferní krve. Mobilizace a odběry HSC z periferní krve dnes mají ve schématech onkologické léčby pevnou pozici, přičemž standardem mobilizace je již více než 10 let podávání G-CSF (granulocyte-colony stimulating factor): buď samostatně, nebo po mobilizační chemoterapii. Bohužel, 10–15 % pacientů, označovaných termínem „poor mobilizers“, nevyplavuje HSC v množství dostatečném pro odběr transplantátu, a vysokodávkovaná terapie tak u nich není možná. Nárůst znalostí o procesu mobilizace však v současnosti přináší nové preparáty, které působí synergisticky s G-CSF a jejichž mobilizační potenciál je velmi vysoký. Plerixafor je první takovou látkou, která se nyní dostává do klinické praxe. Tento antagonista receptoru CXCR4 dokáže s minimálními vedlejšími účinky navodit dostatečnou mobilizaci i u pacientů, které jinak řadíme do skupiny tzv. poor mobilizerů. V blízké budoucnosti můžeme s využitím plerixaforu a podobných látek očekávat celkové zjednodušení a urychlení procesu mobilizace a odběru HSC.

Hematopoietic stem cell transplantation (HSC7) is a standard and essential part of treatment of particularly hematological malignancies. Basic methods of hematopoietic stem cell (HSC) collections and transplantations were developed more than 40 years ago, but complicated obtaining of HSC by bone marrow collections was the main reason which hindered wider broadening of this treatment modality. The massive expansion of autologous HSCT in 90th of the last century was facilitated by utilization of mobilization and collection of HSC from peripheral blood. The mobilization and collection of HSC from peripheral blood is currently a part of many protocols for treatment of hematopoietic malignancies, and administration of G-CSF (granulocyte-colony stimulating factor), after a chemotherapy or alone, became a standard for mobilization more than 10 years ago. Unfortunately, 10-15 % of patients represent a group of poor mobilizers who do not reach blood concentrations of HCS sufficient for their successful collection and subsequent transplantaXion. However, an increase in knowledge about processes during mobilization enabled development of new drugs, which act synergically with G-CSF and which mobilization potential is very high. Plerixafor is the first new substance which is currently available for the clinical practice. This antagonist of a CXCR4 receptor is able to mobilize adequate numbers of HSC with minimal adverse effects even in poor mobilizers. We can expect that utilization of plerixafor and similar new drugs will make HSC mobilizations and collections more simple and rapid in the near future.

• Keywords
• G-CSF, plerixafor,
• MeSH
• Lymphocyte Activation drug effects   MeSH
• Transplantation, Autologous MeSH
• Cytokines MeSH
• Granulocyte Colony-Stimulating Factor administration & dosage   immunology   MeSH
• Heterocyclic Compounds therapeutic use   MeSH
• Humans MeSH
• Hematopoietic Stem Cell Mobilization methods   MeSH
• Receptors, CXCR4 antagonists & inhibitors   MeSH
• Hematopoietic Stem Cell Transplantation methods   MeSH
• Check Tag
• Humans MeSH

Introduction: Diabetes requires a high level of disease management to be executed by the patient himself in order to succeed in treatment and for improving or at least preserving his health status. Aim: The main objective of the presented project is to design and implement a web technology based application framework. It shall provide sufficient means for selfmanagement and enable patient empowerment within the treatment process. Its underlying concept will be outlined in this work. Methods: Common techniques on requirements’ engineering have been applied to derive an initial concept. It is based on a comprehensive state of the art analysis drawn from literature and web search.

• MeSH
• Diabetes Mellitus * therapy   MeSH
• Electronic Health Records MeSH
• Expert Systems * MeSH
• Humans MeSH
• Decision Support Techniques MeSH
• Software Design MeSH
• Self Care MeSH
• Pilot Projects MeSH
• Diffusion of Innovation MeSH
• Telemedicine MeSH
• Knowledge Bases MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Germany MeSH
• Turkey MeSH

INTRODUCTION: The COVID-19 pandemic underlined that guidelines and recommendations must be made more accessible and more understandable to the general public to improve health outcomes. The objective of this study is to evaluate, quantify, and compare the public's understanding, usability, satisfaction, intention to implement, and preference for different ways of presenting COVID-19 health recommendations derived from the COVID-19 Living Map of Recommendations and Gateway to Contextualization (RecMap). METHODS AND ANALYSIS: This is a protocol for a multi-method study. Through an online survey, we will conduct pragmatic allocation-concealed, blinded superiority randomized controlled trials (RCTs) in three populations to test alternative formats of presenting health recommendations: adults, parents, and youth, with at least 240 participants in each population. Prior to initiating the RCT, our interventions will have been refined with relevant stakeholder input. The intervention arm will receive a plain language recommendation (PLR) format while the control arm will receive the corresponding original recommendation format as originally published by the guideline organizations (standard language version). Our primary outcome is understanding, and our secondary outcomes are accessibility and usability, satisfaction, intended behavior, and preference for the recommendation formats. Each population's results will be analyzed separately. However, we are planning a meta-analysis of the results across populations. At the end of each survey, participants will be invited to participate in an optional one-on-one, virtual semi-structured interview to explore their user experience. All interviews will be transcribed and analyzed using the principles of thematic analysis and a hybrid inductive and deductive approach. ETHICS AND DISSEMINATION: Through Clinical Trials Ontario, the Hamilton Integrated Research Ethics Board has reviewed and approved this protocol (Project ID: 3856). The University of Alberta has approved the parent portion of the trial (Project ID:00114894). Findings from this study will be disseminated through open-access publications in peer-reviewed journals and using social media. TRIAL REGISTRATION: Clinicaltrials.gov NCT05358990 . Registered on May 3, 2022.

• MeSH
• COVID-19 * MeSH
• Adult MeSH
• Humans MeSH
• Meta-Analysis as Topic MeSH
• Adolescent MeSH
• Surveys and Questionnaires MeSH
• Randomized Controlled Trials as Topic MeSH
• SARS-CoV-2 MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Ontario MeSH

As the green transformation sweeps across industries in the digital age, tourism stakeholders face a pressing need to utilize online platforms and digital influencers for sustainability messaging. Drawing on the Motivation-Opportunity-Ability framework, this study investigates the influence of green ownership psychology and green knowledge sharing on tourists' repatronage intentions. It focuses on the mediating role of cooperative green activity programs and the moderating impact of tourists' green trust in social media influencers. Results from a two-wave survey of 602 tourists in Vietnam show that green practices directly increase repatronage intentions. Cooperative green activity programs significantly mediate this relationship, enhancing the impact of green marketing practices on repatronage intentions. Furthermore, tourists' green trust in social media influencers is a crucial moderating factor. It increases the effectiveness of green ownership psychology and green knowledge sharing in influencing repatronage intentions through cooperative green activity programs. The study highlights how the emotional and cognitive aspects of green marketing contribute to tourists' decisions to revisit or continue using tourism services. Offering original insights into the interplay of these elements in green marketing within the tourism industry, this research enriches the application of the Motivation-Opportunity-Ability framework. It provides valuable implications for tourism companies aiming to foster sustainable practices and enhance customer loyalty, highlighting the role of digital influencer engagement and cooperative sustainability initiatives in green marketing strategies.

• MeSH
• Adult MeSH
• Trust MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Motivation MeSH
• Social Media MeSH
• Tourism * MeSH
• Intention MeSH
• Ownership * MeSH
• Conservation of Natural Resources MeSH
• Knowledge MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Vietnam MeSH

Nowadays, artificial intelligence (AI) affects our lives every single day and brings with it both benefits and risks for all spheres of human activities, including education. Out of these risks, the most striking seems to be ethical issues of the use of AI, such as misuse of private data or surveillance of people's lives. Therefore, the aim of this systematic review is to describe the key ethical issues related to the use of AI-driven mobile apps in education, as well as to list some of the implications based on the identified studies associated with this research topic. The methodology of this review study was based on the PRISMA guidelines for systematic reviews and meta-analyses. The results indicate four key ethical principles that should be followed, out of which the principle of algorithmovigilance should be considered in order to monitor, understand and prevent the adverse effects of algorithms in the use of AI in education. Furthermore, all stakeholders should be identified, as well as their joint engagement and collaboration to guarantee the ethical use of AI in education. Thus, the contribution of this study consists in emphasizing the need for joint cooperation and research of all stakeholders when using AI-driven mobile technologies in education with special attention to the ethical issues since the present research based on the review studies is scarce and neglected in this respect.

• MeSH
• Algorithms MeSH
• Humans MeSH
• Mobile Applications * MeSH
• Educational Status MeSH
• Artificial Intelligence * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Systematic Review MeSH

• MeSH
• Medical Informatics MeSH
• Telemedicine MeSH
• Publication type
• Congress MeSH
• Collected Work MeSH

• Conspectus
• Veřejné zdraví a hygiena
• NML Fields
• lékařská informatika

This paper analyses the contemporary public debate about vaccination, and medical knowledge more broadly, in the context of social media. The study is focused on the massive online debate prompted by the Facebook status of the digital celebrity Mark Zuckerberg, who posted a picture of his two-month-old daughter, accompanied by a comment: 'Doctor's visit - time for vaccines!' Carrying out a qualitative analysis on a sample of 650 comments and replies, selected through systematic random sampling from an initial pool of over 10,000 user contributions, and utilising open and axial coding, we empirically inform the theoretical discussion around the concept of the reflexive patient and introduce the notion of multi-layered reflexivity. We argue that the reflexive debate surrounding this primarily medical problem is influenced by both biomedical and social scientific knowledge. Lay actors therefore discuss not only vaccination, but also its political and economic aspects as well as the post-truth information context of the debate. We stress that the reflexivity of social actors related to the post-truth era re-enters and influences the debate more than ever. Furthermore, we suggest that the interconnection of different layers of reflexivity can either reinforce certainty or deepen the ambiguity and uncertainty of reflexive agents.

• MeSH
• Humans MeSH
• Social Media * MeSH
• Vaccination psychology   MeSH
• Health Knowledge, Attitudes, Practice * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Je dokumentován případ úspěšné mobilizace a odběru periferních krvetvorných buněk (PBSC) u 52leté pacientky léčené nejprve imatinibem a následně nilotinibem pro chronickou myeloidní leukemii diagnostikovanou v roce 2002 se středním prognostickým rizikem dle Sokala a Hasforda. Po selhání léčby s interferonem alfa a imatinibem bylo dosaženo kompletní cytogenetické remise po šesti měsících a první kompletní molekulární remise po šestnácti měsících léčby s nilotinibem. Za využití stimulace filgrastimem v dávce 10 μg/kg/den byla v den +4 provedena jedna leukocytaferéza se ziskem produktu autologního štěpu s obsahem 2,98 x 106/kg CD34+ buněk. Štěp byl kryoprezervován a vyšetřen: RT-PCR prokázala BCR-ABL pozitivitu (BCR-ABL/ABL poměr 0,0017 dle RQ-PCR), analýza FISH byla negativní. Podle našich vědomostí je toto první případ dokumentovaného odběru PBSC u pacienta léčeného imatinibem a následně nilotinibem.

Here we report a case of successful mobilization and harvest of peripheral hematopoietic stem cells in imatinib pretreated and nilotinib treated 52-years old woman, who was diagnosed with chronic myeloid leukemia, Sokal and Hasford intermediate risk group, in 2002. She failed interferon-alfa and imatinib treatment and achieved first complete molecular remission after 16 months of nilotinib treatment. The patient was mobilized with filgrastim at the dose of 10 μg/kg/day. On the day +4, single leukapheresis was performed and autologous graft containing 2,9 x 106/kg CD34+ cell was harvested. The apheresis product was cryopreserved and analyzed: the RT-PCR analysis revealed BCR-ABL positivity (BCR-ABL/ABL ratio 0,0017 in RQ-PCR), the FISH analysis was negative. To our knowledge, this is the first report of successful PBSC harvest in a patient significantly pretreated with imatinib and nilotinib.

• MeSH
• Financing, Organized MeSH
• Leukapheresis MeSH
• Middle Aged MeSH
• Humans MeSH
• Hematopoietic Stem Cell Mobilization MeSH
• Leukemia, Myeloid therapy   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

Každý tisící občan této planety je postižený spasticitou. Je zajímavé, že USA stál výzkum a léčba tohoto syndromu již 11,2 miliardy dolarů. Spasticita je často chápána jako nemoc, ale ve skutečnosti se jedná o syndrom, který doprovází řadu onemocnění, a není jednoduché definovat, co je jeho příčinou. Z tohoto důvodu se popisují charakteristické projevy nebo se vyjmenovávají onemocnění, u kterých se vyskytuje. Je nutné chápat spastický syndrom jako součást poruchy způsobené centrální lezí, která způsobuje poruchy hybnosti (parézy, plegie), patologické synergie, spastické dystonie a patologickou hypertonii – spasticitu. Nedílnou součástí léčby tohoto syndromu je ošetřovatelská péče, která po celou dobu hospitalizace pacienta v jeho akutní fázi hraje zásadní úlohu v budoucím vývoji jeho zdravotního stavu. Následující text se zabývá definicí, hodnocením a léčbou spastického syndromu se zřetelem na ošetřovatelskou část péče, která se často opomíjí a nedoceňuje. Centrální poruchu můžeme rozdělit podle místa vzniku na centrální a spinální, anebo na syndrom horního motoneuronu s pozitivními či negativními symptomy.

One in thousand inhabitants of our planet suffers from spasticity. Interestingly, the price of the research and therapy of this syndrome has already been as high as 11.2 milliard dollars. Spasticity is frequently considered as a disease, but it is actually a syndrome accompanying a number of diseases and its cause is not easy to define. Due to this, characteristic manifestations are described or diseases are listed, which it occurs in. Spastic syndrome should be understood as a part of disorders resulting from a central lesion, which causes disorders of the mobility (paresis, plegia), pathological synergy, spastic dystonia and pathological hypertonia – spasticity. An integral part of the treatment of this syndrome is the nursing care, which is necessary for the whole period of the patient hospitalization at the acute stage, and which plays a principal role in the future development of the patient health condition. The following text is aimed at the evaluation and treatment of spastic syndrome with taking into account the nursing care, which is frequently omitted and underestimated. The disorders can be categorized depending on the site of their origination into central and spinal or into syndrome of the upper motoneurone with positive or negative symptoms.

• MeSH
• Humans MeSH
• Neurologic Manifestations MeSH
• Nursing Care MeSH
• Nursing Process MeSH
• Muscle Spasticity etiology   nursing   rehabilitation   MeSH
• Check Tag
• Humans MeSH