effective number theory
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A series of triterpenoids of the lupane, taraxastane, friedelane and baccharane type were oxidized using selenium dioxide (SeO2) and benzeneseleninic anhydride (BSA) under various conditions. Depending on the reaction conditions, different reaction pathways were observed, including dehydrogenation, allylic oxidation, and 1,2-diketone formation. In this way, derivatives functionalized in the triterpene core (especially in rings A, D, and E), difficult to obtain by other methods, can be easily prepared. In some cases, rarely observed α-phenylseleno-ketones were isolated. An unexpected reaction involving the cleavage of the carbon-carbon double bond was observed in the presence of stoichiometric amounts of osmium tetroxide. Further transformations of selected intermediates facilitated the synthesis of new, functionally enriched derivatives. The key reaction pathways were investigated using density functional theory (DFT), focusing on bond length variations and transition states, revealing energetically favored pathways and critical transition structures, including covalent and noncovalent interactions. Solvent and isomerization equilibrium effects were proposed to explain the experimentally observed discrepancies. Cytotoxic activity of selected derivatives was investigated. Derivatives 4 and 38 showed strongest cytotoxicity in cancer cells and fibroblasts (IC50 2.6-26.4 μM); some compounds were selective for G-361 or HeLa cells. These results suggest that they may find application in pharmaceuticals.
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- lidé MeSH
- molekulární struktura MeSH
- nádorové buněčné linie MeSH
- oxidace-redukce MeSH
- pentacyklické triterpeny MeSH
- proliferace buněk účinky léků MeSH
- protinádorové látky * farmakologie chemie chemická syntéza MeSH
- screeningové testy protinádorových léčiv MeSH
- selen * chemie MeSH
- teorie funkcionálu hustoty MeSH
- triterpeny * chemie farmakologie chemická syntéza MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Chronic low back pain (CLBP) is one of the most common musculoskeletal problems worldwide. Even though regular exercise is recommended as the primary conservative approach in treating this condition, significant part of patients lead sedentary lifestyle. Motivation to exercise is one of the variables that effects the adherence of exercise-based treatments. This study aimed to characterize the motives for exercise, as posited by self-determination theory, in persons with CLBP, and to identify subgroups (clusters) of motivational profiles in combination with socioeconomic and clinical characteristics using k-means cluster analysis. METHODS: Data were collected between September 2022 and September 2023. A total of 103 adults with CLBP completed the paper-pencil Exercise Self-Regulation Questionnaire (SRQ-E) and provided self-reported measures on anthropometric and socio-economic characteristics. Inclusion criteria were age (≥ 18 years) and non-specific CLBP (lasting longer than 12 weeks). Exclusion criteria included specific lumbar spine pathology (e.g., fracture, cancer), worsening neurological symptoms, recent injection therapy (within 3 months), and current alcohol or drug misuse. RESULTS: Three distinct motivational clusters were identified among the 103 participants: two clusters were characterized by predominantly autonomous motivation (moderately motivated cluster: 31.1%; highly motivated cluster: 54.4%), while one cluster (controlled convinced cluster: 14.6%) showed a higher level of controlled motivation. Associations were observed between the controlled cluster and factors such as higher disability scores, longer duration of pain, greater number of completed physiotherapy sessions, and elevated BMI. Notably, the controlled motivation cluster was linked with poorer clinical outcomes. CONCLUSIONS: This study provides insights into the exercise motivation of patients with CLBP, revealing that while most patients were primarily autonomously motivated, a notable subgroup exhibited lower, controlled motivation. The presence of controlled motivation was associated with worse functioning, longer pain duration, and increased utilization of physiotherapy services. Although these findings suggest a link between motivational profiles and clinical outcomes, the cross-sectional design limits causal inferences. Further research is needed to explore these relationships longitudinally. TRIAL REGISTRATION: ClinicalTrials.Gov Identifier: NCT05512338 (22.8.2022, NCT05512338).
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- chronická bolest * psychologie terapie rehabilitace MeSH
- cvičení psychologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lumbalgie * psychologie terapie rehabilitace MeSH
- motivace * MeSH
- průzkumy a dotazníky MeSH
- senioři MeSH
- terapie cvičením * metody MeSH
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- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Úvod: Zlepšenie ľudského zdravia moduláciou mikrobiálnej interakcie počas všetkých fáz života je vyvíjajúci sa koncept, ktorý je čoraz dôležitejší pre spotrebiteľov, výrobcov potravín, odborníkov v oblasti zdravotnej starostlivosti a regulátorov. S rozvojom uvedených poznatkov, vedeckých dôkazov, teórií a hypotéz sa vyvíjali aj „nové“ označenia a definície základných pojmov, ktoré sú dôležité pre systémový pohľad a pochopenie významu a súčasného stavu poznatkov v tejto oblasti. Kontext: Uvádzame recentné definície základných pojmov čiastočne s ich vysvetlením, aby pomohli pediatrom lepšie sa zorientovať v rastúcom počte informácií v oblasti modulácií mikrobioty, ale tiež v rastúcom počte liečiv či výživových doplnkov, ktoré nie vždy uvádzajú relevantné a správne informácie o ich zložení a účinkoch. Viaceré z uvedených pojmov sú niekedy aj komerčne zneužívané. Záver: Pediatri, všeobecní lekári pre deti a dorast spolu s neonatológmi môžu svojimi vedomosťami a radami významne ovplyvňovať výživu novorodencov a dojčiat. K tomu neoddeliteľne patria aj základné informácie o platných definíciách a charakteristike pojmov, ktoré sa v týchto odporúčaniach používajú.
Introduction: Improving human health through the modulation of microbial interaction during all stages of life is an evolving concept that is increasingly important to consumers, food manufacturers, healthcare professionals and regulators. With the development of the aforementioned knowledge, scientific evidence, theories and hypotheses, "new" designations and definitions of basic terms were also developed, which are important for a systemic view and understanding of the meaning and current state of knowledge in this area. Context: We present recent definitions of basic terms, partly with their explanation, to help pediatricians better navigate the growing number of information in the field of microbiota modulation, but also in the growing number of drugs or nutritional supplements that do not always provide relevant and correct information about their composition and effects. Several of the mentioned terms are sometimes also commercially abused. Conclusion: Pediatricians, general practitioners for children and adolescents, together with neonatologists, can significantly influence the nutrition of newborns and infants with their knowledge and advice. Basic information about the valid definitions and characteristics of the terms used in these recommendations is integral to this.
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- fyziologie výživy kojenců MeSH
- kojenec MeSH
- lidé MeSH
- mateřské mléko chemie MeSH
- náhražky mateřského mléka analýza normy MeSH
- oligosacharidy fyziologie metabolismus normy terapeutické užití MeSH
- potravní doplňky * klasifikace normy MeSH
- střevní mikroflóra MeSH
- synbiotika * analýza klasifikace MeSH
- terminologie jako téma MeSH
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- kojenec MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
BACKGROUND: Many anti-stigma programs for healthcare workers already exist however there is less research on the effectiveness of training in skills for health professionals to counter stigma and its impacts on patients. AIMS: The objective of this study was to examine the theory base, content, delivery, and outcomes of interventions for healthcare professionals which aim to equip them with knowledge and skills to aid patients to mitigate stigma and discrimination and their health impacts. METHODS: Five electronic databases and grey literature were searched. Data were screened by two independent reviewers, conflicts were discussed. Quality appraisal was realized using the ICROMS tool. A narrative synthesis was carried out. RESULTS: The final number of studies was 41. In terms of theory base, there are three strands - responsibility as part of the professional role, correction of wrongful practices, and collaboration with local communities. Content focusses either on specific groups experiencing health-related stigma or health advocacy in general. CONCLUSIONS: Findings suggest programs should link definitions of stigma to the role of the professional. They should be developed following a situational analysis and include people with lived experience. Training should use interactive delivery methods. Evaluation should include follow-up times that allow examination of behavioural change. PROSPERO, ID: CRD42020212527.
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- lidé MeSH
- ochrana zájmů pacientů MeSH
- společenské stigma * MeSH
- zdravotnický personál * psychologie výchova MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- systematický přehled MeSH
Oral cancer is a paradigm of Slaughter's concept of field cancerization, where tumors are thought to originate within an area of cells containing genetic alterations that predispose to cancer development. The field size is unclear but may represent a large area of tissue, and the origin of mutations is also unclear. Here, we analyzed whole exome and transcriptome features in contralateral tumor-distal tongue (i.e. distant from the tumor, not tumor-adjacent) and corresponding tumor tissues of 15 patients with squamous cell carcinoma of the oral tongue. The number of point mutations ranged from 41 to 237 in tumors and from one to 78 in tumor-distal samples. Tumor-distal samples showed mainly clock-like (associated with aging) or tobacco smoking mutational signatures. Tumors additionally showed mutations that associate with cytidine deaminase AID/APOBEC enzyme activities or a UV-like signature. Importantly, no point mutations were shared between a tumor and the matched tumor-distal sample in any patient. TP53 was the most frequently mutated gene in tumors (67%), whereas a TP53 mutation was detected in only one tumor-distal sample, and this mutation was not shared with the matched tumor. Arm-level copy number variation (CNV) was found in 12 tumors, with loss of chromosome (Chr) 8p or gain of 8q being the most frequent events. Two tumor-distal samples showed a gain of Chr8, which was associated with increased expression of Chr8-located genes in these samples, although gene ontology did not show a role for these genes in oncogenic processes. In situ hybridization revealed a mixed pattern of Chr8 gain and neutral copy number in both tumor cells and adjacent nontumor epithelium in one patient. We conclude that distant field cancerization exists but does not present as tumor-related mutational events. The data are compatible with etiologic field effects, rather than classical monoclonal field cancerization theory. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
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- jazyk patologie MeSH
- lidé MeSH
- nádory jazyka * genetika MeSH
- nádory úst * patologie MeSH
- spinocelulární karcinom * patologie MeSH
- variabilita počtu kopií segmentů DNA MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
[Defibrillation from the point of view of electrophysiology]
Defibrilace je nedílnou součástí léčby maligních arytmií a doporučených postupů kardiopulmonální resuscitace. Od doby svého prvního klinického užití ve 40. letech minulého století doznala značného pokroku, miniaturizace a poznání na základě výzkumu elektrofyziologie myokardu. Vývoj poznání elektrofyziologie myokardu se opíral o řadu teorií a modelů, ale ani dnes není účinek elektrického výboje na myokard plně vysvětlen. První defibrilátory dávaly monofázický výboj, ale účinnější se později ukázaly výboje bifázické, které jsou bezpečnější z hlediska snížení energie výboje.
Defibrillation is an integral part of the treatment of malignant arrhythmias, and it is embedded in the international guidelines on cardiopulmonary resuscitation. Since its first clinical use in the 1940s, it has undergone considerable progress, miniaturization, and research-based knowledge of myocardial electrophysiology. The development of knowledge of myocardial electrophysiology was based on a number of theories and models, but even nowadays the effect of electrical shock on the myocardium is not fully explained. The first defibrillators produced a monophasic shock, but later biphasic shocks proved to be more effective and safer in terms of reducing the shock energy.
Recently deceased professor Luboslav Stárka was a world-renowned doctor who devoted his whole life to the study and therapeutic use of steroids, and was particularly interested in vitamin D. He knew from his own experience and from deep knowledge that this vitamin, one of the oldest steroids in development, must have a number of effects in addition to the undeniably positive effects on bones. He commissioned our task force to address the issues surrounding vitamin D, leading to years of studies with robust results made possible by the use of chromatography coupled with mass spectrometry (LC-MS), a so-called gold standard of measurement that is a cornerstone of recent scientific studies. This led to a whole series of scientific publications, the aim of which was to point out the possibility of using the abilities of vitamin D and thus also the gift that nature has given us.
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- chromatografie kapalinová MeSH
- hormony MeSH
- lidé MeSH
- steroidy * MeSH
- vitamin D * MeSH
- vitaminy MeSH
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- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Předsudky vůči Romům, tedy antipatie vůči členům a členkám romské menšiny, jsou v Evropě hluboce zakořeněné. Předsudky vůči Romům jsou navíc oproti předsudkům vůči jiným menšinám v České republice specifické, neboť odráží společností obecně přijímané normy o akceptovatelnosti nepřátelských postojů k Romům. Snižování předsudků vůči Romům je tak jedním z nejaktuálnějších témat nejen v českém, ale v celoevropském kontextu. Rada Evropské unie například upozorňuje na značnou diskriminaci Romů a v souvislosti s tím tvrdí, že v průběhu příštího desetiletí je nutno prosazovat politická opatření k řešení nerovností, kterými trpí většina romské populace v EU (The Council of The European Union, 2021). Navzdory své aktuálnosti je téma antigypsismu v sociální psychologii poměrně zanedbáváno, stejně jako téma meziskupinových vztahů mezi Romy a Neromy. Tato přehledová studie přináší současné poznatky o možnostech zlepšení vztahů mezi Romy s Neromy. Nejprve se zabývá psychologickým pozadím předsudků a teoriemi jejich vzniku. Hlavní část je věnována předsudkům vůči Romům a možnostem jejich snižování. Zaměřuje se především na východiska teorie meziskupinového kontaktu, jejíž účinnost byla potvrzena velkým množstvím studií. Jako jedna z dalších možností ke zlepšování meziskupinových vztahů mezi Romy a Neromy je představen normativní přístup, který byl v psychologii meziskupinových vztahů dlouhou dobu opomíjen. Závěr přehledové studie je věnován aplikačnímu potenciálu teoretických přístupů, tedy jak poznatky současného výzkumu využít v praktických intervencích. Downloads PDF Published 2023-12-30 How to Cite Koky, R., & Graf, S. (2023). Jak snižovat předsudky vůči Romům? Sociálně-psychologická perspektiva. Československá Psychologie, 67(6), 406-422. https://doi.org/10.51561/cspsych.67.6.406 Issue Vol. 67 No. 6 (2023) Section Articles License Copyright (c) 2023 Roman Koky, Sylvie Graf Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Prejudice against Roma – antipathy towards members of the Roma minority, is deeply rooted in Europe. Moreover, prejudice against the Roma is specifically compared to prejudice against other minorities in the Czech Republic, as it reflects the generally accepted norms of society regarding the acceptance of hostile attitudes towards the Roma. Reducing prejudice against the Roma is thus one of the most current topics not only in the Czech Republic but also in the European context. The Council of the European Union points out the significant discrimination against Roma and in this context calls for that promotion policies over the next decade to eliminate the inequalities of the Roma minority in the EU (The Council of the European Union, 2021). Despite its topicality, the issue of antigypsyism is relatively neglected in social psychology, as well as the topic of intergroup relations between Roma and non-Roma. In this literature review, the authors present the current knowledge on the possibilities for improving relations between Roma and non-Roma. First, the authors look at the psychological background of prejudice and theories about its origins and then devote the main section to the prejudices against the Roma and the ways in which these can be overcome. The study focuses primarily on the starting points of the theory of intergroup contact, the effectiveness of which has been confirmed by a large number of studies. As one of the other possibilities for improving intergroup relations between Roma and non-Roma, the authors present a normative approach that has long been neglected in the psychology of intergroup relations. The authors conclude the literature review focusing on the application potential of the theoretical approaches, i.e. how the findings of current research can be used in practical interventions.
Nonaqueous capillary electrophoresis (NACE) using methanol (MeOH) as a solvent of the BGEs and quantum mechanical density functional theory (DFT) have been applied to determine the thermodynamic acidity (ionization) constants (pKa ) of mono- and diaza[5]helicenes, mono- and diaza[6]helicenes, and their dibenzo derivatives in MeOH and water. First, the mixed acidity constants, pKa,MeOHmix${\rm{p}}K_{{\rm{a,MeOH}}}^{{\rm{mix}}}$ , of ionogenic pyridinium groups of azahelicenes and their derivatives in MeOH were obtained by nonlinear regression analysis of pH dependence of their effective electrophoretic mobilities. The effective mobilities were measured by NACE in a large series of methanolic BGEs within a wide conventional pH range (pHMeOH 1.6-12.0) and at ambient temperature (21-26°C) in a home-made CE device. Prior to mixed acidity constant calculation, the effective mobilities were corrected to reference temperature (25°C) and constant ionic strength (25 mM). Then, the mixed acidity constants were recalculated to the thermodynamic acidity constants pKa,MeOH by the Debye-Hückel theory of nonideality of electrolyte solutions. Finally, from the methanolic thermodynamic pKa,MeOH values, the aqueous thermodynamic pKa,H2O${\rm{p}}{K_{{\rm{a,}}{{\rm{H}}_{\rm{2}}}{\rm{O}}}}$ constants were estimated using the empirical relations between methanolic and aqueous acidity constants derived for structurally related pyridine derivatives. Depending on the number and position of the nitrogen atoms in their molecules, the analyzed azahelicenes were found to be weak to moderate bases with methanolic pKa,MeOH in the range 2.01-8.75 and with aqueous pKa,H2O${\rm{p}}{K_{{\rm{a,}}{{\rm{H}}_{\rm{2}}}{\rm{O}}}}$ in the range 1.67-8.28. The thermodynamic pKa,MeOH obtained by the DFT calculations were in a good agreement with those determined experimentally by NACE.
Prior research suggests a relationship between number of sons and maternal long-term health outcomes, including dementia. We assessed the relationship between having sons and parental cognitive aging. Specifically, we investigated the relationship between having at least 1 son and parental baseline cognition level and rate of cognitive decline, accounting for life course sociodemographic characteristics in a cohort of 13 222 adults aged ≥50 years from the US Health and Retirement Study. We included only participants with at least one child. We further explored whether this relationship varies by parental sex and whether the magnitude of the relationship increases with each additional son. Cognition was assessed biennially for a maximum of nine times as a sum of scores from immediate and delayed 10-noun free recall tests, a serial 7s subtraction test, and a backwards counting test. Associations were evaluated using linear mixed-effects models, stepwise adjusting for sociodemographic and health-related factors. In our analytic sample of parents, a total of 82.3% of respondents had at least 1 son and 61.6% of respondents were female. Parents of at least 1 son had a faster rate of cognitive decline in comparison to parents without any son. Our results also suggest that cognitive decline was faster among parents of multiple sons, compared to parents with only daughters. Thus, the results support the theory that having sons might have a long-term negative effect on parental cognition.
