triazine Dotaz Zobrazit nápovědu
[Polarographic determination of triazine herbicides]
- MeSH
- polarografie MeSH
- MeSH
- biochemická analýza krve metody přístrojové vybavení využití MeSH
- biochemické jevy účinky léků MeSH
- Cyprinidae krev růst a vývoj MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- hematologické testy metody využití MeSH
- pesticidy krev otrava škodlivé účinky MeSH
- ryby MeSH
- statistika jako téma metody MeSH
- testy akutní toxicity metody využití MeSH
- triaziny krev otrava škodlivé účinky MeSH
OBJECTIVES: Crustacea are at high risk of toxic effects of agricultural pesticides. Currently, many questions regarding the toxicity of triazine herbicides to crayfish remain unresolved. The aim of this research was to evaluate the acute toxicity of atrazine, hexazinone, metribuzine, prometryne, simazine, and terbutryne to juvenile signal crayfish (Pacifastacus leniusculus). DESIGN: Acute toxicity tests were performed in accordance with standardized guidelines for testing of chemicals, OECD no. 203, using a semistatic test system. Signal crayfish juveniles (n=672) of 49.0-81.5 mg weight and 12.8-16.0 mm total length were used for the bioassay. Mortalities were recorded daily to 96 h. Each pesticide was tested at concentrations of 1, 10, 40, 70, and 100 mg.l-1. Percent mortalities were analyzed by linear regression, and median lethal concentration (LC50) values were computed using probit analysis EKO-TOX 5.2 software. RESULTS: 96hLC50 values for juvenile signal crayfish were 12.1 mg.l-1 for atrazine, 13.9 mg.l-1 for terbutryne, 14.4 mg.l-1 for prometryne, 19.5 mg.l-1 for hexazinone, 30.6 mg.l-1 for metribuzine, and 77.9 mg.l-1 for simazine. Atrazine showed the greatest toxicity to signal crayfish. CONCLUSIONS: The present study demonstrated that triazines are toxic to signal crayfish. Signal crayfish is more sensitive than the fish for atrazine, hexazine, metribuzine, and for these triazines signal crayfish can be used as a bio-indicator of environmental contamination.
- MeSH
- chování zvířat účinky léků MeSH
- pesticidy toxicita MeSH
- pohybová aktivita účinky léků MeSH
- severní raci účinky léků fyziologie MeSH
- testy akutní toxicity MeSH
- triaziny toxicita MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: The widespread importance of the synthesis and modification of anticancer agents has given rise to many numbers of medicinal chemistry programs. In this regard, triazine derivatives have attracted attention due to their remarkable activity against a wide range of cancer cells. This evaluation covers work reports to define the anticancer activity, the most active synthesized compound for the target, the SAR and, when described, the probable MOA besides similarly considered to deliver complete and target-pointed data for the development of types of anti-tumour medicines of triazine derivatives. Triazine scaffold for the development of anticancer analogues. Triazine can also relate to numerous beneficial targets, and their analogues have auspicious in-vitro and in-vivo anti-tumour activity. Fused molecules can improve efficacy, and drug resistance and diminish side effects, and numerous hybrid molecules are beneath diverse stages of clinical trials, so hybrid derivatives of triazine may offer valuable therapeutic involvement for the dealing of tumours. OBJECTIVE: The objective of the recent review was to summarize the recent reports on triazine as well as its analogues with respect to its anticancer therapeutic potential. CONCLUSION: The content of the review would be helpful to update the researchers working towards the synthesis and designing of new molecules for the treatment of various types of cancer disease with the recent molecules that have been produced from the triazine scaffold. Triazine scaffolds based on 1,3,5-triazine considerably boost molecular diversity levels and enable covering chemical space in key medicinal chemistry fields.
- MeSH
- antitumorózní látky * farmakologie chemie terapeutické užití MeSH
- léky antitumorózní - screeningové testy MeSH
- lidé MeSH
- nádory farmakoterapie MeSH
- triaziny * farmakologie chemie terapeutické užití MeSH
- vyvíjení léků metody MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The Department of Defense has developed new explosive formulations in which traditionally used cyclic nitramines such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) have been updated with the insensitive munition (IM) 2,4-dinitroanisole (DNAN). Understanding combined degradation of both compounds at explosive-contaminated sites will allow remediation approaches that simultaneously target both contaminants. DNAN reduction in the presence of RDX was evaluated in abiotic experiments using substoichiometric, stoichiometric, and superstoichiometric concentrations of ferrous iron and anthrahydroquinone disulfonate within a pH range from 7.0 to 9.0. Biological degradation was investigated in resting cell suspensions of Geobacter metallireducens strain GS-15, a model Fe(III)-reducing Bacteria. Cells were amended into anoxic tubes buffered at pH 7.0, with initial 100 μM DNAN and 40-50 μM RDX. In both abiotic and biological experiments, the DNAN was reduced through the intermediate 2-methoxy-5-nitroaniline or 4-methoxy-3-nitroaniline to 2,4-diaminoanisole. In biological experiments, the RDX was reduced to form methylenedinitramine, formaldehyde (HCHO), and ammonium (NH4+). Cells were able to reduce both DNAN and RDX most readily in the presence of extracellular electron shuttles and/or Fe(III). DNAN degradation (abiotic and biotic) was faster than degradation of RDX, suggesting that the reduction of IMs will not be inhibited by cyclic nitramines, but degradation dynamics did change in mixtures when compared to singular compounds.
- MeSH
- anisoly MeSH
- Geobacter MeSH
- triaziny * MeSH
- železité sloučeniny * MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Spojené státy americké MeSH
The application of differential pulse polarography to elucidation of the mechanisms of electroreduction of some heterocyclic herbicides is presented, showing that modern polarographic techniques are useful in fields different from electroanalysis. The methodology is briefly exposed and the results of its application to reduction of 1,3,5-triazine and pyridine herbicides are discussed.
An efficient and simple methodology for Ullmann Cu(I)-catalyzed synthesis of di- and trisubstituted 1,3,5-triazine derivatives from dichlorotriazinyl benzenesulfonamide and corresponding nucleophiles is reported. Cations Cu(I) supported on macroporous and weakly acidic, low-cost industrial resin of polyacrylate type were used as a catalyst. The reaction times and yields were compared with traditional synthetic methods for synthesis of substituted 1,3,5-triazine derivatives via nucleophilic substitution of chlorine atoms in dichlorotriazinyl benzenesulfonamide. It was found that Ullmann-type reactions provide significantly shortened reaction times and, in some cases, also higher yields. Finally, trisubstituted s-triazine derivatives were effectively prepared via Ullmann-type reaction in a one-pot synthetic design. Six new s-triazine derivatives with potential biological activity were prepared and characterized.
- MeSH
- katalýza MeSH
- měď chemie MeSH
- molekulární struktura MeSH
- poréznost MeSH
- triaziny chemická syntéza chemie MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
The sensitivity of early life stages of marbled crayfish (Procambarus fallax f. virginalis) to chronic exposure of one out of three triazine metabolites (terbuthylazine 2-hydroxy - T2H, terbuthylazine-desethyl - TD, and atrazine 2-hydroxy - A2H) and their mixture at maximal environmentally real concentrations was evaluated under laboratory conditions. The effects were assessed on the basis of mortality, growth, development, oxidative stress biomarkers, antioxidant enzymes activity and histopathology. Single metabolites (T2H - 0.73 μg/L; TD - 1.80 μg/L; A2H - 0.66 μg/L) and their mixture were not associated with negative effects on mortality, behaviour and early ontogeny, however, two metabolites (TD and A2H) and mixtures caused significantly lower growth and significantly higher catalase activity of early life stages of marbled crayfish. No histopathological changes of gills were observed after exposure to all tested triazine treatments, however, apparent histological differences in structural cells organization such as superiority in numbers of lipid resorptive cells were recorded in after exposition to TD and mixture. In conclusion, this study shows potential risk of using triazine herbicides in agriculture due to effects of their degradation products on non-target organisms.
- MeSH
- antioxidancia metabolismus MeSH
- chemické látky znečišťující vodu metabolismus toxicita MeSH
- herbicidy metabolismus toxicita MeSH
- látky reagující s kyselinou thiobarbiturovou metabolismus MeSH
- oxidační stres účinky léků MeSH
- severní raci účinky léků růst a vývoj metabolismus MeSH
- testy toxicity MeSH
- triaziny metabolismus toxicita MeSH
- žábry účinky léků růst a vývoj metabolismus MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
