A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.

Annotation

also called granulomatous disease of childhood

DUI

D006105 MeSH Browser

CUI

M0009615

Previous indexing

Granuloma (1966-1971); Immunologic Deficiency Syndromes (1968-1971); Phagocyte Bactericidal Dysfunction (1972-1977); Phagocytosis (1966-1971)

History note

78(75); was see under PHAGOCYTE BACTERICIDAL DYSFUNCTION 1972-77

Online note

search PHAGOCYTE BACTERICIDAL DYSFUNCTION 1972-74

Public note

78; was see under PHAGOCYTE BACTERICIDAL DYSFUNCTION 1972-77