• MeSH
• Hypertension drug therapy   MeSH
• Canrenoic Acid MeSH
• Heart Diseases drug therapy   MeSH
• Pregnadienes pharmacology   MeSH
• Spironolactone pharmacology   therapeutic use   MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• vnitřní lékařství
• kardiologie

• MeSH
• Genetic Diseases, Inborn MeSH
• Genetics, Medical MeSH
• Trace Elements MeSH
• Metabolism, Inborn Errors MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• vnitřní lékařství

BACKGROUND: Limited prospective data are available on the long-term safety of darbepoetin alfa (DA) for treating anemia in children with chronic kidney disease (CKD). METHODS: In this prospective, phase IV, observational registry study, children ≤16 years of age with CKD anemia and receiving DA were observed for ≤2 years. Adverse events (AEs), DA dosing, hemoglobin (Hb) concentrations, and transfusions were recorded. RESULTS: A total of 319 patients were included in the analysis (mean age, 9.1 years), 158 (49.5%) of whom were on dialysis at study entry. Of 434 serious AEs reported in 162 children, the most common were peritonitis (10.0%), gastroenteritis (6.0%), and hypertension (4.1%). Six patients (1.9%) died (unrelated to DA). Four patients (1.3%) experienced six serious adverse drug reactions. The geometric mean DA dose range was 1.4-2.0 μg/kg/month. Mean baseline Hb concentration was 11.1 g/dl; mean values for children receiving and not receiving dialysis at baseline ranged between 10.9 and 11.5 g/dl and 11.2-11.7 g/dl, respectively. Overall, 48 patients (15.0%) received ≥1 transfusion. CONCLUSIONS: No new safety signals for DA were identified in children receiving DA for CKD anemia for ≤2 years. Based on Hb concentrations and transfusion requirements, DA was effective at managing anemia in these patients.

• MeSH
• Anemia blood   diagnosis   drug therapy   etiology   MeSH
• Biomarkers blood   MeSH
• Time Factors MeSH
• Renal Insufficiency, Chronic blood   complications   diagnosis   therapy   MeSH
• Darbepoetin alfa adverse effects   therapeutic use   MeSH
• Renal Dialysis * adverse effects   MeSH
• Child MeSH
• Hematinics adverse effects   therapeutic use   MeSH
• Hemoglobins metabolism   MeSH
• Infant MeSH
• Blood Transfusion MeSH
• Humans MeSH
• Adolescent MeSH
• Child, Preschool MeSH
• Prospective Studies MeSH
• Registries MeSH
• Risk Factors MeSH
• Age Factors MeSH
• Treatment Outcome MeSH
• Check Tag
• Child MeSH
• Infant MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Clinical Trial, Phase IV MeSH
• Multicenter Study MeSH
• Observational Study MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Europe MeSH

• MeSH
• Cyclic AMP antagonists & inhibitors   physiology   MeSH
• Glucagon physiology   MeSH
• Thyroid Diseases MeSH

• MeSH
• Addison Disease * mortality   MeSH
• Diabetes Mellitus epidemiology   MeSH
• Adult MeSH
• Endocrinology MeSH
• Glucocorticoids administration & dosage   MeSH
• Cohort Studies MeSH
• Comorbidity MeSH
• Humans MeSH
• Odds Ratio MeSH
• Survival MeSH
• Retrospective Studies MeSH
• Risk MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Overall MeSH
• Geographicals
• Sweden MeSH

• MeSH
• Addison Disease etiology   complications   physiopathology   MeSH
• Diagnosis, Differential MeSH
• Histological Techniques MeSH
• Comorbidity MeSH
• Humans MeSH
• Melanoma diagnosis   MeSH
• Melanosis diagnosis   etiology   drug therapy   classification   pathology   therapy   MeSH
• Drug-Related Side Effects and Adverse Reactions MeSH
• Pigmentation Disorders * diagnosis   etiology   drug therapy   classification   pathology   therapy   MeSH
• Mouth * pathology   MeSH
• Dental Amalgam adverse effects   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Emergency Treatment MeSH
• Internal Medicine MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• vnitřní lékařství
• urgentní lékařství

• MeSH
• Adrenoleukodystrophy genetics   MeSH
• Research Support as Topic MeSH
• Genes MeSH
• Mutation MeSH
• Publication type
• Congress MeSH

• MeSH
• ATP-Binding Cassette Transporters genetics   MeSH
• Adrenoleukodystrophy genetics   MeSH
• X Chromosome genetics   MeSH
• Genetic Linkage genetics   MeSH
• Humans MeSH
• Check Tag
• Humans MeSH

• MeSH
• Adrenoleukodystrophy diagnosis   genetics   MeSH
• Fabry Disease diagnosis   etiology   genetics   MeSH
• Genes MeSH
• Mutation MeSH
• DNA Mutational Analysis MeSH
• Metabolism, Inborn Errors diagnosis   etiology   genetics   MeSH
• Publication type
• Congress MeSH