• MeSH
• chování účinky léků   MeSH
• elektrochemie MeSH
• mozek - chemie MeSH
• neurochemie metody   MeSH
• perfuze MeSH
• psychiatrie MeSH
• Publikační typ
• kongresy MeSH
• sborníky MeSH

• Konspekt
• Psychologie

The high level of the long lasting acceleration with both an extensive gradient of the acceleration onset and vector alterations belong to the flight specificity in a cockpit of agile aircraft with high manoeuvring capabilities. In these cases the so-called push-pull (PP) effect has its particular significance. This means the tolerance decrease to the plus gravitational acceleration turns up after an exposure to the microgravity on the acceleration level between zero and +0.8 Gz or after previous action of negative acceleration values. The resulting activation of the sympathicus during plus gravitational acceleration process is up to several seconds behind time and pilot's performance is reduced. At the same time both an impairment of the threshold of the vision failure and G-LOC occur. The gravitational acceleration fatigue effect escalates, too.

• MeSH
• abdominální dekomprese MeSH
• časové faktory MeSH
• fyziologická adaptace MeSH
• kardiovaskulární detrénovanost MeSH
• krevní tlak MeSH
• letecké a kosmické lékařství MeSH
• lidé MeSH
• simulace stavu beztíže MeSH
• srdce inervace   MeSH
• srdeční frekvence MeSH
• sympatický nervový systém fyziologie   MeSH
• zrychlení MeSH
• Check Tag
• lidé MeSH

Dvojbalonová enteroskopie (push-and-pull enteroscopy) je nová metoda, která umožňuje endoskopické vyšetření celého tenkého střeva u většiny pacientů. V této technické poznámce popisujeme případ 51-letého nemocného, u kterého byla metodou dvojbalonové enteroskopie vyjmuta retinovaná endoskopická kapsle z distálního ilea. Díky tomuto výkonu (který trval 75 min.) nemusel pacient podstoupit chirurgické odstranění retinované endoskopické kapsle.

Push-and-pull enteroscopy using the double-balloon technique (double-balloon enteroscopy) enables investigation of the entire small intestine in most cases. We describe a technical note showing in a 51- year-old man with Crohn's disease that double-balloon enteroscopy can be easily used to retrieve a retained wireless capsule endoscope from the ileum and thus prevent the patient from having to undergo surgery to remove the capsule.

• MeSH
• cizí tělesa MeSH
• Crohnova nemoc MeSH
• gastrointestinální endoskopie metody   trendy   MeSH
• iatrogenní nemoci MeSH
• ileum MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• kazuistiky MeSH

• Publikační typ
• abstrakty MeSH

Global investments in the field of nanomedicine and nanotechnology drive the scientific innovations at nano level. This paper identifies the factors of Indian Healthcare which promotes (pull) and suppresses (push) the growth of nano medicine research in India. Pull factors such as shift in healthcare collaborations, strong information technology platforms, budding innovations in the field of nanomedicine and interdisciplinary approach in India’s scientific output are the potential drivers of nanomedicine research in India. Push factors highlighted the inefficiency in healthcare regulation, novel versus Generic mind and lack of political will to invest in nanomedicine research. These acknowledged push and pull factors can be helpful during health policy reforms and to plan research and development investments in India.

• MeSH
• lidé MeSH
• nanomedicína * MeSH
• veřejné zdravotnictví MeSH
• výzkum MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Indie MeSH

• MeSH
• chelátory farmakologie   MeSH
• deferoxamin MeSH
• ischemie MeSH
• kočky MeSH
• krysa rodu rattus MeSH
• reperfuzní poškození etiologie   MeSH
• retina patologie   MeSH
• volné radikály toxicita   MeSH
• zinek MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• krysa rodu rattus MeSH
• zvířata MeSH

• MeSH
• audiovizuální záznam využití   MeSH
• chirurgie trávicího traktu metody   přístrojové vybavení   využití   MeSH
• diagnostické techniky gastrointestinální klasifikace   využití   MeSH
• gastrointestinální endoskopie metody   využití   MeSH
• lidé MeSH
• miniinvazivní chirurgické výkony metody   přístrojové vybavení   využití   MeSH
• Check Tag
• lidé MeSH

The spatial organization and dynamic interactions between excitatory and inhibitory synaptic inputs that define the receptive field (RF) of simple cells in the cat primary visual cortex (V1) still raise the following paradoxical issues: (1) stimulation of simple cells in V1 with drifting gratings supports a wiring schema of spatially segregated sets of excitatory and inhibitory inputs activated in an opponent way by stimulus contrast polarity and (2) in contrast, intracellular studies using flashed bars suggest that although ON and OFF excitatory inputs are indeed segregated, inhibitory inputs span the entire RF regardless of input contrast polarity. Here, we propose a biologically detailed computational model of simple cells embedded in a V1-like network that resolves this seeming contradiction. We varied parametrically the RF-correlation-based bias for excitatory and inhibitory synapses and found that a moderate bias of excitatory neurons to synapse onto other neurons with correlated receptive fields and a weaker bias of inhibitory neurons to synapse onto other neurons with anticorrelated receptive fields can explain the conductance input, the postsynaptic membrane potential, and the spike train dynamics under both stimulation paradigms. This computational study shows that the same structural model can reproduce the functional diversity of visual processing observed during different visual contexts.SIGNIFICANCE STATEMENT Identifying generic connectivity motives in cortical circuitry encoding for specific functions is crucial for understanding the computations implemented in the cortex. Indirect evidence points to correlation-based biases in the connectivity pattern in V1 of higher mammals, whereby excitatory and inhibitory neurons preferentially synapse onto neurons respectively with correlated and anticorrelated receptive fields. A recent intracellular study questions this push-pull hypothesis, failing to find spatial anticorrelation patterns between excitation and inhibition across the receptive field. We present here a spiking model of V1 that integrates relevant anatomic and physiological constraints and shows that a more versatile motif of correlation-based connectivity with selectively tuned excitation and broadened inhibition is sufficient to account for the diversity of functional descriptions obtained for different classes of stimuli.

• MeSH
• akční potenciály fyziologie   MeSH
• kočky MeSH
• modely neurologické * MeSH
• nervový přenos fyziologie   MeSH
• nervový útlum fyziologie   MeSH
• neurony fyziologie   MeSH
• synapse fyziologie   MeSH
• zraková percepce fyziologie   MeSH
• zrakové dráhy fyziologie   MeSH
• zrakové korové centrum fyziologie   MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH

• MeSH
• chelátory železa MeSH
• chelátory MeSH
• kyselina askorbová MeSH
• měď MeSH
• paraquat toxicita   MeSH
• volné radikály MeSH
• zinek MeSH

• MeSH
• cholinesterasové inhibitory MeSH
• cholinesterasy MeSH
• dealkylace MeSH
• soman škodlivé účinky   MeSH