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RATIONALE, AIMS AND OBJECTIVES: Measuring self-reported adherence may contribute to minimizing the risk of therapy failure. Hence, the main aim of the study was to assess the psychometric properties of the Czech version of Medication Adherence Report Scale (MARS-CZ) and its appropriateness for use in long-term statin therapy where goal levels of low-density lipoprotein cholesterol (LDL-c) should be achieved. METHODS: Anonymous structured interview was performed to determine self-reported adherence by MARS-CZ in outpatients chronically treated with statins. At the same time, medication records were reviewed for inclusion of patients into groups of those who achieved and do not achieved LDL-c goal according to cardiovascular risk level. Reliability and validity of MARS-CZ were tested as well as the relationship between adherence and LDL-c goal achievement was examined. RESULTS: A total of 136 (86.6%) patients completed the interview; mean age was 66.1 years; 49.3% were male. The mean score of MARS-CZ was 24.4 and showed positive skewing. Satisfactory internal consistency (Cronbach's α=0.54), strong test-retest reliability (r=0.83, P<0.001; intra-class correlation=0.63, 95% confidence interval: 0.35-0.81) and positive correlation with eight-item Morisky Medication Adherence Scale (r=0.62, P<0.001) were indicated. Low validity values were found between MARS-CZ and 12-item Short Form Health Survey mental and physical subscales. MARS-CZ score significantly correlated with LDL-c goal achievement (P<0.05) when all patients who achieved LDL-c goal (35%) reported high adherence to statin. MARS-CZ score also correlated with cardiovascular risk level and doctor's judgments on adjusting treatment targets for each patient. CONCLUSION: This study proved MARS-CZ as an acceptable self-reported adherence measure. In routine clinical practice, MARS-CZ could be helpful to reveal medication non-adherence before the alteration of drug regimen and thereby contributing to enhancement of statin therapy management.

MeSH
adherence k farmakoterapii psychologie statistika a číselné údaje MeSH
cíle MeSH
LDL-cholesterol účinky léků MeSH
lidé středního věku MeSH
lidé MeSH
psychometrie MeSH
reprodukovatelnost výsledků MeSH
rizikové faktory MeSH
senioři MeSH
socioekonomické faktory MeSH
statiny aplikace a dávkování terapeutické užití MeSH
zdravé chování MeSH
zpráva o sobě * MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Geografické názvy
Česká republika MeSH

Článek

Farmaceut jako aktivní člen týmu pečujícího o pacienty s osteoporózou – možnosti jeho intervencí
[Pharmacist as an active member of the team caring of patients with osteoporosis – possibilities of intervention]

Praktické lékárenství. 2013 ; 9 (4-5) : 187-191.

Prakt. lékárenství
ISSN 1801-2434
Medvik
Zdroj

Osteoporóza je chronické systémové onemocnění často s bezpříznakovým průběhem. Přestože se na léčbě podílí lékaři – specialisté, bylo by velkou chybou opomenout farmaceuty. Odhalením rizikových faktorů nebo lékových problémů může farmaceut přispět k záchytu pacientů s rizikem fraktur, dále poskytovat poradenství v oblasti prevence a být nápomocen při edukaci pacientů zaměřené na dodržování léčebného plánu pacienta. Významným způsobem tak může ovlivnit výsledek terapie a minimalizovat její případná rizika včetně podpory compliance. Cílem sdělení je nastínit možnosti farmaceutické péče u pacientů s osteoporózou.

Osteoporosis is a chronic, systemic, and often asymptomatic disease. Although physician-specialists are involved in the treatment, it would be a big mistake to omit pharmacists. The pharmacist can contribute to the identification of patients at risk of fractures by revealing risk factors or drug-related problems, as well as provide advice on prevention and assist in patient education focused on adhering to the treatment plan. This may importantly influence the treatment outcomes and minimize potential risks of therapy, including the support of compliance. The aim of the paper is to outline possibilities of pharmaceutical care of patients with osteoporosis.

Abstrakt

Relative bioavailability of two molsidomine formulations in healthy volunteers

Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic. 2013 ; 157 (Supplement 1) : S28. (63. Czech and Slovak Pharmacological Days. Olomouc, September 11-13, 2013)

ISSN 1213-8118
Medvik
Zdroj

63. Czech and Slovak Pharmacological Days. 2013 ; () : S28.

Medvik
Zdroj

Publikační typ
abstrakt z konference MeSH

Článek

Severe hypoglycaemia requiring the assistance of emergency medical services - frequency, causes and symptoms

Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic. 2012 ; 156 (3) : 271-277.

Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print)
ISSN 1213-8118
Medvik
Zdroj

AIMS: To evaluate the incidence of severe hypoglycaemia (SH) requiring the assistance of Emergency Medical Services (EMS) in the general population of the Hradec Králové region, in a 1 year period; to describe the distribution of these events throughout the day, and to analyse the symptoms and causes. METHODS: The outcome data were obtained from special forms which were filled in by EMS medical staff. Incidence of SH was calculated and the distribution of events throughout the day was analysed using contingency tables. The relationship between blood glucose levels and the presence or absence of causes and symptoms of hypoglycaemia was evaluated using a general linear model and the regression tree technique. RESULTS: In all, a total of 338 events of SH were recorded in 262 patients. 150 episodes appeared in type 2 diabetic patients, 83 episodes in type 1 diabetic patients. 258 events were documented in insulin-treated patients. The incidence of SH was 2.4 and 0.4 episodes/100 patients/year for type 1 and type 2 diabetic patients, respectively. A significantly greater number of hypoglycaemic episodes was documented between 2 pm and 6 pm (P<0.001). Insulin therapy and alcohol consumption were the most dangerous causes of SH. CONCLUSIONS: Hypoglycaemia requiring the assistance of EMS represents an essential problem, especially in type 1 diabetic patients. The percentage of SH is comparable to other frequent diagnoses requiring the assistance of EMS in the region. This study reflects the behaviour of diabetic patients and highlights information which is important in the prevention of SH.