Aim: Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. Methods: Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. Results: We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. Conclusion: The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.
- MeSH
- dospělí MeSH
- inhalační expozice * škodlivé účinky MeSH
- lidé MeSH
- messenger RNA genetika MeSH
- mikro RNA * genetika MeSH
- nanočástice chemie MeSH
- nanokompozity * chemie MeSH
- oxidační stres účinky léků MeSH
- pracovní expozice škodlivé účinky MeSH
- transkriptom * účinky léků MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
V roce 2023 bylo v České republice u 6156 osob (4960 žen a 1196 mužů) hlášeno celkem 7001 profesionálních onemocnění, z toho bylo 6937 nemocí z povolání a 64 ohrožení nemocí z povolání. Incidence profesionálních onemocnění představovala 147,3 případů na 100 tisíc nemocensky pojištěných zaměstnanců v civilním sektoru, vztaženo k prvnímu pololetí 2023. Nejvíce profesionálních onemocnění bylo hlášeno z Olomouckého kraje (1065, tj. 15,2 % případů) a z Plzeňského kraje (1059, tj. 15,1 % případů). Nejčastěji onemocněli pracovníci v Sekci ekonomické činnosti Q „zdravotní a sociální péče“ (CZ-NACE Q86-89 celkem 6196, tj. 88,5 % případů). V kategorii nemocí z povolání byla nejčastěji zastoupena diagnóza COVID-19 (6285, tj. 89,8 % případů). Přitom 96,6 % onemocnění COVID-19 hlášených v tomto roce vzniklo již v letech 2020–2022. U ohrožení nemocí z povolání dominoval syndrom karpálního tunelu (55, tj. 85,9 % případů).
A total of 7,001 cases of occupation-related diseases in 6,156 persons (4,960 women and 1,196 men) were reported in the Czech Republic in 2023. Of those, 6,937 were occupational diseases and 64 cases were given the status of “endangerment by an occupational disease”. The incidence of occupational diseases was 147.3 cases per 100,000 health-insured employees in the public sector. Most of the occupational diseases occurred in the Olomouc region (1,065 cases, i.e., 15.2%) and Pilsen region (1,059 cases, i.e. 15.1%). Most of the recognized cases occurred in the economic sector Q “Health and Social Care” (CZ-NACE Q86-88 – a total of 6,196 cases, i.e. 88.5%). COVID-19 (6,285 cases, i.e. 89.8%) was the most frequently reported occupational disease. However, about 96.6% of COVID-19 cases reported this year already occurred in 2020 and 2022. The carpal tunnel syndrome predominated among the cases reported as “endangerment by an occupational disease” (55 cases, i.e., 85.9%).
- MeSH
- incidence MeSH
- lidé MeSH
- nemoci z povolání * etiologie klasifikace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (FG/100), in contrast to a significant 37.8% (p<0.05) increase of numerical aberrations caused by monosomies (p<0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.
- MeSH
- chromozomální aberace MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- malování chromozomů MeSH
- nanokompozity * toxicita chemie MeSH
- pracovní expozice * škodlivé účinky MeSH
- zubní materiály toxicita MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16.5%) were excluded because of uncertain ingestion. In 116 children (46 boys and 70 girls, mean age 2 years and 9 months ± 1 year and 1 month), the majority of children developed no symptoms (87 children, 75%, mean age 3 years±1 year) and the remaining 29 children (25%, mean age 2 years and 11 months ± 1 year and 3 months) developed only mild and spontaneously resolving symptoms of poisoning after a dose of 0.82 ± 0.32 mg/kg b.w. (range 0.26-1.82 mg/kg). In 98% of all cases, hospitalized children were observed for a maximum 24 h, and their condition did not require specific treatment. In conclusion, the prognosis for accidental dimetindene poisoning in children appears to be good and the minimum toxic dose has been determined to be 0.5 mg/kg b.w.
- MeSH
- antagonisté histaminu H1 MeSH
- dimethinden * MeSH
- dítě MeSH
- hospitalizace MeSH
- lidé MeSH
- otrava * terapie MeSH
- předškolní dítě MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016-2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019-2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers' personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01); postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.
OBJECTIVES: This study aims to present an overview of the formal recognition of COVID-19 as occupational disease (OD) or injury (OI) across Europe. METHODS: A COVID-19 questionnaire was designed by a task group within COST-funded OMEGA-NET and sent to occupational health experts of 37 countries in WHO European region, with a last update in April 2022. RESULTS: The questionnaire was filled out by experts from 35 countries. There are large differences between national systems regarding the recognition of OD and OI: 40% of countries have a list system, 57% a mixed system and one country an open system. In most countries, COVID-19 can be recognised as an OD (57%). In four countries, COVID-19 can be recognised as OI (11%) and in seven countries as either OD or OI (20%). In two countries, there is no recognition possible to date. Thirty-two countries (91%) recognise COVID-19 as OD/OI among healthcare workers. Working in certain jobs is considered proof of occupational exposure in 25 countries, contact with a colleague with confirmed infection in 19 countries, and contact with clients with confirmed infection in 21 countries. In most countries (57%), a positive PCR test is considered proof of disease. The three most common compensation benefits for COVID-19 as OI/OD are disability pension, treatment and rehabilitation. Long COVID is included in 26 countries. CONCLUSIONS: COVID-19 can be recognised as OD or OI in 94% of the European countries completing this survey, across different social security and embedded occupational health systems.
- MeSH
- COVID-19 * epidemiologie MeSH
- lidé MeSH
- nemoci z povolání * epidemiologie terapie MeSH
- postakutní syndrom COVID-19 MeSH
- pracovní expozice * škodlivé účinky MeSH
- zaměstnání MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
- Publikační typ
- abstrakt z konference MeSH
BACKGROUND: Sensory deficits can result in limitations regarding how well neuropsychological test findings can be interpreted. Only a few studies have investigated the influence of vision alteration on neuropsychological tests. In 2012 the Czech Republic experienced mass methanol poisoning. Methanol metabolites cause histotoxic hypoxia to the optic nerve. OBJECTIVE: In the current study, the effect of the toxic damage on the parts of the visual pathway on visual and non-visual neuropsychological measures was investigated using electrophysiological methods (visual evoked potential (VEP) and optical coherence tomography (OCT) with retinal nerve fibre layer (RNFL) thickness measurement. METHODS: 53 individuals who experienced methanol poisoning participated in this research (76% men; ages 24 to 74 years, mean = 43.8±14.6 years; education 11.9±1.4 years). Each participant underwent comprehensive neurological, ophthalmological, and neuropsychological examinations. RESULTS: The results of mixed-effect models revealed significant small to a medium association between the Stroop test weak interference and Grooved Pegboard with the left eye global, nasal and temporal RNFL thickness. Also, medium associations between the Finger Tapping test and the Stroop test weak interference and left eye temporal RNFL, right eye temporal RNFL, and the latency P1 of VEP in the left eye were significant. CONCLUSION: The results of this study found a small to medium association (r = .15- .33; p = .010- .046) between RNFL thickness and cognitive visual test performance. Careful interpretation is suggested regarding results obtained from visual tests of the executive or motor functioning with participants with RNFL decrease or other types of early visual processing damage.
- MeSH
- kognice MeSH
- lidé MeSH
- methanol * MeSH
- neuropsychologické testy MeSH
- přežívající MeSH
- zrakové evokované potenciály * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- hlášení nemocí statistika a číselné údaje MeSH
- lidé MeSH
- nemoci z povolání * epidemiologie MeSH
- Check Tag
- lidé MeSH
