Background: Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Aim of our work was to describemost important of them.Methods: systematically scan of available scientifi c resources.Results: Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasmavalues are elevated in individuals with heart failure and have high diagnostic effi cacy for the heart failure. Plasma valuesare also an independent prognostic factor. Preliminary fi ndings suggest that the determination of plasma cardiotrophin-1may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 also plays animportant cardioprotective eff ect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro andin vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play also an important protectiverole in other organ systems (such as hematopoietic, neuronal, developmental).Conclusion: Cardiotrophin is a newly discovered chemokin with a lot of system eff ects and is stable in systemcirculation hence permitting its development in the routine clinical investigation.
- MeSH
- akutní koronární syndrom diagnóza MeSH
- biologické markery krev metabolismus MeSH
- chemokiny diagnostické užití terapeutické užití MeSH
- cytokiny diagnostické užití terapeutické užití MeSH
- ELISA metody využití MeSH
- kardiomyocyty metabolismus účinky léků MeSH
- kardiovaskulární nemoci diagnóza MeSH
- krevní nemoci diagnóza MeSH
- lidé MeSH
- medicína založená na důkazech MeSH
- metabolický syndrom diagnóza MeSH
- nádory diagnóza MeSH
- nemoci jater diagnóza MeSH
- nemoci nervového systému diagnóza MeSH
- plicní nemoci diagnóza MeSH
- srdeční selhání diagnóza MeSH
- zánět diagnóza MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
Moderate alcohol consumption is associated with increased insulin sensitivity and a reduced risk for type 2 diabetes. An important endogenous mediator of insulin sensitivity is adiponectin (AN), an adipokine that displays numerous antiatherogenic, antidiabetogenic and antiinflammatory effects. Recently, acute increase in alcohol consumption has been shown to be associated with increase in plasma adiponectin and, concomitantly, insulin sensitivity. Whether chronic alcohol consumption predicts an increase in plasma AN and whether this is independent of adiposity, markers of liver dysfunction, and plasma adipokines such as tumor necrosis factor (TNF)-alpha is not known. We, therefore, investigated these relationships in 75 men who were diagnosed with liver steatosis using ultrasound/liver biopsy. We examined 75 men, who were diagnosed for having liver steatosis (ultrasound/liver biopsy). Each filled in a questionnaire on alcohol intake. Subjects were divided into two subgroups according to alcohol history and CDT concentrations--drinkers and non-drinkers. All individuals were examined for serum concentrations of AN, glucose, triglycerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutamate transferase (GMT) activity; carbohydrate-deficient transferrin (CDT%) a marker of chronic alcohol consumption, insulin and TNF-alpha. The Quicki insulin sensitivity index was calculated. Forty-eight individuals were found to be moderate drinkers and 27 subjects non-drinkers. Moderate drinkers had significantly higher concentrations of AN (13.8 +/- 3,7 versus 9.1 +/- 5.4 mg/l, means +/- SD, p = 0.012) compared with non-drinkers, independent of adiposity. Plasma AN concentrations in the whole group were positively correlated with TNF-alpha concentrations (r = 0.6; p = 0.0001), CDT (r = 0.26; p = 0.0084), AST/ALT index (r = 0.3, p = 0.009), AST (r = 0.29; p = 0.011) and GMT (r = 0.29; p = 0.011) and negatively with BMI (r = -0.48; p = 0.0002) and glycemia (r = -0.22; p = 0.049). The positive associations of AN with TNF-alpha (0.8; p = 0.001), CDT (0.55; p = 0.017), AST/ALT index (0.55; p = 0.019) and the negative correlation with glycemia (-0.35; p = 0.0158) were independent of BMI. Stratified according to alcohol intake, in moderate drinkers, a positive correlation was found between AN and TNF-alpha concentrations (r = 0.6, p = 0.0001, AST/ALT index (r = 0.34, p = 0.0295) whereas in non-drinkers no such correlations were found. The concentration of AN and BMI displayed a negative correlation in both drinker and nondrinker patients (r = -0.42, p = 0.01 and -0.61; p = 0.012, respectively). We concluded that plasma AN is higher in moderate drinkers compared to non-drinkers, even after correction for BMI. Drinkers suffering from liver steatosis were found to have a positive correlation between AN concentrations, laboratory markers of liver disease and TNF-alpha. Such correlation was absent in non-drinkers suffering from liver steatosis. This suggests that alcohol may modulate the inhibitory effect of TNF-alpha on AN production, and thus, increase its plasma concentrations.
- MeSH
- adiponektin krev MeSH
- alkoholické nemoci jater krev diagnóza MeSH
- biologické markery krev MeSH
- index tělesné hmotnosti MeSH
- inzulinová rezistence MeSH
- lidé MeSH
- pití alkoholu metabolismus MeSH
- ROC křivka MeSH
- senzitivita a specificita MeSH
- TNF-alfa analýza MeSH
- ztučnělá játra krev MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Aim of study was determine if a correlation exists between bone mass density and concentration of osteoprotegerin. We examined the group of 199 patients of mean age of 63 years. Of the group under study, 31 patients had normal bone density (T score > -1 and < 1) and 168 probands had osteopenia or osteoporosis (T < -1). Persons with normal BMD values had median values of OPG 60.8 ng/l, while patients with reduced bone density had median values of 73 ng/l OPG. Cut-off for reduction of bone density was 128 ng/l OPG. We demonstrated that OPG concentrations vary inversely with bone density values (correlation coefficient -0.31). These results suggest that determination of OPG could allow discrimination of individuals with normal bone density and those with reduced bone density.
- MeSH
- dospělí MeSH
- glykoproteiny metabolismus MeSH
- kostní denzita * MeSH
- lidé středního věku MeSH
- lidé MeSH
- metabolické nemoci kostí metabolismus MeSH
- osteoporóza metabolismus MeSH
- osteoprotegerin MeSH
- receptory cytoplazmatické a nukleární metabolismus MeSH
- receptory TNF MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism. RANKL may promote osteoresorption by induction of cathepsin K gene expression. The present paper summarizes the most significant data in osteoprotegerin, RANK and RANKL problems obtained.
- MeSH
- glykoproteiny fyziologie MeSH
- lidé MeSH
- ligand RANK MeSH
- membránové glykoproteiny fyziologie MeSH
- osteoklasty fyziologie MeSH
- osteoprotegerin MeSH
- protein RANK MeSH
- receptory cytoplazmatické a nukleární fyziologie MeSH
- receptory TNF MeSH
- transportní proteiny fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Leptin receptors are supposed to have signal effects and are located in most tissues in the organism but we failed to find literary data on concentration (measurement) of leptin receptors in the system circulation. We examined by the method of randomized selection the group of 20 patients with manifested atherosclerosis in whom BMI was calculated. Then we analyzed concentration of leptin receptor (double sandwich ELISA, standard recombinant human leptin), leptin, glucose, insulin, proinsulin, CRP and uric acid in the serum. The control group consisted of 103 probands without signs of atherosclerosis or other manifested diseases. The control group was subjected to determination of BMI, leptin and leptin receptor in the serum. Concentration of leptin receptor does not differ significantly between the patients with atherosclerosis and normal population. Probands with atherosclerosis showed a very close negative correlation between concentration of leptin receptor and leptinemia which is absent in normal population.
- MeSH
- arterioskleróza * krev patofyziologie MeSH
- index tělesné hmotnosti MeSH
- inzulin krev MeSH
- krevní glukóza analýza MeSH
- leptin krev MeSH
- leptinové receptory MeSH
- lidé MeSH
- náhodné rozdělení MeSH
- receptory buněčného povrchu * MeSH
- referenční hodnoty MeSH
- transportní proteiny * krev MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
78 l. : il. ; 32
Předčasný porod může být vyvolán rozvojem klinicky a častěji subklinicky probíhající infekce v plodovém vejci. Zjištění epidemiologických aspektů a diagnostických metod vede ke kauzální léčbě a tím ke snížení počtu předčasných porodů. XXX XXX XXX
- MeSH
- amnion mikrobiologie MeSH
- bakteriální vaginóza mikrobiologie MeSH
- infekční komplikace v těhotenství MeSH
- Konspekt
- Gynekologie. Porodnictví
- NLK Obory
- gynekologie a porodnictví
- gynekologie a porodnictví
- NLK Publikační typ
- závěrečné zprávy o řešení grantu IGA MZ ČR
