Objective: Photobiomodulation therapy (PBMT) applies therapeutic lasers or light-emitting diodes radiation to the surface of the body. From the medical point of view, PBMT systems have been employed for reducing pain, inflammation, and edema, promoting healing of wounds, deeper tissues and nerves, preventing tissue damage, etc. Background data: PBMT or biostimulation has a wide range of applications in maxillofacial surgery. It is known that the therapy effect using three-dimensional (3D) image was not really clear during the healing process. Materials and methods: The treatment group comprised 38 patients, 18 of them were treated with laser radiation (diode laser 808 nm) and 20 patients presented the control group. The surgery plan was monitored using cone beam computed tomography, in particular the number, shape, and size of mesiodens were registered. The effectivity of laser therapy was assessed based on immunological tests-secretory immunoglobulin A (sIgA) and lysozyme levels measured in nonstimulated saliva before and after treatment. Results: For sIgA (both in millimeters and milligrams per liter), the measurements displayed differences between pre- and postsurgery values, the postsurgery values being significantly lower than the presurgery values. In addition, interaction with the laser treatment plan was found, meaning that the laser treatment affected the sIgA levels. The decrease in sIgA levels in the control group was statistically significant. However, there was no significant change in sIgA levels in the laser group. The lysozyme trends appeared to be identical to the sIgA levels, that is, rising in the laser group and decreasing in the control group. The initial values for each group, however, go in the opposite direction. Conclusions: The study has shown that the 3D techniques and technologies in combination with therapeutic laser systems could support not only a treatment plan, but they also directly influence the process of healing and reduce inflammation. The study was carried out under clinical project No. 00064203 (FN MOTOL).

• MeSH
• Biomarkers MeSH
• Immunoglobulin A, Secretory MeSH
• Low-Level Light Therapy * methods   MeSH
• Lasers, Semiconductor MeSH
• Humans MeSH
• Muramidase MeSH
• X-Rays MeSH
• Inflammation MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Controlled Clinical Trial MeSH

OBJECTIVE: To describe effects of non-ablative erbium-doped:yttrium-aluminium-garnet (Er:YAG) laser on vaginal atrophy induced by iatrogenic menopause in the ewe. DESIGN: Animal experimental, randomised, sham and estrogen-treatment controlled study with blinding for primary outcome. SETTING: KU Leuven, Belgium. SAMPLE: Twenty-four ewes. METHODS: Menopause was surgically induced, after which the ewes were randomised to three groups receiving vaginal Er:YAG laser application three times, with a 1-month interval; three sham manipulations with a 1-month interval; or estrogen replacement and sham manipulations. At given intervals, ewes were clinically examined and vaginal wall biopsies were taken. Vaginal compliance was determined by passive biomechanical testing from explants taken at autopsy. MAIN OUTCOME MEASURES: Vaginal epithelial thickness (primary), composition of the lamina propria (collagen, elastin, glycogen and vessel content), vaginal compliance, clinical signs. RESULTS: Animals exposed to Er:YAG laser application and sham manipulation, but not to estrogens, displayed a significant and comparable increase in vaginal epithelial thickness between baseline and 7 days after the third application (69% and 67%, respectively, both P < 0.0008). In laser-treated ewes, temporary vaginal discharge and limited thermal injury were observed. Estrogen-substituted ewes displayed a more prominent increase in epithelial thickness (202%; P < 0.0001) and higher vaginal compliance (P < 0.05). None of the interventions induced changes in the lamina propria. CONCLUSIONS: Vaginal Er:YAG laser has comparable effect to sham manipulation in menopausal ewes. TWEETABLE ABSTRACT: Vaginal Er:YAG laser has comparable effect to sham manipulation in menopausal ewes #LASER #GSM #RCT.

• MeSH
• Atrophy * diagnosis   drug therapy   etiology   radiotherapy   MeSH
• Biopsy methods   MeSH
• Estrogen Replacement Therapy methods   MeSH
• Estrogens pharmacology   MeSH
• Low-Level Light Therapy * adverse effects   methods   MeSH
• Lasers, Solid-State therapeutic use   MeSH
• Menopause * MeSH
• Disease Models, Animal MeSH
• Sheep MeSH
• Vagina pathology   MeSH
• Vaginal Diseases * drug therapy   pathology   radiotherapy   MeSH
• Treatment Outcome MeSH
• Animals MeSH
• Check Tag
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH

We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a sensitivity test (Plantar test). The locomotor tests showed a significant improvement of the locomotor functions of the rats after laser treatment from the first week following lesioning, compared to the controls. The laser treatment significantly diminished thermal hyperalgesia after SCI as measured by the Plantar test. The atrophy of the soleus muscle was reduced in the laser treated rats. The histopathological investigation showed a positive effect of the laser therapy on white and gray matter sparing. Our data suggests an upregulation of M2 macrophages in laser treated animals by the increasing number of double labeled CD68+/CD206+ cells in the cranial and central parts of the lesion, compared to the control animals. A shift in microglial/macrophage polarization was confirmed by gene expression analysis by significant mRNA downregulation of Cd86 (marker of inflammatory M1), and non-significant upregulation of Arg1 (marker of M2). These results demonstrated that the combination of 808 nm and 905 nm wavelength light is a promising non-invasive therapy for improving functional recovery and tissue sparing after SCI.

• MeSH
• B7-2 Antigen genetics   metabolism   MeSH
• Antigens, Differentiation, Myelomonocytic genetics   metabolism   MeSH
• Antigens, CD genetics   metabolism   MeSH
• Rats MeSH
• Low-Level Light Therapy methods   MeSH
• Lectins, C-Type genetics   metabolism   MeSH
• Mannose-Binding Lectins genetics   metabolism   MeSH
• Locomotion MeSH
• Spinal Cord metabolism   pathology   MeSH
• Spinal Cord Injuries therapy   MeSH
• Rats, Wistar MeSH
• Receptors, Cell Surface genetics   metabolism   MeSH
• Spinal Cord Regeneration MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Child MeSH
• Herpes Simplex radiotherapy   MeSH
• Wound Healing radiation effects   MeSH
• Cicatrix prevention & control   radiotherapy   MeSH
• Skin Diseases radiotherapy   MeSH
• Low-Level Light Therapy * economics   methods   instrumentation   MeSH
• Humans MeSH
• Child, Preschool MeSH
• Primary Health Care MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Pain MeSH
• Pressure Ulcer therapy   MeSH
• Low-Level Light Therapy * methods   MeSH
• Humans MeSH
• Pain Management * methods   instrumentation   MeSH
• Check Tag
• Humans MeSH

OBJECTIVE: The goal of this investigation is to analyze the effect of therapeutic low-level laser therapy (LLLT) to have a possibility to check pain and inflammation connected with surgical removal of impacted lower third molars in general anesthesia or even phobia [not accompanied by pain or fear of dental treatment, using immunologic markers-secretory immunoglobulin A (sIgA) and lysozyme]. The healing process was also monitored by infrared thermography. BACKGROUND DATA: LLLT can accelerate the proliferation phase of healing and decrease the inflammatory reaction, but the effect is not really clear. MATERIALS AND METHODS: The treatment group comprised 213 impacted third molars (144 laser group and 74 placebo group). Laser radiation (diode laser 830 nm) was applied. The effectivity of laser therapy was evaluated based on immunological tests, that is, before and after treatment with sIgA and lysozyme in nonstimulated saliva. Thermographic examination was performed by infrared camera. RESULTS: After laser irradiation, the sIgA decreases from 546.91 mg/L (SD 354.58) to 304.91 mg/L (SD 191.96), and in the control group from 602.25 mg/L (SD 343.62) to 425.62 mg/L (SD 220.51); the differences were significant, the lysozyme value being lower. After laser therapy, the laser and placebo sides in the area of the third molars were differed in 0.2°C. CONCLUSIONS: The 830 nm wavelength penetrates to deep-seated tissues. A positive association was found between concentration of salivary sIgA and lysozyme in the saliva after LLLT application. The deep-seated wounds after wisdom teeth extraction had no effect on temperature rise in the face.

• MeSH
• Adult MeSH
• Tooth Extraction * MeSH
• Wound Healing radiation effects   MeSH
• Immunoglobulin A analysis   MeSH
• Low-Level Light Therapy methods   MeSH
• Humans MeSH
• Pain Measurement MeSH
• Adolescent MeSH
• Molar, Third surgery   MeSH
• Muramidase analysis   MeSH
• Pain, Postoperative prevention & control   MeSH
• Saliva chemistry   MeSH
• Thermography MeSH
• Treatment Outcome MeSH
• Tooth, Impacted surgery   MeSH
• Inflammation prevention & control   MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Kvantové zesilovače světla, známé jako lasery, jednoznačně posunuly vpřed řadu medicínských oborů, ale jejich místo v terapii akutní i chronické bolesti je stále nejasné. Klíčovým problémem je roztříštěnost postupů popsaných v mnoha klinických i preklinických studiích, která neumožňuje jasně stanovit jednotná kritéria. A tak zatímco je třeba léčba nízkovýkonovými lasery v české republice uznávaná a populární, v jiných zemích má pozici vědecky uznané, leč alternativní léčby a jsou i země, kde se pohybuje vysloveně v alternativní medicíně. Naše poznatky se v této oblasti v posledních letech velmi rozšířily. Přibylo nejenom studií, ale hlavně se zvýšilo řádově dávkování, objevily se nové systémy pro léčbu jak ve smyslu vysoce výkonných laserů v ordinacích, tak i přístrojů k domácímu použití u pacientů. Léčba bolesti lasery se dramaticky proměňuje a na tuto změnu musí reagovat lékařská obec, která ji aplikuje.

Quantum amplifiers of light, known as lasers, have changed a range of medical specialties dramatically, but its place in the therapy of acute and chronic pain remains unclear. The key problem is the fragmentation of the treatment strategies described in many clinical and preclinical studies, which blocks establishing of the uniform guideline. Moreover, while it is low-level laser therapy recognized in the Czech Republic, it has the position of scientifically tolerated unless alternative treatment modality; they are countries, where it is, relegated in the so-called alternative medicine. Our knowledge greatly expanded in this area in recent years. The number of studies is increased as well the dosage of light energy. Laser companies introduced new treatment systems with high-power lasers for clinics, as well home-devices used by patients. Lasers for pain management are dramatically changing, and this change must respond to the medical community, which it applies.

• MeSH
• Acute Pain radiotherapy   MeSH
• Pain * radiotherapy   MeSH
• Chronic Pain radiotherapy   MeSH
• Low-Level Light Therapy methods   MeSH
• Laser Therapy * methods   MeSH
• Lasers MeSH
• Humans MeSH
• Pain, Postoperative radiotherapy   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Antidepressive Agents therapeutic use   MeSH
• Betahistine pharmacology   therapeutic use   MeSH
• Ginkgo biloba MeSH
• Incidence MeSH
• Low-Level Light Therapy methods   MeSH
• Humans MeSH
• Nootropic Agents therapeutic use   MeSH
• Prevalence MeSH
• Risk Factors MeSH
• Plant Extracts therapeutic use   MeSH
• Aged MeSH
• Tinnitus * diagnosis   epidemiology   etiology   therapy   MeSH
• Check Tag
• Humans MeSH
• Aged MeSH
• Publication type
• Review MeSH

• MeSH
• Electrodiagnosis methods   utilization   MeSH
• Extracellular Fluid MeSH
• Head pathology   MeSH
• Neck pathology   MeSH
• Low-Level Light Therapy * methods   utilization   MeSH
• Humans MeSH
• Lymphedema * diagnosis   therapy   MeSH
• Neoplasms MeSH
• Practice Guidelines as Topic MeSH
• Check Tag
• Humans MeSH

• Keywords
• překonané Arndt-Schulzovo pravidlo, Hight Laser Intensity Therapy, Multiwave Locked System,
• MeSH
• General Surgery MeSH
• Low-Level Light Therapy * history   classification   methods   standards   instrumentation   utilization   MeSH
• Laser Therapy methods   utilization   MeSH
• Humans MeSH
• Check Tag
• Humans MeSH
• Publication type
• Newspaper Article MeSH