- MeSH
- adaptivní imunita MeSH
- dítě MeSH
- funkční potraviny MeSH
- imunomodulační látky * terapeutické užití MeSH
- infekce dýchací soustavy terapie MeSH
- klinická studie jako téma MeSH
- lidé MeSH
- Pleurotus * MeSH
- reinfekce terapie MeSH
- selen terapeutické užití MeSH
- vyvíjení léků MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Klíčová slova
- koenzym Q 10,
- MeSH
- lidé MeSH
- selen aplikace a dávkování klasifikace metabolismus terapeutické užití MeSH
- ubichinon aplikace a dávkování klasifikace metabolismus terapeutické užití MeSH
- zdraví MeSH
- Check Tag
- lidé MeSH
Selenium is an essential trace element that is crucial for cellular antioxidant defense against reactive oxygen species (ROS). Recently, many selenium-containing compounds have exhibited a wide spectrum of biological activities that make them promising scaffolds in Medicinal Chemistry, and, in particular, in the search for novel compounds with anticancer activity. Similarly, certain tellurium-containing compounds have also exhibited substantial biological activities. Here we provide an overview of the biological activities of seleno- and tellurocompounds including chemopreventive activity, antioxidant or pro-oxidant activity, modulation of the inflammatory processes, induction of apoptosis, modulation of autophagy, inhibition of multidrug efflux pumps such as P-gp, inhibition of cancer metastasis, selective targeting of tumors and enhancement of the cytotoxic activity of chemotherapeutic drugs, as well as overcoming tumor drug resistance. A review of the chemistry of the most relevant seleno- or tellurocompounds with activity against resistant cancers is also presented, paying attention to the synthesis of these compounds and to the preparation of bioactive selenium or tellurium nanoparticles. Based on these data, the use of these seleno- and tellurocompounds is a promising approach in the development of strategies that can drive forward the search for novel therapies or adjuvants of current therapies against drug-resistant cancers.
- MeSH
- antitumorózní látky * chemie farmakologie terapeutické užití MeSH
- chemorezistence MeSH
- lidé MeSH
- mnohočetná léková rezistence MeSH
- nádory * farmakoterapie MeSH
- nanočástice * MeSH
- reaktivní formy kyslíku MeSH
- selen * chemie farmakologie terapeutické užití MeSH
- telur chemie farmakologie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- antioxidancia farmakologie terapeutické užití MeSH
- glutathion * farmakologie fyziologie terapeutické užití MeSH
- kyselina askorbová * farmakologie fyziologie terapeutické užití MeSH
- lidé MeSH
- oxidační stres účinky léků MeSH
- potravní doplňky MeSH
- selen farmakologie fyziologie terapeutické užití MeSH
- vitamin E farmakokinetika farmakologie terapeutické užití MeSH
- Check Tag
- lidé MeSH
Avermectins are used in animals and humans for their broad-spectrum effects against parasites causing cytotoxicity and damage to the cellular DNA. In this study, we examined the toxicological changes of ivermectin (IVM) and doramectin (DME) with or without the co-administration of vitamin E (Vit. E) and selenium (Se). The drugs used were for animal use. Twenty-five adult male rats were divided into five groups. Group 1 (control) was given saline, Group 2 was given IVM (0.2 mg/kg b.w.), Group 3 was given IVM and Vit. E/Se (80/1.6 mg/kg b.w., respectively), Group 4 received DME (0.2 mg/kg b.w.), and Group 5 received DME and Vitamin E/Se. Both IVM and DME were given by subcutaneous injections whereas Vit. E and Se were given orally. All the treatments were given once per week throughout the eight weeks. Although the doses were off-label use, they were given in a long-term course to unveil their toxicity effects in a clear manner and the response of the amelioration. By 24-h after the 8th week, the rats were sacrificed. Their blood was sampled for the haematological and serobiochemical examinations. Histopathological changes and caspase-3 were determined in the hepatic and renal tissues. The histopathological findings showed that Vit. E and Se reduced the cellular changes induced by IVM or DME, indicating that Vit. E and Se protect against both types of avermectins, and that DME was safer than IVM. The cytotoxicity was assessed on a human embryo kidney (HEK) and skin cells by the SRB/IC50 method and AO/EB (acridine orange-ethidium bromide) staining. Both IVM and DME caused apoptosis in the cultured HEK more than in the skin cells (80% vs. 30%, respectively). The cellular apoptosis in response to the IVM was more than that of DME, and the use of Vit. E and Se reduced the cytotoxicity as observed by caspase-3, in vivo, and IC50, in vitro.
- Klíčová slova
- doramektin,
- MeSH
- anthelmintika škodlivé účinky toxicita MeSH
- antioxidancia terapeutické užití MeSH
- ivermektin * analogy a deriváty škodlivé účinky toxicita MeSH
- krysa rodu rattus MeSH
- lékové postižení jater diagnóza prevence a kontrola veterinární MeSH
- nemoci ledvin chemicky indukované prevence a kontrola veterinární MeSH
- nežádoucí účinky léčiv diagnóza prevence a kontrola veterinární MeSH
- selen terapeutické užití MeSH
- vitamin E * terapeutické užití MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- klinické zkoušky veterinární MeSH
- MeSH
- antioxidancia terapeutické užití MeSH
- beta-karoten terapeutické užití MeSH
- fytoterapie metody MeSH
- Ginkgo biloba MeSH
- imunomodulace MeSH
- karnitin nedostatek terapeutické užití MeSH
- kyselina askorbová terapeutické užití MeSH
- léčivé rostliny MeSH
- lidé MeSH
- probiotika terapeutické užití MeSH
- roční období MeSH
- selen terapeutické užití MeSH
- syndromy imunologické nedostatečnosti prevence a kontrola terapie MeSH
- ubichinon terapeutické užití MeSH
- únava * imunologie prevence a kontrola terapie MeSH
- vitamin A terapeutické užití MeSH
- vitamin E terapeutické užití MeSH
- Check Tag
- lidé MeSH
- MeSH
- dietní proteiny normy MeSH
- fyziologie výživy * MeSH
- lidé MeSH
- minerály normy terapeutické užití MeSH
- selen normy terapeutické užití MeSH
- směrnice jako téma MeSH
- vitaminy normy MeSH
- výživové doporučené dávky * trendy MeSH
- zinek normy terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Německo MeSH
- Rakousko MeSH
- Švýcarsko MeSH
- MeSH
- antioxidancia terapeutické užití MeSH
- beta-glukany MeSH
- COVID-19 * imunologie prevence a kontrola MeSH
- dieta * MeSH
- dietní proteiny aplikace a dávkování MeSH
- dietní tuky MeSH
- imunitní systém MeSH
- jídelníček MeSH
- lidé MeSH
- probiotika MeSH
- selen terapeutické užití MeSH
- vitaminy MeSH
- zinek terapeutické užití MeSH
- Check Tag
- lidé MeSH
Selén ako antioxidant priťahuje pozornosť predovšetkým vďaka svojej protirakovinovej aktivite. Tento prehľad prináša pohľad na selén a jeho zlúčeniny ako látky schopné pôsobiť proti nádorom v mäkkých tkanivách. Výsledky štúdií odhaľujú signifikantný vzťah medzi nízkou hladinou selénu v krvi a rizikom vzniku rakoviny. Selénová suplementácia je dôležitá v prevencii vzniku nádorových metastáz. V súčasnosti je snaha lepšie objasniť antikancerózny účinok selénu a poskytnúť ďalšie dôkazy terapeutického využitia doposiaľ málo preskúmaných látok obsahujúcich organické zlúčeniny selénu.
Selenium as an antioxidant has attracted attention because of its anticancer activity. This review presents a view on selenium and its compounds exerting influence against cancer in the soft tissues. The results reveal a significant strong association between a low selenium level in blood and a cancer risk. Seleno-supplementation is important in the prevention of metastatic cancer. These results help to elucidate the anticancer effect of selenium providing further evidence to exploit novel anticancer agents targeting selenium-containing organic compounds.
- MeSH
- karcinogeneze MeSH
- lidé MeSH
- nádory měkkých tkání prevence a kontrola terapie MeSH
- nádory * prevence a kontrola terapie MeSH
- selen * imunologie nedostatek terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Chronic obstructive pulmonary disease (COPD) is a slowly progressive, largely non-reversible pulmonary disease that is characterized by airflow limitation. The disease encompasses multiple structural and functional components, but inflammation is at the core of the disease affecting both the lungs and other organs. A number of studies have shown an increased oxidant burden and con-sequently increased markers of oxidative stress in the air-spaces, breath, blood and urine in patients with COPD. The presence of oxidative stress has important conse-quences for the pathogenesis of COPD. Excess reactive oxygen species (ROS) production is regarded as one of the causes of COPD, as it is known to damage tissues. As for antioxidants, there are various enzymes eliminating over-produced ROS. Superoxide dismutase (SOD) can be clas-sified into copper/zinc-SOD (CuZn-SOD), manganese-SOD (Mn-SOD) and iron-SOD (Fe-SOD), depending on differences in metals that are necessary for the activity. Trace elements such as Zn, Se, Mn, Cu and Fe are consid-ered to be essential for living organisms, and their supple-mentation effectively suppresses oxidative stress, inflam-mation and fibrosis, suggesting that the essential elements can potentially be used as therapeutic agents in the treat-ment of pulmonary inflammatory diseases. Trace elements concentrations in COPD patients are related to the role of each of the elements in the immune system.
- MeSH
- chronická obstrukční plicní nemoc * terapie MeSH
- klinická studie jako téma MeSH
- lidé MeSH
- mangan analýza krev terapeutické užití MeSH
- měď analýza krev terapeutické užití MeSH
- selen analýza krev terapeutické užití MeSH
- stopové prvky analýza krev terapeutické užití MeSH
- zinek analýza krev terapeutické užití MeSH
- Check Tag
- lidé MeSH