INTRODUCTION: Various analgesics are used to control intense headaches in patients following subarachnoid hemorrhage. In addition to pain control, it has been shown that some analgesics can affect various pathophysiological cascades. Therefore, we devised a study to assess whether the use of metamizole has a significant impact on the development of ischemic complications, hydrocephalus, and the overall outcome in patients following aneurysmal subarachnoid hemorrhage in the context of the other non-opioids and opioids effects. METHODS: In our retrospective, single-center cohort study, we enrolled 192 patients diagnosed with subarachnoid hemorrhage. We recorded their initial clinical status, comorbidities, and the daily dosage of analgesics over 14 days of hospitalization after the onset of subarachnoid hemorrhage. Using univariate and subsequent multivariate logistic regression analysis, we assessed the influence of various factors, including analgesics, on the development of delayed cerebral ischemia and hydrocephalus, as well as on 2-week and 6-month outcomes. RESULTS: Although the administration of non-opioids, in general, had no effect on the development of delayed cerebral ischemia or hydrocephalus, the use of metamizole as the main analgesic was associated with a significantly lower chance of poor outcome at both 2-weeks and 6-months, as well as the development of delayed cerebral ischemia. As opioids were indicated primarily for analgosedation in mechanically ventilated patients with poor clinical status, their usage was associated with a significantly higher chance of poor outcome, delayed cerebral ischemia, and hydrocephalus. CONCLUSION: Our results suggest that the prescription of metamizole may be associated with better outcomes and a lower chance of delayed cerebral ischemia development in patients after subarachnoid hemorrhage. Considering the retrospective nature of our study and the limited worldwide availability of metamizole due to its prohibition in some countries, our results do not demonstrate a clear benefit but rather justify the need for subsequent prospective studies.

• MeSH
• Analgesics therapeutic use   administration & dosage   MeSH
• Anti-Inflammatory Agents, Non-Steroidal * therapeutic use   administration & dosage   MeSH
• Adult MeSH
• Hydrocephalus etiology   MeSH
• Brain Ischemia drug therapy   MeSH
• Middle Aged MeSH
• Humans MeSH
• Dipyrone * therapeutic use   administration & dosage   MeSH
• Retrospective Studies MeSH
• Aged MeSH
• Subarachnoid Hemorrhage * drug therapy   complications   MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Publikace je studií, která se zaměřuje na psychoanalytickou analýzu a terapii a na téma smrti a sebevraždy. Určeno odborné veřejnosti.

• MeSH
• Jungian Theory MeSH
• Attitude to Death MeSH
• Psychoanalytic Therapy MeSH
• Psychoanalysis MeSH
• Self Concept MeSH
• Suicide MeSH

• Conspectus
• Fyzioterapie. Psychoterapie. Alternativní lékařství
• NML Fields
• psychoterapie
• psychologie, klinická psychologie
• NML Publication type
• studie

Publikace se zabývá soudním lékařstvím. Určeno studentům i odborné nelékařské veřejnosti.

• MeSH
• Police MeSH
• Jurisprudence MeSH
• Wounds and Injuries MeSH
• Forensic Medicine MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Kriminalistika
• Učební osnovy. Vyučovací předměty. Učebnice
• NML Fields
• soudní lékařství
• NML Publication type
• učebnice vysokých škol

BACKGROUND: The war in Ukraine has led to significant migration to neighboring countries, raising public health concerns. Notable tuberculosis (TB) incidence rates in Ukraine emphasize the immediate requirement to prioritize approaches that interrupt the spread and prevent new infections. METHODS: We conducted a prospective genomic surveillance study to assess migration's impact on TB epidemiology in the Czech Republic and Slovakia. Mycobacterium tuberculosis isolates from Ukrainian war refugees and migrants, collected from September 2021 to December 2022 were analyzed alongside 1574 isolates obtained from Ukraine, the Czech Republic, and Slovakia. RESULTS: Our study revealed alarming results, with historically the highest number of Ukrainian tuberculosis patients detected in the host countries. The increasing number of cases of multidrug-resistant TB, significantly linked with Beijing lineage 2.2.1 (p < 0.0001), also presents substantial obstacles to control endeavors. The genomic analysis identified the three highly related genomic clusters, indicating the recent TB transmission among migrant populations. The largest clusters comprised war refugees diagnosed in the Czech Republic, TB patients from various regions of Ukraine, and incarcerated individuals diagnosed with pulmonary TB specialized facility in the Kharkiv region, Ukraine, pointing to a national transmission sequence that has persisted for over 14 years. CONCLUSIONS: The data showed that most infections were likely the result of reactivation of latent disease or exposure to TB before migration rather than recent transmission occurring within the host country. However, close monitoring, appropriate treatment, careful surveillance, and social support are crucial in mitigating future risks, though there is currently no evidence of local transmission in EU countries.

• MeSH
• Adult MeSH
• Incidence MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Molecular Epidemiology * MeSH
• Tuberculosis, Multidrug-Resistant epidemiology   MeSH
• Mycobacterium tuberculosis * genetics   isolation & purification   MeSH
• Transients and Migrants * statistics & numerical data   MeSH
• Armed Conflicts MeSH
• Prospective Studies MeSH
• Tuberculosis * epidemiology   transmission   MeSH
• Refugees * statistics & numerical data   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH
• Slovakia MeSH
• Ukraine MeSH

• MeSH
• Cognition MeSH
• Humans MeSH
• Mind-Body Relations, Metaphysical MeSH
• Perception MeSH
• Psychophysiology * MeSH
• Spirituality MeSH
• Consciousness MeSH
• Knowledge MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Cognition MeSH
• Cognitive Science MeSH
• Humans MeSH
• Mind-Body Relations, Metaphysical MeSH
• Parapsychology MeSH
• Spirituality MeSH
• Consciousness * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Philosophy MeSH
• Humans MeSH
• Mind-Body Relations, Metaphysical MeSH
• Religion and Psychology MeSH
• Self Concept MeSH
• Spirituality MeSH
• Consciousness * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Cognition MeSH
• Humans MeSH
• Mind-Body Relations, Metaphysical MeSH
• Religion and Psychology MeSH
• Social Change MeSH
• Spirituality MeSH
• Artificial Intelligence MeSH
• Consciousness * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Quantum Theory MeSH
• Humans MeSH
• Memory MeSH
• Models, Theoretical MeSH
• Consciousness * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

Paroxysmální noční hemoglobinurie (PNH) je lionální onemocnění kmenové krvetvorné buňky charakterizované deficitem inhibitorů komplementu na povrchu buněk. Nekontrolovaná aktivace komplementu vede k intravaskulární hemoiýze erytrocytů s vysokým rizikem trombotických komplikací a k selhání kostní dřeně. Anemie a cytopenie v dalších krevních řadách patří společně s hemoglobinurií a vysokou incidencí trombotických komplikací k hlavním příznakům onemocnění. Onemocnění vede k postižení orgánů, zejména k renální insuficienci a plicní hypertenzi. V diagnostice hraje zásadní roii detekce deficitu inhibitorů pomocí průtokové cytometrie. Na PNH je třeba myslet u stavů s negativním Coombsovým testem na hemolytickou anemii, zejména se současnou cytopenií v dalších řadách, u aplastické anemie či při suspekci na myeiodysplastický syndrom a rovněž u nemocných s trombózou, zejména v atypických lokalizacích u mladších nemocných. V léčbě se používají u stavů s opakovanou těžkou hemolýzou inhibitory složky C5 a C3 komplementu. Nemocní s hypoplastickou formou PNH a selháním kostní dřeně jsou indikováni k transliantaci krvetvorných buněk, alternativou u těchto nemocných je podání kombinované imunosuprese.

Paroxysmal nocturnal hemoglobinuria (PNH) represents a clonal disorder of pluripotent hematopoietic stem cell. The disease is characterized by deficiency of complement inhibitors on the cell surface. Uncontrolled activation of complement leads to intravascular hemolysis of red blood cells with high risk of thrombotic complications. The disease is usually connected with chronic kidney disease and pulmonary hypertension. Detection of a lack of inhibitory molecules on cell surface by flow cytometry plays a crucial role in the diagnosis of the disease. PNH should be considered in all patients with Coombs negative hemolytic anemia, especially in those with combination of cytopenia in other cell lines as well as in patients with aplastic anemia or suspected myelodysplastic syndrome. PNH must be also excluded in patients with thrombotic complications, mainly in those with thrombosis occurring in atypical localizations and at a younger age. PNH patients with recurrent episodes of severe intravascular hemolysis are indicated for treatment with inhibitors of C3 or C5 part of complement. Patients with hypoplastic PNH are candidates for hematopoietic stem cell transplantation, an alternative treatment approach to these patients may be combination immune suppression.