IPOS
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Background: Patients with advanced kidney disease suffer from burdensome symptoms, which should be assessed by valid and reliable patient-reported outcome measures. This study aimed to provide a translation, cultural adaptation, and validation of the Czech version of the IPOS-r. Methods: The IPOS-r was translated to Czech and culturally adapted using cognitive interviews. During the validation phase, patients and staff in dialysis centres and outpatient renal clinics completed the IPOS-r. Internal consistency was tested with Cronbach’s alpha, its reliability via intraclass correlation coefficient for total IPOS-r score, and weighted Kappa (for test-retest and interrater reliability of individual items). Convergent validity was tested with Spearman correlation to Kidney Disease Quality of Life Survey-Short Form 1.2 (KDQOL-SF 1.2). We assessed sensitivity to change using a distribution-based approach. Results: Two sets of translators independently performed forward and backward translations of the IPOS-r. Ten patients and ten health care professionals participated in cognitive pre-testing. The sample size for validation included 88 patients (mean age 66 ± SD13.8; 58% men) who were treated with haemodialysis (70.5%), home haemodialysis (5.5%), peritoneal dialysis (3%), and conservative management (21%). Cronbach’s alpha was 0.72, and the intraclass correlation was 0.84 for test-retest reliability and 0.73 for interrater reliability. The IPOS-r correlated with KDQOL-SF 1.2 had a rho between 0.4–0.8 for most of the IPOS-r items, showing good convergent validity. The IPOS-r measure is feasible and takes 9 minutes to complete. Patients who reported a change in health status after one month demonstrated a total IPOS-r score change of eight points in both positive and negative directions. Conclusions: The process of translation and cultural adaptation of the IPOS-r was successful, and the Czech IPOS-r measure is a valid and reliable tool. The Czech IPOS-r can be used to assess symptoms in patients with advanced chronic kidney disease. Trial registration: GAUK [82121].
- Klíčová slova
- IPOS-r,
- MeSH
- chronické selhání ledvin psychologie MeSH
- kvalita života psychologie MeSH
- lidé MeSH
- nemoci ledvin * psychologie MeSH
- průzkumy a dotazníky * MeSH
- reprodukovatelnost výsledků MeSH
- validační studie jako téma MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: Patients with advanced kidney disease suffer from burdensome symptoms, which should be assessed by valid and reliable patient-reported outcome measures. This study aimed to provide a translation, cultural adaptation, and validation of the Czech version of the IPOS-r. METHODS: The IPOS-r was translated to Czech and culturally adapted using cognitive interviews. During the validation phase, patients and staff in dialysis centres and outpatient renal clinics completed the IPOS-r. Internal consistency was tested with Cronbach's alpha, its reliability via intraclass correlation coefficient for total IPOS-r score, and weighted Kappa (for test-retest and interrater reliability of individual items). Convergent validity was tested with Spearman correlation to Kidney Disease Quality of Life Survey-Short Form 1.2 (KDQOL-SF 1.2). We assessed sensitivity to change using a distribution-based approach. RESULTS: Two sets of translators independently performed forward and backward translations of the IPOS-r. Ten patients and ten health care professionals participated in cognitive pre-testing. The sample size for validation included 88 patients (mean age 66 ± SD13.8; 58% men) who were treated with haemodialysis (70.5%), home haemodialysis (5.5%), peritoneal dialysis (3%), and conservative management (21%). Cronbach's alpha was 0.72, and the intraclass correlation was 0.84 for test-retest reliability and 0.73 for interrater reliability. The IPOS-r correlated with KDQOL-SF 1.2 had a rho between 0.4-0.8 for most of the IPOS-r items, showing good convergent validity. The IPOS-r measure is feasible and takes 9 minutes to complete. Patients who reported a change in health status after 1 month demonstrated a total IPOS-r score change of eight points in both positive and negative directions. CONCLUSIONS: The process of translation and cultural adaptation of the IPOS-r was successful, and the Czech IPOS-r measure is a valid and reliable tool. The Czech IPOS-r can be used to assess symptoms in patients with advanced chronic kidney disease. TRIAL REGISTRATION: GAUK [82121].
- MeSH
- kvalita života * psychologie MeSH
- lidé MeSH
- nemoci ledvin * psychologie MeSH
- průzkumy a dotazníky MeSH
- psychometrie MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- srovnání kultur MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: Outcome measurement is an essential part of the evaluation of palliative care and the measurements need to be reliable, valid and adapted to the culture in which they are used. The Integrated Palliative Outcome Scale (IPOS) is a widely used tool for assessing personal-level outcomes in palliative care. The aim of this study was to provide Czech version of IPOS and assess its psychometric properties. METHODS: Patients receiving palliative care in hospice or hospitals completed the IPOS. The reliability of Czech IPOS was tested with Cronbach alpha (for internal consistency), the intraclass correlation coefficient for total IPOS score and weighted Kappa (for test-retest reliability of individual items). Factor analysis was used for elucidating the construct (Exploratory Factor Analysis). Convergent validity was tested with correlation analysis (Spearman correlation) in a part of the sample, who completed also the Edmonton Symptom Assessment System (ESAS) and the Palliative Performance Scale (PPS). RESULTS: The sample consisted of 140 patients (mean age 72; 90 women; 81% oncological disease). The Cronbach alpha was 0.789; intraclass correlation was 0.88. The correlations of IPOS with ESAS was R = 0.4 and PPS R = - 0.2. Exploratory factor analysis revealed a 2-factor solution on our data. The first factor covers emotional and information needs and the second factor covers physical symptoms. CONCLUSION: Czech IPOS has very good reliability regarding both internal consistency and test-retest reliability. Together with an item analysis results, we can conclude that the Czech adaptation of the tool was successful. The convergent validity needs to be assessed on the larger sample and the proposed 2-factor internal structure of the questionnaire has to be confirmed by using CFA.
- MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče normy statistika a číselné údaje MeSH
- kvalita života psychologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- paliativní péče metody normy statistika a číselné údaje MeSH
- průzkumy a dotazníky MeSH
- psychometrie přístrojové vybavení metody normy MeSH
- reprodukovatelnost výsledků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Česká republika MeSH
PURPOSE: Despite the current guidelines supporting open communication about serious news, the evidence about the impact of prognostic awareness on the quality of life in cancer patients is not clear. The aim of this study was to assess the association between quality of life and prognostic awareness in patients with advanced cancer. METHODS: This was a cross-sectional study which involved patients (n = 129) with incurable advanced cancer (estimated by oncologist using 12-month surprise question). Data were collected at oncology departments at 3 hospitals using structured interview in which patients were asked about their quality of life (using Integrated Palliative Outcome Scale-IPOS and a single-item global measure), prognostic awareness, information needs and demographics. RESULTS: Only 16% of the sample was completely aware of prognosis and 57% was partially aware. Accurate prognostic awareness was significantly associated (p = 0.02) with lower level of quality of life between (when measured by both the IPOS and the single-item scale) patients with accurate prognostic awareness (M = 37.1; 10.4) and partially aware (M = 31.9; 9.1) and unaware patients (M = 30; 7.4). Detailed analysis showed that significant difference between groups was found only for physical symptoms subscales (p = 0.002), not for emotional and communication subscales. CONCLUSION: Prognostic awareness was found to be negatively associated with physical domain of quality of life, but not with emotional and communication domains. More research is needed on personality factors that might influence the development of prognostic awareness and quality of life.
- MeSH
- kvalita života * psychologie MeSH
- lidé MeSH
- nádory * psychologie MeSH
- paliativní péče MeSH
- prognóza MeSH
- průřezové studie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
... and WHO 12 -- 2.8 IPOS Project on Dose-Response Modelling 12 -- 2.9 Joint FAO/WHO Project to Update the ...
WHO technical report series, ISSN 0512-3054 928
viii, 157 s. : il., tab. ; 24 cm
Práce dokladuje vývoj proočkovanosti dětské populace a možné dopady na výskyt a incidenci invazivních pneumokokových onemocnění v České republice. Využívá i dat o výskytu invazivních pneumokokových onemocnění (IPO) získaných z celorepublikového programu surveillance IPO, který probíhá v souladu s Metodickým návodem z roku 2008 a Vyhláškou č. 275/2010. Systém má k dispozici data za tříleté období sledování. Práce porovnává incidenci IPO s daty o proočkovanosti dětské populace se zaměřením se na kategorii dětí do 1 roku věku za období roku 2008, 2009 a 2010.
The paper documents the development of vaccination rate of the paediatric population and incidence of invasive pneumococcal diseases in the Czech Republic. It also avails of data on the occurrence of invasive pneumococcal diseases (IPO) obtained from the national IPO surveillance programme in compliance with the 2008 Methodological Guideline and Decree No 275/2010. The system consists of data from three years of monitoring. The paper compares IPO incidence with data on the vaccination rate of the paediatric population, focusing upon the category of children up to 1 year of age for the period of 2008, 2009, and 2010.
- Klíčová slova
- proočkovanost, invazivní pneumokoková onemocnění,
- MeSH
- dítě MeSH
- dobrovolné programy ekonomika organizace a řízení MeSH
- hodnocení programu statistika a číselné údaje MeSH
- incidence MeSH
- interpretace statistických dat MeSH
- lidé MeSH
- novorozenec MeSH
- očkovací programy organizace a řízení statistika a číselné údaje MeSH
- pneumokokové infekce epidemiologie prevence a kontrola MeSH
- pneumokokové vakcíny terapeutické užití MeSH
- retrospektivní studie MeSH
- sběr dat MeSH
- vakcinace statistika a číselné údaje trendy MeSH
- zdravotní pojištění MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
Invazívne pneumokokové ochorenia (IPO) a pneumónie získané v komunite (CAP), vyvolané Streptococcus pneumoniae, zvyšujú morbiditu a mortalitu u starších pacientov. Najvýznamnejší pokrok v znížení mortality pri IPO a CAP bol dosiahnutý zavedením očkovania proti pneumokokovi. V súčasnosti sú dostupné dve pneumokokové vakcíny: 23-valentná polysacharidová pneumokoková vakcína (PPV23) a 13-valentná konjugovaná pneumokoková vakcína (PCV13). Obe vakcíny pokrývajú väčšinu pneumokokových sérotypov zodpovedných za patogenézu CAP. V súčasnosti niekoľko štúdií naznačuje, že očkovanie, najmä pneumokokovými vakcínami, môže mať ochranný účinok proti symptomatickým formám COVID-19 a súvisiacej smrti.
Invasive pneumococcal disease (IPO) and community-acquired pneumonias (CAP) caused by Streptococcus pneumoniae increase morbidity and mortality in the elderly. The most significant progress in the fight to reduce the mortality of IPO and CAP has been achieved mainly through the introduction of pneumococcal vaccination. There are currently available two pneumococcal vaccines: a 23-valent pneumococcal simple polysaccharide vaccine (PPV23), and a 13-valent pneumococcal conjugate vaccine (PCV13). Both vaccines cover the majority of the Pneumococcus serotypes involved in CAP pathogenesis. Currently, some recent studies suggest that vaccination, particularly with pneumococcal vaccines, may have a protective effect against symptomatic forms of COVID-19 and related death.
Východiska. Jednou z nejčastějších psychických poruch vyskytujících se u drogově závislých je porucha osobnosti. Jedno z možných vysvětlení je předpoklad existence osobnostní psychopatologie, která zvyšuje riziko vzniku závislosti. Východiskem pro naši práci je Kernbergův koncept hraniční organizace osobnosti, podle kterého můžeme hodnocením dimenzí obranné mechanismy, integrace identity a schopnosti testování reality zjistit závažnost osobnostní psychopatologie a tím i možný výskyt poruchy osobnosti. Cíle. Cílem práce bylo popsat osobnostní organizaci podle Kernberga u jednotlivých typů závislostí, na jejímž základě bychom mohli předpokládat míru závažnosti osobnostní psychopatologie. Nad rámec výzkumných hypotéz jsme se zabývali také analýzou vztahů mezi dotazníky, které by podpořily Kernbergův koncept. Metody. Výzkum byl proveden pomocí dotazníkového šetření. Pro zjištění daných dimenzí jsme použili Kernbergovu metodu IPO, která byla doplněna testy IPDE, DSQ-40 a BPQ. Soubor | Celkem je do výzkumu zahrnuto 211 probandů, které jsme rozdělili podle primární závislosti na alkoholovou závislost, drogovou závislost, patologické hráčství a kombinovanou závislost. Výsledky. Z výsledků můžeme pozorovat u různých typů závislosti rozdíly ve struktuře osobnosti podle Kernbergovy koncepce. Nejnižší úroveň osobnostní organizace se objevuje u kombinovaných závislostí. Nejvyšší úroveň osobnostní organizace se objevuje naopak u alkoholové závislosti. Sledujeme také signifikantní korelace mezi metodou IPO a ostatními metodami. Závěry. Na základě výsledků můžeme uvažovat nad větší závažností osobnostní psychopatologie u kombinované závislosti a u patologického hráčství a v nižší míře také u drogové závislosti oproti alkoholové závislosti.
Background. Personality disorders are common mental health conditions among drug-dependent individuals. This may be due to an underlying personality psychopathology which increases the risk of the development of addiction. Our work was based on Kernberg's concept of borderline personality organisation, which proposes that the severity of the personality psychopathology and, accordingly, the possible presence of a personality disorder can be established by means of the evaluation of the Defence Mechanisms, Identity Integration, and Reality Testing Ability dimensions. Aims. The objective of this research project was to describe the personality organisation according to Kernberg for different types of addiction for potential use in estimating the severity of the personality psychopathology. In addition to research hypotheses, we examined whether Kernberg's concept may be supported by relationships between the questionnaires used. Methods. The research involved a questionnaire survey. The measures of the dimensions were obtained using Kernberg's IPO method, complemented with the administration of the IPDE, DSQ-40, and BPQ tests. Sample | The research sample included a total of 211 participants. According to their primary addiction, the participants were divided into four categories: alcohol addiction, drug addiction, pathological gambling, and multiple addiction. Results. The results suggest differences in the personality structure according to Kernberg for each type of addiction. The lowest level of personality organisation was found in multiple addictions. Conversely, the highest level of personality organisation was shown for alcohol addiction. We also identified significant correlations between the IPO questionnaire and other psychometric instruments which support Kernberg's theory. Conclusions. The results suggest a higher rate of borderline signs and a greater severity of personality psychopathology in people with multiple addiction, pathological gambling, and, to a lesser degree, drug addiction in comparison with alcohol-dependent individuals
Východisko. Reaktivní formy kyslíku se významně uplatňují v pařogenezi experimenřální adriamycinové nehropafie. Cyklosporin A (CsA) snižuje proteinurii u nefrofického syndromu, ale zároveň zvyšuje lipoperoxidaci (LPO), která se může uplatňovat v patogenezi cyklosporinové nefrotoxicity. Metody. Sledovali jsme proto vliv léčby CsA u laboratorních potkanů s adriamyánovou neřropatií na lipoperoxidaci a aktivitu antioxidačního enzymu - superoxiddismutózy (SOD). Laboratorní potkaryi byli rozdíěler]i do 4 skupin: K - konřroly, A - zvířata s nefrotickým syndromem (jednorázové i.v. podání adriamycinu), CsA (denní i.p. podávání cyklosporinu A) a ACsA - zvířata s nefrotickým syndromem léčena CsA. Lipoperoxidoce byla stanovována pomocí reakce kyseliny řhiobarbifurové s malondialdehydem (MDA) v krvi a v homogenáfu ledvin pomocí spekřrofotometrickéfio stanovení a stanovení vysokoúčinnou kapalinovou chromařografií (HPLC). Aktivita SOD V erytrocytech byla stanovována modifíkovanou Sunovou metodou. Závér. Lipoperoxidoce stimulovaná cyklosporinem A může být účinně potlačována zvýšenou aktivitou antioxidačního enzymu SOD. Snížení proteinurie u laboratorních potkanů léčených CsA u nefrotického syndromu múze být zprostředkováno i aktivizací antioxidačních enzymů chránících glomeruly před působením volných radikálů tvořených adriamycinem.
Backgrounds. Reactive oxygen species ore supposed to ploy on important role in the pathogenesis of experimental odriamycine nephropothy. Cyclosporine A (CyA) was shown to reduce proteinuria in nephrotic syndrome, but its use may be limitedy by nephrotoxicity which may be, at least partially, mediated by increased lipid peroxidation (LPO). Methods. So we studied the influence of CyA treatment of rats with adriamycme nephropathy on the IPO and activity of antioxidant enzyme - superoxide dismutose (SOD). Rats were subdivided into 4 groups: C - control rats, A - nephrotic rats (i.v. single dose of adriamycine), CsA (daily i.p. application of cyclosporine A) and ACsA - nephrotic rats treated by cyclosporine A. LPO was asessed by thiobarbituric acid reaction with malondialdehyde (MDA) in blood and kidney homogenotes by spectrophotometric and HPLC assays. SOD activity in erythrocytes was determined by modified Sun's method. Conclusions. Lipid peroxidation stimulated by cycloporine A may be effectively counteracted by the stimulation of antioxidant enzyme SOD. Reduction of proteinuria in CyA treated rats with odriamycine nephropa^y could be at least partially explained by the mobilisation of antioxidant enzymes preventing glomeruli from damage caused by reactive oxygen species whose formation is induced by adriamycine.
