Lamina Dotaz Zobrazit nápovědu
Mnohopočetný myelóm je 2. najčastejšie vyskytujúce sa nádorové ochorenie krvi. V typickom prípade dochádza k infiltrácii kostnej drene nádorovými plazmatickými bunkami, tvorbe monoklonálnych protilátok a tvorbe osteolytických kostných ložísk. Vyskytujú sa i menej typické, kožné formy myelómu. Výskyt metastázy mnohopočetného myelómu do lamina interna praeputii penis prezentovaného v našej kazuistike patrí medzi raritné nálezy. Správanie sa nádoru ako i hojenie operačnej rany v tejto lokalizácii bolo bez akýchkoľvek komplikácií. Napriek tomu výskyt kožnej metastázy je predzvesťou zhoršenia celkového ochorenia.
Multiple myeloma is a progressive hematologic disease. It is a plasma cell, an important part of the immune system that produces immunoglobulins to help fight infection and disease. Multiple myeloma is characterized by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin or Bence-Jones protein. A 77-year-old male patient presented with a 3- year history therapy bone form multiple myeloma with finding fibrousus deposit into lamina interna praeputii penis. The tumor was removed surgicaly. Histologic results: metastatic multiple myleoma into dermis. This localization is very rare. Occurence cutaneous form multiple myeloma is prognostic worsen disease.
- MeSH
- lidé MeSH
- metastázy nádorů MeSH
- mnohočetný myelom epidemiologie MeSH
- nádory penisu chirurgie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Lamina termínalis je anatomická struktura, která znovu přitahuje pozornost neurochirurgů. Současná komplexní léčba subarachnoideálního krvácení po rupture aneuryzmatu je typickou týmovou spoluprací, která je založena na principu neustálé dostupnosti moderních zobrazovacích metod, standardní mikrotechniky, endovaskulární léčby a dokonalé péče pooperační. Snížení výskytu chronického hydrocefalu po SAH díky fenestraci lamina terminalis bylo v posledních letech opakovaně referováno. Precizní znalosti anatomických vztahů a mikroanatomických pomeru, získané studiemi na kadaverech a overené v průběhu operací, jsou nezbytné pro širší klinickou aplikaci. Autoři referují o makroanatomických vztazích, zaměřených především na anatomickou definici lamina terminalis a zabývají se neurovaskulárními závislostmi této krajiny. V histologických nálezech sledovali přítomnost neurální, vaskulární a neurosekrekční tkáně. Data byla ověřená studií 24 kadaverů. Peroperačně byla lamina terminalis otevřena u více než 40 pacientů.
The lamina terminalis is an anatomical structure that has again attracted the attention of neurosurgeons. The present complex treatment of SAH caused by a rupture of an intracranial aneurysm is a typical teamwork based on the accessibility of modern diagnostic methods, microsurgical and endovascular techniques and good postoperative care at ICUs. The reduced incidence of post SAH hydrocephalus due to opening the lamina terminalis has been published recentlv. Excellent knowledge of anatomical and micro-anatomical relationships acquired at cadaver dissections and verified during operations is necessary for a wider clinical application. The authors have reported about macro-anatomical relationship focused on the anatomical definition of lamina terminalis and dealt with the neurovascular dependences of this region. They have observed neural. vascular and neurosecretory tissues in histological findings. The data were verified by studying 24 cadavers. The lamina terminalis were opened in more than 40 operations.
- MeSH
- discus nervi optici anatomie a histologie patologie MeSH
- glaukom s otevřeným úhlem diagnóza komplikace MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- hodnotící studie MeSH
- MeSH
- autolýza MeSH
- embryonální struktury MeSH
- epitel embryologie MeSH
- larynx embryologie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- MeSH
- elektrofyziologie MeSH
- hmyz fyziologie MeSH
- svaly MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
The nuclear lamina supports many functions, including maintaining nuclear structure and gene expression control, and correct spatio-temporal assembly is vital to meet these activities. Recently, multiple lamina systems have been described that, despite independent evolutionary origins, share analogous functions. In trypanosomatids the two known lamina proteins, NUP-1 and NUP-2, have molecular masses of 450 and 170 kDa, respectively, which demands a distinct architecture from the ∼60 kDa lamin-based system of metazoa and other lineages. To uncover organizational principles for the trypanosome lamina we generated NUP-1 deletion mutants to identify domains and their arrangements responsible for oligomerization. We found that both the N- and C-termini act as interaction hubs, and that perturbation of these interactions impacts additional components of the lamina and nuclear envelope. Furthermore, the assembly of NUP-1 terminal domains suggests intrinsic organizational capacity. Remarkably, there is little impact on silencing of telomeric variant surface glycoprotein genes. We suggest that both terminal domains of NUP-1 have roles in assembling the trypanosome lamina and propose a novel architecture based on a hub-and-spoke configuration.
The nuclear lamina represents a multifunctional platform involved in such diverse yet interconnected processes as spatial organization of the genome, maintenance of mechanical stability of the nucleus, regulation of transcription and replication. Most of lamina activities are exerted through tethering of lamina-associated chromatin domains (LADs) to the nuclear periphery. Yet, the lamina is a dynamic structure demonstrating considerable expansion during the cell cycle to accommodate increased number of LADs formed during DNA replication. We analyzed dynamics of nuclear growth during interphase and changes in lamina structure as a function of cell cycle progression. The nuclear lamina demonstrates steady growth from G1 till G2, while quantitative analysis of lamina meshwork by super-resolution microscopy revealed that microdomain organization of the lamina is maintained, with lamin A and lamin B microdomain periodicity and interdomain gap sizes unchanged. FRAP analysis, in contrast, demonstrated differences in lamin A and B1 exchange rates; the latter showing higher recovery rate in S-phase cells. In order to further analyze the mechanism of lamina growth in interphase, we generated a lamina-free nuclear envelope in living interphase cells by reversible hypotonic shock. The nuclear envelope in nuclear buds formed after such a treatment initially lacked lamins, and analysis of lamina formation revealed striking difference in lamin A and B1 assembly: lamin A reassembled within 30 min post-treatment, whereas lamin B1 did not incorporate into the newly formed lamina at all. We suggest that in somatic cells lamin B1 meshwork growth is coordinated with replication of LADs, and lamin A meshwork assembly seems to be chromatin-independent process.
- MeSH
- Cricetulus MeSH
- interfáze * MeSH
- jaderná lamina chemie metabolismus MeSH
- kultivované buňky MeSH
- lidé MeSH
- myši MeSH
- prasata MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
