- MeSH
- Electroencephalography MeSH
- Evoked Potentials MeSH
- Humans MeSH
- Brain physiology MeSH
- Visual Perception MeSH
- Check Tag
- Humans MeSH
- MeSH
- Child MeSH
- Adult MeSH
- Electrophysiology MeSH
- Evoked Potentials MeSH
- Physical Stimulation MeSH
- Middle Aged MeSH
- Humans MeSH
- Ocular Physiological Phenomena MeSH
- Eye MeSH
- Developmental Biology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
Neuroborreliosis is a form of borreliosis that affects the central and/or peripheral nervous system. Although it can mimic neurologic and ophthalmologic disorders such as multiple sclerosis and optic neuritis, visual evoked potential (VEP) examination is usually not used in neuroborreliosis diagnostics. Combined VEP testing (pattern-reversal VEPs and VEPs produced in response to linear and radial motion) was performed in 81 patients with neuroborreliosis verified by laboratory results (positive polymerase chain reaction or intrathecal antibodies production). Thirty-four patients reported diplopia or blurred vision related to borreliosis. In 33 (40%) patients the VEPs were delayed: motion-onset VEPs were pathologic in 22 (27%) patients, reversal VEPs in 5 (6%) patients, and both VEP types in 6 (7%) patients. The findings suggest that VEP testing (especially the motion-onset VEP testing) can confirm CNS involvement. Much higher sensitivity of motion-onset VEPs in comparison with reversal VEPs can result from rather selective (earlier) involvement of the magnocellular system or the dorsal stream of the visual pathway.
- MeSH
- Borrelia MeSH
- Adult MeSH
- Financing, Organized MeSH
- Middle Aged MeSH
- Humans MeSH
- Linear Models MeSH
- Lyme Neuroborreliosis diagnosis physiopathology MeSH
- Reaction Time physiology MeSH
- Retrospective Studies MeSH
- Pattern Recognition, Visual physiology MeSH
- Motion Perception physiology MeSH
- Evoked Potentials, Visual physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
Úvod: Stanovení habituace (redukce odpovědi na opakovaný podnět) pomocí amplitudy zrakových evokovaných potenciálů (Visual Evoked Potentials, VEP) se běžně neužívá, představuje tudíž inovativní metodiku VEP s potenciálem pro výzkumné aplikace napříč neurovědními obory. Cíl: Cílem této studie bylo ověřit použitelnost VEP pro stanovení habituace a prozkoumat, který typ zrakového podnětu (pohybový nebo strukturální s nízkým či vysokým kontrastem) je v daném případě nejvýtěžnější. Metodika: Testován byl soubor 12 zdravých dobrovolníků (9 žen, 3 muži) ve věku 22 až 39 let pomocí tří druhů VEP – s užitím reverzačního stimulačního podnětu (Pattern Reversal VEP, PR-VEP) s kontrastem 14, resp. 85 % a stimulace pohybem (Motion-onset VEP, M-VEP). VEPs byly snímány v pěti blocích o 60 odpovědích. Výsledky: Hodnocena byla změna amplitudy hlavních komponent jednotlivých typů VEP. Přes vysokou variabilitu výsledků jsme zjistili, že s výjimkou vysokého kontrastu statisticky významně souvisel faktor času s amplitudami VEPs (ANOVA s opakováním). Při srovnávání průměrných amplitud prvního a druhého bloku VEPs s pátým jsme nalezli statisticky menší amplitudy pro M-VEPs. U reverzační stimulace byl pokles statisticky významný pouze při srovnání druhého a pátého bloku (Wilcoxonův párový test). Závěr: M-VEP se jeví jako výhodnější pro studie s habituací ve srovnání s PR-VEP.
Introduction: Assessment of habituation (reduced response to repeated stimuli) using visual evoked potential (VEP) amplitudes represents an innovative and so far infrequent application of VEP that, nevertheless, has a potential to be used in research across all disciplines of neuroscience. Objective: The aim of this study was to verify applicability of VEP in assessing habituation and to identify types of visual stimuli (motion versus structural with low or high contrast) that would be the most useful in specific cases. Methods: A study group of 12 healthy volunteers (9 women, 3 men) aged 22–39 years was tested using three kinds of VEP – Pattern Reversal VEP (PR-VEP) with 14% and 85% luminance contrasts, respectively, and Motion-onset VEP (M-VEP). VEPs were recorded in 5 blocks of 60 responses. Results: The study evaluated amplitude variations of the main components of each type of VEP. Despite high variability in the results and with an exception of the high contrast stimulus, a statistically significant association was found between the time factor and VEP amplitudes (repeated measures ANOVA). Comparison of the mean amplitude of the first and second block of VEPs with the fifthrevealed statistically smaller amplitudes for the M-VEPs. In the pattern reversal stimulation, the amplitude drop was only statistically significant when comparing the second and the fifth block (Wilcoxon paired test). Conclusion: M-VEP, as opposed to PR-VEP, seems more suited for the study of habituation.
- MeSH
- Time Factors MeSH
- Adult MeSH
- Habituation, Psychophysiologic * physiology MeSH
- Humans MeSH
- Young Adult MeSH
- Statistics, Nonparametric MeSH
- Pilot Projects MeSH
- Reaction Time MeSH
- Pattern Recognition, Visual physiology MeSH
- Motion Perception physiology MeSH
- Evoked Potentials, Visual * physiology MeSH
- Visual Cortex physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
A rapid checkerboard pattern change is used to elicit pattern-reversal visual evoked potentials (PR VEPs). CRT or LCD monitors do not allow immediate reversal of the entire pattern. The study aimed to construct a new stimulator whose characteristics approximate an instantaneous reversal and verify whether the improvement is reflected in PR VEPs. A new stimulator using a matrix of 12 × 48 independent white square LEDs was designed and compared with LCDs and CRTs. The effect on the PR VEP peak times and amplitudes of N70, P100, and P140 waves was evaluated in ten subjects. The LED stimulator showed significantly better performance in the rate of change of illuminance, change of pattern, luminance settling and stability. The PR VEP amplitudes of N75, P100, and N140 did not show significant differences. The sum of interpeak amplitudes was significantly larger for the LCD than for the other monitors. The peak times of the waves evoked by the LED were shorter than those evoked by the LCD and CRT for the N75 wave and a check size of 30 ́. LED stimulators are a better alternative to CRTs for PR VEPs than current LCDs. LEDs also seem to be better than CRTs, but further research is necessary to obtain significant results.
- Publication type
- Journal Article MeSH
