ejaculate
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Předčasná ejakulace je jednou z běžných sexuálních poruch mužů. V naší studii jsme se zaměřili na předčasnou ejakulaci jako možný problém celého sexuálního páru. Hodnotili jsme možný vliv předčasné ejakulace mužů na vznik sexuální dysfunkce u jejich partnerek a následné odstranění této ženské dysfunkce pouze léčbou mužů. Z 95 párů bylo do pilotní studie zařazeno 50 párů, které splnily daná kritéria na základě diagnostických nástrojů. U mužů byla potvrzena předčasná ejakulace, u žen sexuální dysfunkce, jejímž zdrojem byla pouze předčasná ejakulace. Výsledky škály Arizona Sexual Experience Scale-Male a Female vykazují Spearmanovu korelaci před léčbou (R = 0,68) a po 6 měsících léčby (R = 0,90). Dále jsme potvrdili vztah mezi Arizona Sexual Experience Scale-Female a Female Sexual Function Index před léčbou (R = 0,42) a po léčbě (R = 0,59). Všechna data byla potvrzena Mannovým-Whitneyovým testem. Výsledky naší pilotní studie poukazují na málo prozkoumaný fakt, že předčasná ejakulace není pouze problémem mužů, ale může se stát následným sexuálním problémem celého páru. Výsledky této pilotní studie představují důležité zjištění o pozitivním účinku léčby mužů s předčasnou ejakulací na následnou sexuální dysfunkci jejich sexuálních partnerek.
Premature ejaculation is one of the common sexual disorders of men. In our study we focused on premature ejaculation as a possible problem for the entire sexual couple. We evaluated the possible effect of men premature ejaculation on the development of sexual dysfunction in their wives and the subsequent elimination of this female dysfunction if only men are treated. Out of 95 couples, 50 couples who met the given criteria based on the diagnostic tools were included in the pilot study. In men, premature ejaculation was confirmed, in women, sexual dysfunction, the source of which was only premature ejaculation. Results of the Arizona Sexual Experience Scale-Male and Female relationship are characterized by Spearman’s correlation before treatment (R = 0.68), after 6 months of treatment (R = 0.90). Furthermore, we confirmed the relationship between Arizona Sexual Experience Scale-Female and Female Sexual Function Index before treatment (R = 0.42) and after treatment (R = 0.59). All data were confirmed by the Mann-Whitney test. The results of our pilot study point to the little-explored fact that premature ejaculation is not only a problem for men, but can also form a subsequent sexual problem for the couple as a whole. The results of this pilot study represent important findings regarding the positive effect of treatment of men with premature ejaculation on the resulting sexual dysfunction in their sexual partners.
- MeSH
- lidé MeSH
- paroxetin aplikace a dávkování terapeutické užití MeSH
- pilotní projekty MeSH
- předčasná ejakulace * diagnóza farmakoterapie MeSH
- průzkumy a dotazníky MeSH
- selektivní inhibitory zpětného vychytávání serotoninu MeSH
- sexuální dysfunkce fyziologická diagnóza MeSH
- sexuální dysfunkce psychické diagnóza MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Vitamin D hraje velice významnou roli pro lidské zdraví. Jeho nedostatek je spojen s mnoha zdravotními komplikacemi. Obecně je ale méně známý jeho vliv na reprodukci a sexuální funkce mužů i žen. V článku přinášíme přehledné informace o této problematice a informujeme i o možnostech suplementace vitaminu D. Suplementace vitaminu D je pro zdraví a kvalitu života přínosná téměř ve všech oblastech. Nejúčinnější je léčba přípravky na lékařský předpis. Nová možnost léčby kalcifediolem je ještě efektivnější a bezpečnější volbou.
Vitamin D plays a very significant role in human health. Its deficiency is associated with many health complications. However, its influence on reproduction and sexual function in both men and women is generally less known. This article provides an overview of this issue and informs about the possibilities of vitamin D supplementation. Vitamin D supplementation is beneficial for health and quality of life in almost all areas. The most effective treatment is with prescription drugs. A new treatment option with calcifediol is an even more effective and safer choice.
- MeSH
- avitaminóza etiologie farmakoterapie MeSH
- erektilní dysfunkce farmakoterapie prevence a kontrola MeSH
- fertilita účinky léků MeSH
- lidé MeSH
- menstruační cyklus metabolismus účinky léků MeSH
- předčasná ejakulace farmakoterapie prevence a kontrola MeSH
- reprodukční zdraví * MeSH
- syndrom polycystických ovarií farmakoterapie MeSH
- testosteron fyziologie MeSH
- vitamin D * fyziologie metabolismus MeSH
- Check Tag
- lidé MeSH
Potíže s ejakulací jsou zejména u urologických nemocných poměrně časté a nezřídka vedou ke zhoršení kvality sexuálního života i partnerského soužití. Přesto jsou často opomíjené. Bohužel ne vždy jsou ovlivnitelné. Muže je třeba náležitě poučit o možných negativních vlivech urologické medikace i operačních výkonů na ejakulaci. Následující text se zaměřuje na anejakulaci, retrográdní ejakulaci, opožděnou ejakulaci a bolestivou ejakulaci.
Difficulties with ejaculation are particularly common among urological patients and often lead to deterioration in quality of sexual life and partnership. Yet are often not disussed. Unfortunatelly, not always are influenceable. Patients should be properly informed about possible negative effects of urological medication or surgical procedures on ejaculation. The following text focuses on anejaculation, retrograde ejaculation, delayed ejaculation and painful ejaculation.
RATIONALE: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses. OBJECTIVE: The present study examined the acute, subchronic, and chronic dose-response effects of CAB and a derivative dimethylcabergoline (DMC) which acts as an antagonist instead of agonist at 5-HT 2B receptors, on appetitive and consummatory sexual behaviors of male rats. METHODS: CAB (0, 0.03, 0.15, or 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 68 days. Sexual behavior was tested every 4 days during this period for a total of 16 trials. On the 17th trial, rats were administered their dose of CAB, and 4 h after were overdosed with sodium pentobarbital, perfused intracardially, and their brains processed for Fos immunohistochemistry. DMC (0, 0.03, 0.15, 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 36 days. Sexual behavior was tested every 4 days for a total of 9 trials. RESULTS: CAB increased anticipatory level changes, intromissions, and ejaculations significantly across all timepoints, with the medium and high doses being most potent. The medium and high doses also increased Fos protein significantly within the medial preoptic area, whereas in the nucleus accumbens shell, the low and medium doses decreased Fos protein but the high dose increased it significantly from control. Similar to CAB, the medium and high doses of DMC increased the number of ejaculations significantly. Rats in all drug dose groups appeared healthy for the duration of the experiments. CONCLUSIONS: Both CAB and DMC facilitate ejaculations, and CAB further facilitates measures of anticipatory sexual motivation and intromissions. These data suggest that both could be used as treatments for sexual arousal disorders and ejaculation/orgasm disorders with little or no untoward side effects at low doses.
- MeSH
- kabergolin farmakologie MeSH
- kopulace * MeSH
- krysa rodu rattus MeSH
- motivace MeSH
- mozek MeSH
- pohlavní steroidní hormony MeSH
- receptory dopaminu D2 MeSH
- sexuální chování zvířat * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The recovery of autonomic functions and the ability to reproduce in particular is of the highest priority to individuals with spinal cord injury (SCI). The potential of epidural spinal cord stimulation (ESCS) for promoting recovery of sensorimotor functions in the chronic phase of SCI has long been studied. In recent years, several studies have emerged confirming the positive effect of ESCS also on the cardiovascular system and neurogenic bladder and bowel. However, the potential of ESCS in restoring sexual function, especially ejaculation, has not yet been addressed. CASE REPORT: Two cases of people with chronic sensorimotor complete SCI in the 4th thoracic spinal segment are presented. Both men were also diagnosed with severe erectile dysfunction and anejaculation. Thanks to ESCS, Participant 1 successfully restored the ejaculatory reflex using PVS in his home environment. His outcome was subsequently verified under clinical conditions. During ESCS, Participant 1 was also able to achieve ejaculation by masturbation; moreover, he conceived a child naturally without the need for IVF. In Participant 2, we then demonstrated the same effect of ESCS on the restoration of the ejaculatory reflex when targeting the stimulation to the same spinal segment. CONCLUSION: This is the first report on the potential of ESCS for restoring the ability to ejaculate in individuals with complete SCI. Confirmation of these results could significantly reduce the need for assisted reproduction and improve the quality of life of men after SCI in the future.
- MeSH
- dospělí MeSH
- ejakulace * fyziologie MeSH
- epidurální prostor MeSH
- erektilní dysfunkce etiologie terapie patofyziologie MeSH
- hrudní obratle MeSH
- lidé MeSH
- míšní stimulace * metody MeSH
- poranění míchy * komplikace patofyziologie terapie rehabilitace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Obesity represents a growing problem due to its impacts on human health and reproduction. In this study, we analysed semen quality, sperm DNA integrity and gene-specific CpG methylation in 116 healthy men from normal population. The men were divided into three groups according to their body mass index (BMI), and their ejaculates were analysed using standard methods, sperm chromatin structure assay (SCSA), methylation next generation sequencing (NGS) and amplicon sequencing. The sperm methylation NGS revealed six significantly differentially methylated regions (DMRs). Using subsequent targeted amplicon sequencing in 116 men, two of the DMRs were proved as differentially methylated in sperm of men with normal BMI vs. BMI ≥ 25. The DMRs were located in the EPHA8 and ANKRD11 gene. Also, we detected a significant decline in the EPHA8, ANKRD11 and CFAP46 gene methylation in association with increasing BMI values. The genes EPHA8 and ANKRD11 are involved in the nervous system and brain development; the CFAP46 gene plays a role in a flagellar assembly and is associated with sperm motility. Significantly lower rates of motile and progressive motile sperm were observed in men with BMI ≥ 30. Our results show that excess body weight can modify CpG methylation of specific genes, affect sperm motility, and compromise sperm chromatin integrity. These factors can stand behind the observed reduced fertility in men with obesity. The methylation changes might be transmitted to their offspring through sperm, and become a basis for possible developmental and reproductive issues in the next generation.
- MeSH
- analýza spermatu * MeSH
- chromatin * metabolismus MeSH
- CpG ostrůvky MeSH
- dospělí MeSH
- index tělesné hmotnosti * MeSH
- lidé MeSH
- metylace DNA * MeSH
- mladý dospělý MeSH
- motilita spermií genetika MeSH
- obezita genetika MeSH
- spermie * metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Research shows that male body odor plays an important role in women's mate choice and that olfactory abilities are associated with women's sexual functioning. What remains unclear is what types of partner's odor actually shape women's experience during intimate activities. This study therefore explored women's experience associated with the partner's various odors and investigated how they affect women's intimate and sexual encounters. We performed semi-structured individual interviews with 20 single women and 20 women in a long-term relationship. Thematic analysis revealed four key natural odor types of the partner: body odor, sweat, genital odor, and semen odor. Further, we have identified three main types of fragrance odor (cologne, shower gel, and laundry agents) and investigated their perception in both intimate (hugging, kissing, cuddling, lying side by side) and sexual (intercourse, oral sex, ejaculation) contexts. Both partner's natural odor and fragrance affected women's emotional state (ranging from pleasant to unpleasant) and behavioral response (ranging from approach to avoidance of partner). Women's odor perception was frequently context-dependent, so that even mostly negatively perceived odors (e.g., semen, genital odor) were often accepted as part of sexual encounter. Finally, women's perception was negatively modified by partner's specific sweat (after workday, workout, or when the partner is ill) during intimate encounters. Our results highlight the complexity and interindividual variability of partner's odor perception.
- MeSH
- čich fyziologie MeSH
- čichová percepce fyziologie MeSH
- dospělí MeSH
- interpersonální vztahy MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- odoranty * MeSH
- pot MeSH
- sexuální chování * psychologie MeSH
- sexuální partneři * psychologie MeSH
- sperma MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
PURPOSE: There is a paucity of long-term objective and patient-reported outcomes after definitive perineal urethrostomy for complex urethral strictures. Our objective is to determine comprehensive long-term success of perineal urethrostomy with our 15-year experience at a reconstructive referral center. MATERIALS AND METHODS: Patients who underwent perineal urethrostomy between 2009 and 2023 were identified. A comprehensive long-term follow-up was conducted, evaluating both objective outcomes (retreatment-free survival) and subjective outcomes through the use of validated questionnaires. Additionally, to provide further context for our findings, we conducted a scoping review of all studies reporting outcomes following perineal urethrostomy. RESULTS: Among 76 patients, 55% had iatrogenic strictures, with 82% previously undergoing urethral interventions. At a median follow-up of 55 months, retreatment-free survival was 84%, with 16% of patients experiencing perineal urethrostomy recurrent stenosis. Patient-reported outcomes revealed a generally satisfactory voiding function (Urethral Stricture Surgery Patient-Reported Outcome Measure Lower Urinary Tract Symptoms score) and continence (International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form), with median scores of 4 (range 0-24) and 0 (range 0-21), but with bimodal distributions of sexual function scores (median International Index of Erectile Function-Erectile Function domain: 3.5; median Male Sexual Health Questionnaire-Ejaculation Scale: 21). Treatment satisfaction was very high with a median International Consultation on Incontinence Questionnaire-Satisfaction outcome score of 21 (range 0-24). The scoping review revealed varying success rates ranging from 51% to 95%, highlighting difficulties in comparison due to variable success definitions and patient case mix. CONCLUSIONS: Perineal urethrostomy provides effective treatment for complex anterior urethral strictures, with high patient satisfaction, preserved continence function, and favorable voiding outcomes. It presents a viable option for older and comorbid patients, especially after thorough counseling on expected outcomes and potential risks.
- MeSH
- časové faktory MeSH
- dospělí MeSH
- hodnocení výsledků péče pacientem * MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- perineum * chirurgie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- striktura uretry * chirurgie MeSH
- uretra chirurgie MeSH
- urologické chirurgické výkony u mužů metody MeSH
- výsledek terapie MeSH
- zákroky plastické chirurgie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Volné kyslíkové radikály hrají významnou roli v plodnosti i neplodnosti mužů. Jsou nezbytné pro fyziologické pochody, ale při nadměrné koncentraci mohou být příčinou různých patologií spermií. Hlavním zdrojem kyslíkových radikálů v ejakulátu jsou seminální leukocyty a patologicky abnormální spermie. Negativně ovlivňují kvalitu spermií, vč. zhoršení DNA fragmentace a motility spermií. Při řešení zvýšené koncentrace reaktivních forem kyslíku existuje řada vhodných režimových opatření a změn životního stylu, které zahrnují užívání antioxidantů, léčení urogenitálních infekcí, řešení varikokély, redukci hmotnosti a další. V mnoha případech je tak možné dosáhnout úpravy stavu a zlepšení kvality spermatu. Toto zlepšení může následně vést ke zlepšení výsledků asistované reprodukce či dokonce i ke zvýšení pravděpodobnosti přirozeného početí. V některých případech může být eliminována potřeba použití spermatu od dárce. Klíčovým faktorem je však dodržení dostatečně dlouhé léčby, což vyžaduje trpělivost jak ze strany lékaře, tak pacienta.
Reactive oxygen species play a significant role in male fertility and infertility. They are essential for physiological processes, but when their concentration becomes excessive, they can be a cause of various sperm pathologies. Seminal leukocytes and pathologically abnormal sperm are the primary sources of oxygen radicals in ejaculate. They negatively affect sperm quality, including DNA fragmentation and sperm motility impairment. Addressing increased concentrations of reactive oxygen species involves various appropriate lifestyle modifications and measures, including the use of antioxidants, treatment of urogenital infections, management of varicocele, weight reduction, and others. In many cases, these interventions can lead to adjustments in the condition and improvement in sperm quality. Such improvements can subsequently lead to enhanced outcomes in assisted reproduction or even an increased likelihood of natural conception. In some instances, the need for donor sperm may be eliminated. However, a key factor is adhering to a sufficiently prolonged treatment, which requires patience on the part of both, the physician and the patient.
- MeSH
- fertilita fyziologie MeSH
- lidé MeSH
- mužská infertilita * etiologie metabolismus MeSH
- reaktivní formy kyslíku metabolismus MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- přehledy MeSH
Sialic acids are negatively charged carbohydrates that are components of saccharide chains covalently linked to macromolecules. Sialylated glycoproteins are important for most biological processes, including reproduction, where they are associated with spermatogenesis, sperm motility, immune responses, and fertilization. Changes in the glycoprotein profile or sialylation in glycoproteins are likely to affect the quality of ejaculate. The aim of this study was to determine differences in the degree of sialylation between normozoospermic ejaculates and ejaculates with a pathological spermiogram using two lectins, Sambucus nigra (SNA) and Maackia amurensis (MAL II/MAA) recognizing α-2,6 or α-2,3 linkage of Sia to galactosyl residues. Our results show a close relationship between seminal plasma (SP) sialoproteins and the presence of anti-sperm antibodies in the ejaculate, apoptotic spermatozoa, and ejaculate quality. Using mass spectrometry, we identified SP sialoproteins such as, semenogelins, glycodelin, prolactin-inducible protein, lactotransferrin, and clusterin that are associated with spermatozoa and contribute to the modulation of the immune response and sperm apoptosis. Our findings suggest a correlation between the degree of SP glycoprotein sialylation and the existence of possible pathological states of spermatozoa and reproductive organs. Glycoproteins sialylation represents a potential parameter reflecting the overall quality of ejaculate and could potentially be utilised in diagnostics.
- MeSH
- analýza spermatu metody MeSH
- apoptóza MeSH
- ejakulace MeSH
- glykodelin metabolismus MeSH
- glykoproteiny metabolismus MeSH
- klusterin metabolismus MeSH
- kyseliny sialové metabolismus MeSH
- laktoferrin metabolismus MeSH
- lektiny metabolismus chemie MeSH
- lidé MeSH
- motilita spermií MeSH
- proteiny semenné plazmy metabolismus MeSH
- sekreční proteiny semenných váčků metabolismus MeSH
- sperma * metabolismus chemie MeSH
- spermie * metabolismus MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
