- MeSH
- Angiography MeSH
- Biomedical Research MeSH
- Adult MeSH
- Electrocardiography methods instrumentation MeSH
- Middle Aged MeSH
- Humans MeSH
- Computers MeSH
- Heart Conduction System physiopathology MeSH
- Aged MeSH
- Arrhythmias, Cardiac diagnosis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
Studie ČSAV ; č. 8
113 s. : il.
- MeSH
- Adrenergic beta-Antagonists therapeutic use MeSH
- Electrocardiography MeSH
- Ventricular Fibrillation drug therapy MeSH
- Middle Aged MeSH
- Arrhythmias, Cardiac diagnosis drug therapy MeSH
- Syndrome MeSH
- Syncope drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg) and 37 °C (CaCl2, 1.2 mM). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT (p < 0.001) and QTc (p < 0.05) in group 1. In group 2, QT and QTc prolongation was less pronounced (p < 0.05). A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant. We conclude that although phenothiazines are still medicaments of choice in certain psychoses, their cardiovascular side effects should be always taken in consideration.
- Keywords
- prodloužení QT,
- MeSH
- Electrophysiologic Techniques, Cardiac MeSH
- Perphenazine * pharmacology MeSH
- Rats, Wistar MeSH
- Isolated Heart Preparation MeSH
- Heart MeSH
- Arrhythmias, Cardiac MeSH
- Cardiac Electrophysiology * MeSH
- Heart Rate MeSH
- Heart Ventricles MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Angiography MeSH
- Biomedical Research MeSH
- Adult MeSH
- Electrocardiography methods instrumentation MeSH
- Middle Aged MeSH
- Humans MeSH
- Computers MeSH
- Heart Conduction System physiopathology MeSH
- Aged MeSH
- Arrhythmias, Cardiac diagnosis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
- MeSH
- Adult MeSH
- Electric Stimulation MeSH
- Electrocardiography methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Heart Conduction System physiopathology MeSH
- Aged MeSH
- Arrhythmias, Cardiac diagnosis MeSH
- Heart Block MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study – amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic changes in a manner which can be easily observed and evaluated. Ischemia was analysed in seven isolated hearts of New Zealand white rabbits. It was found that (a) ischemia changes heart electric vector, (b) ischemic preconditioning has a protective effect, and (c) both of these findings can be clearly observed by the proposed method.
- MeSH
- Action Potentials MeSH
- Electrophysiologic Techniques, Cardiac MeSH
- Financing, Organized MeSH
- Image Interpretation, Computer-Assisted MeSH
- Myocardial Ischemia diagnosis prevention & control MeSH
- Ischemic Preconditioning, Myocardial MeSH
- Rabbits MeSH
- Models, Cardiovascular MeSH
- Disease Models, Animal MeSH
- Predictive Value of Tests MeSH
- Vectorcardiography MeSH
- Imaging, Three-Dimensional MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Review MeSH
