electrogram Dotaz Zobrazit nápovědu

Přesná shoda Sémantické

The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg) and 37 °C (CaCl2, 1.2 mM). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT (p < 0.001) and QTc (p < 0.05) in group 1. In group 2, QT and QTc prolongation was less pronounced (p < 0.05). A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant. We conclude that although phenothiazines are still medicaments of choice in certain psychoses, their cardiovascular side effects should be always taken in consideration.

Klíčová slova
prodloužení QT,
MeSH
elektrofyziologické techniky kardiologické MeSH
perfenazin * farmakologie MeSH
potkani Wistar MeSH
preparace izolovaného srdce MeSH
srdce MeSH
srdeční arytmie MeSH
srdeční elektrofyziologie * MeSH
srdeční frekvence MeSH
srdeční komory MeSH
zvířata MeSH
Check Tag
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
práce podpořená grantem MeSH

Článek

Neinvazivnaja elektrogramma pucka Gisa [Noninvasive electrogram of the bundle of his]
[Noninvasive electrogram of the bundle of His]

Čechoslovackaja medicina. 1987 ; Roč. 10 (č. 3) : S. 162-170.

ISSN 0139-9225
Medvik
Zdroj

MeSH
angiografie MeSH
biomedicínský výzkum MeSH
dospělí MeSH
elektrokardiografie metody přístrojové vybavení MeSH
lidé středního věku MeSH
lidé MeSH
počítače MeSH
převodní systém srdeční patofyziologie MeSH
senioři MeSH
srdeční arytmie diagnóza MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
srovnávací studie MeSH

Článek online

Three-dimensional electrogram in spherical coordinates: application to ischemia analysis

... Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. ...

Physiological research. 2010 ; 59 (Suppl. 1) : S51-S58.

Medvik
Zdroj

Methods in experimental and clinical cardiovascular research. 2010 ; 59 (Suppl. 1) : S51-S58.

Medvik
Zdroj

Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study – amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic changes in a manner which can be easily observed and evaluated. Ischemia was analysed in seven isolated hearts of New Zealand white rabbits. It was found that (a) ischemia changes heart electric vector, (b) ischemic preconditioning has a protective effect, and (c) both of these findings can be clearly observed by the proposed method.