BACKGROUND: Combination of platinum derivatives with paclitaxel is currently the standard front line regimen for patients with epithelial ovarian carcinoma, and represents also an active regimen in patients with metastatic breast or unknown primary carcinomas. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal mucositis induced by chemotherapy, but little is known about intestinal permeability in patients treated with paclitaxel or platinum. METHODS: Intestinal permeability was assessed in 36 breast and ovarian cancer patients treated with paclitaxel/platinum combination by measuring, using capillary gas chromatography, urinary sucrose, lactulose, xylose and mannitol after oral challenge. The significance of differences during the therapy compared to pre-treatment values was studied by Wilcoxon paired test. The differences between groups of patient were studied by Mann-Whitney U test. Fisher exact test was used to compare the frequency in different subgroups. RESULTS: After administration of the first dose, a significant (p < 0.05) decrease in xylose absorption and increased lactulose/mannitol, sucrose/mannitol, lactulose/xylose and sucrose/xylose ratios were observed, but these parameters returned subsequently to pre-treatment levels. Patients who experienced serious (grade 3 or 4) toxicity had at baseline significantly lower percentages of xylose, mannitol and sucrose, and higher lactulose/mannitol ratio. Nine of 13 (69%) patients with baseline lactulose/mannitol ratio 0.070 or above experienced serious toxicity compared to 4 out of 23 patients (17%) with the ratio below 0.070 (p = 0.002). Post-treatment lactulose, lactulose/mannitol, sucrose/mannitol and lactulose/xylose ratios were significantly increased in patients with serious toxicity. CONCLUSION: A transient significant increase in lactulose/monosaccharide and sucrose/monosaccharide ratios was observed in ovarian and breast cancer patients treated with paclitaxel and platinum. Increased lactulose absorption, lactulose/mannitol, sucrose/mannitol and lactulose/xylose ratios were evident in patients with grade 3 or 4 toxicity, and increased baseline lactulose/mannitol ratio predicted serious toxicity.
- MeSH
- adenokarcinom farmakoterapie metabolismus patologie MeSH
- cisplatina aplikace a dávkování MeSH
- dospělí MeSH
- financování organizované MeSH
- gastrointestinální trakt metabolismus MeSH
- intestinální absorpce účinky léků MeSH
- karboplatina aplikace a dávkování MeSH
- laktulosa metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mannitol metabolismus MeSH
- monoklonální protilátky aplikace a dávkování MeSH
- nádory glandulární a epitelové farmakoterapie metabolismus patologie MeSH
- nádory prsu farmakoterapie metabolismus patologie MeSH
- nádory vaječníků farmakoterapie metabolismus patologie MeSH
- paclitaxel aplikace a dávkování MeSH
- permeabilita buněčné membrány účinky léků MeSH
- protokoly antitumorózní kombinované chemoterapie terapeutické užití MeSH
- sacharasa metabolismus MeSH
- senioři MeSH
- xylosa metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
Production of glycerol, tetritols, pentitols, hexitols and heptitols was tested with 193 strains of yeasts and yeast-like microorganisms belonging to 13 genera. According to the production of alditols, the yeast species were divided into four groups. The largest group consisted of pentitol-producing yeasts. Only few species produced glycerol, tetritol and hexitol. Production of heptitols was found mainly in sporulating yeasts.
- MeSH
- antibakteriální látky biosyntéza MeSH
- cyklopentany MeSH
- fosfáty metabolismus MeSH
- fruktosa metabolismus MeSH
- galaktosa metabolismus MeSH
- glukosa metabolismus MeSH
- kultivační média MeSH
- mitosporické houby metabolismus růst a vývoj MeSH
- peptony metabolismus MeSH
- stopové prvky metabolismus MeSH
- xylosa metabolismus MeSH
- MeSH
- aerobióza MeSH
- aktivní transport MeSH
- anaerobióza MeSH
- buněčná stěna metabolismus MeSH
- glukosa metabolismus MeSH
- hexokinasa metabolismus MeSH
- mannosa metabolismus MeSH
- matematika MeSH
- metody MeSH
- oxidativní fosforylace MeSH
- rotace MeSH
- Saccharomyces cerevisiae enzymologie metabolismus růst a vývoj MeSH
- Saccharomyces enzymologie metabolismus růst a vývoj MeSH
- stereoizomerie MeSH
- světlo MeSH
- xylosa metabolismus MeSH
- MeSH
- aktivní transport MeSH
- arabinosa metabolismus MeSH
- Candida metabolismus růst a vývoj MeSH
- cukerné alkoholy metabolismus MeSH
- erythritol metabolismus MeSH
- galaktosa metabolismus MeSH
- glukosa metabolismus MeSH
- izotopy uhlíku MeSH
- mannitol metabolismus MeSH
- manometrie MeSH
- mitosporické houby metabolismus MeSH
- monosacharidy metabolismus MeSH
- ribosa metabolismus MeSH
- sorbitol metabolismus MeSH
- sorbosa metabolismus MeSH
- stereoizomerie MeSH
- xylitol metabolismus MeSH
- xylosa metabolismus MeSH
