UNLABELLED: Potassium chlorate has long been utilized as an excellent oxidizing agent in pyrotechnics and explosives. As mixtures of potassium chlorate and any type of combustible material can be explosive, there is a potential risk of misuse in homemade explosives. Unlike commercial explosives, homemade chlorate and oil mixtures do not have a constant composition, which limits their understanding. This study reports the effects of two types of oil (motor oil and cooking oil) and their ratios (ranging from 2.5% to 40.0% (w/w)) on the explosive properties of such mixtures. The impact sensitivity was highest at a motor oil ratio of 5%. The friction sensitivity increased with an increasing oil ratio, reaching a maximum at an oil ratio of ~22.5%, and was close to those of primary explosives. The motor oil mixtures exhibited higher sensitivity than the cooking oil mixtures at oil ratios of 25.0% or less. A 10% oil mixture, which was close to the ratio of oxygen balance equal to zero, detonated in weak confinement, such as a paper cylinder. The highest detonation velocities in a polypropylene tube were ~2 300 and 2 550 m/s at a 10% ratio of motor oil and cooking oil, respectively. The velocities of the metal case wall, measured by photonic Doppler velocimetry, reached ~1 100 m/s near the end of acceleration. These results show that homemade chlorate and oil mixtures are capable of detonation and quite sensitive over a wide range of oil ratios, with sufficient power to cause damage in the vicinity. KEY POINTS: Simple mixtures of potassium chlorate and oil can be used as a homemade explosives.Oil types and ratios considerably affect the sensitivity and detonation velocity.Mixtures are sufficiently potent to generate hazardous fragments.Long-term storage causes an internal oil gradient.Mixtures with wide-ranging oil ratios can have highly sensitive points.
- Publication type
- Journal Article MeSH
OBJECTIVE: Little is known about the association between subjectively experienced levels of diabetes distress (DD) and personality traits (PTs), even when levels of DD appear stable over time. This study aimed to use the Alternative Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Model for Personality Disorders (AMPD) to associate specific maladaptive PTs with experienced DD and to describe differences in the constellation of PTs between people with type 1 diabetes (PWT1D) and type 2 diabetes (PWT2D). METHODS: A total of 358 participants with diabetes mellitus (DM) (56.2% female, mean age 42.33 years, standard deviation (SD) = 14.33) were evaluated using the Diabetes Distress Scale (DDS) and the shortened 160-item version of the Personality Inventory for DSM-5 (PID-5). Psychometric properties of the DDS were evaluated first, then the association between DDS and PID-5 scores, and the differences between groups based on diabetes type and DD level, were analyzed. RESULTS: Strong associations were found between the PID-5 Negative Affectivity (NEF) domain and the emotional burden (β = 0.852, pHolm < 0.001) and regimen distress (β = 0.435, pHolm = 0.006) DDS subscale scores. PWT1D had a higher level of personality pathology than PWT2D, as did participants with elevated levels of DD across most domains and facets of PID-5. CONCLUSIONS: Our findings suggest that attention should be paid to the level of NEF among people with diabetes in relation to their emotional burden and perception of regimen distress. We recommend a distinction between people based on their diabetes type. Implications for clinical practice and interventions for DD perceived through the lens of the dimensional DSM-5 PT model are discussed.
- Publication type
- Journal Article MeSH
Background: Comparative efficacy of rehabilitation interventions in persons with acute ischemic stroke (PwS) is limited. This randomized trial assessed the immediate and lasting effects of five interventions on clinical and mobility outcomes in 75 PwS. Methods: Five days after stroke, 75 PwS were randomized into five groups: physical therapy (CON, standard care, once daily); walking with a soft robotic exoskeleton (ROB, once daily); agility exergaming once (EXE1, once daily) or twice daily (EXE2, twice daily); and combined EXE1+ROB in two daily sessions. Interventions were performed 5 days per week for 3 weeks. Outcomes were assessed at baseline, post-intervention, and after 5 weeks of detraining. Results: Modified Rankin Scale (primary outcome) and Barthel Index showed no changes. EXE1, EXE2, ROB, and EXE1+ROB outperformed standard care (CON) in five secondary outcomes (Berg balance scale, 10m walking speed, 6-min walk test with/without robot, standing balance), with effects sustained after 5 weeks. Dose effects (EXE1 vs. EXE2) were minimal, while EXE1+ROB showed additive effects in 6-min walk tests. Conclusions: These novel comparative data expand evidence-based options for therapists to design individualized rehabilitation plans for PwS. Further confirmation is needed.
- Publication type
- Journal Article MeSH
We designed and synthesized a set of four 2'-deoxyribonucleoside 5'-O-triphosphates (dNTPs) bearing cationic substituents (protonated amino, methylamino, dimethylamino and trimethylammonium groups) attached to position 5 of pyrimidines or position 7 of 7-deazapurines through hex-1-ynyl or propargyl linker. These cationic dNTPs were studied as substrates in enzymatic synthesis of modified and hypermodified DNA using KOD XL DNA polymerase. In primer extension (PEX), we successfully obtained DNA containing one, two, three, or (all) four modified nucleotides, each bearing a different cationic modification. The cationic dNTPs were somewhat worse substrates compared to previously studied dNTPs bearing hydrophobic or anionic modifications, but the polymerase was still able to synthesize sequences up to 73 modified nucleotides. We also successfully combined one cationic modification with one anionic and two hydrophobic modifications in PEX. In polymerase chain reaction (PCR), we observed exponential amplification only in the case of one cationic modification, while the combination of more cationic nucleotides gave either very low amplification or no PCR product. The hypermodified oligonucleotides prepared by PEX were successfully re-PCRed and sequenced by Sanger sequencing. Biophysical studies of hybridization, denaturation, and circular dichroism spectroscopy showed that the presence of cationic modifications increases the stability of duplexes.
- MeSH
- Deoxyribonucleotides metabolism chemistry MeSH
- DNA-Directed DNA Polymerase * metabolism chemistry MeSH
- DNA * chemistry biosynthesis metabolism MeSH
- Cations * chemistry MeSH
- Polymerase Chain Reaction MeSH
- Purines chemistry biosynthesis MeSH
- Pyrimidines chemistry MeSH
- Publication type
- Journal Article MeSH
První vydání 53 stran : ilustrace ; 20 cm
Deník české autorky, ve kterém líčí své zkušenosti s paranoidní schizofrenií.
- MeSH
- History, 21st Century MeSH
- Persons with Psychiatric Disorders history psychology MeSH
- Homeopathy MeSH
- Schizophrenia, Paranoid history MeSH
- Women psychology MeSH
- Check Tag
- History, 21st Century MeSH
- Publication type
- Diary MeSH
- Geographicals
- Czech Republic MeSH
- Conspectus
- Psychiatrie
- Biografie
- NML Fields
- psychiatrie
Učební texty Univerzity Karlovy
3. vydání 112 stran : ilustrace ; 21 cm
Vysokoškolská učebnice, která se zaměřuje na fyziologii gastrointestinálního systému člověka.; Učební text obsahuje přednášky z fyziologie trávicího traktu a je doplněn o patofyziologické nebo klinické poznámky související s popisovaným tématem.
- Conspectus
- Fyziologie člověka a srovnávací fyziologie
- Učební osnovy. Vyučovací předměty. Učebnice
- NML Fields
- fyziologie
- NML Publication type
- učebnice vysokých škol
According to recent research, many family caregivers lack the necessary knowledge and skills to provide effective care for individuals who have survived a stroke. Interventions such as psychoeducational training have demonstrated the potential to enhance caregiver competence and patient outcomes. Utilizing virtual reality to deliver educational content to family caregivers represents a novel approach to addressing the challenges encountered by caregivers of post-stroke survivors. In a quasi-experimental study employing a one-group, pre-test and post-test design, we recruited a cohort of 30 family caregivers responsible for providing care to stroke survivors within their homes. The study sample was drawn from a hospital in Surabaya, Indonesia. Participating family caregivers of stroke survivors completed a four-week psychoeducational program, following which data on effectiveness and feasibility were collected. The findings revealed a statistically significant reduction in the DASS-42 score after the program (t = 31.22, p < 0.001), indicating that the psychoeducational program was perceived as beneficial for family caregivers of stroke patients. Subsequently, the next phase will involve the implementation of the psychoeducational program with a broader group of family caregivers of stroke survivors.
- Keywords
- psychoedukace,
- MeSH
- Stroke nursing MeSH
- Mental Health MeSH
- Humans MeSH
- Caregivers * psychology education MeSH
- Pilot Projects MeSH
- Family psychology MeSH
- Virtual Reality * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Germline genetic susceptibilities of rare cancers of the esophagus, stomach, small intestine, testis, (nonmedullary) thyroid gland and bone with high familial risks are not well known. Here, we use familial risk data from the Swedish Family-Cancer Database which contains records of cancers in Swedish families obtained over a century. We compare familial risks for offspring diagnosed with any of these cancers when their parent had or had not that cancer. We review the global literature of the reported constitutional variants that may explain part of the familial risk. MAIN BODY: Familial risks for esophageal and stomach cancers are about 2.0 and apart from early-onset stomach cancer few high-risk variants are known. Genetic studies may be hampered by dominant environmental risk factors for these cancers. Small intestinal carcinoids have a very high familial risk (28 between siblings) but no high-risk genes have been identified to explain this. Low-risk polygenic variants have been identified. Small intestinal adenocarcinoma is a manifestation in Lynch syndrome. Testicular and thyroid cancers are characterized by high familial risk (about 5) which may be explained largely by a polygenic background, although thyroid cancer is a component in a number of rare cancer syndromes. Several predisposing genes have been identified for bone cancer (familial risk 7). CONCLUSIONS: The discussed cancers are rare and they present with a relatively high familial risk, in spite of lacking identified high-penetrant constitutional variants. It is possible that the polygenic component, already recognized for testis cancer, is stronger than previously expected. Thus polygenic models with rare high/moderate- and low-risk variants could fit the familial risk and shape the germline genetic landscape of these cancers. Polygenic background may have clinical implications.
- Publication type
- Journal Article MeSH
- Review MeSH
