Adaptive
Dotaz
Zobrazit nápovědu
- MeSH
- adaptace psychologická fyziologie klasifikace MeSH
- diagnostické techniky a postupy psychologie statistika a číselné údaje využití MeSH
- finanční podpora výzkumu jako téma MeSH
- lidé MeSH
- počítače MeSH
- testování osobnosti statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
[1. Aufl.] xii, 440 s. : il.
... Computerized Adaptive Testing (CAT): Historical and Conceptual Origins 44 -- 6. ... ... control 62 -- 6.5 Evaluation of item selection and trait estimation methods used in computerized adaptive ... ... 125 -- Appendix D - Example of R code used to create Figure 1 Appendix E - Online application for adaptive ...
1. elektronické vydání 1 online zdroj (134 stran)
- Klíčová slova
- Ostatní lékařské obory,
- MeSH
- interpretace statistických dat MeSH
- počítačová simulace MeSH
- průzkumy a dotazníky MeSH
- psychometrie MeSH
- NLK Obory
- statistika, zdravotnická statistika
[1st ed.] ix, 270 s., grafy
The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of 'privileged' adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes 'steal the show'. Recent advancements on the molecular and cellular levels have shaken the traditional view of adaptive and innate immunity. The innate immune memory or 'trained immunity' based on metabolic changes and epigenetic reprogramming is a complementary process insuring adaptation of host defense to previous infections.Innate immune cells are able to recognize large number of pathogen- or danger- associated molecular patterns (PAMPs and DAMPs) to behave in a highly specific manner and regulate adaptive immune responses. Innate lymphoid cells (ILC1, ILC2, ILC3) and NK cells express transcription factors and cytokines related to subsets of T helper cells (Th1, Th2, Th17). On the other hand, T and B lymphocytes exhibit functional properties traditionally attributed to innate immunity such as phagocytosis or production of tissue remodeling growth factors. They are also able to benefit from the information provided by pattern recognition receptors (PRRs), e.g. γδT lymphocytes use T-cell receptor (TCR) in a manner close to PRR recognition. Innate B cells represent another example of limited combinational diversity usage participating in various innate responses. In the view of current knowledge, the traditional black and white classification of immune mechanisms as either innate or an adaptive needs to be adjusted and many shades of gray need to be included.
- MeSH
- adaptivní imunita * MeSH
- B-lymfocyty imunologie MeSH
- buňky NK imunologie MeSH
- cytokiny genetika imunologie MeSH
- lidé MeSH
- přirozená imunita * MeSH
- T-lymfocyty imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
