• MeSH
• farmaceutický průmysl MeSH
• infekční nemoci MeSH
• kontrola léčiv a omamných látek MeSH
• léčivé přípravky MeSH
• Publikační typ
• kongresy MeSH

• Konspekt
• Farmacie. Farmakologie
• NLK Obory
• farmacie a farmakologie
• infekční lékařství

• MeSH
• diagnostické zobrazování MeSH
• oči MeSH
• oftalmologie přístrojové vybavení   MeSH
• optická koherentní tomografie MeSH
• tomografie MeSH

• NLK Obory
• oftalmologie

• O autorovi
• Loewenstein, Anat Autorita
• Loewenstein, Anat Autorita
• Loewenstein, Anat Autorita
• Loewenstein, Anat Autorita
• Loewenstein, Anat Autorita
• Bandello, Francesco Autorita
• Bandello, Francesco Autorita
• Loewenstein, Anat Autorita

• MeSH
• diagnostické techniky oftalmologické MeSH
• oční nemoci diagnóza   MeSH
• optická koherentní tomografie metody   přístrojové vybavení   trendy   MeSH
• pooperační péče MeSH
• předoperační vyšetření MeSH
• Publikační typ
• sborníky MeSH

• Konspekt
• Ortopedie. Chirurgie. Oftalmologie
• NLK Obory
• oftalmologie
• radiologie, nukleární medicína a zobrazovací metody

OBJECTIVE: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. METHODS: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial APOSTEL recommendations via online surveys following the principle of a modified Delphi method. The results were evaluated and discussed by a panel of experts and changes to the initial recommendations were proposed. A final survey was recirculated among the corresponding authors to obtain a majority vote on the proposed changes. RESULTS: A total of 116 authors participated in the surveys, resulting in 15 suggestions, of which 12 were finally accepted and incorporated into an updated 9-point checklist. We harmonized the nomenclature of the outer retinal layers, added the exact area of measurement to the description of volume scans, and suggested reporting device-specific features. We advised to address potential bias in manual segmentation or manual correction of segmentation errors. References to specific reporting guidelines and room light conditions were removed. The participants' consensus with the recommendations increased from 80% for the previous APOSTEL version to greater than 90%. CONCLUSIONS: The modified Delphi method resulted in an expert-led guideline (evidence Class III; Grading of Recommendations, Assessment, Development and Evaluations [GRADE] criteria) concerning study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition analysis, nomenclature and abbreviations, and statistical approach. It will be essential to update these recommendations to new research and practices regularly.

• MeSH
• delfská metoda MeSH
• konsensus MeSH
• lidé MeSH
• nemoci retiny diagnostické zobrazování   MeSH
• oftalmologie metody   MeSH
• optická koherentní tomografie * MeSH
• výzkumný projekt * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• emoce MeSH
• interpersonální vztahy MeSH
• kognice MeSH
• lidé MeSH
• mozek MeSH
• neurobiologie MeSH
• psychofyziologie MeSH
• rozvoj osobnosti MeSH
• srdeční frekvence MeSH
• životní smysluplnost MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

Management of calcified coronary lesions remains challenging, with frequent stent underexpansion and suboptimal results, which lead to early and late stent failure. Appropriate lesion preparation and optimal stent expansion are the keys to prevent stent failure. We present an unusual case of extensive sever right coronary artery calcified stenosis, in which both rotational atherectomy (RA) and non-compliant balloons failed to dilate the lesion and finally the Shockwave lithotripsy balloon offered optimal lesion dilation and successful stent deployment. Furthermore, optical coherence tomography provided mechanistic insight into the differential effect of Shockwave balloon versus RA for extensively calcified lesions.

• MeSH
• koronární aterektomie * MeSH
• lidé MeSH
• litotripse * MeSH
• nemoci koronárních tepen * diagnóza   chirurgie   MeSH
• optická koherentní tomografie MeSH
• vaskulární kalcifikace * diagnostické zobrazování   chirurgie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

BACKGROUND AND OBJECTIVES: Optical coherence tomography angiography (OCTA) is a noninvasive high-resolution imaging technique for assessing the retinal vasculature and is increasingly used in various ophthalmologic, neuro-ophthalmologic, and neurologic diseases. To date, there are no validated consensus criteria for quality control (QC) of OCTA. Our study aimed to develop criteria for OCTA quality assessment. METHODS: To establish criteria through (1) extensive literature review on OCTA artifacts and image quality to generate standardized and easy-to-apply OCTA QC criteria, (2) application of OCTA QC criteria to evaluate interrater agreement, (3) identification of reasons for interrater disagreement, revision of OCTA QC criteria, development of OCTA QC scoring guide and training set, and (4) validation of QC criteria in an international, interdisciplinary multicenter study. RESULTS: We identified 7 major aspects that affect OCTA quality: (O) obvious problems, (S) signal strength, (C) centration, (A) algorithm failure, (R) retinal pathology, (M) motion artifacts, and (P) projection artifacts. Seven independent raters applied the OSCAR-MP criteria to a set of 40 OCTA scans from people with MS, Sjogren syndrome, and uveitis and healthy individuals. The interrater kappa was substantial (κ 0.67). Projection artifacts were the main reason for interrater disagreement. Because artifacts can affect only parts of OCTA images, we agreed that prior definition of a specific region of interest (ROI) is crucial for subsequent OCTA quality assessment. To enhance artifact recognition and interrater agreement on reduced image quality, we designed a scoring guide and OCTA training set. Using these educational tools, 23 raters from 14 different centers reached an almost perfect agreement (κ 0.92) for the rejection of poor-quality OCTA images using the OSCAR-MP criteria. DISCUSSION: We propose a 3-step approach for standardized quality control: (1) To define a specific ROI, (2) to assess the occurrence of OCTA artifacts according to the OSCAR-MP criteria, and (3) to evaluate OCTA quality based on the occurrence of different artifacts within the ROI. OSCAR-MP OCTA QC criteria achieved high interrater agreement in an international multicenter study and is a promising QC protocol for application in the context of future clinical trials and studies.

• MeSH
• fluoresceinová angiografie metody   MeSH
• konsensus MeSH
• lidé MeSH
• optická koherentní tomografie * MeSH
• retina diagnostické zobrazování   MeSH
• retinální cévy * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH

Intravascular optical coherence tomography (IVOCT) is used to assess stent tissue coverage and malapposition in stent evaluation trials. We developed the OCT Image Visualization and Analysis Toolkit for Stent (OCTivat-Stent), for highly automated analysis of IVOCT pullbacks. Algorithms automatically detected the guidewire, lumen boundary, and stent struts; determined the presence of tissue coverage for each strut; and estimated the stent contour for comparison of stent and lumen area. Strut-level tissue thickness, tissue coverage area, and malapposition area were automatically quantified. The software was used to analyze 292 stent pullbacks. The concordance-correlation-coefficients of automatically measured stent and lumen areas and independent manual measurements were 0.97 and 0.99, respectively. Eleven percent of struts were missed by the software and some artifacts were miscalled as struts giving 1% false-positive strut detection. Eighty-two percent of uncovered struts and 99% of covered struts were labeled correctly, as compared to manual analysis. Using the highly automated software, analysis was harmonized, leading to a reduction of inter-observer variability by 30%. With software assistance, analysis time for a full stent analysis was reduced to less than 30 minutes. Application of this software to stent evaluation trials should enable faster, more reliable analysis with improved statistical power for comparing designs.

• MeSH
• endovaskulární výkony přístrojové vybavení   metody   MeSH
• lidé MeSH
• optická koherentní tomografie přístrojové vybavení   metody   MeSH
• senzitivita a specificita MeSH
• software normy   MeSH
• stenty škodlivé účinky   normy   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• hodnotící studie MeSH
• Research Support, N.I.H., Extramural MeSH

OBJECTIVES: This study used optical coherence tomography to investigate the mechanism of false lumen (FL) formation in spontaneous coronary artery dissection (SCAD) by studying: 1) differences between fenestrated and nonfenestrated SCAD; 2) vasa vasorum density; and 3) light attenuation characteristics of the FL. BACKGROUND: SCAD is an increasingly recognized cause of acute coronary syndromes, characterized by FL formation and compression of the true lumen (TL). The mechanisms underlying FL formation remain poorly understood. METHODS: A total of 65 SCAD patients (68 vessels) who underwent acute OCT imaging as part of routine clinical care were included. Images were classified by the absence or presence of a connection (fenestration) between the TL and FL. Indexed measurements of TL stenosis, external elastic lamina (EEL) area, FL area, and light attenuation of the FL were assessed. Vasa vasorum densities of SCAD cases were compared with those in control non-SCAD myocardial infarction cases. RESULTS: In nonfenestrated cases, there was significantly larger expansion of the EEL area (9.1% vs. -1.9%; p <0.05) and a larger FL area (73.6% vs. 53.2%, respectively; p <0.05) in dissected segments. No significant differences were found between vasa vasorum density in SCAD and those in control subjects. The FL contents were heterogeneous but attenuated less light than whole blood or thrombus (4.28 ± 0.55 mm-1 vs. 5.08 ± 0.56 mm-1; p < 0.05; vs. 4.96 ± 0.56 mm-1; p < 0.05). CONCLUSIONS: These observational data suggest that the absence of a fenestration leads to increased FL pressure and compression of the TL. Although vasa vasorum may still be implicated in pathogenesis, increased vasa vasorum density could be an epiphenomenon of vascular healing.

• MeSH
• anomálie koronárních cév diagnostické zobrazování   patofyziologie   terapie   MeSH
• dospělí MeSH
• koronární cévy diagnostické zobrazování   patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nemoci cév vrozené   diagnostické zobrazování   patofyziologie   terapie   MeSH
• optická koherentní tomografie * MeSH
• prediktivní hodnota testů MeSH
• prognóza MeSH
• registrace MeSH
• remodelace cév MeSH
• retrospektivní studie MeSH
• vasa vasorum diagnostické zobrazování   patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Evropa MeSH

V předkládané studii se zabýváme souvislostmi mezi osobnostními charakteristikami a aktivní sportovní činností. Cílovou skupinou byli studenti Fakulty tělesné výchovy a sportu Univerzity Karlovy v Praze. Pro zkoumání jednotlivých sportovních aktivit byly vybrány sportovní specializace plavání, fotbal, gymnastika, atletika. Tito studenti byli porovnáváni s kontrolní skupinou studentů, kteří se aktivně nevěnují sportovním činnostem. Celkově se korelační studie zúčastnilo 179 respondentů. Jako výzkumné metody byly aplikovány osobnostní dotazník 4Elements Inventory a Dotazník sportovních aktivit. Z výsledků měření vyplývá statisticky významná souvislost mezi sportovní aktivitou a živly Ohně a Vody. Nebyla prokázána souvislost mezi konkrétní sportovní specializací a některým z živlů. Souvislost jsme nalezli ve frekvenci sportovní činnosti a ohňového živlu. Zkoumaná skupina se liší oproti populaci v živlech Země a Ohně.

In present article we focus on the relationship between personaltrait and particular sport activity. Being specific we have tried to discover, whe ther the choice of sport activity has coherence with personal trait. The aim group was consisted of students of Faculty of Physical Education and Sport at Charles University in Prague. Those students were specialists at swimming, football, gymnastic and athletics. This group of students was compared with control group of students who do not attend sports actively. The research sample consists of 179 students. As a research method was used a personality test 4Elements Inventory and the Questionnaire of sport activites. The results proved a statistically important coherence between particular sport specialization and the elements Fire and Water. The rewas no proof of coherence between particular sport specialization and any of Elements. We found coherence in a frequence of sport activity and Fire element. The examined group differences from population in Fire and Earth element.

• Klíčová slova
• živly,
• MeSH
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• osobnost * klasifikace   MeSH
• osobnostní testy statistika a číselné údaje   MeSH
• sportovci * psychologie   MeSH
• sporty psychologie   MeSH
• statistika jako téma MeSH
• studenti MeSH
• testování osobnosti statistika a číselné údaje   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH