Molecular immunology, ISSN 0161-5890 vol. 44, no. 16, September 2007
xvii, 3810-3994 s. : il., tab. ; 28 cm
- MeSH
- Complement Activation MeSH
- Complement Pathway, Alternative immunology MeSH
- Immunologic Techniques trends MeSH
- Complement System Proteins immunology MeSH
- Molecular Biology MeSH
- Immune System Diseases MeSH
- Immunologic Deficiency Syndromes MeSH
- Publication type
- Congress MeSH
- Collected Work MeSH
- Conspectus
- Patologie. Klinická medicína
- NML Fields
- alergologie a imunologie
- biologie
- MeSH
- Immunodiffusion MeSH
- Complement System Proteins analysis blood MeSH
- Humans MeSH
- Menstruation MeSH
- Check Tag
- Humans MeSH
- Female MeSH
Clinical and experimental immunology ; Supplement Vol. 97. 2
[1st ed.] 56 s. : tab. ; 26 cm
Current topics in microbiology and immunology, ISSN 0070-217X 121
191 s. : il., tab., grafy ; 26 cm
- MeSH
- Complement Activation MeSH
- Child MeSH
- Adult MeSH
- Complement C4 immunology MeSH
- Complement C1 immunology MeSH
- Complement C2 immunology MeSH
- Complement C3 immunology MeSH
- Complement C5 immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Lupus Erythematosus, Systemic immunology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- MeSH
- Complement Activation MeSH
- Glomerulonephritis physiopathology MeSH
- Hemolytic-Uremic Syndrome physiopathology MeSH
- Glomerulonephritis, IGA physiopathology MeSH
- Complement Inactivator Proteins therapeutic use MeSH
- Humans MeSH
- Lupus Nephritis physiopathology MeSH
- Kidney Diseases physiopathology MeSH
- Check Tag
- Humans MeSH
Komplementový systém je klíčovou složkou vrozené imunity. Skládá se z 50 plazmatických a membránových proteinů, které tvoří tři odlišné, ale překrývající se dráhy aktivace, stejně jako společnou terminální lytickou kaskádu a síť regulátorů a receptorů. Poruchy komplementu se mohou podílet na vzniku imunodeficiencí, autoimunit, malignit, infekčních onemocnění a na chorobách spojených s dysregulací komplementu. Striktní dodržování pravidel preanalytické fáze vyšetření je zásadní pro laboratorní diagnostiku. Pro komplexní posouzení funkce a zapojení komplementu do imunopatologických procesů, musíme testovat celou paletu vyšetření (od funkčních testů, vyšetření jednotlivých složek komplementu, až po genetickou analýzu).
The complement system is a key component of innate immunity. It consists of 50 plasma and membrane proteins that form three distinct but overlapping pathways of activation, as well as a common terminal lytic cascade and a network of regulators and receptors. Complement disorders may contribute to immunodeficiencies, autoimmunity, malignancies, infectious diseases, and diseases associated with complement dysregulation. Strict adherence to the rules of the preanalytical phase of the examination is essential for laboratory diagnosis. To comprehensively assess the function and involvement of complement in immunopathological processes, we need to perform a whole range of investigations (from functional tests, examination of individual complement components, to genetic analysis).
- MeSH
- Atypical Hemolytic Uremic Syndrome diagnosis genetics MeSH
- Complement System Proteins MeSH
- Humans MeSH
- Complement Hemolytic Activity Assay * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
