• MeSH
• Asthma MeSH
• Nasal Surgical Procedures MeSH
• Chronic Disease MeSH
• Comorbidity MeSH
• Drug Hypersensitivity MeSH
• Nasal Polyps MeSH
• Cross-Sectional Studies MeSH
• Rhinosinusitis MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• otorinolaryngologie
• pneumologie a ftizeologie
• NML Publication type
• studie

• MeSH
• Contraception utilization   MeSH
• Humans MeSH
• Adolescent MeSH
• Puberty physiology   MeSH
• Vital Statistics MeSH
• Pregnancy, Unwanted statistics & numerical data   MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Female MeSH
• Geographicals
• Yugoslavia MeSH

Cíl studie: Vyhodnocením základních spermiologických parametrů podle standardů WHO u potenciálních dárců spermatu přispět k současné diskusi o mužském faktoru neplodnosti. Typ studie: Retrospektivní demografická studie. Název a sídlo pracoviště: Gyn.-por. klinika LF UP a FN Olomouc, Ústav biologie LF UP Olomouc. Metodika: V období leden 2000 – duben 2004 se dostavilo ke vstupnímu vyšetření celkem 108 potenciálních dárců spermií ve věku 18–35 let. Spermiologické vyšetření čerstvého semene získaného masturbací bylo provedeno podle standardů WHO. Vyhodnocovanými parametry byly objem ejakulátu, koncentrace spermií a celková motilita. Výsledky: Normospermie byla zjištěna jen u 46 mužů (42,6 %). U tří mužů (2,8 %) byla prokázána azoospermie. Nejčastějším patologickým nálezem byla astenospermie, která byla zjištěna u 49 (46,6 %) mužů. Závěr: Na základě rozboru získaných dat můžeme usuzovat na zřejmý pokles kvality spermiologických parametrů mladé české populace. Podle našeho názoru by provedení multicentrické analýzy se zaměřením na hodnocení plodnosti českých mužů bylo vysoce žádoucí.

Objective: To contribute to the contemporary discussion on the male factor infertility through the evaluation of the basic spermatological parameters in men recruiting for semen donation. Design: A retrospective demographic study. Setting: Dept. of Obstetrics and Gynaecology, Dept. of Biology, Faculty of Medicine, Palacký University, Olomouc. Methods: A total of 108 men aged 18 to 35 years came to the preliminary examination for the potential semen donors between January 2000 and April 2004. Spermatological analysis of the fresh ejaculates obtained by masturbation was performed according to WHO guidelines. The following parameters were evaluated: the volume of ejaculate, sperm concentration and total percent motility. Results: Normospermia was found in only 46 men (42.6%). Three males (2.8%) were azoospermic. The most frequent problem was asthenospermia, which was documented in 49 (46.6%) men. Conclusion: The analysis of the obtained data may suggest a marked semen quality decline in the Czech male population. In our opinion, further multicentric epidemiological studies concerning fertility potential in Czech male population seem highly needed.

• MeSH
• Adult MeSH
• Research Support as Topic MeSH
• Humans MeSH
• Sperm Motility MeSH
• Infertility, Male diagnosis   pathology   MeSH
• Sperm Count MeSH
• Reproductive Medicine MeSH
• Retrospective Studies MeSH
• Sperm Banks MeSH
• Living Donors MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Male MeSH

Wild boar (Sus scrofa), one of the most widespread wildlife species, has entered a stage of continuous growth in Europe, and could even be considered a pest species. We analysed microsatellite variability in 723 wild boars from across Europe, including the northern Dinaric Balkans. Our aims were: (1) to define the population structure of wild boars in the Balkans and its relation with other European populations; (2) to estimate effective populations sizes, levels of intra- and inter-population diversity, inbreeding migration and gene flow patterns; (3) to test subpopulations for bottlenecks; (4) to interpret these results in light of current knowledge about the demographic history of wild boars in Europe; and (5) to discuss the relevance of these findings for management and conservation. Strong population structuring was observed and 14 subpopulations were revealed. High genetic diversity was found, and besides the well-known identity of the Italian populations of Sardinia and Castelporziano, we bring new insights into other potential relevant, refugial populations such as Littoral Slovenia, South Portugal, North-western Iberia and an entire cluster in the Balkans. There was evidence of gene flow going from these refugial subpopulations towards less peripheral and more admixed subpopulations. Recent population bottlenecks and expansions were detected, mostly in the peninsular refuge subpopulations. The results are consistent with the fluctuations of wild boar numbers in Europe since the beginning of the twentieth century. These results should be taken into account in future conservation and management plans for wild boar populations in Europe.

• MeSH
• Gene Frequency MeSH
• Genetic Variation * MeSH
• Genotyping Techniques MeSH
• Population Density MeSH
• Inbreeding MeSH
• Microsatellite Repeats MeSH
• Models, Genetic MeSH
• Population Dynamics MeSH
• Genetics, Population * MeSH
• Models, Statistical MeSH
• Sus scrofa genetics   MeSH
• Gene Flow * MeSH
• Conservation of Natural Resources MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Balkan Peninsula MeSH
• Europe MeSH

Cervical cancer is still one of the most prevalent cancers in women and a significant cause of mortality. Cytokine gene variants and socio-demographic characteristics have been reported as biomarkers for determining the cervical cancer risk in the Indian population. This study was designed to apply a machine learning-based model using these risk factors for better prognosis and prediction of cervical cancer. This study includes the dataset of cytokine gene variants, clinical and socio-demographic characteristics of normal healthy control subjects, and cervical cancer cases. Different risk factors, including demographic details and cytokine gene variants, were analysed using different machine learning approaches. Various statistical parameters were used for evaluating the proposed method. After multi-step data processing and random splitting of the dataset, machine learning methods were applied and evaluated with 5-fold cross-validation and also tested on the unseen data records of a collected dataset for proper evaluation and analysis. The proposed approaches were verified after analysing various performance metrics. The logistic regression technique achieved the highest average accuracy of 82.25% and the highest average F1-score of 82.58% among all the methods. Ridge classifiers and the Gaussian Naïve Bayes classifier achieved the highest sensitivity-85%. The ridge classifier surpasses most of the machine learning classifiers with 84.78% accuracy and 97.83% sensitivity. The risk factors analysed in this study can be taken as biomarkers in developing a cervical cancer diagnosis system. The outcomes demonstrate that the machine learning assisted analysis of cytokine gene variants and socio-demographic characteristics can be utilised effectively for predicting the risk of developing cervical cancer.

• MeSH
• Bayes Theorem MeSH
• Cytokines genetics   MeSH
• Demography MeSH
• Humans MeSH
• Uterine Cervical Neoplasms * epidemiology   genetics   MeSH
• Machine Learning MeSH
• Check Tag
• Humans MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Glyphosate is an herbicide that is used worldwide with potential environmental risks to nontarget organisms. We applied an age-stage, two-sex life table approach to assess the sublethal effects of short-term oral exposure to a glyphosate-based herbicide on the life table parameters and biocontrol potential of Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae). Aphids (Metopolophium dirhodum (Walker) (Sternorrhyncha: Aphididae)) treated with herbicide (an isopropylamine-salt of glyphosate) at low recommended, maximum recommended, and double the maximum recommended concentration for agricultural situations, and untreated controls were offered to the fourth instar of H. axyridis for 24 h. Development, consumption, and fecundity were measured daily until death. We detected minor differences in the hatching rate and mean generation time, whereas the longevity, fecundity, net reproductive rate, intrinsic rate of increase, finite rate of increase, and consumption were unaffected across treatments. We conclude that biocontrol potential of H. axyridis was not affected by acute oral intoxication by a glyphosate-based herbicide during the larval stage for 24 h under the study design.

• MeSH
• Pest Control, Biological MeSH
• Coleoptera drug effects   growth & development   physiology   MeSH
• Glycine analogs & derivatives   toxicity   MeSH
• Insecticides toxicity   MeSH
• Pupa drug effects   growth & development   physiology   MeSH
• Larva drug effects   growth & development   physiology   MeSH
• Aphids chemistry   growth & development   MeSH
• Nymph chemistry   growth & development   MeSH
• Food Chain * MeSH
• Predatory Behavior drug effects   MeSH
• Animals MeSH
• Life History Traits * MeSH
• Check Tag
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

OBJECTIVE: Diabetes mellitus (DM) has been one of the leading chronic diseases worldwide over past decades. The objective of the study was to identify predictors associated with health-related quality of life (HRQOL) in diabetic patients. METHODS: A cross-sectional questionnaire-based study was conducted at the General Hospital of the city of Leskovac, between June and November 2015. The Short Form-36 (SF-36) questionnaire, EuroQol-5D (EQ-5D) and EuroQol-VAS (EQ-VAS) questionnaires were used. Univariate and multivariate linear regression analyses were performed. RESULTS: The total number of patients was 285, 112 men (39.3%) and 173 women (60.7%), average age 63.92 ± 1.07 years. The results of multiple linear regression of socio-demographic characteristics in relation to dimensions of the quality of life measured by SF-36 and EQ-VAS showed that age, country (rural) life, low level of education, retirement, and poor economic status are predictors of lower quality of life. Our results showed that employment has a significant association with higher Physical Component Score (PCS), Mental Component Score (MCS) and EQ-VAS score, which can be explained with higher incomes, improved economic status and less possibility for the occurrence of depressive mood. Patients without formal education have lower QOL. Univariate multiple regression analysis of the presence of micro- and macrovascular complications of DM showed that angina pectoris, heart failure, diabetic retinopathy, and diabetic nephropathy are the most important factors affecting the quality of life in our population. After including the multivariate model, all tested complications remained statistically significant. CONCLUSION: Our results showed that both socioeconomic and chronic complications are relevant factors of HRQOL in type 1 and 2 diabetes mellitus patients. Age, rural lifestyle, retirement, lower level of education and low socioeconomic status, as well as DM complications (angina pectoris, hearth failure, diabetes nephropathy, and diabetes retinopathy) were found to be independent risk factors for the component scores of SF-36 and EQ-VAS score. Taking into consideration the results obtained, health practitioners should be aware not only of the clinical parameters of patients with DM, but also of their educational level and working status.

• MeSH
• Demography MeSH
• Diabetes Mellitus epidemiology   MeSH
• Diabetes Complications epidemiology   MeSH
• Quality of Life * MeSH
• Middle Aged MeSH
• Humans MeSH
• Cross-Sectional Studies MeSH
• Risk Factors MeSH
• Socioeconomic Factors MeSH
• Health Status * MeSH
• Health Surveys MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Serbia MeSH

Aim: The aim of the present study was to evaluate the effects of music on preoperative state anxiety and physiological parameters including heart rate, respiratory rate and mean systolic, and diastolic blood pressure in 60 patients undergoing general surgery. Methods: The study was designed as a randomized quasi-experimental trial. A total of 60 patients were allocated to two equal groups. Subjects in the trial group listened to non-vocal classical music through headphones for 20 minutes before entering the operating theater. State anxiety was measured by the State-Trait Anxiety Inventory (STAI), and the physiological parameters by pulse CO-oximeter (Masimo RAD-57C, Finland). The results obtained were finally analyzed by SPSS software version 16 using chi-square and t-tests. Results: There was an insignificant difference in demographic data between the two groups (p > 0.05), but before and after listening to music, a significant difference was observed in state anxiety (p < 0.01). Conclusions: Significant differences in both state anxiety and physiological parameters confirmed that music as a non-pharmacological intervention can be used as a complementary tool in nursing care.

• MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Monitoring, Physiologic statistics & numerical data   MeSH
• Music Therapy * statistics & numerical data   MeSH
• Pragmatic Clinical Trials as Topic statistics & numerical data   MeSH
• Preoperative Period MeSH
• Preoperative Care * methods   statistics & numerical data   MeSH
• Psychological Tests statistics & numerical data   MeSH
• Aged MeSH
• Anxiety * diagnosis   prevention & control   psychology   therapy   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Evaluation Study MeSH

Orius strigicollis (Poppius) is an anthocorid bug with high foraging ability on thrips as well as on mites, and the bug has been considered as a potential biological control agent in Taiwan. Life table and predation studies of O. strigicollis fed on Cadra cautella (Walker) and Tetranychus urticae (Koch) eggs were conducted at 25 ± 1°C. Data were analyzed and compared using TWOSEX-MSChart and CONSUME-MSChart software. O. strigicollis fed on eggs of C. cautella, a substitute prey, showed significantly higher survival rate and developmental rate than individuals fed on their natural prey, T. urticae eggs. The fecundity of O. strigicollis fed on C. cautella eggs was, on average, 13.2 times higher than that of those fed on T. urticae eggs, despite of the fact that during the entire nymphal stage, the consumption rate of O. strigicollis on T. urticae eggs was ca. 9 times higher than on almond moth eggs The conversion rate (i.e., number of prey eggs needed to produce one predator egg) for this predatory bug reared on T. urticae eggs and almond moth eggs were 604.6 and 6.0, respectively, indicating that almond moth eggs served as an effective alternative prey for ensuring the predator's reproduction. This is the first study pertaining to the population parameters and predation rates of O. strigicollis using the age-stage two-sex approach to describe differences between O. strigicollis populations reared on natural and alternative preys. This information may be useful in mass rearing programs and field application involving this biological control agent.

• MeSH
• Pest Control, Biological * MeSH
• Diet MeSH
• Heteroptera growth & development   physiology   MeSH
• Moths * growth & development   MeSH
• Nymph growth & development   physiology   MeSH
• Ovum MeSH
• Predatory Behavior * MeSH
• Life Tables MeSH
• Tetranychidae * growth & development   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH

Aim: To describe the demographic and clinical characteristics of patients with Charcot neuro-osteoarthropathy (CNO) and to examine for differences between participants with Type 1 diabetes mellitus (DM) (T1DM) and Type 2 diabetes mellitus (T2DM). Materials and Methods: Multicenter observational study in eight diabetic foot clinics in six countries between January 1, 1996, and December 31, 2022. Demographic, clinical, and laboratory parameters were obtained from the medical records. Analyses were performed using parametric or nonparametric statistical tests for variables with normally or nonnormally distributed values, respectively. Comparisons of the qualitative data were performed using the chi-square test. Results: Seven hundred seventy-four patients with DM and CNO were included. The mean age at diagnosis of CNO was 54.5 ± 11.7 years, and the median (interquartile range (IQR)) diabetes duration at diagnosis of CNO was 15 (10-22) years. Among participants, 71.8% (n = 546) were male and 83.2% (n = 634) had T2DM. Neuropathy was present in 91.7% (n = 688), retinopathy in 60.2% (n = 452), and nephropathy in 45.2% (n = 337). Subjects with T1DM, compared to T2DM, were diagnosed with CNO at a younger age (46.9 ± 11.0 vs. 57.9 ± 10.2 years, p < 0.001), had longer diabetes duration (median value (IQR): 29.0 (21.0-38.0) vs. 14.0 (8.0-20.0) years, p < 0.001), and had more often microvascular complications (neuropathy, 95.2% in T1DM vs. 87.4% in T2DM, p = 0.006; retinopathy, 83.3% vs. 55.4%, p < 0.001; and nephropathy 67.5% vs. 40.5%, p < 0.001). Conclusions: CNO is predominant in males, occurs in long-standing DM, and is often accompanied by microvascular complications. People with T1DM, compared to those with T2DM, are affected at a younger age, have longer diabetes duration, and have more often microvascular complications.

• MeSH
• Diabetes Mellitus, Type 1 * epidemiology   complications   MeSH
• Diabetes Mellitus, Type 2 * epidemiology   complications   MeSH
• Diabetic Foot epidemiology   diagnosis   MeSH
• Diabetic Retinopathy epidemiology   MeSH
• Diabetic Neuropathies epidemiology   diagnosis   MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Arthropathy, Neurogenic * epidemiology   MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH
• Observational Study MeSH