Distribution
Dotaz
Zobrazit nápovědu
- MeSH
- experimentální nádory MeSH
- myši MeSH
- radioizotopy ytria MeSH
- tkáňová distribuce MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- MeSH
- experimentální nádory MeSH
- experimenty na zvířatech MeSH
- fibrosarkom chemicky indukované MeSH
- krysa rodu rattus MeSH
- pohyb buněk MeSH
- reakce štěpu proti hostiteli MeSH
- T-lymfocyty MeSH
- techniky in vitro MeSH
- transplantace nádorů MeSH
- transplantační imunologie MeSH
- Check Tag
- krysa rodu rattus MeSH
Chest, ISSN 0012-3692 vol. 96, no. 3, suppl., September 1989
301S-378S s. : il., tab., grafy ; 28 cm
- MeSH
- obstrukční plicní nemoci MeSH
- rizikové faktory MeSH
- Publikační typ
- kongresy MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- epidemiologie
- pneumologie a ftizeologie
- MeSH
- adrenalin MeSH
- dopamin MeSH
- krysa rodu rattus MeSH
- mozek analýza MeSH
- noradrenalin MeSH
- serotonin MeSH
- Check Tag
- krysa rodu rattus MeSH
OBJECTIVE: The distribution of different antidepressants between plasma and red blood cells (RBCs) or between water and erythrocyte membranes (ghosts) has not been sufficiently compared so far. MATERIALS AND METHODS: Distribution of seven antidepressants (amitriptyline, nortriptyline, imipramine, desipramine, didesmethylimipramine, dothiepin, and citalopram) was measured in vitro in small volumes of blood or erythrocyte membrane suspension using radiolabeled drugs. Blood samples were taken from healthy subjects. RESULTS: The distribution of antidepressants between plasma and RBCs is strongly affected by temperature; however, it does not depend on the antidepressant concentration in the range of their therapeutic concentrations. The data analysis proved that the ratio of RBCs to plasma volume concentrations is the suitable parameter characterizing antidepressant distribution in whole blood. Significantly higher ratios of RBCs to plasma concentrations were found for demethylated metabolites of tricyclic antidepressants and in the case of citalopram. Citalopram showed the highest accumulation in intact RBCs and at the same time the lowest binding to isolated membranes. The binding of drugs to isolated erythrocyte membranes was much higher than in whole blood. CONCLUSION: The concentration ratio of antidepressant in RBCs and in plasma is sensitive not only to the binding properties of plasma proteins and cell membranes, but also to changes in drug molecule, both in aminopropyl chain and in aromatic rings. This ratio is to a large extent characteristic of a particular antidepressant.
