• MeSH
• Biocompatible Materials MeSH
• Biomimetics * MeSH
• Nanotechnology MeSH
• Publication type
• Periodical MeSH

• Conspectus
• *Technika, technologie, inženýrství
• NML Fields
• technika lékařská, zdravotnický materiál a protetika

• MeSH
• Biomedical Engineering MeSH
• Publication type
• Abstracts MeSH
• Congress MeSH
• Collected Work MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• biomedicínské inženýrství

• MeSH
• Ergonomics MeSH
• Computers MeSH
• Workplace MeSH
• Software MeSH
• Publication type
• Review MeSH

Enzymes are efficient and specific catalysts for many essential reactions in biotechnological and pharmaceutical industries. Many times, the natural enzymes do not display the catalytic efficiency, stability or specificity required for these industrial processes. The current enzyme engineering methods offer solutions to this problem, but they mainly target the buried active site where the chemical reaction takes place. Despite being many times ignored, the tunnels and channels connecting the environment with the active site are equally important for the catalytic properties of enzymes. Changes in the enzymatic tunnels and channels affect enzyme activity, specificity, promiscuity, enantioselectivity and stability. This review provides an overview of the emerging field of enzyme access tunnel engineering with case studies describing design of all the aforementioned properties. The software tools for the analysis of geometry and function of the enzymatic tunnels and channels and for the rational design of tunnel modifications will also be discussed. The combination of new software tools and enzyme engineering strategies will provide enzymes with access tunnels and channels specifically tailored for individual industrial processes.

• MeSH
• Biotechnology * MeSH
• Catalytic Domain MeSH
• Catalysis MeSH
• Protein Engineering MeSH
• Software * MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH

• MeSH
• Hypertension MeSH
• Software MeSH
• Telecommunications utilization   MeSH
• Telemedicine methods   MeSH
• Medical Informatics Applications MeSH
• Publication type
• Practice Guideline MeSH

Určeni vhodné nury frekvence výsUyůi jistého onemocnení je v epidemiologu nezbytným prostředkem při porovnávání sledovaných populací, a tedy určení příčin onemocněnu Dvě porovnávané frekvence jistého onemocněni mohou být zkombinovány do jediného souhrnného parametru, který odhaduje souvislosti meú nemocí a rizikovými faktory. Tento parantetr může být reprezentován bud' pomJěrem frekvenci onemocnění u dvou populací, který naznačuje, kolikrát je pravděpodobnost výskytu onemocněni v jedné populaci vyšší nd ve druhé, nebo razdňem těchto frekvencí, který ukazjuje, o kolik je vyšší výskyt nemoci v jedné z populací. K výpočtu výše zmíněných měr výskytu onemocnění můžeme použň statistici^ software. Ten však vždy nebývá nejvhodnější pro analýzu dat z epidemiologických studií V EuroMlSE Centru Univerzity Karlovy a Ákadenúe věd České republiky byl s podporou projektu Copernicus JRP-10053 vyvinut program E.T. (Epidemiology Tools) . Tento program je vhodný pro praktickou analýzu dat z retrospektivních či prospektivních studií Slouží také pro porovnávám'úmrtnosti a nemocnosti populací (metoda standardizace). Úplatném'nachází i při výuce epidemiologie.

In epidemiological research the calculation of appropriate measures of disease frequency is the basis for a comparison of populations and, herefore, the identification of disease determinants. Two frequencies being compared can be combined into a single summary parameter that estimates the associctiion between an exposure and a disease. This ľort fee accomplished by calculation either the ratio of the measures of disease frequency for two populations which incäcates how much likely one population is to develop a disease than another, or the difference between the frequencies which indicates how much greater the frequency of a cäsease is in one population compared with the other. In epidemiology we often need to compute measures of disease f requency mentioned above. We can do that by means of complex statistical software, but sometimes it is not easy or possible to use these software for an analysis of epidemiological data. At the EuroMISE Zenter of Charies University and Academy of Sciences in frame of the research supported from grant COPERNICUS JRP-10053 the E.T. program (Epidenúology took) was developed This program can be uedfor practical analysis of data from retrospective (case-control) studies or prospective (cohort) stiidies and for the standardization. However, the program can be also useful teaching tod in the epidemiology courses.

• MeSH
• Epidemiology MeSH
• Humans MeSH
• Software MeSH
• Check Tag
• Humans MeSH

• MeSH
• Biomedical Engineering MeSH
• Genetic Engineering MeSH

Herein, the recent advances in the development of resorbable polymeric-based biomaterials, their geometrical forms, resorption mechanisms, and their capabilities in various biomedical applications are critically reviewed. A comprehensive discussion of the engineering approaches for the fabrication of polymeric resorbable scaffolds for tissue engineering, drug delivery, surgical, cardiological, aesthetical, dental and cardiovascular applications, are also explained. Furthermore, to understand the internal structures of resorbable scaffolds, representative studies of their evaluation by medical imaging techniques, e.g., cardiac computer tomography, are succinctly highlighted. This approach provides crucial clinical insights which help to improve the materials' suitable and viable characteristics for them to meet the highly restrictive medical requirements. Finally, the aspects of the legal regulations and the associated challenges in translating research into desirable clinical and marketable materials of polymeric-based formulations, are presented.

• MeSH
• Biocompatible Materials chemistry   MeSH
• Drug Delivery Systems * methods   MeSH
• Humans MeSH
• Polymers * chemistry   MeSH
• Tissue Engineering * methods   MeSH
• Tissue Scaffolds chemistry   MeSH
• Absorbable Implants MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

• MeSH
• Biocompatible Materials therapeutic use   MeSH
• Biomedical Engineering MeSH
• Publication type
• Periodical MeSH

• Conspectus
• Biotechnologie. Genetické inženýrství
• NML Fields
• biomedicínské inženýrství

• MeSH
• Engineering MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• radiologie, nukleární medicína a zobrazovací metody
• technika
• NML Publication type
• elektronické časopisy