Pose scoring
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... Score with LKES 7 -- Correlation Among POSE Score, LKES, and Subjective Measures 7 -- Correlation Between ... ... POSE Score and LKES 8 -- Predictive Power of POSE Score 8 -- Comparison between Treatment Groups Using ... ... Outcomes (Symptoms) 10 -- Impact of Steroids on Objective Outcomes (Endoscopy) 10 -- Comparison of the POSE ... ... of CRS 22 -- Endoscopic Evaluation of ESS and Nasal Polyposis 22 -- Perioperative Sinus Endoscopy Score ... ... (POSE Score) 23 -- General Objective 2 23 -- Appendices Bibliography 23 -- Appendix II Online Only - ...
The laryngoscope, ISSN 0023-852X Volume 117, no. 11 Part 2 supplementum, November 2007
28 stran : tabulky ; 28 cm
- MeSH
- endoskopie MeSH
- nosní polypy chirurgie MeSH
- otorinolaryngologické chirurgické výkony MeSH
- perioperační medicína MeSH
- rinosinusitida chirurgie MeSH
- steroidy MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- otorinolaryngologie
- pneumologie a ftizeologie
- NLK Publikační typ
- studie
BACKGROUND: Pre-hospital blood transfusion (PHBT) is a safe and gradually expanding procedure applied to trauma patients. A proper decision to activate PHBT with the presently limited diagnostic options at the site of an incident poses a challenge for pre-hospital crews. The purpose of this study was to compare the selected scoring systems and to determine whether they can be used as valid tools in identifying patients with PHBT requirements. METHODS: A retrospective single-center study was conducted between June 2018 and December 2020. Overall, 385 patients (aged [median; IQR]: 44; 24-60; 73% males) were included in this study. The values of five selected scoring systems were calculated in all patients. To determine the accuracy of each score for the prediction of PHBT, the Receiver Operating Characteristic (ROC) analysis was used and to measure the association, the odds ratio with 95% confidence intervals was counted (Fig. 1). RESULTS: Regarding the proper indication of PHBT, shock index (SI) and pulse pressure (PP) revealed the highest value of AUC and sensitivity/specificity ratio (SI: AUC 0.88; 95% CI 0.82-0.93; PP: AUC 0.85 with 95% CI 0.79-0.91). CONCLUSION: Shock index and pulse pressure are suitable tools for predicting PHBT in trauma patients.
Mobile wireless communication technologies have now become an everyday part of our lives, 24 hours a day, 7 days a week. Monitoring the autonomous system under exposition to electromagnetic fields may play an important role in broading of our still limited knowledge on their effect on human body. Thus, we studied the interaction of the high frequency electromagnetic field (HF EMF) with living body and its effect on the autonomic control of heart rate using Heart Rate Variability (HRV) linear and nonlinear analyses in healthy volunteers. A group of young healthy probands (n=30, age mean: 24.2 ± 3.5 years) without any symptoms of disease was exposed to EMF with f=2400 MHz (Wi Fi), and f=2600 MHz (4G) for 5 minutes applied on the chest area. The short-term heart rate variability (HRV) metrics were used as an indicator of complex cardiac autonomic control. The evaluated HRV parameters: RR interval (ms), high frequency spectral power (HF-HRV in [ln(ms2)]) as an index of cardiovagal control, and a symbolic dynamic index of 0V %, indicating cardiac sympathetic activity. The cardiac-linked parasympathetic index HF-HRV was significantly reduced (p =0.036) and sympathetically mediated HRV index 0V % was significantly higher (p=0.002) during EMF exposure at 2400 MHz (Wi-Fi), compared to simulated 4G frequency 2600 MHz. No significant differences were found in the RR intervals. Our results revealed a shift in cardiac autonomic regulation towards sympathetic overactivity and parasympathetic underactivity indexed by HRV parameters during EMF exposure in young healthy persons. It seems that HF EMF exposure results in abnormal complex cardiac autonomic regulatory integrity which may be associated with higher risk of later cardiovascular complications already in healthy probands.
- MeSH
- autonomní nervový systém MeSH
- dospělí MeSH
- elektromagnetická pole * škodlivé účinky MeSH
- kardiovaskulární nemoci * MeSH
- lidé MeSH
- mladý dospělý MeSH
- rizikové faktory kardiovaskulárních chorob MeSH
- rizikové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- Publikační typ
- časopisecké články MeSH
We have recently introduced the "SQM/COSMO" scoring function which combines a semiempirical quantum mechanical description of noncovalent interactions at the PM6-D3H4X level and the COSMO implicit model of solvation. This approach outperformed standard scoring functions but faced challenges with a metalloprotein featuring a Zn(2+)···S(-) interaction. Here, we invoke SCC-DFTB3-D3H4, a higher-level SQM method, and observe improved behavior for the metalloprotein and high-quality results for the other systems. This method holds promise for diverse protein-ligand complexes including metalloproteins.
- MeSH
- kvantová teorie * MeSH
- ligandy MeSH
- metaloproteiny metabolismus MeSH
- termodynamika MeSH
- vazba proteinů MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- diabetes mellitus 2. typu * diagnóza farmakoterapie MeSH
- diabetická ketoacidóza MeSH
- diabetická retinopatie MeSH
- diabetické nefropatie MeSH
- diabetické neuropatie MeSH
- hyperosmolární hyperglykemické kóma MeSH
- hypoglykemie diagnóza farmakoterapie klasifikace MeSH
- komplikace diabetu * klasifikace MeSH
- lidé MeSH
- management nemoci MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- přehledy MeSH
OBJECTIVE: To evaluate the course of pregnancy and puerperium in asymptomatic carriers of FV Leiden and FII prothrombin mutation in heterozygous configuration in terms of risk of thrombembolic disease (TED) and late pregnancy complications. To evaluate whether global prophylactic LMWH administration during pregnancy benefits these women. METHODS: We monitored the incidence of thrombembolic events and severe late pregnancy complications in 473 asymptomatic carriers of FV Leiden and FII prothrombin mutation in heterozygous configuration. In 253 women, preventive LMWH application was introduced already during pregnancy. In 220 women, the application of LMWH was commenced as late as on the delivery day. In both groups application of LMWH continued during the puerperium. RESULTS: The incidence of TED in the whole group of carriers of thrombophylic mutations accounted for 0.19%. The incidence of severe late pregnancy complications was low - 2.5% compared with general population of pregnant women (6.4%). CONCLUSIONS: No direct causal relationship was established between asymptomatic carriage of Leiden and prothrombin mutation in heterozygous configuration and the occurrence of severe late pregnancy complications. There was no benefit from general LMWH prophylaxis started as early as pregnancy in these women and thus we consider it unnecessary.
- MeSH
- antikoagulancia terapeutické užití MeSH
- faktor V genetika MeSH
- heparin nízkomolekulární terapeutické užití MeSH
- heterozygot * MeSH
- incidence MeSH
- kardiovaskulární komplikace v těhotenství epidemiologie genetika prevence a kontrola MeSH
- komplikace porodu epidemiologie genetika prevence a kontrola MeSH
- lidé MeSH
- mutace MeSH
- poporodní období MeSH
- protrombin genetika MeSH
- rizikové faktory MeSH
- těhotenství MeSH
- tromboembolie epidemiologie genetika prevence a kontrola MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
In today's biometric and commercial settings, state-of-the-art image processing relies solely on artificial intelligence and machine learning which provides a high level of accuracy. However, these principles are deeply rooted in abstract, complex "black-box systems". When applied to forensic image identification, concerns about transparency and accountability emerge. This study explores the impact of two challenging factors in automated facial identification: facial expressions and head poses. The sample comprised 3D faces with nine prototype expressions, collected from 41 participants (13 males, 28 females) of European descent aged 19.96 to 50.89 years. Pre-processing involved converting 3D models to 2D color images (256 × 256 px). Probes included a set of 9 images per individual with head poses varying by 5° in both left-to-right (yaw) and up-and-down (pitch) directions for neutral expressions. A second set of 3,610 images per individual covered viewpoints in 5° increments from -45° to 45° for head movements and different facial expressions, forming the targets. Pair-wise comparisons using ArcFace, a state-of-the-art face identification algorithm yielded 54,615,690 dissimilarity scores. Results indicate that minor head deviations in probes have minimal impact. However, the performance diminished as targets deviated from the frontal position. Right-to-left movements were less influential than up and down, with downward pitch showing less impact than upward movements. The lowest accuracy was for upward pitch at 45°. Dissimilarity scores were consistently higher for males than for females across all studied factors. The performance particularly diverged in upward movements, starting at 15°. Among tested facial expressions, happiness and contempt performed best, while disgust exhibited the lowest AUC values.
- MeSH
- algoritmy * MeSH
- automatizované rozpoznávání obličeje * metody MeSH
- biometrická identifikace metody MeSH
- dospělí MeSH
- hlava - pohyby fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- obličej anatomie a histologie MeSH
- počítačové zpracování obrazu metody MeSH
- postura těla fyziologie MeSH
- výraz obličeje * MeSH
- zobrazování trojrozměrné MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Aim: The aim of the study was to identify the challenges and problems faced by student nurses and paramedic students during the clinical practice stage of their education. Design: The current study utilized a cross-sectional research design. Methods: A sample of 259 students was selected through convenience sampling, comprising 127 student nurses and 132 paramedic students. An adapted self-administered questionnaire, the Clinical Learning Environment Supervision and Nurse Teacher (CLES+T) evaluation scale was used to collect data, with the permission of the author. Socio-demographic characteristics were shown in the form of frequency and percentages. Findings concerning the evaluation of clinical learning were calculated in the context of descriptive statistical analysis, such as mean and standard deviation. An independent sample t-test was applied to compare the findings. Results: The mean age of respondents was 21.39 years, of whom 60 (61.8%) were male and 99 (32.2%) were female. The highest mean score (3.87 ± 0.77) was awarded to Nursing Care Provided on the Ward, while the lowest mean score was achieved for Supervisory Relationships on the Ward (3.71 ± 0.84). Conclusion: The study showed overall satisfaction with the clinical environment. Male and paramedic students were least satisfied. Considerable improvement is needed in the context of Pedagogical Atmosphere and Supervisory Relationships on the ward.
G protein-coupled receptors (GPCRs) are hard to crystallize. However, attempts to predict their structure have boomed as a result of advancements in crystallographic techniques. This trend has allowed computer-aided molecular modeling of GPCRs. We analyzed the performance of four molecular modeling programs in pose evaluation of re-docked antagonists / inverse agonists to 11 original crystal structures of aminergic GPCRs using an induced fit-docking procedure. AutoDock and Glide were used for docking. AutoDock binding energy function, GlideXP, Prime MM-GB/SA, and YASARA binding function were used for pose scoring. Root mean square deviation (RMSD) of the best pose ranged from 0.09 to 1.58 Å, and median RMSD of the top 60 poses ranged from 1.47 to 3.83 Å. However, RMSD of the top pose ranged from 0.13 to 7.33 Å and ranking of the best pose ranged from the 1st to 60th out of 60 poses. Moreover, analysis of ligand-receptor interactions of top poses revealed substantial differences from interactions found in crystallographic structures. Bad ranking of top poses and discrepancies between top docked poses and crystal structures render current simple docking methods unsuitable for predictive modeling of receptor-ligand interactions. Prime MM-GB/SA optimized for 3NY9 by multiple linear regression did not work well at 3NY8 and 3NYA, structures of the same receptor with different ligands. However, 9 of 11 trajectories of molecular dynamics simulations by Desmond of top poses converged with trajectories of crystal structures. Key interactions were properly detected for all structures. This procedure also worked well for cross-docking of tested β2-adrenergic antagonists. Thus, this procedure represents a possible way to predict interactions of antagonists with aminergic GPCRs.
Východiska: Císařský řez patří mezi nejčastější porodnické operace, kterými je ukončován porod a těhotenství ve třetím trimestru. Jde o chirurgický výkon, a proto jako každá operace skýtá svá rizika jak pro matku, tak pro novorozence. Po provedeném císařském řezu je dle studií možné pozorovat souvislost mezi císařským řezem a vznikem gynekologických potíží, komplikací v následujících graviditách a dysfunkcí pánevního dna u matky. Cíl: Hlavním cílem přehledové práce byla prezentace a sumarizace publikovaných poznatků o problematice císařského řezu z hlediska rizik pro matku. Metody: K vyhledávání literárních zdrojů byly využity elektronické informační databáze PubMed, EBSCO, Medvik (BMČ) a databáze Google Scholar. Dokumenty byly vyhledávány ve stanoveném období 2007-2018 pomocí klíčových slov ověřených v třídníku tezauru Medical Subject Headings a kombinování pomocí Booelovských operátorů. Výsledky: Z hlediska krátkodobých rizik je plánovaný císařský řez srovnatelný s vaginálním porodem. Akutní císařský řez je však provázen vyšším výskytem krevních ztrát, viscerálních poranění, infekčních a tromboembolických komplikací. Mezi dlouhodobá rizika, na která může mít císařský řez vliv, lze zařadit gynekologické potíže jako je intermenstruační spotting, dysmenorea a pelvialgie. Významná rizika představuje císařský řez pro následující těhotenství. Závěry: Mnoho studií zabývající se riziky císařského řezu ukazuje rozpoluplné výsledky. V souvislosti se zvyšujícím se počtem císařských řezů jsou zapotřebí další a podrobnější výzkumy, které by pomohly osvětlit další souvislosti. Nelze také zapomínat na to, že císařský řez může představovat rizika nejen pro matku, ale i pro novorozence.
Introduction: Caesarean section is the most common obstetric operation that ends the delivery and pregnancy in the third trimester. It is the surgical procedure and like any other operation, it can pose risks to both, the mother and the newborn child. According to current studies, after the caesarean section is perfermed it is possible to observe a link between the operation and occurence of gynecological problems, complications in subsequent pregnancies, and dysfunction of mother ́s pelvic floor. Aim: The main aim of this review was to present and summarize the published findings of the issue of caesarean section from the perspective of maternal risks. Methodology: Electronic information databases PubMed, EBSCO, Medvik (BMČ), and Google Scholar were used for searching literal sources. Documents from the period of 2007-2018 were searched using keywords verified in the Medical Subject Headings thesaurus and combined via using Booel ́s operators. Results: In the perspective of short-term risks, planned CS is comparable with vaginal birth. However, acute SC is associated with a higher incidence of blood loss, visceral injury, infectious and thromboembolic complications. The long-term risks of CS consist of gynecological problems such as intermenstrual spotting, dysmenorrhoea, and pelipathy. CS also poses significant risks for next pregnancies. Conclusion: Many studies dealings with the risks of caesarean section show inconsistent results. In the context of the increasing number of caesarean sections, more detailed research is needed to clarify this area of interest. It should also be noted that caesarean section may pose risks not only to the mother but also to the newborn child.
