svazky : ilustrace ; 24 cm
- MeSH
- Cognition * physiology MeSH
- Psychological Phenomena MeSH
- Psychology MeSH
- Publication type
- Periodical MeSH
- Conspectus
- Psychologie
- NML Fields
- psychologie, klinická psychologie
Informační teorie je teoretickým rámcem pro vysvětlení vzniku psychopatologie i mechanizmu léčby. Schizofrenii je možné interpretovat jako důsledek poruchy zpracování informací při snížené konektivitě populací pyramidových neuronů. Antipsychotika modulují informační processing svým ovlivněním dopaminergní aktivity a optimalizují poměr signál/šum. Tímto mechanizmem kompenzují deficit synaptické konektivity. Antipsychotika 2. generace ve srovnání s klasickými antipsychotiky nejen mediotemporálně blokují D2 receptory, ale mechanizmem blokády 5-HT2 receptorů také zvyšují hladinu dopaminu v prefrontální kůře. Tím ovlivňují příznaky negativní i kognitivní dysfunkce u schizofrenie.
Information theory is the conceptual framework for understanding the psychopathology and mechanisms of psychiatric treatment. Schizophrenia as the disorder of information processing should be the result of the decrease connectivity of pyramidal neurons. Antipsychotic drugs modulate information processing by the regulation of dopaminergic activity and this way they optimize the signal/noise ratio. By this mechanism the antipsychotics compensates the deficit of synaptic connectivity. Second generation antipsychotics in comparison with classical ones not only block the D2 receptors but also due to the 5-HT2 antagonism also increase the dopamine in prefrontal kortex. The increased dopamine in prefrontal kortex leads to the amelioration of negative symptoms and cognitive dysfunction.
elektronický časopis
- MeSH
- Behavior and Behavior Mechanisms MeSH
- Cognitive Behavioral Therapy MeSH
- Psychotherapeutic Processes MeSH
- Psychotherapy, Rational-Emotive MeSH
- Conspectus
- Psychiatrie
- NML Fields
- psychiatrie
- NML Publication type
- elektronické časopisy
BACKGROUND AND PURPOSE: Cognitive impairment (CI) in multiple sclerosis (MS) is associated with bidirectional changes in resting-state centrality measures. However, practicable functional magnetic resonance imaging (fMRI) biomarkers of CI are still lacking. The aim of this study was to assess the graph-theory-based degree rank order disruption index (kD) and its association with cognitive processing speed as a marker of CI in patients with MS (PwMS) in a secondary cross-sectional fMRI analysis. METHODS: Differentiation between PwMS and healthy controls (HCs) using kD and its correlation with CI (Symbol Digit Modalities Test) was compared to established imaging biomarkers (regional degree, volumetry, diffusion-weighted imaging, lesion mapping). Additional associations were assessed for fatigue (Fatigue Scale for Motor and Cognitive Functions), gait and global disability. RESULTS: Analysis in 56 PwMS and 58 HCs (35/27 women, median age 45.1/40.5 years) showed lower kD in PwMS than in HCs (median -0.30/-0.06, interquartile range 0.55/0.54; p = 0.009, Mann-Whitney U test), yielding acceptable yet non-superior differentiation (area under curve 0.64). kD and degree in medial prefrontal cortex (MPFC) correlated with CI (kD/MPFC Spearman's ρ = 0.32/-0.45, p = 0.019/0.001, n = 55). kD also explained fatigue (ρ = -0.34, p = 0.010, n = 56) but neither gait nor disability. CONCLUSIONS: kD is a potential biomarker of CI and fatigue warranting further validation.
- MeSH
- Adult MeSH
- Cognitive Dysfunction etiology physiopathology diagnostic imaging MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging * MeSH
- Cross-Sectional Studies MeSH
- Multiple Sclerosis * complications diagnostic imaging physiopathology MeSH
- Processing Speed MeSH
- Fatigue * physiopathology etiology diagnostic imaging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
