Background/Objectives: Post-activation performance enhancement (PAPE) has been explored for its potential to improve general performance in combat sports. This systematic review and meta-analysis investigated the effects of PAPE protocols on physical performance, focusing on differences across disciplines, competitive levels, and testing methods. Methods: A PRISMA-guided search (2010-2023) identified 19 studies examining PAPE protocols in combat sports athletes. The inclusion criteria required human trials using defined PAPE protocols, with outcomes of general performance indicators such as countermovement jumps (CMJs). A meta-analysis was conducted on data from 866 athletes using random effects modeling. Results: The PAPE protocols yielded a pooled effect size of 0.136 (95% CI, 0.008-0.263) across 866 athletes. Taekwondo athletes exhibited the most pronounced improvements in CMJ performance, particularly when using protocols that combined repeated vertical jumps with heavy-resistance cluster sets, and with dynamic, sport-specific movements such as the bandal chagui protocol achieving an effect size of 1.19 (p < 0.001). Conversely, Muay Thai athletes experienced performance declines when the protocols incorporated highly specific techniques, such as roundhouse kicks (ES = -1.36, p = 0.009). Analysis by competitive level revealed pooled effect sizes of 0.14 (95% CI, -0.01 to 0.29) for amateur athletes and 0.13 (95% CI, -0.11 to 0.38) for elite athletes, with no statistically significant differences observed between these groups. Conclusions: PAPE's effectiveness depends on tailoring protocols to the competitive level and discipline. Short rest intervals support plyometric protocols for amateurs, while heavy-resistance exercises enhance elite performers. Further research is needed to standardize PAPE protocols and explore discipline-specific adaptations.
- Publication type
- Journal Article MeSH
- Review MeSH
PURPOSE: Para-karate has been gaining popularity rapidly; however, scientific research on the subject remains limited. This study aims to examine the kata preferences at top-level para-karate events and explore the relationship between sport class (type of impairment) and kata selection. METHODS: Data was collected from nine events-four World Para-Karate Championships (2016, 2018, 2021, 2023) and five European Para-Karate Championships (2018, 2019, 2021, 2022, 2023). A total of 906 katas were performed: 567 by males and 339 by females. Descriptive statistics and chi-square tests were used for analysis. RESULTS: Top-level para-karate athletes utilized 62 katas (61%) from the official WKF list (102 katas). The most popular katas were Gojushiho Sho (19.9%), Unsu (11.5%), Kanku Sho (9.5%), Suparinpei (6.7%), and Jion (6.2%). A significant relationship was found between sport class and kata selection (p ≤ 0.05). The most popular kata for K30 was Unsu (15%), while K10 and K21 + K22 classes predominantly chose Gojushiho Sho (16.6% and 30.3%, respectively). CONCLUSIONS: Kata selection for para-karate athletes is influenced by the type of impairment. Intellectually impaired athletes and their coaches often select a single, challenging kata with a balanced fast-to-slow movement ratio, such as Gojushiho Sho, to optimize performance.
- Publication type
- Journal Article MeSH
AIM: Assessment of blood pressure during exercise is routine in athletes, but normal values remain equivocal. This study examines the response of systolic blood pressure (SBP) to exercise in a large cohort of athletes and establishes normative values by sex and age. METHODS: Competitive athletes free of cardiovascular disease underwent pre-participation exercise testing on a bicycle ergometer. Resting (SBPrest) and peak blood pressure (SBPpeak), heart rate (HRrest and HRpeak), and power output (WR) were recorded. Workload indexed values were calculated. RESULTS: The cohort included 12,083 athletes (median age 15 years, 26.9% female). Median peak exercise SBP was similar between sexes, but WR-indexed measures including SBP/WR ratio and SBP/(WR/kg) slope were higher in females (0.9 vs. 0.7, p < 0.001; 10.94 vs. 9.52, p < 0.001). Univariate analyses revealed significant associations between SBPpeak and several predictors, including sex, age, weight, height, SBPrest, DBPrest, HRrest, HRpeak, and WR (all p < .001). Multivariate analysis showed that SBPrest (beta = 0.353, 95% CI [0.541, 0.609], p < 0.001), height (beta = 0.303, 95% CI [0.360, 0.447], p < 0.001), WR (beta = 0.171, 95% CI [0.029, 0.045], p < 0.001), and age (beta = 0.093, 95% CI [0.162, 0.241], p < 0.001) were the strongest predictors of SBPpeak. CONCLUSION: This study provides reference values for the interpretation of SBP responses to exercise in athletes. Multivariate analyses highlight the complex interplay of factors influencing peak SBP, including SBPrest, height, WR, age, DBPrest, sex, endurance sport category, and weight. In future studies, these findings may inform the development of personalised training strategies and risk stratification models in athletic populations.
- Publication type
- Journal Article MeSH
This study investigated the impact of Hofstede cultural dimensions on sustainable competitive advantage with the mediating role of entrepreneurial innovativeness among Malays, Malaysian Chinese, and Malaysian Indian entrepreneurs in the retail industry. This study involved a quantitative approach with standardized questionnaires distributed among target respondents through non-probability sampling techniques, including snowball sampling, quota sampling, and convenience sampling. The data were collected in a cross-sectional setting from Malaysian retail ethnic entrepreneurs. AMOS-SEM and SPSS were used to analyze the data. The findings of this study revealed a positive and significant influence of indulgence, long-term orientation, masculinity, and low power distance on sustainable competitive advantage among Chinese, Malay, and Indian entrepreneurs. Furthermore, the direct effect of entrepreneurial innovativeness was also positive and significant in terms of sustainable competitive advantage among Chinese, Malay, and Indian entrepreneurs. Finally, the indirect effects of collectivism, indulgence, low uncertainty avoidance, low power distance, masculinity, and long-term orientation on sustainable competitive advantage through mediator entrepreneurial innovativeness were positive and significant among Malaysian Chinese. However, in Malay (indulgence) and India (collectivism, low uncertainty avoidance, and low power distance), these were not significant. Our results suggest that academics and businesses should consider how cultural norms of masculinity, long-term orientation, and uncertainty avoidance impact sustainable competitive advantage activities. Rewards encouraging sustainable competitive advantage in one subculture may not promote it in another. Subcultural norms influence entrepreneurs' decisions, expectations, and incentives in a culturally diverse community.
- MeSH
- Adult MeSH
- Ethnicity psychology MeSH
- Competitive Behavior MeSH
- Creativity MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Masculinity MeSH
- Entrepreneurship * MeSH
- Cross-Sectional Studies MeSH
- Surveys and Questionnaires MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Malaysia MeSH
Maximal athletic performance can be limited by various factors, including restricted respiratory function. These limitations can be mitigated through targeted respiratory muscle training, as supported by numerous studies. However, the full potential of respiratory training in competitive finswimming has not been fully investigated. This case study aims to evaluate the effects of eight-week respiratory muscle training (RMT) on performance variability during the underwater phases of a 200 m bi-fins race simulation in an elite finswimmer (current world record holder and multiple world championship medalist). Performance variability was assessed based on pre-test, inter-test, and post-test data. Each measurement included pulmonary function and swim performance evaluations. In this study, underwater performance parameters, such as distance, time, velocity, and number of kicks, were assessed using video analysis synchronized with race timing and evaluated using the Dartfish software. The swimmer followed a 28-day training program with an Airofit PROTM respiratory trainer between tests, with daily sessions targeting both inspiratory and expiratory muscles. The training involved 6-10 min of targeted exercises per day. Significant improvements were observed in Wilcoxon's paired-sample test between the pre-test and post-test results in terms of underwater distance (p = 0.012; d = 1.26), underwater time (p = 0.012; d = 1.26), and number of underwater kicks (p = 0.043; d = 1.01), resulting in a 14.23% longer underwater distance, 14.08% longer underwater time, and 14.94% increase in underwater kicks. Despite the increased distance and time, underwater velocity remained stable, indicating improved underwater performance efficiency. Despite some improvements, it is not possible to conclude that respiratory muscle training (RMT) can contribute to improved finswimming performance during the underwater phases of a 200 m bi-fins race simulation in this particular athlete's case. Further research with a larger sample size is necessary to fully understand the impact of RMT on finswimming performance.
- Publication type
- Journal Article MeSH
The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor integral to various physiological and pathological processes. Among its diverse ligands, indole-based compounds have garnered attention due to their significant biological activity and potential therapeutic applications. This study explores the activation of AhR by structurally diverse halogenated indoles. We evaluated the transcriptional activity of AhR and cell viability in the human LS174T-AhR-luc reporter cell line. Among the tested compounds, 4-FI, 7-FI, 6-BrI, 7-BrI, 6-Cl-2-ox, 5-Br-2-ox, and 6-Br-2-ox activated AhR in a concentration-dependent manner, displaying high efficacy and potency. Molecular docking analysis revealed moderate binding affinities of these compounds to the PAS-B domain of AhR, corroborated by competitive radioligand binding assays. Functional assays showed that halogenated indoles induce the formation of AhR-ARNT heterodimer and enhance the binding of the AhR to the CYP1A1 promoter. Additionally, 4-FI and 7-FI exhibited anti-inflammatory properties in Caco-2 cell models, highlighting their potential for therapeutic applications. This study underscores the significance of the type and position of halogen moiety in indole scaffold, suggesting their potential as candidates for developing therapeutics drugs to treat conditions such as inflammatory bowel disease via AhR activation.
- MeSH
- Cytochrome P-450 CYP1A1 metabolism MeSH
- Halogenation MeSH
- Indoles * chemistry pharmacology MeSH
- Humans MeSH
- Molecular Structure MeSH
- Receptors, Aryl Hydrocarbon * metabolism chemistry MeSH
- Molecular Docking Simulation * MeSH
- Basic Helix-Loop-Helix Transcription Factors MeSH
- Cell Survival drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Background: Recent research has linked the spread of microribonucleic acid (miRNA) to numerous disorders, either as a stimulant or an inhibitor. One of these is miRNA-22, which research has connected to oxidative stress and thyroid issues. However, the underlying mechanisms are unknown. This study investigates the expression of miRNA-22 in hypothyroid women and its relationship to the rise in oxidative stress in the patient population.Materials and Methods: 40 women patients with Hypothyroid and 40 in this study, healthy volunteers who served as controls were included. The levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) were measured by sandwich assay, while free triiodothyronine (FT3) and thyroxine (T4) levels were measured competitive binding immunoenzymatic assay. To assess lipid profiles, an automated analyzer was employed. By enzyme-linked immunosorbent assay (ELISA), Interleukin 6 (IL-6) levels were measured. Malondialdehyde (MDA), superoxide dismutase activity (SOD), catalase activity (CAT), and advanced oxidation protein products (AOPPs), and assessed using a colorimetric technique. The quantitative polymerase chain reaction was used to evaluate the expression of serum miRNA-22.Results: Significantly more SOD and CAT activity was identified in patient groups than in the control group (P<0.05), also the patient group's AOPP and MDA concentrations were discovered to significantly outweigh those of the control group. (P< 0.05). IL-6 levels were significantly higher in the patient group than in (P<0.05) the control group. The level of miRNA-22 was higher in the sick group as compared to the control groups (P<0.05).Conclusions: The pathophysiology of oxidative stress brought on by hypothyroidism involves miRNA-22 expression, there is a reciprocal relationship between the increase in gene expression of the miRNA-22 and the increase in oxidative stress, which results in the disease's development.
- MeSH
- Biomarkers blood MeSH
- Chemistry Techniques, Analytical methods instrumentation MeSH
- Adult MeSH
- Hormones blood MeSH
- Hypothyroidism * blood MeSH
- Humans MeSH
- MicroRNAs * blood MeSH
- Oxidative Stress MeSH
- Spectrum Analysis methods instrumentation MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Clinical Study MeSH
BACKGROUND: The aim of the research was to evaluate outdoor aerobic sport activities (OASA) in the physical education (PE) of university students using wearables and their potential to personalize the learning process and enhance motivation. METHODS: In total, 368 university students participated. The OASA structure and the key points of application in PE were described. Descriptive statistics of the training units (n = 3,680) were processed. The students recorded their training data in the Strava app (10 sessions per semester), and the data were shared in the online sport community created on the Strava platform. Motivation was evaluated using a questionnaire. The focus was both on intrinsic motivation and extrinsic "ICT" motivation, based on Strava app features and tools. RESULTS: The most preferred outdoor aerobic sport activities were running (58%), cycling (13%), and walking (16%). The results provided insight into motivation and performance analysis. Students' motivation to participate in OASA was mainly in health concerns, such as staying in shape (94%), staying healthy (90%), and psychological concerns, such as having fun (88%), improving state of mind (88%), or relieving stress (83%). In achievement concerns, the motivation was a personal challenge (72%), while competing with others was ranked lowest (32%). The Strava app was a motivating tool for students to record, monitor, and analyze their individual activities and feel "connectedness" to the online sport community. 70% of students were motivated by the non-competitive character of PE, which gave them a personalized opportunity to train without being compared to others. DISCUSSION: The OASA management, with the use of blended learning methods and the Strava app, uses a motivational approach to create, support, and maintain students' healthy habits of physical activity through PE lessons. The need for students to be motivated to exercise can be confirmed in the analysis of the statistical descriptive parameters of running, cycling, and walking. There was a tendency for students to complete only the minimum required distance/time (not more). On the other hand, students enjoyed the training, and 99% of students confirmed that they would enroll again. That fact underlined the importance of motivating students with an effective learning strategy and giving support and guidance.
- Publication type
- Journal Article MeSH
Citrulline is a non-proteinogenic amino acid that forms as by-product in nitric oxide (NO) synthesis from arginine and may act in concert with NO as an independent signaling molecule that involves in the mechanism of vascular smooth muscle vasodilation. In this study we examined the effects of citrulline on pulmonary artery smooth muscles. Experimental design comprised outward potassium currents measurements in enzymatically isolated rat pulmonary artery smooth muscle (PASMc) cells using whole-cell patch clamp technique, isometric contractile force recordings on rat pulmonary artery rings and method of molecular docking simulation. Citrulline in a concentration 10-9-10-5 M relaxed phenylephrine (PHE)-preactivated SM of rat pulmonary artery in a dose-dependent manner (EC50 0,67 μM). This citrulline-induced relaxation was dependent on an intact endothelium. Bath application of citrulline (10-8-10-5 M) on isolated PASMc induced a significant increase in the amplitude of outward potassium current (Ik). The adenosine antagonist caffeine (10-6 M) effectively blocked both the citrulline-induced relaxation response and Ik increment. Molecular docking modeling suggests that caffeine blocking the potent activity of citrulline results from competitive interactions at the A2 adenosine receptor binding site. In summary, our data suggest that citrulline, released with NO at low concentrations, can effectively interact with adenosine receptors in smooth muscle cells, causing their relaxation, indicating surprising interaction between NO and adenosine pathways.
- MeSH
- Pulmonary Artery drug effects metabolism MeSH
- Citrulline * pharmacology metabolism MeSH
- Rats MeSH
- Rats, Wistar MeSH
- Receptors, Purinergic P1 metabolism MeSH
- Molecular Docking Simulation * MeSH
- Muscle, Smooth, Vascular metabolism drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: An interesting and little-reported problem in the literature is the scale of asymmetry in table tennis players, the magnitude of which should perhaps be treated as a risk for injury. Determining the degree of asymmetry in table tennis players can indicate the need to appropriately manage the training process, including compensatory or corrective exercises in the training program, especially since recent studies confirm that training interventions can reduce sporting asymmetries and improve performance. This study aimed to assess the amount of asymmetry in the trunk regarding the frontal plane and the difference between limb circumferences in female table tennis players compared to the control group (non-athletes). METHODS: Twenty-two women took part in the study. Ten of them were table tennis professionals with an average training experience of 7 ± 4.3 years (the exclusion criterion of the study was a minimum of 3 years of training experience). As a comparison group, the study included 12 female students who did not participate in competitive sports. Body posture was assessed in all subjects using equipment for computer analysis of asymmetry in the torso using the photogrammetric method. Additionally, all the subjects had their upper and lower limb circumferences measured. RESULTS: The results of the conducted research showed asymmetry in the frontal plane in the table tennis player group. As many as six parameters-regarding the pelvic rotation angle, angle of trunk inclination, the height of the angles of the lower shoulder blades and their distance from the spine, as well as the waist triangles, difference in the width and height of the waist triangles and the angle of trunk inclination-indicated asymmetry in this group but significantly differed from the control group (p ≤ 0.05) only in the first parameter given above. The calculated differences in circumference between the right and left sides in the individual groups were statistically different in several cases (p ≤ 0.05). This concerned the circumferences of the arms, forearms, elbows, and knees of table tennis players. CONCLUSIONS: The research carried out in this study allowed us to determine the occurrence of asymmetry in the frontal plane of the trunk and between the limbs of table tennis players. According to some studies, this may be a risk factor for injury. However, despite the lack of uniform views in the literature on the importance and threats resulting from asymmetries, it appears that, if only for aesthetic reasons, table tennis would require compensatory or corrective training aimed at developing symmetry of the body structure.
- MeSH
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Posture physiology MeSH
- Athletes MeSH
- Tennis * physiology MeSH
- Torso * anatomy & histology physiology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
