BACKGROUND: The fear of taking away hope hinders clinicians' willingness to share serious news with patients with advanced disease. Unrealistic illness expectations, on the other hand, can complicate decision making and end-of-life care outcomes. Exploration of the association between hope and illness expectations can support clinicians in better communication with their patients. AIM: The aim of this study was to explore whether realistic illness expectations are associated with reduced hope in people with advanced cancer. DESIGN: This is a cross-sectional secondary analysis of baseline data from a primary palliative care cluster-randomized trial CONNECT (data collected from July 2016 to October 2020). Hope was measured by Herth Hope Index. Illness expectations were measured by assessing patients' understanding of their treatment goals, life expectancy, and terminal illness acknowledgement. Multivariable regression was performed, adjusting for demographical and clinical confounders. SETTING/PARTICIPANTS: Adult patients with advanced solid cancers recruited across 17 oncology clinics. RESULTS: Data from 672 patients were included in the study, with mean age of 69.3 years (±10.2), 53.6% were female. Proportion of patients indicating realistic expectations varied based on which question was asked from 10% to 46%. Median level of hope was 39 (IQR = 36-43). Multivariate non-inferiority regression did not find any significant differences in hope between patients with more and less realistic illness expectations. CONCLUSIONS: Our results suggest that hope can be sustained while holding both realistic and unrealistic illness expectations. Communication about serious news should focus on clarifying the expectations as well as supporting people's hopes.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- motivace MeSH
- naděje MeSH
- nádory * terapie MeSH
- paliativní péče metody MeSH
- péče o umírající * MeSH
- průřezové studie MeSH
- randomizované kontrolované studie jako téma MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- inteligence MeSH
- kybernetika MeSH
- lidé MeSH
- modely neurologické MeSH
- mozek fyziologie MeSH
- nervová síť MeSH
- neuronové sítě (počítačové) MeSH
- pud MeSH
- robotika MeSH
- umělá inteligence * MeSH
- vědomí MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- entropie MeSH
- inteligence MeSH
- kvantová teorie MeSH
- lidé MeSH
- mozek fyziologie MeSH
- systémová teorie MeSH
- teoretické modely MeSH
- vědomí * MeSH
- znalosti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
RATIONALE: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses. OBJECTIVE: The present study examined the acute, subchronic, and chronic dose-response effects of CAB and a derivative dimethylcabergoline (DMC) which acts as an antagonist instead of agonist at 5-HT 2B receptors, on appetitive and consummatory sexual behaviors of male rats. METHODS: CAB (0, 0.03, 0.15, or 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 68 days. Sexual behavior was tested every 4 days during this period for a total of 16 trials. On the 17th trial, rats were administered their dose of CAB, and 4 h after were overdosed with sodium pentobarbital, perfused intracardially, and their brains processed for Fos immunohistochemistry. DMC (0, 0.03, 0.15, 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 36 days. Sexual behavior was tested every 4 days for a total of 9 trials. RESULTS: CAB increased anticipatory level changes, intromissions, and ejaculations significantly across all timepoints, with the medium and high doses being most potent. The medium and high doses also increased Fos protein significantly within the medial preoptic area, whereas in the nucleus accumbens shell, the low and medium doses decreased Fos protein but the high dose increased it significantly from control. Similar to CAB, the medium and high doses of DMC increased the number of ejaculations significantly. Rats in all drug dose groups appeared healthy for the duration of the experiments. CONCLUSIONS: Both CAB and DMC facilitate ejaculations, and CAB further facilitates measures of anticipatory sexual motivation and intromissions. These data suggest that both could be used as treatments for sexual arousal disorders and ejaculation/orgasm disorders with little or no untoward side effects at low doses.
- MeSH
- kabergolin farmakologie MeSH
- kopulace * MeSH
- krysa rodu rattus MeSH
- motivace MeSH
- mozek MeSH
- pohlavní steroidní hormony MeSH
- receptory dopaminu D2 MeSH
- sexuální chování zvířat * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: In today's digital age, demanding to interpret vast quantities of visual information with speed and accuracy, nonverbal Intelligence has become increasingly crucial for children, as it plays a key role in cognitive development and learning. While motor proficiency has been positively linked to various cognitive functions in children, its relationship with nonverbal Intelligence remains an open question. This study, therefore, explored the structural associations between motor proficiency and nonverbal Intelligence in school-aged children (6 to 11 years), focusing on potential age and sex-specific patterns. METHODS: Data were obtained from 396 children aged 6 to 11 (214 boys, 182 girls; mean age 8.9 years ±1.3) divided into younger children 6-8 years and older Children 9-11 years. Motor proficiency was assessed using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2), and non-verbal Intelligence was evaluated with the Raven Progressive Matrices (RPM). We conducted multigroup structural modelling with non-verbal Intelligence as a dependent latent variable. RESULTS: The BOT-2 and RPM models demonstrated an acceptable fit in Czech children. Strength-agility and Fine motor control emerged as the strongest predictors of nonverbal intelligence level assessed by five sets of RPM. Age-specific analyses revealed that the Strength-agility construct was consistently a significant predictor of nonverbal intelligence level in both age categories. However, in older children, also Fine motor control was significantly linked to nonverbal intelligence level. Sex-specific differences were also observed in the structural modelling results, indicating significant predictor non-invariance based on participants' sex. In girls, both Fine motor control and the Strength-agility constructs were significant predictors of nonverbal Intelligence level, showing stronger associations with nonverbal Intelligence than boys. For boys, only the Strength-agility construct was a significant predictor of RPM performance. CONCLUSION: This study reveals a nuanced age- and sex-specific relationship between children's motor proficiency and nonverbal Intelligence. The findings underscore the need for targeted physical interventions, particularly those emphasising fine motor and strength-agility exercises, to ensure equitable opportunities for motor skill development. Such interventions may enhance physical abilities and support cognitive development in an increasingly digital world.
- MeSH
- analýza latentních tříd MeSH
- dítě MeSH
- inteligence * fyziologie MeSH
- lidé MeSH
- motorické dovednosti * fyziologie MeSH
- sexuální faktory MeSH
- věkové faktory MeSH
- vývoj dítěte fyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Prehabilitation aims to improve patients' physical condition before a stressful event, such as surgery, and enhance recovery. Despite its potential benefits, many emerging prehabilitation programs face challenges in enrolling or retaining patients. In our prehabilitation study PHOCUS, which aims to prepare ovarian cancer patients for surgery, we have also encountered lower acceptance and retention rates. Particularly the most vulnerable patients, who are old and frail, and may benefit the most from the prehabilitation, decline participation due to the complexity of the proposed program. In our review we discussed obstacles and barriers that prevent patients' participation based on both literature and our experience. Among the main reasons are patient's low motivation, high intensity of the program and a lack of social support. To overcome these challenges, we suggest increasing the program's flexibility, adapting the program according to individual patient's needs and enhancing patients' education about the benefits of prehabilitation.
- MeSH
- fyzioterapie v předoperační přípravě * psychologie MeSH
- lidé MeSH
- motivace MeSH
- nádory vaječníků chirurgie MeSH
- nádory ženských pohlavních orgánů * rehabilitace chirurgie MeSH
- pacientův souhlas se zdravotní péčí psychologie MeSH
- předoperační péče metody MeSH
- sociální opora MeSH
- vzdělávání pacientů jako téma metody MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
BACKGROUND: Alcohol use is one of the leading public health concerns in the Czech Republic. Drinking motives play a vital role in both initiation and subsequent alcohol use. A revised version of the self-report Drinking Motives Questionnaire (DMQ-R) has been proposed to assess these motives. The present study aims to validate the DMQ-R in the Czech general population. METHODS: A total sample of 1,784 Czech participants completed a national survey. For the analysis, only a sub-sample of the past 12 months alcohol users was used: N = 1,123; 52.8% male; mean (SD) age = 40.2 (13.3). Drinking motives were assessed by the adopted Czech version of the DMQ-R. Both confirmatory (CFA) and exploratory factor analysis (EFA) were conducted to examine the factorial structure of the instrument. The age of the participant was additionally considered in the analysis (15-24 years as opposed to 25-64 years). RESULTS: The CFA supported the four-factor model in the 25-64 age group. The analysis supported the construct validity of the Social, Conformity, and Coping factors. The Enhancement factor retained only two items and was found to refer more to a domain of 'Pleasant Feeling'. For the 15-24 age group, the hypothesised four-factor structure was not corroborated. CONCLUSIONS: The Czech version of the DMQ-R was found to be a reliable measurement tool of the Social, Conformity, and Coping motives. Future research should investigate the dimensionality of the instrument items presumed to correspond to the Enhancement motives. This should be conducted particularly among adolescents and young adults aged 15-24 years, where administering the DMQ-R with a large enough sample is also needed.
- MeSH
- adaptace psychologická MeSH
- dospělí MeSH
- faktorová analýza statistická MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- motivace * MeSH
- pití alkoholu * psychologie epidemiologie MeSH
- průzkumy a dotazníky normy MeSH
- psychometrie MeSH
- reprodukovatelnost výsledků MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- validační studie MeSH
- Geografické názvy
- Česká republika MeSH
Aim: The aim of the study was to investigate the relationship between Hungarian nursing students' career choices and nursing professionalism in the context of sex and gender roles. Design: A cross-sectional study. Methods: The study, conducted between March 2023 and June 2023, employed a combination of a self-developed questionnaire and validated measurement instruments (Bem Sex Role Inventory 12 - BSRI-12; Nurse Professional Competence Scale - NPC Scale; 10-item Gender Role Beliefs Scale - GRBS). Statistical analysis was performed using SPSS software. The sample consisted of 252 BSc nursing students in Hungary (53 males, 199 females). Results: It was found that most students surveyed exhibited feminine traits (n = 84) and adhered to traditional gender roles (n = 132). Statistical analysis demonstrated significant associations between nursing students' gender roles (p = 0.004), adherence to traditional gender roles (p < 0.000), and levels of nursing professionalism. Notably, an androgynous gender role correlated with heightened nursing professionalism (p < 0.001). Additionally, career choice motivations were influenced by sex, gender role, and individual perceptions of gender roles. Conclusion: A diversity of gender roles which influence individuals' future careers in nursing was identified. Different motivating factors play a role in male and female nursing students' career choices, knowledge of which would be useful in student recruitment in order to reduce nursing staff shortages.
Aim: To measure the level of emotional intelligence in medical-surgical nursing specialist nurses. Design: A quantitative descriptive cross-sectional study. Methods: Data were collected through a digital form comprising a questionnaire divided into two sections: first - sociodemographic and professional characterization; second - a Portuguese version of the Schutte Emotional Intelligence Scale. The internal consistency of the instrument, measured by Cronbach's alpha (unidimensional), was 0.878. Data were collected between 27 January and 16 March 2023. A non-probability convenience sampling technique was used to enroll the participants. Results: The final sample consisted of 168 medical-surgical nursing specialist nurses. Their mean emotional intelligence score was 105.28 points, with a standard deviation of 10.56 points. The variables academic degree (p = 0.002) and gender (p = 0.035) showed a statistically significant association with the total emotional intelligence score. Conclusion: This study allowed to measure the level of emotional intelligence in medical-surgical nursing specialist nurses, yielding high mean scores. Nevertheless, it is essential to invest in strategies for the acquisition of emotional intelligence skills by professionals with low mean scores.
