- MeSH
- Autistic Disorder * diagnosis prevention & control therapy MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Humans MeSH
- Neurodevelopmental Disorders diagnosis classification MeSH
- Child Development Disorders, Pervasive diagnosis classification MeSH
- Autism Spectrum Disorder diagnosis classification prevention & control MeSH
- Social Behavior MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- MeSH
- Asperger Syndrome diagnosis etiology therapy MeSH
- Autistic Disorder diagnosis etiology therapy MeSH
- Intelligence Tests MeSH
- Humans MeSH
- Adolescent MeSH
- Neuropsychological Tests MeSH
- Neurodevelopmental Disorders * diagnosis etiology therapy MeSH
- Child Development Disorders, Pervasive diagnosis etiology classification therapy MeSH
- Autism Spectrum Disorder diagnosis etiology psychology therapy MeSH
- Motor Skills Disorders diagnosis etiology therapy MeSH
- Learning Disabilities diagnosis etiology therapy MeSH
- Child, Preschool MeSH
- Rett Syndrome diagnosis etiology genetics MeSH
- Treatment Outcome MeSH
- Language Development Disorders diagnosis etiology therapy MeSH
- Developmental Disabilities diagnosis etiology therapy MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Asperger Syndrome history etiology therapy MeSH
- Autistic Disorder * diagnosis etiology classification psychology therapy MeSH
- Diagnosis, Differential MeSH
- Humans MeSH
- Neurodevelopmental Disorders classification MeSH
- Child Development Disorders, Pervasive * etiology classification MeSH
- Child Behavior Disorders diagnosis classification complications physiopathology psychology therapy MeSH
- Psychotropic Drugs administration & dosage adverse effects therapeutic use MeSH
- Check Tag
- Humans MeSH
- MeSH
- Autistic Disorder * diagnosis epidemiology classification psychology MeSH
- Child MeSH
- Comorbidity MeSH
- Communication Disorders MeSH
- Humans MeSH
- Child Development Disorders, Pervasive classification MeSH
- Social Behavior Disorders diagnosis classification MeSH
- Prognosis MeSH
- Age Factors MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- MeSH
- Asperger Syndrome diagnosis MeSH
- Autistic Disorder diagnosis MeSH
- Diagnosis, Differential * MeSH
- Child MeSH
- Mental Disorders diagnosis classification MeSH
- Comorbidity MeSH
- Humans MeSH
- Child Development Disorders, Pervasive * diagnosis classification MeSH
- Speech Disorders diagnosis MeSH
- Rett Syndrome diagnosis MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Keywords
- autismus, velmi nízká porodní hmotnost, extrémně nízká porodní hmotnost, screening,
- MeSH
- Autistic Disorder * diagnosis etiology prevention & control MeSH
- Early Diagnosis MeSH
- Child MeSH
- Infant MeSH
- Humans MeSH
- Infant, Low Birth Weight * growth & development MeSH
- Infant, Very Low Birth Weight * growth & development MeSH
- Infant, Newborn MeSH
- Child Development Disorders, Pervasive etiology classification MeSH
- Autism Spectrum Disorder MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Risk Factors MeSH
- Child Development MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Autizmus je komplexní, závažná a biologicky založená porucha vývoje mozku. V klinickém obraze jsou charakteristické sociální deficity, abnormity v interpersonální komunikaci, repetitivní chování a kognitivní inflexibilita. V současnosti je chápán jako klinicky a etiopatogeneticky extrémně heterogenní spektrum kognitivně-behaviorálních a emočních symptomů s různou expresí jejich tíže. Dosud neexistuje žádný specifický biochemický indikátor nebo neuroanatomická abnormalita, která by jej jasně identifikovala; diagnostika poruchy je nadále založena na klinickém a behaviorálním hodnocení a kritériích MKN-10 či DSM-IV klasifikaci. V etiopatogenezi poruchy se uplatňují genetické, epigenetické i environmentální faktory. Přes veškerý přínos vědy zůstávají jádrové příznaky farmakologicky neovlivnitelné a možnosti terapie jsou omezené na edukační a kognitivně-behaviorální intervence. Článek stručně a didakticky rekapituluje historické aspekty vývoje koncepce autizmu, používanou nomenklaturu, diagnostické postupy a klasifikační systémy, nové poznatky o klinických projevech poruchy, etiopatogenezi a možnostech terapie.
Autism is a complex, serious and biologically-based disorder of the development of the brain. Its clinical picture involves characteristic social deficits, abnormalities in interpersonal communication, repetitive behaviour and cognitive inflexibility. It is currently understood as a clinically and aetiologically extremely heterogeneous spectrum of cognitive-behavioural and emotional symptoms with various expressions of respective severity. So far there exists no specific biochemical indicator or neuro-anatomical abnormality by which it might be identified explicitly. The disorder diagnosis continues to be based on clinical and behavioural assessment and on MKN-10 criteria or DSM-IV classifications. Genetic, epigenetic as well as environmental factors play their roles in the aetiology of the disease. In spite of a great number of research contributions, the core symptoms remain inaccessible to pharmacology, with therapeutic possibilities limited to educational and cognitive-behavioural interventions. This paper provides a brief and didactic overview of the disorder: historical aspects of the development of the concept of autism; the nomenclature used; diagnostic methods and classification systems; new insights into clinical manifestations; and aetiology and therapeutic possibilities.
- Keywords
- autizmus, autistické spektrum, pervazivní vývojové poruchy, širší autistický fenotyp, neurodevelopmentální poruchy,
- MeSH
- Asperger Syndrome diagnosis etiology genetics MeSH
- Autistic Disorder history epidemiology etiology MeSH
- Behavioral Symptoms diagnosis psychology therapy MeSH
- Diagnostic Techniques, Neurological classification standards utilization MeSH
- Diagnostic Imaging methods utilization MeSH
- Drug Therapy methods utilization MeSH
- Phenotype MeSH
- Genetic Phenomena genetics MeSH
- Disease Attributes MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods utilization MeSH
- International Classification of Diseases classification utilization MeSH
- Child Development Disorders, Pervasive classification psychology therapy MeSH
- Tomography, X-Ray Computed methods utilization MeSH
- Rett Syndrome diagnosis etiology genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
The report has given a basic and complex survey of contemporary information concerning the problems of autism, its classification, etiopathogenesis, diagnostic algorithm, differential diagnosis and therapy. It is determined to general practitioners working with children and adolescents because they, as the first of physicians, often meet this highly severe disturbance of many psychic functions occurring in children patients.
- MeSH
- Asperger Syndrome diagnosis therapy MeSH
- Autistic Disorder diagnosis therapy MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Drug Therapy methods MeSH
- Comorbidity MeSH
- Humans MeSH
- Child Development Disorders, Pervasive genetics classification therapy MeSH
- Signs and Symptoms MeSH
- Surveys and Questionnaires MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- MeSH
- Asperger Syndrome MeSH
- Autistic Disorder diagnosis epidemiology etiology MeSH
- Diagnosis, Differential MeSH
- Communication Disorders epidemiology etiology classification MeSH
- Humans MeSH
- Intellectual Disability epidemiology etiology classification MeSH
- Child Development Disorders, Pervasive epidemiology etiology classification MeSH
- Child Behavior Disorders epidemiology etiology classification MeSH
- Psychomotor Disorders epidemiology etiology classification MeSH
- Rett Syndrome MeSH
- Check Tag
- Humans MeSH
