Současné metody asistované reprodukce je možné využít pro ochranu reprodukce onkologických pacientů. Základem je dobrá informovanost a spolupráce onkologů s centrem asistované reprodukce, které je schopné zajistit potřebné výkony včetně operačních. Pro ochranu reprodukce mužů je základem kryokonzervace spermatu. U žen je možné využít blokádu ovarií analogy gonadoliberinu, ovariální stimulaci s odběrem a zamrazením oocytů nebo embryí, případně odběr a kryokonzervaci kůry ovarií s její následnou autotransplantací.
Current assisted reproduction techniques can be used to protect reproductive functions of oncological patients. The key factorstowards successful clinical implementation of these methods are good awareness and collaboration between clinical oncologistsand the assisted reproduction center with established reproductive protection program including surgical interventions onovaries and testes. Sperm cryopreservation represents the basic technique to protect the reproduction of men. The recognizedfertility preservation methods available for women are ovarian suppression with gonadoliberine analogues, ovarian stimulationwith oocytes and embryos collection and subsequent cryopreservation or ovarian cortex tissue collection and cryopreservation.
- MeSH
- Reproductive Techniques, Assisted trends utilization MeSH
- Combined Modality Therapy adverse effects MeSH
- Cryopreservation methods trends utilization MeSH
- Medical Oncology * methods organization & administration trends MeSH
- Humans MeSH
- Interdisciplinary Communication MeSH
- Oocyte Retrieval methods utilization MeSH
- Sperm Retrieval utilization MeSH
- Ovary transplantation MeSH
- Embryo Transfer methods utilization MeSH
- Antineoplastic Agents adverse effects MeSH
- Reproductive Medicine * methods organization & administration trends MeSH
- Statistics as Topic MeSH
- Vitrification MeSH
- Fertility Preservation * methods utilization MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Keywords
- spermiogram,
- MeSH
- Reproductive Techniques, Assisted * trends utilization MeSH
- Fertility * physiology MeSH
- Infertility * diagnosis etiology prevention & control MeSH
- Humans MeSH
- Statistics as Topic MeSH
- World Health Organization MeSH
- Healthy Lifestyle physiology MeSH
- Environment MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Newspaper Article MeSH
- News MeSH
- Geographicals
- Czech Republic MeSH
- MeSH
- Adaptation, Psychological MeSH
- Reproductive Techniques, Assisted utilization MeSH
- Erectile Dysfunction diagnosis etiology physiopathology therapy MeSH
- Phosphodiesterase 5 Inhibitors * administration & dosage pharmacology therapeutic use MeSH
- Humans MeSH
- Spinal Cord Injuries * diagnosis pathology MeSH
- Prostaglandins E administration & dosage pharmacology therapeutic use MeSH
- Sexual Dysfunction, Physiological * diagnosis pathology therapy MeSH
- Sexology * methods manpower trends education MeSH
- Practice Guidelines as Topic MeSH
- Patient Education as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- Interview MeSH
- Keywords
- fyziologická regulační medicína,
- MeSH
- Reproductive Techniques, Assisted * trends utilization MeSH
- Cytokines administration & dosage isolation & purification therapeutic use MeSH
- Adult MeSH
- Infertility diagnosis etiology complications MeSH
- Interleukins antagonists & inhibitors administration & dosage therapeutic use MeSH
- Humans MeSH
- Luteinizing Hormone administration & dosage therapeutic use MeSH
- Melatonin administration & dosage therapeutic use MeSH
- Statistics as Topic MeSH
- Outcome and Process Assessment, Health Care * MeSH
- Infertility, Female * diagnosis complications therapy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Roztroušená skleróza je časté neurologické autoimunitní onemocnění, které postihuje nejvíce pacienty ve věku od 20 do 40 let. V tomto období se dostává do popředí otázka plánování těhotenství. U pacientů s roztroušenou sklerózou je popisován určitý trend ke snížené plodnosti. Její příčinou jsou jednak sexuální dysfunkce, které patří mezi relativně časté symptomy tohoto onemocnění, jednak předpokládaný vliv dalších faktorů, např. hormonální dysbalance, přidružených onemocnění a specifické terapie roztroušené sklerózy. Důležitou roli hrají také psychosociální vlivy ovlivňující plodnost i následnou terapii. Cílem tohoto sdělení je popis faktorů, které se mohou podílet na ovlivnění ženské i mužské plodnosti u pacientů s roztroušenou sklerózou, a možnosti terapie neplodnosti metodami asistované reprodukce a jejich vliv na následný průběh roztroušené sklerózy. Klíčová slova: roztroušená skleróza – neplodnost – fertilizace in vitro – endometrióza – sexuální dysfunkce – pohlavní hormony
Multiple sclerosis is a common autoimmune disease affecting young people, with onset usually at the age of 20–40 years. During these decades patients are usually planning pregnancy. In patients with multiple sclerosis fertility seems to be slightly impaired. Several factors might contribute to this condition. It is mainly sexual dysfunctions, which belong to comparatively common symptoms of the disease, hormonal alteration, concomitant (autoimmune) disease and specific therapy of multiple sclerosis. Psychosocial factors have an influence on fertility and its therapy. The aim of this review is description of factors potentially interfering with fertility in multiple, the current applications of assisted reproductive techniques and its influence on course of multiple sclerosis. Key words: multiple sclerosis – infertility – in vitro fertilisation – endometriosis – sexual dysfunctions – sexual hormons The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
- MeSH
- Reproductive Techniques, Assisted * trends utilization MeSH
- Autoimmune Diseases diagnosis etiology complications MeSH
- Endometriosis diagnosis complications therapy MeSH
- Fertilization in Vitro methods trends utilization MeSH
- Infertility * diagnosis etiology therapy MeSH
- Comorbidity MeSH
- Humans MeSH
- Endocrine System Diseases diagnosis etiology complications MeSH
- Drug-Related Side Effects and Adverse Reactions complications therapy MeSH
- Psychosocial Deprivation MeSH
- Multiple Sclerosis * diagnosis complications therapy MeSH
- Sexual Dysfunction, Physiological diagnosis etiology therapy MeSH
- Sexual Dysfunctions, Psychological diagnosis etiology therapy MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- MeSH
- Semen Analysis methods utilization MeSH
- Anovulation etiology therapy MeSH
- Reproductive Techniques, Assisted * history trends utilization MeSH
- Endometriosis etiology therapy MeSH
- Infertility * etiology therapy MeSH
- In Vitro Oocyte Maturation Techniques * methods utilization MeSH
- Clomiphene therapeutic use MeSH
- Humans MeSH
- Sperm Motility physiology drug effects MeSH
- Infertility, Male etiology therapy MeSH
- Embryo Disposition utilization MeSH
- Ovulation drug effects MeSH
- Statistics as Topic MeSH
- Age Factors MeSH
- Infertility, Female etiology therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Interview MeSH
- MeSH
- Reproductive Techniques, Assisted trends utilization MeSH
- Biomedical Research * methods trends MeSH
- Immunosuppression Therapy methods adverse effects utilization MeSH
- Humans MeSH
- Reproductive Medicine methods trends MeSH
- Risk Factors MeSH
- Organ Transplantation * methods trends utilization MeSH
- Vagina * surgery MeSH
- Age Factors MeSH
- Donor Selection methods utilization MeSH
- Genitalia, Female surgery MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Geographicals
- Sweden MeSH
- MeSH
- Reproductive Techniques, Assisted trends utilization MeSH
- Atherosclerosis MeSH
- Early Diagnosis * MeSH
- Diabetes Mellitus, Type 2 MeSH
- Diet utilization MeSH
- Child MeSH
- Adult MeSH
- Endocrine Disruptors * adverse effects MeSH
- Hypertension MeSH
- Insulin Resistance * MeSH
- Cardiovascular Diseases mortality MeSH
- Humans MeSH
- Metabolic Syndrome * diagnosis etiology chemically induced classification prevention & control therapy MeSH
- Adolescent MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Obesity drug therapy chemically induced metabolism MeSH
- Motor Activity MeSH
- Primary Prevention MeSH
- Secondary Prevention MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
BACKGROUND: Delayed childbearing in European countries has resulted in an increase in the number of women having children later in life. Thus more women face the problem of age-related infertility and cannot achieve their desired number of children. Childbearing postponement is one of the main reasons for the increasing use of assisted reproductive technology (ART) and conversely, the latter may be one of the factors contributing to the rise in female childbearing age. The research goal of our article is to evaluate the demographic importance of ART increased use and to examine its impact on both the fertility rate and birth timing. METHODS: Comparative analysis based on demographic and ART data collected by the European IVF-monitoring (EIM) Consortium for the European Society of Human Reproduction and Embryology (ESHRE). RESULTS: Most countries with a higher total fertility rate (TFR) also registered a higher number of treatment cycles per 1 million women of reproductive age. Despite the positive relationship between the postponement rate and the demand for ART among women aged 35 and older, the highest share of children born after ART was not found in countries characterized by a "delayed" fertility schedule. Instead, the highest proportion of ART births was found in countries with fertility schedules concentrated on women aged between 25 and 34. Accordingly, the effective use of ART can be expected in populations with a less advanced postponement rate. CONCLUSIONS: ART can have a demographic relevancy when women take advantage of it earlier rather than later in life. Furthermore it is suggested that the use of ART at a younger age increases women's chance of achieving their reproductive goals and reduces the risk of age-related infertility and failed ART. Based on a demographic approach, reproductive health policy may become an integral part of policies supporting early childbearing: it may keep women from delaying too long having children and increase the chance of diagnosing potential reproductive health problems requiring a timely ART application.
- MeSH
- Reproductive Techniques, Assisted statistics & numerical data utilization MeSH
- Adult MeSH
- Humans MeSH
- Birth Rate MeSH
- Reproductive Behavior statistics & numerical data MeSH
- Maternal Age MeSH
- Age Factors MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Europe MeSH
