BACKGROUND: In December 2019, a new coronavirus, SARS-CoV-2, appeared in Wuhan, China. This virus is the cause of the COVID-19 disease. This infection later spread to the whole world. The goal of this article is to present the clinical and laboratory characteristics of patients with COVID-19 treated in the Faculty Hospital Pilsen. METHODS: In this monocentric, retrospective study, clinical and biochemical data of 89 adult patients with COVID-19 was analyzed. These patients were in the care of the Faculty Hospital Pilsen between March 14 and April 7. RESULTS: In this cohort, made up of 89 patients, 63 were treated as outpatients and 26 were hospitalized. 10 patients required intensive care. The most common symptoms among patients were cough and fever. Dyspnea was present in 29 patients. A CT scan showed bilateral pneumonia in 23 of the admitted patients. Fever and bilateral pneumonia were significantly more common in patients ≥ 60 years old (p=0.047, and p=0.001, respectively). Of lab results, the patients in intensive care had significantly higher values of C-reactive protein, procalcitonin, lactate dehydrogenase, interleukin 6, myoglobin and ferritin. CONCLUSION: The most common symptoms of COVID-19 are fever and cough. These two symptoms are simultaneously present in more than half the cases. Approximately 1/10th of patients requires intensive care. Higher values of lactate dehydrogenase, myoglobin and ferritin on patient admission appear to be a strong predictive factor of the patient's status progressing into requiring ICU attention.
- MeSH
- ambulantní péče statistika a číselné údaje MeSH
- artralgie patofyziologie MeSH
- bolesti hlavy patofyziologie MeSH
- C-reaktivní protein metabolismus MeSH
- COVID-19 krev epidemiologie patofyziologie MeSH
- diabetes mellitus epidemiologie MeSH
- dospělí MeSH
- dyspnoe patofyziologie MeSH
- ferritin krev MeSH
- horečka patofyziologie MeSH
- hospitalizace statistika a číselné údaje MeSH
- hypertenze epidemiologie MeSH
- interleukin-6 krev MeSH
- jednotky intenzivní péče MeSH
- kašel patofyziologie MeSH
- komorbidita MeSH
- L-laktátdehydrogenasa krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- myalgie patofyziologie MeSH
- myoglobin krev MeSH
- obezita epidemiologie MeSH
- počítačová rentgenová tomografie MeSH
- prokalcitonin krev MeSH
- SARS-CoV-2 MeSH
- senioři MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters. METHODS: A total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum levels of CLU were significantly lower in patients with hand OA than in control subjects (p < 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = - 0.275; p = 0.013 and r = - 0.220; p = 0.049, respectively). CONCLUSION: The present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.
- MeSH
- artralgie krev diagnostické zobrazování patofyziologie MeSH
- biologické markery krev MeSH
- down regulace MeSH
- ELISA MeSH
- klouby ruky diagnostické zobrazování metabolismus patofyziologie MeSH
- klusterin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření bolesti MeSH
- osteoartróza krev diagnostické zobrazování patofyziologie MeSH
- prediktivní hodnota testů MeSH
- průřezové studie MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- ultrasonografie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
BACKGROUND: During the transition to rheumatoid arthritis (RA) many patients pass through a phase characterised by the presence of symptoms without clinically apparent synovitis. These symptoms are not well-characterised. This taskforce aimed to define the clinical characteristics of patients with arthralgia who are considered at risk for RA by experts based on their clinical experience. METHODS: The taskforce consisted of 18 rheumatologists, 1 methodologist, 2 patients, 3 health professionals and 1 research fellow. The process had three phases. In phase I, a list of parameters considered characteristic for clinically suspect arthralgia (CSA) was derived; the most important parameters were selected by a three-phased Delphi approach. In phase II, the experts evaluated 50 existing patients on paper, classified them as CSA/no-CSA and indicated their level of confidence. A provisional set of parameters was derived. This was studied for validation in phase III, where all rheumatologists collected patients with and without CSA from their outpatient clinics. RESULTS: The comprehensive list consisted of 55 parameters, of which 16 were considered most important. A multivariable model based on the data from phase II identified seven relevant parameters: symptom duration <1 year, symptoms of metacarpophalangeal (MCP) joints, morning stiffness duration ≥60 min, most severe symptoms in early morning, first-degree relative with RA, difficulty with making a fist and positive squeeze test of MCP joints. In phase III, the combination of these parameters was accurate in identifying patients with arthralgia who were considered at risk of developing RA (area under the receiver operating characteristic curve 0.92, 95% CI 0.87 to 0.96). Test characteristics for different cut-off points were determined. CONCLUSIONS: A set of clinical characteristics for patients with arthralgia who are at risk of progression to RA was established.
- MeSH
- artralgie etiologie patofyziologie MeSH
- časové faktory MeSH
- cirkadiánní rytmus MeSH
- delfská metoda MeSH
- hodnocení rizik metody MeSH
- konsensus MeSH
- lidé MeSH
- metakarpofalangeální kloub patofyziologie MeSH
- revmatoidní artritida diagnóza genetika patofyziologie MeSH
- rizikové faktory MeSH
- rozsah kloubních pohybů MeSH
- senzitivita a specificita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- konsensus - konference MeSH
- multicentrická studie MeSH
- validační studie MeSH
- MeSH
- artralgie * diagnóza patofyziologie MeSH
- chronická bolest patofyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mapování mozku MeSH
- měření bolesti metody MeSH
- osteoartróza * diagnóza patofyziologie terapie MeSH
- percepce bolesti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- souhrny MeSH
- MeSH
- artralgie * epidemiologie etiologie patofyziologie MeSH
- artritida ekonomika epidemiologie etiologie MeSH
- biologické markery * krev moč MeSH
- celosvětové zdraví MeSH
- chronická bolest epidemiologie MeSH
- klouby inervace MeSH
- lidé MeSH
- lumbalgie epidemiologie MeSH
- neuralgie diagnóza patofyziologie MeSH
- osteoartróza * diagnóza epidemiologie MeSH
- revmatoidní artritida diagnóza patofyziologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- souhrny MeSH
- MeSH
- artralgie * diagnóza patofyziologie MeSH
- chronická bolest patofyziologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mapování mozku MeSH
- měření bolesti metody MeSH
- osteoartróza * diagnóza patofyziologie terapie MeSH
- percepce bolesti MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- souhrny MeSH
V přehledném referátu jsou pojednány některé charakteristické rysy revmatické bolesti. Stručně jsou uvedeny patotyziologické mechanismy vzniku a vnímání revmatické bolesti a popsány její klinické aspekty u některých modelových revmatických onemocnění, jako jsou revmatoidní artritida, osteoartróza, regionální bolestivé syndromy a syndrom bolestivých zad. Uvedeny jsou možnosti nefarmakologické a farmakologické léčby revmatické bolesti.
- MeSH
- antiflogistika nesteroidní klasifikace terapeutické užití MeSH
- artralgie komplikace patofyziologie terapie MeSH
- komplexní regionální syndromy bolesti klasifikace terapie MeSH
- lidé MeSH
- opioidní analgetika klasifikace terapeutické užití MeSH
- osteoartróza komplikace terapie MeSH
- paracetamol terapeutické užití MeSH
- revmatoidní artritida komplikace terapie MeSH
- Check Tag
- lidé MeSH
Aby nemoc nevyhrála ; Sv. 2
31 s. : il. ; 16 cm
- MeSH
- artralgie patofyziologie rehabilitace prevence a kontrola MeSH
- cvičení MeSH
- dieta MeSH
- Publikační typ
- populární práce MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- revmatologie
- zdravotní výchova
