- MeSH
- Health Services Accessibility MeSH
- Delivery of Health Care, Integrated * MeSH
- Humans MeSH
- Social Work MeSH
- Check Tag
- Humans MeSH
- Publication type
- Editorial MeSH
Objectives: The main objective was to determine the prevalence of depression and anxiety in older adults living in the Moravian-Silesian region. Methods: Empirical data was collected using a set of questionnaires and a personal data form. These tools were the Geriatric Scale of Depression, the Inventory of Geriatric Anxiety, the OPQoL-brief questionnaire, the Rosenberger Self-Esteem Scale, and the Social Support Questionnaire. A total of 935 older adults participated in the research. Results: Depression symptoms were found in 17.2% of older adults and anxiety symptoms in 22.8%. A correlation was shown between a higher prevalence of depression and anxiety and between the number of diseases and low social support. A higher prevalence of depression was also associated with older age (r = 0.162, p = 0.039). Older adults with depression and anxiety also showed a lower quality of life (r = -0.529, p < 0.001; r = -0.362, p < 0.001), lower self-assessment (r = -0.464, p < 0.001; r = -0.429, p < 0.001), and little social support (r = -0.260, p < 0.001; r = -0.211, p < 0.001). Conclusion: Depression and anxiety in older people is underdiagnosed and treated in primary care settings, although it significantly affects morbidity and quality of life in affected persons.
- MeSH
- Depression * diagnosis epidemiology MeSH
- Mental Health MeSH
- Middle Aged MeSH
- Cross-Sectional Studies MeSH
- Surveys and Questionnaires MeSH
- Aged MeSH
- Social Support MeSH
- Anxiety diagnosis epidemiology psychology MeSH
- Check Tag
- Middle Aged MeSH
- Aged MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Background: An update of the nursing core curriculum was released in 2019 and revised to meet the challenges of the Israeli health system. The revision was based on the Advisory Committee's (2017) recommendations and outcomes of a Nursing Administration Inspection (2018). The implementation process of the nursing core curriculum has never been broadly evaluated in Israel. This study aimed to examine factors associated with concerns of nursing educators during the implementation process. Methods: A cross-sectional study was performed on a representative sample of nursing educators in Israel. 107 nursing educators answered two questionnaires distributed from November 2019 until September 2020: Stages of Concern Questionnaire (SOCQ) and a questionnaire designed for the current research. The statistical analysis included Pearson and Spearman correlations and multiple linear regressions. Results: The findings revealed several associations regarding nursing and educational experience, familiarity, perception, and use of the current (2012) and new (2020) core curriculum, as well as organizational climate, with the nursing faculty members' concerns during innovation implementation. Training was positively related to the final stages of concern, supporting the effectiveness of educators' preparation in the implementation process. Conclusion: A comprehensive approach to the core curriculum revision based on collaboration with educators and advance training on innovation involves the educators in the task and reduces their concerns during the implementation process.
Introduction: The shortage of nursing staff is a major problem in an ageing population. One of the reasons for leaving the profession is an unsupportive working environment, including bullying. The aim of this study is to gain an in-depth insight into nurses' perceptions of workplace bullying. Methods: A qualitative descriptive interpretive method was used. A semi-structured interview was used to collect data. Nine nurses from all levels of healthcare participated in the study. Thematic analysis of qualitative data was used to analyse the data. Results: Respondents described in detail their views on bullying in nursing and their personal experiences. Data analysis identified five themes: (1) causes of workplace bullying, (2) experiences of workplace bullying, (3) characteristics of perpetrators and victims, (4) ways of responding to and coping with bullying, and (5) consequences of workplace bullying. This study provides a comprehensive examination of nurses' perceptions of workplace bullying, underscoring its pervasiveness in healthcare settings. It underscores the imperative for organisational interventions to mitigate its impact. Conclusion: To improve conditions in healthcare and reduce bullying, it is necessary to implement organisational changes that focus on zero-tolerance policies, staff education, and improved staff relations.
Introduction: Pressure injuries have been identified as a problem in adults, but there is increasing recognition that they also occur in pediatric patients. Specific prevention in this population is essential because a high percentage of pressure injuries can be prevented. Objective: To identify interventions that prevent pressure injuries in the clinical pediatric care setting. Methods: Systematic review with a conducted search in CINAHL, PubMed, and Cochrane databases. A total of 301 articles were found, 225 were excluded after reviewing the title and abstract. The remaining papers were subjected to a full-text screening. Eligible studies were those that (a) described interventions to prevent pressure injuries, (b) were specifically aimed at pediatric patients (0-18 years), (c) were published in English or German, and (d) were conducted in a hospital. Results: A total of 37 studies were included. The data on interventions from the studies were extracted and clustered. The following eight categories of interventions for the prevention of pressure injury in pediatric patients were identified: (1) (Skin)Assessments, (2) Medical devices, (3) Positioning, (4) Education, (5) Moisture Management, (6) Nutrition Management, (7) Surfaces, and (8) Intervention bundles. The included studies described various interventions for pressure injury prevention. Most reported a significant reduction in pressure injury rates when intervention bundles were implemented. Conclusion: Nurses have to know about pressure injury causation, risk factors, and prevention strategies to implement the identified interventions and prevent pressure injuries in pediatric patients during hospital stays.
- MeSH
- Pressure Ulcer * prevention & control MeSH
- Child, Hospitalized MeSH
- Education, Nursing, Continuing MeSH
- Humans MeSH
- Nursing Care MeSH
- Skin Care MeSH
- Patient Positioning MeSH
- Check Tag
- Humans MeSH
- Publication type
- Systematic Review MeSH
BACKGROUND: Heterogeneity in temperature-mortality relationships across locations may partly result from differences in the demographic structure of populations and their cause-specific vulnerabilities. Here we conduct the largest epidemiological study to date on the association between ambient temperature and mortality by age and cause using data from 532 cities in 33 countries. METHODS: We collected daily temperature and mortality data from each country. Mortality data was provided as daily death counts within age groups from all, cardiovascular, respiratory, or noncardiorespiratory causes. We first fit quasi-Poisson regression models to estimate location-specific associations for each age-by-cause group. For each cause, we then pooled location-specific results in a dose-response multivariate meta-regression model that enabled us to estimate overall temperature-mortality curves at any age. The age analysis was limited to adults. RESULTS: We observed high temperature effects on mortality from both cardiovascular and respiratory causes compared to noncardiorespiratory causes, with the highest cold-related risks from cardiovascular causes and the highest heat-related risks from respiratory causes. Risks generally increased with age, a pattern most consistent for cold and for nonrespiratory causes. For every cause group, risks at both temperature extremes were strongest at the oldest age (age 85 years). Excess mortality fractions were highest for cold at the oldest ages. CONCLUSIONS: There is a differential pattern of risk associated with heat and cold by cause and age; cardiorespiratory causes show stronger effects than noncardiorespiratory causes, and older adults have higher risks than younger adults.
- Publication type
- Journal Article MeSH
BACKGROUND AND AIMS: The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA.Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their potential as HA biomarkers. METHODS: Our cross-sectional observational study encompassed 30 HA patients and 15 healthy subjects. Plasma samples were pooled into three groups of 15 samples from those with severe haemophilic arthropathy (sHA), mild haemophilic arthropathy (mHA) and healthy controls. Proteomic analysis was performed using liquid chromatography-mass spectrometry. The severity of HA was assessed using the World Federation of Haemophilia Physical Examination Score and ultrasonography following the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) guidelines. RESULTS: A total of 788 proteins were identified, with 97% of the uniquely identified proteins being expressed in all analysed groups. We identified several up and downregulated proteins across the groups that were mainly related to inflammatory and immunity-modulating processes, as well as joint degeneration. We highlighted ten proteins relevant for the development of HA: cathepsin G, endoplasmic reticulum aminopeptidase 2, S100-A9, insulin-like growth factor I, apolipoprotein (a), osteopontin, pregnancy zone protein, cartilage oligomeric matrix protein, CD44, and cadherin-related family member 2. CONCLUSION: Our analysis identified several proteins that shed further light on the distinctive pathogenesis of HA and could serve for biomarker research. However, these results need to be validated on a larger patient group.
- Publication type
- Journal Article MeSH
Tick-borne encephalitis (TBE) virus (TBEV) is transmitted to humans via tick bites. Infection is benign in >90% of the cases but can cause mild (<5%), moderate (<4%), or severe (<1%) encephalitis. We show here that ∼10% of patients hospitalized for severe TBE in cohorts from Austria, Czech Republic, and France carry auto-Abs neutralizing IFN-α2, -β, and/or -ω at the onset of disease, contrasting with only ∼1% of patients with moderate and mild TBE. These auto-Abs were found in two of eight patients who died and none of 13 with silent infection. The odds ratios (OR) for severe TBE in individuals with these auto-Abs relative to those without them in the general population were 4.9 (95% CI: 1.5-15.9, P < 0.0001) for the neutralization of only 100 pg/ml IFN-α2 and/or -ω, and 20.8 (95% CI: 4.5-97.4, P < 0.0001) for the neutralization of 10 ng/ml IFN-α2 and -ω. Auto-Abs neutralizing type I IFNs accounted for ∼10% of severe TBE cases in these three European cohorts.
- MeSH
- Autoantibodies * immunology MeSH
- Adult MeSH
- Interferon Type I * immunology MeSH
- Encephalitis, Tick-Borne * immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Antibodies, Neutralizing * immunology MeSH
- Aged MeSH
- Encephalitis Viruses, Tick-Borne immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Czech Republic MeSH
- Austria MeSH
We explored how a simple retrovirus, Mason-Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase, typically engaged in RNA processing. Through advanced genetic engineering techniques, we showed that M-PMV recruits DHX15 by mimicking cellular mechanisms, relocating it from the nucleus to the cytoplasm to aid in viral assembly. This interaction is essential for the correct packaging of the viral genome and critical for its infectivity. Our findings offer unique insights into the mechanisms of viral manipulation of host cellular processes, highlighting a sophisticated strategy that viruses employ to leverage cellular machinery for their replication. This study adds valuable knowledge to the understanding of viral-host interactions but also suggests a common evolutionary history between cellular processes and viral mechanisms. This finding opens a unique perspective on the export mechanism of intron-retaining mRNAs in the packaging of viral genetic information and potentially develop ways to stop it.
- MeSH
- Cell Nucleus metabolism virology MeSH
- DEAD-box RNA Helicases metabolism genetics MeSH
- Genome, Viral MeSH
- HEK293 Cells MeSH
- Humans MeSH
- Mason-Pfizer monkey virus * genetics metabolism physiology MeSH
- Virus Replication genetics physiology MeSH
- RNA, Viral * metabolism genetics MeSH
- RNA Helicases metabolism genetics MeSH
- Virus Assembly * genetics physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
