Vancomycin
Dotaz
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- MeSH
- dítě MeSH
- lidé MeSH
- nemoci novorozenců farmakoterapie MeSH
- novorozenec MeSH
- vankomycin farmakokinetika MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- novorozenec MeSH
Clinical infectious diseases, ISSN 1058-4838 vol. 42, suppl. 1, January 2006
61 s. : il., tab. ; 28 cm
- MeSH
- rezistence na vankomycin imunologie MeSH
- vankomycin farmakologie farmakokinetika terapeutické užití MeSH
- Publikační typ
- sborníky MeSH
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- infekční lékařství
- farmacie a farmakologie
Autoři popisují výskyt vankomycin-rezistentních enterokoků ve Fakultní nemocnici v Olomouci a uvádějí pravděpodobnou souvislost se selekčním tlakem glykopeptidových antibiotik. Současně navrhují možné řešení situace s cílem zabránit šíření těchto nebezpečných bakteriálních kmenů.
The authors describe the occurrence of vancomycin-resistant enterococci in Teaching Hospital, Olomouc and discuss a possible connection with the selection stress of glycopeptide antibiotics. They suggest a solution to the situation with the aim to stop spreading those dangerous bacterial strains.
Ve sdělení jsou popsány první dva případy izolace vankomycin-rezistentních enterokoků ve FN v Plzni, které byly s největší pravděpodobností zavlečeny z jiných zdravotnických zařízení.
The paper describes first two cases of isolation of vancomycin-resistant enterococci in the Faculty Hospital in Plzen. The strains were most probably transferred from other healthcare establishments.
- MeSH
- antibiotická rezistence MeSH
- bronchoalveolární lavážní tekutina mikrobiologie MeSH
- dospělí MeSH
- Enterococcus izolace a purifikace účinky léků MeSH
- infekce spojené se zdravotní péčí prevence a kontrola MeSH
- lidé středního věku MeSH
- lidé MeSH
- moč mikrobiologie MeSH
- nemocnice MeSH
- vankomycin MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Vancomycin is frequently used in haemodialysis (HD) patients but generally accepted target serum ranges and dosing strategy are still lacking in this group. Based on retrospective analysis of data from 118 HD patients treated with vancomycin the interdialytic elimination constant (Ke), apparent volume of distribution (Vd) and dialysis efficacy were calculated. The influence of possible clinical variables on the pharmacokinetic parameters of vancomycin have been tested. The median of Ke in interdialytic periods, corresponding half-life and Vd were 0.0073 h-1, 95.0 h and 0.87 L/kg, respectively. We found significant positive correlation between time in dialysis program and Ke. The Vd correlated best with lean body mass (LBM). For high- and low flux membrane HD of 4 hours duration the decline in vancomycin levels was 20.88% and 12.86%, respectively. Based on these data loading dose for vancomycin in HD patient should be calculated as 24.483 × LBM (kg) + 455 mg. The utility of this equation for entire HD population should be also verified prospectively.
- MeSH
- antibakteriální látky MeSH
- dialýza ledvin MeSH
- lidé MeSH
- monitorování léčiv * MeSH
- poločas MeSH
- retrospektivní studie MeSH
- vankomycin * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The topical application of Vancomycin is increasingly being used in orthopedics because of the development of methicillin resistant bacteria. Consequently, resistance to Vancomycin has recently been on the rise. One possible explanation for this phenomenon could be the thermal degradation of Vancomycin to antibacterially inactive crystalline degradation products (CDP-1s). The aim of our in vitro experiment was to compare the creation and elution characteristics of CDP-1s and the active form of Vancomycin (factor B) released from bone grafts. METHODS: CDP-1s and the factor B released from bone grafts into the buffer solution were measured using the high-performance liquid chromatography method at progressive intervals. RESULTS: The factor B was released from bone grafts at the highest levels, typically on the first day (618.8 mg/L). CDP-1 levels kept increasing until the end of measurement on day 15, when the concentration of CDP-1s (1280.7 mg/L) was much higher compared to that of factor B (217.5 mg/L). CONCLUSIONS: We confirmed the tendency of Vancomycin to convert to antimicrobially ineffective CDP-1s. Although Vancomycin is decomposed into crystalline degradation products, its active forms are released from bone grafts in sufficient concentration for more than two keks (Tab. 3, Fig. 1, Ref. 15).
- MeSH
- antibakteriální látky aplikace a dávkování farmakologie chemie MeSH
- krystalizace MeSH
- lidé MeSH
- nosiče léků * MeSH
- osteomyelitida * MeSH
- techniky in vitro MeSH
- transplantace kostí MeSH
- vankomycin aplikace a dávkování farmakologie chemie MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- Check Tag
- lidé MeSH
