- Keywords
- hypertekóza,
- MeSH
- Acne Vulgaris etiology drug therapy MeSH
- Amenorrhea MeSH
- Androgen Antagonists therapeutic use MeSH
- Cyproterone Acetate therapeutic use MeSH
- Adult MeSH
- Ethinyl Estradiol therapeutic use MeSH
- Drug Combinations MeSH
- Hirsutism * etiology drug therapy MeSH
- Hyperandrogenism * diagnosis drug therapy physiopathology MeSH
- Adrenal Hyperplasia, Congenital diagnosis drug therapy physiopathology MeSH
- Contraceptives, Oral, Combined therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Ovarian Diseases diagnosis surgery MeSH
- Oligomenorrhea MeSH
- Ovariectomy MeSH
- Ovary pathology MeSH
- Progestins therapeutic use MeSH
- Polycystic Ovary Syndrome * diagnosis drug therapy physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Cíl studie: Přehled problematiky hirsutismu, excesivního růstu ochlupení u žen. Přestože na první pohled se jedná o kosmetický problém, většinou je příčinou endokrinní porucha. Typ sudie: Přehledový článek. Materiál a metodika: Hirsutismus je klinická diagnóza definovaná nadměrným růstem ochlupení v androgen-senzitivních oblastech postihující 5–10 % žen v reprodukčním věku. Hirsutismus může být počátečním i jediným příznakem hyperandrogenního stavu. Závěr: Nejčastější příčinou hirsutismu je syndrom polycystických ovarií. Obvykle znamená kromě kosmetického dopadu i vážný psychologický problém pro pacientky, jenž vyžaduje celkovou léčbu. V případě rychle progredujícího a extenzivního hirsutismu, s vysokými hladinami androgenů, je třeba v první řadě vyloučit nejvážnější příčinu, androgen-secernující tumor.
Objective: Overview of excessive hair growth in women, hirsutism. Although women with hirsutism typically present because of cosmetic concerns, the majority also have an underlying endocrine disorder. Design: Review article. Setting: Department of Gynecology and Obstetrics, General Faculty Hospital and 1st Faculty of Medicine of Charles Universtity, Prague. Material and methods: Hirsutism is a clinical diagnosis defined by the presence of excess terminal hair growth (dark, coarse hairs) in androgen-sensitive areas. It affects between five and ten percent of women of reproductive age. It may be the initial, and possibly only, sign of an underlying androgen disorder. Conclusions: The most common cause of hirsutism is polycystic ovary syndrome (PCOS). In some cases, hirsutism is mild and requires only reassurance and local (nonsystemic) therapy, while in others it causes significant psychological distress and requires more extensive therapy. In case of rapid progressive hair growth should be first exclude androgen-secerning tumour (ovarian, adrenal) as the most serious condition.
- Keywords
- androgen-secernující tumor, FG skóre,
- MeSH
- Androgens analysis physiology MeSH
- Androgen Antagonists classification therapeutic use MeSH
- Cyproterone Acetate administration & dosage therapeutic use MeSH
- Diagnosis, Differential MeSH
- Hirsutism * diagnosis etiology therapy MeSH
- Hyperplasia diagnosis MeSH
- Contraceptives, Oral, Combined therapeutic use MeSH
- Humans MeSH
- Spironolactone administration & dosage therapeutic use MeSH
- Polycystic Ovary Syndrome diagnosis MeSH
- Testosterone analysis physiology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Review MeSH
- Keywords
- dienogest, drospirenon, antiandrogenní progestiny,
- MeSH
- Acne Vulgaris * drug therapy MeSH
- Androgens metabolism MeSH
- Androstenes pharmacology therapeutic use MeSH
- Chlormadinone Acetate pharmacology therapeutic use MeSH
- Cyproterone Acetate pharmacology therapeutic use MeSH
- Dehydroepiandrosterone Sulfate metabolism MeSH
- Estradiol analogs & derivatives pharmacology therapeutic use MeSH
- Ethinyl Estradiol pharmacology therapeutic use MeSH
- Sex Hormone-Binding Globulin metabolism drug effects MeSH
- Contraceptives, Oral, Combined * pharmacology therapeutic use MeSH
- Humans MeSH
- Nandrolone analogs & derivatives pharmacology therapeutic use MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Keywords
- Xtandi, enzalutamid, Androcur,
- MeSH
- Adenocarcinoma drug therapy MeSH
- Androgen Antagonists therapeutic use MeSH
- Diphosphonates therapeutic use MeSH
- Cyproterone Acetate administration & dosage MeSH
- Phenylthiohydantoin * analogs & derivatives administration & dosage therapeutic use MeSH
- Imidazoles therapeutic use MeSH
- Remission Induction MeSH
- Drug Therapy, Combination MeSH
- Zoledronic Acid MeSH
- Middle Aged MeSH
- Humans MeSH
- Bone Neoplasms * secondary MeSH
- Prostatic Neoplasms, Castration-Resistant * drug therapy MeSH
- Treatment Refusal MeSH
- Prostate-Specific Antigen blood MeSH
- Treatment Outcome MeSH
- Venous Thrombosis drug therapy complications MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Cyproterone Acetate adverse effects therapeutic use MeSH
- Ethinyl Estradiol adverse effects therapeutic use MeSH
- Contraceptive Agents, Female adverse effects therapeutic use MeSH
- Humans MeSH
- Menstruation Disturbances chemically induced MeSH
- Drug-Related Side Effects and Adverse Reactions etiology MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Alopecia Areata classification MeSH
- Alopecia * diagnosis classification therapy MeSH
- Androgens adverse effects MeSH
- Androgen Antagonists classification MeSH
- Autoimmune Diseases MeSH
- Transplantation, Autologous MeSH
- Cyclobutanes adverse effects therapeutic use MeSH
- Cyclopropanes adverse effects therapeutic use MeSH
- Cyproterone Acetate MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Adult MeSH
- Finasteride MeSH
- Adrenal Cortex Hormones therapeutic use MeSH
- Immunomodulation MeSH
- Immunosuppressive Agents MeSH
- Humans MeSH
- Hair Diseases etiology therapy MeSH
- Trichotillomania diagnosis MeSH
- Vasodilator Agents therapeutic use MeSH
- Hair Follicle physiopathology growth & development MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Publication type
- Review MeSH
- Keywords
- Diane 35, drospirenon,
- MeSH
- Acne Vulgaris * drug therapy MeSH
- Androstenes therapeutic use MeSH
- Androgen Antagonists * adverse effects therapeutic use MeSH
- Cyproterone Acetate administration & dosage adverse effects therapeutic use MeSH
- Ethinyl Estradiol therapeutic use MeSH
- Drug Combinations MeSH
- Flutamide administration & dosage adverse effects therapeutic use MeSH
- 5-alpha Reductase Inhibitors therapeutic use MeSH
- Drug Therapy, Combination methods MeSH
- Contraceptives, Oral, Hormonal adverse effects therapeutic use MeSH
- Contraceptives, Oral, Combined * adverse effects therapeutic use MeSH
- Contraceptives, Oral, Synthetic therapeutic use MeSH
- Pharmaceutical Preparations MeSH
- Humans MeSH
- Spironolactone administration & dosage adverse effects therapeutic use MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Alopecia diagnosis etiology drug therapy MeSH
- Androgens metabolism MeSH
- Androgen Antagonists pharmacology adverse effects therapeutic use MeSH
- Cyproterone Acetate administration & dosage adverse effects therapeutic use MeSH
- Finasteride administration & dosage pharmacology adverse effects MeSH
- 5-alpha Reductase Inhibitors administration & dosage pharmacology therapeutic use MeSH
- Humans MeSH
- Minoxidil administration & dosage pharmacology adverse effects MeSH
- Spironolactone administration & dosage pharmacology adverse effects MeSH
- Vasodilator Agents adverse effects therapeutic use MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
Prezentujeme kazuistiku šestiletého chlapce s germinomem v neobvyklé lokalizaci thalamu, který se klinicky manifestoval předčasnou pseudopubertou na podkladě ektopické sekrece humánního choriogonadotropinu (hCG). Nádor byl potvrzen ze stereotaktické biopsie, následná chemoterapie a radioterapie vedla ke kompletní remisi. Je diskutováno o mechanizmu vzniku předčasné pseudopuberty, klinických i léčebných aspektech germinomů mozku u dětí.
We describe a case of a 6 years old boy with germinoma of an unusual thalamic localization that presented with precocious pseudopuberty based on ectopic human chorionic gonadotropin (hCG) secretion. The tumour was confirmed with stereotactic biopsy; subsequent chemotherapy and radiotherapy led to complete remission. The mechanism of precocious pseudopuberty and clinical and treatment aspects of brain germinomas in children arediscussed.
- Keywords
- pseudopuberta,
- MeSH
- Basal Ganglia pathology MeSH
- Biopsy MeSH
- Chorionic Gonadotropin blood MeSH
- Cyproterone Acetate therapeutic use MeSH
- Child MeSH
- Germinoma * diagnosis pathology therapy MeSH
- Histiocytosis, Langerhans-Cell complications MeSH
- Radiotherapy, Conformal MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Brain Neoplasms * diagnosis pathology therapy MeSH
- Basal Ganglia Diseases diagnosis pathology therapy MeSH
- Puberty, Precocious * etiology complications MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Testosterone blood MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Benzodiazepines administration & dosage adverse effects MeSH
- Cyproterone Acetate administration & dosage adverse effects MeSH
- Pharmacovigilance MeSH
- Drug Evaluation MeSH
- Clinical Trials as Topic MeSH
- Contraceptives, Oral, Hormonal * administration & dosage adverse effects therapeutic use MeSH
- Humans MeSH
- Adolescent MeSH
- Niacin administration & dosage adverse effects MeSH
- Drug Repositioning * MeSH
- Progestins administration & dosage contraindications adverse effects MeSH
- Thromboembolism prevention & control MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Female MeSH
