• MeSH
• Dermatitis, Atopic * drug therapy   MeSH
• Antibodies, Monoclonal, Humanized * MeSH
• Control Groups MeSH
• Leukocytes MeSH
• Humans MeSH
• Pollen MeSH
• Seasons MeSH
• T-Lymphocytes MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH

INTRODUCTION: Many patients have prolonged symptoms after COVID-19 infection, which can affect patient quality of life (QOL). The aim of this study is to determine the quality of life in patients with long COVID, compared with healthy controls. MATERIAL AND METHODS: The study was a prospective cross-sectional study using an anonymous online survey. The SF-36 questionnaire was chosen for quality of life measurement. The survey was distributed through the Facebook social media platform targeting groups of patients with long COVID. The control group was made up of physiotherapy and physical education students. RESULTS: There was a significant difference in physical function, with a mean score of 94.9 (±9.4) among the students, compared to long COVID patients with a mean score of 66.2 (±25.4) (p < 0.001). A similar result was found in the physical role (p < 0.001). The overall quality of life score for college students was 578.0 (±111.9), and the overall score for patients with long COVID was 331.9 (±126.9). CONCLUSIONS: Patients with long COVID had a lower quality of life compared to the healthy control group, and this was associated with the negative effect of long-COVID. Lower quality of life in patients with long COVID is an important therapeutic goal, which requires attention.

• MeSH
• COVID-19 * epidemiology   MeSH
• Control Groups MeSH
• Quality of Life * MeSH
• Humans MeSH
• Post-Acute COVID-19 Syndrome MeSH
• Prospective Studies MeSH
• Cross-Sectional Studies MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH

• MeSH
• Adult MeSH
• Electrical Equipment and Supplies MeSH
• Ankle Joint * physiopathology   MeSH
• Kinesiology, Applied methods   MeSH
• Control Groups MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Joint Instability rehabilitation   MeSH
• Telerehabilitation methods   MeSH
• Exercise Therapy methods   MeSH
• Virtual Reality Exposure Therapy * methods   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Publication type
• Evaluation Study MeSH
• Comparative Study MeSH

Použití levostranných mechanických srdečních podpor (MSP) s kontinuálním tokem, pro částečnou nebo úplnou náhradu funkce selhaného srdce, je důležitou a v současnosti také jednou z hlavních léčebných modalit v terapii srdečního selhání. Dnes jsou MSP používány nejčastěji v indikaci „most k transplantaci srdce“, ale nedostatek dárcovských orgánů, pokroky v dizajnu a zvyšující se spolehlivost MSP umožňují jejich dlouhodobé použití. Studium dlouhodobého použití MSP nabízí příležitost ke komplexnímu porozumění vaskulárních změn u pacientů s MSP a vliv různých typů průtoku na tyto změny. Třicet pacientů s MSP s různým typem flow bude vyšetřeno každé tři měsíce po dobou jednoho roku. Stav vaskulatury bude stanoven z periferní krve (mikro RNA, endoteliální progenitorové buňky, mikročástice), z histologických vzorků (morfologické změny aortální stěny) a neinvazivně (endoteliální reaktivita – EndoPat, ultrazvuk velkých cév). Současně bude vyšetřeno 10 zdravých dobrovolníků. Nulovou hypotézou je, že nebude rozdílu mezi studovanými skupinami pacientů.; Use of left-ventricular assist devices (LVADs) for partial or full support of failing heart have become an important and, at this time, also leading therapeutic option for patients with end-stage heart failure. Currently, LVADs are mostly used as a bridge to heart transplant, but the lack of donor organs, design advancements and increasing reliability of LVADs are widening possibilities of their long-term use. Studying long-term use of LVADs offers opportunity of complex understanding of vascular changes in patients with LVADs and their modification by different flow patterns. Thirty patients with LVADs with different flow types will be examined prospectively every 3 months for one year. Status of vasculature will be assessed from peripheral blood (microRNA, endothelial progenitor cells, microparticles), histological samples (morphological changes in aortic wall) and non-invasively (endothelial reactivity–EndoPat, ultrasound of great vessels). Ten healthy volunteers will be examined as controls. The null hypothesis is that there is no difference between studied groups in these gro...

• MeSH
• Biomarkers MeSH
• Blood Vessels * physiopathology   MeSH
• Endothelial Progenitor Cells MeSH
• Control Groups MeSH
• Blood Circulation MeSH
• Humans MeSH
• MicroRNAs MeSH
• Heart-Assist Devices * MeSH
• Heart Disease Risk Factors MeSH
• Check Tag
• Humans MeSH
• Publication type
• Comparative Study MeSH

• NML Publication type
• závěrečné zprávy o řešení grantu AZV MZ ČR

BACKGROUND: Stress has been suggested to play a potential role in inflammatory bowel disease (IBD) pathogenesis, but studies focussing on the occurrence of specific life stress events among IBD patients are scarce. Therefore, the aim of the present study was to explore the association between various life stress events and IBD. METHODS: Patients with IBD (N = 98, mean age: 38.45, 54.1% men) were compared to a group of healthy controls (N = 405, mean age: 36.45, 58.0% men) originating from a health survey conducted on a representative population sample of Czech adults. The Life Stressor Checklist-Revised (LSC-R) was used to assess the stressors. RESULTS: IBD patients had higher odds of reporting life stressors overall (p < 0.001), life stressors before the age of 16 (p < 0.004) and a higher score in traumatic stress (p < 0.005) and interpersonal violence (p < 0.001) when compared to the control group. Gender- and diagnosis-related differences are discussed. CONCLUSION: Reporting life stressors experienced during childhood or adulthood is strongly associated with IBD. This should be considered in illness management, especially in a severe course of IBD.

• MeSH
• Crohn Disease * MeSH
• Child MeSH
• Adult MeSH
• Inflammatory Bowel Diseases * epidemiology   MeSH
• Control Groups MeSH
• Humans MeSH
• Colitis, Ulcerative * MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH

Cieľ: Cieľom práce bolo porovnanie efektu dynamickej neuromuskulárnej stabilizácie (DNS) v kontexte s klasickou rehabilitáciou v experimentálnej skupine, s klasickou rehabilitáciou v kontrolnej skupine u pacientov po artroskopickej operácii plecového kĺbu. Hodnotený bol efekt liečby a jej vplyv na bolesť, disabilitu, rozsah pohybu plecového kĺbu, ako aj kvalitu života pacientov po operácii. Súbor a metódy: Výskumnú vzorku tvorilo 73 pacientov po artroskopickej operácii plecového kĺbu (s priemerným vekom 46,88 ± 13,74 roka). Náhodným výberom boli pacienti rozdelení do dvoch skupín – experimentálnej (n = 36) a kontrolnej skupiny (n = 37). Intervencia: Dĺžka trvania intervencie bola 2 týždne pre obe skupiny. Experimentálna skupina – DNS 5× týždenne v dĺžke trvania 30 min, kontrolná skupina – klasická rehabilitácia 5× týždenne v dĺžke trvania 30 min. Použili sme dotazník disability ramena (DASH – The Disabilities of the Arm, Shoulder and Hand) pre hodnotenie bolesti a disability ramena. Kvalita života bola hodnotená dotazníkom SF-36 (The Short Form Health Survey 36 items), ktorý hodnotí vnímanie zdravotného stavu, pozostáva z ôsmich subškál, ktoré hodnotia telesný a mentálny komponent. Tento dotazník je vhodný na hodnotenie kvality života ľudí s chronickými bolesťami. Obsahuje sekcie: fyzické fungovanie, obmedzenia v rolách v dôsledku fyzických ťažkostí, telesná bolesť, vnímanie a všeobecného zdravia, vitalita, sociálne fungovanie, obmedzenia v rolách v dôsledku mentálnych ťažkostí, mentálne zdravie, celkové skóre. Výsledky: V hodnotení bolesti a disability boli po liečbe medzi skupinami signifikantné rozdiely p ≤ 0,05 v celkovom skóre dotazníka DASH v prospech experimentálnej skupiny. V hodnotení kvality života prostredníctvom dotazníka SF-36 boli po liečbe medzi skupinami zaznamenané signifikantné rozdiely p ≤ 0,05 v doménach: obmedzenia v rolách v dôsledku fyzických ťažkostí, telesná bolesť, sociálne fungovanie v prospech experimentálnej skupiny. V ostatných doménach kvality života neboli po liečbe medzi skupinami zaznamenané signifikantné rozdiely. Záver: DNS sa ukazuje byť vhodnou a komplexnou metódou pre zníženie disability a bolesti v oblasti ramena u pacientov po artroskopii, je potrebné však uvedenú metodiku cvičiť dlhšie časové obdobie, ktoré je nutné na zlepšenie stability a sily svalov.

Aim: The aim of the work was to compare the effect of dynamic neuromuscular stabilization (DNS) in the experimental group in comparison with classical rehabilitation in the control group in patients after arthroscopic shoulder surgery. The effect of the treatment and its influence on pain, disability, range of motion of the shoulder joint, as well as the quality of life of patients after surgery were evaluated. Sample and methods: The research sample consisted of 73 patients after arthroscopic shoulder surgery (with a mean age of 46.88 ± 13.74 years). They were randomly divided into two groups - experimental (n = 36) and control (n = 37). Intervention: The intervention lasted 2 weeks for both groups. Experimental group – DNS 5 times a week for 30 minutes, control group – classic rehabilitation 5 times a week for 30 minutes. The DASH – Shoulder Disability Questionnaire was used to assess shoulder pain and disability. Quality of life was assessed by the SF-36 questionnaire, which assesses the perception of health status and consists of eight subscales for physical and mental components. This questionnaire is suitable for assessing the quality of life in patients with chronic pain. It contains the following sections: physical functioning, limitations in roles due to physical difficulties, physical pain, perception of general health, vitality, social functioning, limitations in roles due to mental difficulties, mental health, total score. Results: In the assessment of pain and disability after treatment, there were significant differences between the groups – p ≤ 0.05 – in the overall score of the DASH questionnaire in favour of the experimental group. In the evaluation of quality of life using the S-36 (The Short Form Health Survey 36 items) questionnaire, significant differences – p ≤ 0.05 – were noted after treatment between groups in the domains: limitations in roles due to physical difficulties, physical pain, social functioning in favour of the experimental group. In the other quality of life domains, no significant differences were observed between the two groups after treatment. Conclusion: DNS has been shown to be a suitable and complex method for reducing disability and shoulder pain in patients after arthroscopy, but it is necessary to practice this method for a longer period of time to improve muscle stability and strength.

• Keywords
• dynamická neuromuskulární stabilizace,
• MeSH
• Arthroscopy rehabilitation   MeSH
• Shoulder Pain rehabilitation   MeSH
• Control Groups MeSH
• Quality of Life MeSH
• Pain Measurement MeSH
• Movement physiology   MeSH
• Posture MeSH
• Surveys and Questionnaires MeSH
• Shoulder Joint surgery   physiopathology   MeSH
• Range of Motion, Articular MeSH
• Exercise Therapy * methods   MeSH
• Treatment Outcome MeSH
• Publication type
• Comparative Study MeSH

• MeSH
• Meridians MeSH
• Acupuncture Therapy * methods   MeSH
• Comprehensive Health Care MeSH
• Control Groups MeSH
• Baths * methods   MeSH
• Humans MeSH
• Digestive System Diseases therapy   MeSH
• Reflex MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Publication type
• Evaluation Study MeSH

• MeSH
• Acupuncture Therapy * methods   MeSH
• Adult MeSH
• Electroacupuncture methods   MeSH
• Cardiac Complexes, Premature MeSH
• Control Groups MeSH
• Blood Circulation MeSH
• Middle Aged MeSH
• Humans MeSH
• Heart Diseases * therapy   MeSH
• Aged MeSH
• Heart Rate MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Publication type
• Evaluation Study MeSH

Alzheimerova nemoc (AD) je hlavní příčinou demence u seniorů. Farmakologická léčba modifikující průběh nemoci není k dispozici, a proto se více pozornosti věnuje nefarmakologickým přístupům. Hlavním cílem projektu je vytvořit strukturovaný tanečně-pohybový program pro zdravé seniory (HS) a pacienty s mírnou kognitivní poruchou při AD (MCI) a vyhodnotit jeho efekt na změny struktury a funkce mozku u těchto jedinců. Tato 44-měsíční randomizovaná kontrolovaná studie bude provedena na 120 subjektech: 60 HS a 60 pacientech s MCI. Polovina z každé skupiny podstoupí 6ti-měsíční tanečně-pohybovou intervenci (50 cvičebních jednotek v délce 60 min s použitím inovace v taneční choreografii); druhá polovina bude tvořit kontrolní skupinu (život jako doposud). Všichni účastníci budou hodnoceni na začátku studie a po 6 měsících s využitím pokročilého multimodálního MRI protokolu a rezonanční spektroskopie (MRS) a pomocí detailního standardizovaného kognitivního vyšetření. Výsledky projektu prohloubí naše znalosti a porozumění tanečně-pohybové intervenci a jejímu vlivu na HS a pacienty s MCI.; Alzheimer’s disease (AD) is the major cause of dementia in seniors. Pharmacological disease-modifying treatment is not available, and increasing attention is thus being given to non-pharmacological approaches. Our project aim is to develop a structured dance-exercise protocol for healthy seniors (HS) and patients with mild cognitive impairment in AD (MCI) and evaluate its effect on brain structure and function in these populations. A 44-month randomized placebo-controlled study will be performed in 120 subjects: 60 HS and 60 MCI. Half of each group will undergo a 6-month dance-exercise intervention (a total of 50 training units, each lasting for 60 min, with innovative dance choreography); the second half will be a control (life as usual) group. All subjects will be assessed at baseline and after 6 months utilizing a novel advanced multimodal MRI and magnetic resonance spectroscopy protocol and detailed standardized cognitive testing. The project results will enhance our knowledge and understanding of the dance-exercise intervention and its impact on HS and MCI subjects.

• MeSH
• Alzheimer Disease therapy   MeSH
• Early Medical Intervention MeSH
• Program Evaluation MeSH
• Cognition MeSH
• Cognitive Dysfunction therapy   MeSH
• Control Groups MeSH
• Magnetic Resonance Imaging MeSH
• Neuronal Plasticity MeSH
• Neuropsychological Tests MeSH
• Randomized Controlled Trials as Topic MeSH
• Aged MeSH
• Exercise Therapy MeSH
• Dance Therapy MeSH
• Diffusion Tensor Imaging MeSH
• Check Tag
• Aged MeSH

• Conspectus
• Fyzioterapie. Psychoterapie. Alternativní lékařství
• NML Fields
• psychoterapie
• rehabilitační a fyzikální medicína
• neurologie
• NML Publication type
• závěrečné zprávy o řešení grantu AZV MZ ČR

Významná část pacientů s OCD nedosáhne uspokojivé léčebné odpovědi. Využitím komplementárních informací z humánního zobrazení mozku a animálního modelu (senzitizace quinpirolem) cílíme na hlavní nedostatky v poznání OCD a objasníme roli glutamátu, vztah strukturálních a funkčních změn mozku a neurochemické interakce v neuronálních okruzích OCD. Primárně se pak zaměříme na přední cingulum (ACC), které jsme v předchozích studiích identifikovali jako kandidátní region pro rozvoj OCD. Ve skupině 40 nemedikovaných OCD pacientů (a zdravých kontrol) provedeme hodnocení morfometrie, konektivity a hladiny glutamátu v ACC a dalších oblastí mozku. Humánní neurozobrazovací výsledky budeme interpretovat s využitím animálního modelu, který doplní náš heuristický rámec o data, která nejsou měřitelná u lidí. Animální část bude hodnotit neurochemické interakce (microdialýza), funkční konektivitu (qEEG) a expresi časných genů. Naše výsledky přispějí k pochopení neurobiologie OCD a naznačí nové možnosti léčby založené na regionální neurostimulaci a modulaci glutamátu.; Significant portion of OCD patients fail to attain a treatment response. Utilizing the complementary knowledge from human multimodal neuroimaging and animal model (quinpirole sensitization) we aim to remediate the major knowledge gaps in OCD and elucidate role of glutamate, brain structure-function linking, and neurochemical interactions within neuronal circuits of OCD. We will primarily focus on the anterior cingulate (ACC) identified as a candidate region for OCD development by our previous studies. In a group of 40 non-medicated patients (and control subjects) we will assess the morphometry, connectivity, and glutamate in the ACC and other brain areas. The human neuroimaging results will be interpreted using animal model complementing our heuristic framework by data not measurable in humans. Animal part then aims at testing neurochemical interactions (microdialysis), functional connectivity (qEEG) and immediate-early gene imaging. Our results will contribute to OCD neurobiology elucidation and outline novel therapies based on regional neurostimulation and glutamate modulation.

• MeSH
• Quinpirole MeSH
• Gyrus Cinguli physiopathology   MeSH
• Electroencephalography MeSH
• Glutamine MeSH
• Control Groups MeSH
• Glutamic Acid MeSH
• Magnetic Resonance Spectroscopy MeSH
• Magnetic Resonance Imaging MeSH
• Disease Models, Animal MeSH
• Neuronal Plasticity MeSH
• Neurotransmitter Agents MeSH
• Obsessive-Compulsive Disorder physiopathology   MeSH
• Genes, Immediate-Early MeSH
• Translational Research, Biomedical MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• neurologie
• psychiatrie
• biochemie
• NML Publication type
• závěrečné zprávy o řešení grantu AZV MZ ČR