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• MeSH
• dospělí MeSH
• epidemie MeSH
• lidé MeSH
• náchylnost k nemoci MeSH
• spalničková vakcína MeSH
• spalničky * diagnóza   epidemiologie   prevence a kontrola   MeSH
• surveillance populace MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

• MeSH
• bakteriologické techniky MeSH
• řízení kvality MeSH
• testování odbornosti laboratoří * MeSH

• MeSH
• epidemiologie MeSH
• Publikační typ
• biografie MeSH
• nekrology MeSH

• O autorovi
• Brůčková, Marie, 1930-2025 Autorita

• MeSH
• kognice MeSH
• komunikace MeSH
• lékařská etika MeSH
• lidé MeSH
• teoretické modely MeSH
• umělá inteligence MeSH
• využití lékařské informatiky * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• úvodníky MeSH

• MeSH
• brentuximab vedotin terapeutické užití   MeSH
• Hodgkinova nemoc diagnóza   terapie   MeSH
• imunoterapie metody   MeSH
• inhibitory kontrolních bodů terapeutické užití   MeSH
• klinické zkoušky jako téma MeSH
• kombinovaná farmakoterapie MeSH
• kritéria léčebné odpovědi MeSH
• lidé MeSH
• recidiva MeSH
• rizikové faktory MeSH
• staging nádorů MeSH
• transplantace kmenových buněk MeSH
• zohlednění rizika MeSH
• Check Tag
• lidé MeSH

• MeSH
• buňky NK transplantace   MeSH
• haploidentická transplantace * metody   MeSH
• hematologické nádory terapie   MeSH
• imunoterapie metody   MeSH
• klinické zkoušky jako téma MeSH
• lidé MeSH
• protinádorové látky imunologicky aktivní terapeutické užití   MeSH
• reakce štěpu proti leukémii MeSH
• transplantace hematopoetických kmenových buněk * metody   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

OBJECTIVE: The pre-surgical evaluation of epilepsy relies on the electrophysiological recordings of spontaneous seizures. During this period drug dose decreases increase the likelihood of seizures transitioning the brain from a low to high seizure likelihood state, so-called pro-ictal state. This study aimed to identify the dynamic brain changes characteristic of this transition from 386 ten-minute segments of intracranial EEG recordings of 29 patients with drug-refractory temporal lobe epilepsy. METHODS: We studied brain dynamics through mean phase locking value and relative power in gamma band, and autocorrelation function width. We further explored interactions with pro-ictal factors, such as rate of interictal spikes and high frequency oscillations, circadian and multi-day cycles, and clinical outcomes. RESULTS: We observed significant increases in gamma power in the epileptogenic zone, and critical slowing in both the epileptogenic zone and presumably healthy cortex. These changes were linked with increases in spike and high frequency oscillations rate. CONCLUSIONS: Brain dynamics changed on the slow time scale - from the beginning to the end of the multi-day interval - but did not change in the short-term during the pre-ictal interval, thus could reflect pro-ictal changes. SIGNIFICANCE: We highlight gamma power and critical slowing indices as markers of pro-ictal brain states, as well as their potential to track the seizure-related brain mechanisms during the presurgical evaluation of epilepsy patients.

• MeSH
• dospělí MeSH
• elektroencefalografie metody   MeSH
• elektrokortikografie metody   MeSH
• epilepsie temporálního laloku * patofyziologie   diagnóza   MeSH
• gama rytmus EEG * fyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mozek * patofyziologie   MeSH
• refrakterní epilepsie * patofyziologie   MeSH
• záchvaty * patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Respiratory muscle training may improve ventilatory efficiency (VE/VCO2 slope), a strong predictor of postoperative pulmonary complications. We hypothesised that multimodal prehabilitation, incorporating high-intensity respiratory muscle training, before lung resection would reduce postoperative complications and length of hospital stay. METHODS: We conducted a prospective multicentre, randomised controlled trial (NCT04826575) to examine the effect of prehabilitation in individuals undergoing lung resection. Participants were defined as high-risk for postoperative pulmonary complications if they achieved VE/VCO2 slope ≥33, as determined by cardiopulmonary exercise testing. Participants were then randomised to either usual care or multimodal prehabilitation, which consisted of a 14-day programme of high-intensity respiratory muscle training, smoking cessation, nutritional support, and psychological support. The primary outcome were postoperative pulmonary and cardiovascular complications (pneumonia, atelectasis, respiratory failure necessitating mechanical ventilation, adult respiratory distress syndrome, prolonged air leak). RESULTS: A total of 122 patients (46% female; age range: 64-75 yr) completed the study. Postoperative pulmonary complications occurred in 20/58 (34%) of patients randomised to multimodal prehabilitation, compared with 35/64 (55%) patients receiving usual care (odds ratio 2.29 [95% confidence interval 1.10-4.77]; P=0.029). Hospital length of stay was shorter after multimodal rehabilitation compared with patients randomised to receive usual care (from 9 [7-11] days to 7 [6-9] days; P=0.038). After prehabilitation, mean (sd) VE/VCO2 slope decreased from 39 (8) to 36 (9); P=0.01. Prehabilitation also improved patient-reported quality of life measures. CONCLUSIONS: In high-risk patients undergoing elective lung resection surgery, multimodal prehabilitation, including high-intensity respiratory muscle training to target VE/VCO2, reduced postoperative pulmonary complications and hospital length of stay.

• MeSH
• dechová cvičení * metody   MeSH
• délka pobytu statistika a číselné údaje   MeSH
• fyzioterapie v předoperační přípravě * MeSH
• kombinovaná terapie MeSH
• lidé středního věku MeSH
• lidé MeSH
• odvykání kouření MeSH
• plicní nemoci * prevence a kontrola   MeSH
• pneumektomie * MeSH
• pooperační komplikace * prevence a kontrola   MeSH
• předoperační péče * metody   MeSH
• prospektivní studie MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• randomizované kontrolované studie MeSH

INTRODUCTION: While smoking has been consistently identified as a significant contributor to postoperative complications, the existing literature on its association with postoperative pulmonary complications remains conflicting. AIM: We examined the association of preoperative smoking with the occurrence of postoperative pulmonary complications (PPCs). METHODS: Post hoc analysis of an observational study in 146 hospitals across 29 countries. We included patients at increased risk of PPCs, according to the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score (≥ 26 points). The primary endpoint was the occurrence of one or more predefined PPCs in the first five postoperative days, including unplanned postoperative need for supplementary oxygen, respiratory failure, unplanned need for invasive ventilation, ARDS, pneumonia and pneumothorax. Secondary endpoints included length of hospital stay and in-hospital mortality. We performed propensity score matching to correct for factors with a known association with postoperative outcomes. RESULTS: Out of 2632 patients, 531 (20.2 %) patients were smokers and 2102 (79.8 %) non-smokers. At five days after surgery, 101 (19.0 %) smokers versus 404 (19.2) non-smokers had developed one or more PPCs (P = 0.95). Respiratory failure was more common in smokers (5.1 %) than non-smokers (3.0 %) (P = 0.02), while rates of other PPCs like need for supplementary oxygen, invasive ventilation, ARDS, pneumonia, or pneumothorax did not differ between the groups. Length of hospital stay and mortality was not different between groups. Propensity score matching did not change the findings. CONCLUSION: The occurrence of PPCs in smokers is not different from non-smokers. FUNDING: This analysis was performed without additional funding. LAS VEGAS was partially funded and endorsed by the European Society of Anaesthesiology through their Clinical Trial Network and the Amsterdam University Medical Centers, Amsterdam, The Netherlands. REGISTRATION: LAS VEGAS was registered at Clinicaltrials.gov (NCT01601223). PRIOR PRESENTATION: Preliminary study results have been presented at the Euroanaesthesia 2024 International Congress, in Munich, Germany.

• MeSH
• délka pobytu statistika a číselné údaje   MeSH
• kouření * škodlivé účinky   epidemiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mortalita v nemocnicích MeSH
• plicní nemoci * epidemiologie   etiologie   MeSH
• pooperační komplikace * epidemiologie   etiologie   MeSH
• předoperační období MeSH
• rizikové faktory MeSH
• senioři MeSH
• tendenční skóre MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH

AIM: This study examines the combination of FES-PET and FDG-PET as complementary imaging for detection of metastatic ILC. METHODS: We retrospectively evaluated FES and FDG uptake in patients with metastatic ILC from an estrogen receptor (ER) positive primary tumor. We classified lesions into three categories (FES high/FDG low, FES high/FDG high, FES low/FDG low) using SUVmax cut-off values of 1.5 for FES and 5.0 for FDG. Qualitative evaluation included examination of the difference in the extent of disease between FES and FDG. RESULTS: Of the 38 patients, 82% had FES uptake in all tumor sites identified by FDG, with 18% lacking FES uptake in at least one lesion. Mean (range) SUVmax for FES and FDG was 4.0 (0.67-10.6) and 4.6 (1.3-12.5), respectively. The majority of ILC patients (25/38), had lesions with FES high/FDG low uptake, consistent with the strongly ER + indolent nature of ILC. Patients with disease classified as FES high/FDG low had longer median overall survival (OS) (3.2 years) and progression-free survival (PFS) (1.5 years) than FES high/FDG high (OS = 2.1 years and PFS = 0.46 years). The median overall OS for all patients was 3.0 years (95% CI 2.5, 4.8) and PFS of 1.3 years (95% CI 0.6, 2.5). 8 patients (21%) had qualitatively more extensive disease by FES-PET. CONCLUSIONS: Our findings suggest that both FES-PET and FDG-PET can identify metastatic ILC and be useful in detecting the pattern and extent of disease. The imaging combination provides additional information for prognosis and clinical decision making, balancing suitability for endocrine therapy and aggressiveness/indolence of disease.

• MeSH
• dospělí MeSH
• estradiol * analogy a deriváty   chemie   MeSH
• fluorodeoxyglukosa F18 * chemie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lobulární karcinom * diagnostické zobrazování   terapie   patologie   MeSH
• metastázy nádorů MeSH
• nádory prsu * diagnostické zobrazování   patologie   terapie   MeSH
• pozitronová emisní tomografie * metody   MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH