BACKGROUND: High-efficacy disease-modifying therapies have been proven to slow disability accrual in adults with relapsing-remitting multiple sclerosis. However, their impact on disability worsening in paediatric-onset multiple sclerosis, particularly during the early phases, is not well understood. We evaluated how high-efficacy therapies influence transitions across five disability states, ranging from minimal disability to gait impairment and secondary progressive multiple sclerosis, in people with paediatric-onset multiple sclerosis. METHODS: Longitudinal data were obtained from the international MSBase registry, containing data from people with multiple sclerosis from 151 centres across 41 countries, and the Italian Multiple Sclerosis and Related Disorders Register, containing data from people with multiple sclerosis from 178 Italian multiple sclerosis centres. People younger than 18 years at the onset of multiple sclerosis symptoms were included, provided they had a confirmed diagnosis of relapsing-remitting multiple sclerosis and at least four Expanded Disability Status Scale (EDSS) scores recorded within 12-month intervals. The primary outcome was the time to change in disability state: minimal disability (EDSS scores 0, 1·0, and 1·5), mild disability (EDSS scores 2·0 and 2·5), moderate disability (EDSS scores 3·0 and 3·5), gait impairment (EDSS scores ≥4·0), and clinician diagnosed secondary progressive multiple sclerosis. A multi-state model was constructed to simulate the natural course of multiple sclerosis, modelling the probabilities of both disability worsening and improvement simultaneously. The impact of high-efficacy disease-modifying therapies (alemtuzumab, cladribine, daclizumab, fingolimod, mitoxantrone, natalizumab, ocrelizumab, rituximab, or autologous haematopoietic stem cell transplantation) and low-efficacy disease-modifying therapies (dimethyl fumarate, glatiramer acetate, interferon beta, or teriflunomide), compared with no treatment, on the course of disability was assessed. Apart from recruitment, individuals with lived experience of multiple sclerosis were not involved in the design and conduct of this study. FINDINGS: A total of 5224 people (3686 [70·6%] female and 1538 [29·4%] male) with mean age at onset of multiple sclerosis 15·24 years (SD 2·52) were included. High-efficacy therapies reduced the hazard of disability worsening across the disability states. The largest reduction (hazard ratio 0·41 [95% CI 0·31-0·53]) was observed in participants who were treated with high-efficacy therapies while in the minimal disability state, compared with those remained untreated. The benefit of high-efficacy therapies declined with increasing disability. Young people with minimal disability who received low-efficacy therapy also experienced a reduced hazard (hazard ratio 0·65 [95% CI 0·54-0·77]) of transitioning to mild disability, in contrast to those who remained untreated. INTERPRETATION: Treatment of paediatric-onset relapsing-remitting multiple sclerosis with high-efficacy therapy substantially reduces the risk of reaching key disability milestones. This reduction in risk is most pronounced among young people with minimal or mild disability when treatment began. Children with relapsing-remitting multiple sclerosis should be treated early with high-efficacy therapy, before developing significant neurological impairments, to better preserve their neurological capacity. FUNDING: National Health and Medical Research Council, Australia; MSBase Foundation Fellowship; MS Australia Postdoctoral Fellowship.

• MeSH
• chronicko-progresivní roztroušená skleróza * MeSH
• dítě MeSH
• dospělí MeSH
• fingolimod hydrochlorid terapeutické užití   MeSH
• lidé MeSH
• mladiství MeSH
• registrace MeSH
• relabující-remitující roztroušená skleróza * farmakoterapie   MeSH
• roztroušená skleróza * komplikace   farmakoterapie   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Úrazy jsou celosvětově považovány za závažný společenský, sociální a ekonomický problém, jsou nejčastější příčinou morbidity, mortality a trvalého postižení u mladých lidí do 25 let. Myšlenka vytvořit Národní registr dětských úrazů (NRDU) existuje již od roku 2004, postupně a systematicky je rozvíjena v Dětském traumatologickém centru (DTC) Fakultní nemocnice Brno. Metodika zahrnuje tvorbu platformy úrazové databáze, zajištění její bezpečnosti, vypracování systému její ochrany a přístupů, prověření uživatelské přístupnosti a dostatečné odbornosti a kontrolu validity výstupů. Dále je potřeba sestavit jednotlivé moduly pro zadávání dat (Polytraumata, hospitalizovaná monotraumata, ostatní úrazy) a rozšíření mezi odbornou lékařskou veřejnost. K dnešnímu dni se podařilo NRDU dokončit a spustit oficiální webovou verzi, provést seznámení a zaškolení lékařů všech osmi DTC v ČR. V roce 2008 probíhá pilotní registrace všech dětských polytraumat, která byla ošetřena v některém z osmi dětských traumatologických center v roce 2008 a dále dětí, které na úraz zemřeli na místě. Analýza za první pololetí 2008 již vydala první zajímavé výsledky. Vytvoření a rozšíření používání NRDU mezi Dětská traumatologická centra je prvním a zásadním krokem. Možnost provedení analýzy v prvním pololetí roku 2008 a její výsledky jsou důkazem vysoké výtěžnosti a potřebnosti národní úrazové databáze.

Injuries are the consequential social and economical problem and most frequent causes of death in the age group 0–24 years in the world. The idea to create National Children´s trauma register exists since year 2004 and is systematic developed at Clinic of paediatric surgery, orthopaedics abd traumatology (Paediatric trauma centre). To get the total and valid dataset from a large re-gion, it's necessary to assemble them in one common information system. All the data are stored in the central safety database and it´ll be made regularly data analyse and valid data output every year. Separately are collected data of hospitalized monotrauma, polytrauma and slight injuries and system is connected with register of death chidren. Thanks collection and comparision of data from each region (Czech Republic) is possible to define the risk activities and places, and make analyse for more details and create effective preventive measures. All the Paediatric trauma centres are now connected together and they all collect the traumatological data. The first analysis (first half of 2008) is avilable. The creating and currency of National Children´s Trauma Register into the Paediatric trauma centres is the first and very important step. The possibility to analyse injuries in the first half of year 2008 and its results confirms recovery and imporatnce of national injury database.

• MeSH
• dítě MeSH
• lidé MeSH
• polytrauma epidemiologie   MeSH
• registrace MeSH
• skóre závažnosti úrazu MeSH
• úrazy a nehody MeSH
• Check Tag
• dítě MeSH
• lidé MeSH

BACKGROUND: In relapsing-remitting multiple sclerosis (RRMS) the most common treatment strategy has been to start with low-moderate efficacy disease modifying therapy (LE-DMT) and to escalate to more efficacious treatments in cases of breakthrough disease activity. However, recent evidence suggests a better outcome in patients commencing with moderate-high efficacy DMT (HE-DMT) immediately after clinical onset. OBJECTIVE: The aim of this study is to compare disease activity and disability outcomes in patients treated with the two alternative strategies using the Swedish and Czech national multiple sclerosis registries, taking advantage of the fact that the relative frequency of each strategy differs markedly between these two countries. METHODS: Adult RRMS patients who initiated their first-ever DMT between 2013 and 2016 and were included in the Swedish MS register were compared with a similar cohort from the MS register of the Czech Republic using propensity score overlap weighting as a balancing method. The main outcomes of interest were time to confirmed disability worsening (CDW), time to achieve an expanded disability status scale (EDSS) value of 4, time to relapse, and time to confirmed disability improvement (CDI). To support the results, a sensitivity analysis focusing solely on patients from Sweden starting with HE-DMT and patients from the Czech Republic starting with LE-DMT was performed. RESULTS: In the Swedish cohort, 42% of patients received HE-DMT as initial therapy compared to 3.8% of patients in the Czech cohort. The time to CDW was not significantly different between the Swedish and Czech cohorts (p-value 0.2764), with hazard ratio (HR) of 0.89 and a 95% confidence interval (CI) of 0.77-1.03. Patients from the Swedish cohort exhibited better outcomes for all remaining variables. The risk of reaching EDSS 4 was reduced by 26% (HR 0.74, 95%CI 0.6-0.91, p-value 0.0327), the risk of relapse was reduced by 66% (HR 0.34, 95%CI 0.3-0.39, p-value <0.001), and the probability of CDI was three times higher (HR 3.04, 95%CI 2.37-3.9, p-value <0.001). CONCLUSION: The analysis of the Czech and the Swedish RRMS cohorts confirmed a better prognosis for patients in Sweden, where a significant proportion of patients received HE-DMT as initial treatment.

• MeSH
• dospělí MeSH
• lidé MeSH
• recidiva MeSH
• registrace MeSH
• relabující-remitující roztroušená skleróza * farmakoterapie   epidemiologie   MeSH
• roztroušená skleróza * farmakoterapie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH
• Švédsko MeSH

BACKGROUND: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. OBJECTIVES: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. METHODS: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants. RESULTS: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5). CONCLUSIONS: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag.

• MeSH
• lidé MeSH
• postižení * MeSH
• posuzování pracovní neschopnosti MeSH
• progrese nemoci MeSH
• recidiva MeSH
• registrace MeSH
• relabující-remitující roztroušená skleróza * MeSH
• roztroušená skleróza * farmakoterapie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• chromozomální poruchy diagnóza   prevence a kontrola   MeSH
• epidemiologické metody MeSH
• genetické nemoci vrozené diagnóza   epidemiologie   prevence a kontrola   MeSH
• genetické poradenství metody   trendy   využití   MeSH
• lékařská genetika * metody   trendy   MeSH
• lidé MeSH
• politika plánování rodičovství trendy   zákonodárství a právo   MeSH
• populační genetika * metody   trendy   MeSH
• preventivní lékařství etika   metody   MeSH
• registrace * etika   normy   MeSH
• rodina MeSH
• statistika jako téma MeSH
• vládní programy metody   trendy   zákonodárství a právo   MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Československo MeSH

INTRODUCTION: Published prevalence rates of congenital diaphragmatic hernia (CDH) vary. This study aims to describe the epidemiology of CDH using data from high-quality, population-based registers belonging to the European Surveillance of Congenital Anomalies (EUROCAT). METHODS: Cases of CDH delivered between 1980 and 2009 notified to 31 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. RESULTS: There were 3373 CDH cases reported among 12 155 491 registered births. Of 3131 singleton cases, 353 (10.4%) were associated with a chromosomal anomaly, genetic syndrome or microdeletion, 784 (28.2%) were associated with other major structural anomalies. The male to female ratio of CDH cases overall was 1:0.69. Total prevalence was 2.3 (95% CI 2.2 to 2.4) per 10 000 births and 1.6 (95% CI 1.6 to 1.7) for isolated CDH cases. There was a small but significant increase (relative risk (per year)=1.01, 95% credible interval 1.00-1.01; p=0.030) in the prevalence of total CDH over time but there was no significant increase for isolated cases (ie, CDH cases that did not occur with any other congenital anomaly). There was significant variation in total and isolated CDH prevalence between registers. The proportion of cases that survived to 1 week was 69.3% (1392 cases) for total CDH cases and 72.7% (1107) for isolated cases. CONCLUSIONS: This large population-based study found an increase in total CDH prevalence over time. CDH prevalence also varied significantly according to geographical location. No significant association was found with maternal age.

• MeSH
• analýza přežití MeSH
• dospělí MeSH
• gestační stáří MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mnohočetné abnormality epidemiologie   MeSH
• novorozenec MeSH
• porodní hmotnost MeSH
• prevalence MeSH
• registrace MeSH
• surveillance populace MeSH
• věk matky MeSH
• vrozená brániční kýla epidemiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• novorozenec MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Evropa MeSH

V práci jsou prezentována data pacientů s RS léčených v ČR glatiramer acetátem (GA) zadaná do registru Registry of Multiple Sclerosis (ReMuS) retrospektivně i prospektivně. Výstupy z registru byly zpracovány za období od jeho založení 1. 1. 2013 do 30. 6. 2018 se zaměřením na data pacientů léčených přípravkem GA 20 mg/ml (GA20) subkutánně denně nebo 40 mg/ml (GA40) subkutánně 3x týdně. Byla provedena analýza celkem 3 527 pacientů, kteří byli ve sledovaném období léčeni přípravkem GA20 či GA40. Celé sledované období bylo léčeno 868 pacientů (24,6 %) a léčbu v tomto období zahájilo 1 929 pacientů (54,6 %). Na konci sledovaného období, bylo léčeno GA celkem 2 190 pacientů (62,1 %). V této podskupině bylo 205 pacientů (9,4 %) léčeno GA20 a 1 985 pacientů (90,6 %) GA40. Léčbu GA ukončilo 634 (32,9 %) pacientů, z toho 521 (82,2 %) z důvodu eskalace léčby a 113 pacientů (17,8 %) již dále nepokračovalo v imunomodulační léčbě.

The data of patients with MS treated in the Czech Republic with glatirameracetate (GA) entered in both etrospectively and prospectively the Registry of Multiple Sclerosis (ReMuS) registry are presented. Outputs from the registry were processed over the period from its foundation on January 1, 2013 to June 30, 2018 focusing on patients treated daily with subcutaneous 20 mg/ml of GA (GA20) or subcutaneous 40 mg/ml (GA40) 3 times per week. Data of a total of 3,527 patients who were treated with GA20 or GA40 during the period monitored were analysed. 868 patients (24.6%) were treated during the entire monitored period and treatment in this period was started in 1,929 patients (54.6%). At the end of the reference period, a total of 2,190 (62.1%) patients were treated with GA. In this subgroup, 205 patients (9.4%) were treated with GA 20 and 1,985 patients (90.6%) with GA 40. Treatment with GA was finished in 634 (32.9%) patients, out of whom 521 (82.2%) were included for treatment escalation and 113 patients (17.8%) discontinued immunomodulatory therapy.

• MeSH
• demyelinizační nemoci farmakoterapie   MeSH
• dospělí MeSH
• glatiramer acetát * terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• pozorovací studie jako téma MeSH
• registrace MeSH
• retrospektivní studie MeSH
• roztroušená skleróza * farmakoterapie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

Léčba subkutánním inteferonem β-1a (IFN β-1a) snižuje u relaps-remitentní roztroušené sklerózy (RS) riziko klinické i radiologické progrese. Účinnost byla prokázána i ve fázi klinicky izolovaného syndromu. Dlouhodobá data o bezpečnosti IFN β-1a jsou příznivá včetně možnosti léčby v průběhu těhotenství a kojení. Adherenci pacientů k léčbě IFN β-1a zvyšuje užívání elektronického autoinjektoru. Registr ReMuS zajišťuje sběr dat o pacientech s RS v České republice již od roku 2013. Analýza dostupných dat umožňuje podrobnou charakteristiku pacientů léčených subkutánním IFN β-1a. K dispozici jsou informace o vývoji počtu pacientů, jejich fenotypu, těhotenství, práceschopnosti či postavení IFN β-1a v algoritmu léčby RS.

In relapsing-remitting multiple sclerosis, the treatment with subcutaneous interferon β-1a (IFN β-1a) reduces the risk of clinical and radiological progression. Efficacy has been shown even in the stage of clinically isolated syndrome. Long-term data on the safety of IFN β-1a have been promising, including the treatment options during pregnancy and breast-feeding. Patient adherence to treatment with IFN β-1a is increased by the use of an electronic autoinjector. The ReMuS Registry has been collecting data on multiple sclerosis patients in the Czech Republic since 2013. An analysis of available data allows for a detailed characterization of patients treated with subcutaneous IFN β-1a. Information is available on the numbers of patients, their phenotype, pregnancy, capacity for work, or role of IFN β-1a in the treatment algorithm of multiple sclerosis.

• Klíčová slova
• registr ReMuS,
• MeSH
• injekce subkutánní MeSH
• interferon beta 1a * aplikace a dávkování   terapeutické užití   MeSH
• lidé MeSH
• registrace statistika a číselné údaje   MeSH
• relabující-remitující roztroušená skleróza * farmakoterapie   MeSH
• těhotenství účinky léků   MeSH
• Check Tag
• lidé MeSH
• těhotenství účinky léků   MeSH
• Publikační typ
• hodnotící studie MeSH

INTRODUCTION: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined. OBJECTIVE: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. METHODS: Patients with RRMS who were given natalizumab or fingolimod were identified in a merged cohort from three international registries. Efficacy outcomes were compared across subgroups based on patients' sex, age, disease duration, Expanded Disability Status Scale (EDSS) score, and disease and magnetic resonance imaging (MRI) activity 12 months prior to treatment initiation. Study endpoints were number of relapses (analyzed with weighted negative binomial generalized linear model) and 6-month confirmed disability worsening and improvement events (weighted Cox proportional hazards model), recorded during study therapy. Each patient was weighted using inverse probability of treatment weighting based on propensity score. RESULTS: A total of 5148 patients (natalizumab 1989; fingolimod 3159) were included, with a mean ± standard deviation age at baseline of 38 ± 10 years, and the majority (72%) were women. The median on-treatment follow-up was 25 (quartiles 15-41) months. Natalizumab was associated with fewer relapses than fingolimod (incidence rate ratio [IRR]; 95% confidence interval [CI]) in women (0.76; 0.65-0.88); in those aged ≤ 38 years (0.64; 0.54-0.76); in those with disease duration ≤ 7 years (0.63; 0.53-0.76); in those with EDSS score < 4 (0.75; 0.64-0.88), < 6 (0.80; 0.70-0.91), and ≥ 6 (0.52; 0.31-0.86); and in patients with pre-baseline relapses (0.74; 0.64-0.86). A higher probability of confirmed disability improvement on natalizumab versus fingolimod (hazard ratio [HR]; 95% CI) was observed among women (1.36; 1.10-1.66); those aged > 38 years (1.34; 1.04-1.73); those with disease duration > 7 years (1.33; 1.01-1.74); those with EDSS score < 6 (1.21; 1.01-1.46) and ≥ 6 (1.93; 1.11-3.34); and patients with no new MRI lesion (1.73; 1.19-2.51). CONCLUSIONS: Overall, in women, younger patients, those with shorter disease durations, and patients with pre-treatment relapses, natalizumab was associated with a lower frequency of multiple sclerosis relapses than fingolimod. It was also associated with an increased chance of recovery from disability among most patients, particularly women and those with no recent MRI activity.

• MeSH
• dospělí MeSH
• fingolimod hydrochlorid terapeutické užití   MeSH
• imunologické faktory terapeutické užití   MeSH
• imunosupresiva terapeutické užití   MeSH
• internacionalita * MeSH
• kohortové studie MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• následné studie MeSH
• natalizumab terapeutické užití   MeSH
• registrace * MeSH
• relabující-remitující roztroušená skleróza diagnóza   farmakoterapie   epidemiologie   MeSH
• sekundární prevence MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH

Úvod: Kardiovaskulární onemocnění jsou hlavní příčinou úmrtí v České republice. Od roku 1958 úmrtnost na kardiovaskulární onemocnění klesá a snižuje se rovněž jejich incidence včetně incidence cévních mozkových příhod (CMP). Vyhodnocováním kombinované incidence CMP se u nás zjistilo vyšší procento recidiv než v ostatních zemích západní Evropy. Incidence je ovlivněna rizikovým profilem nemocných po CMP. Cílem této práce je zjistit procento výskytu hlavních rizikových faktorů nemocných (rizikový profil) po ischemické CMP v České republice, jež se může významně podílet na vysokém procentu recidiv CMP u nás. Metody a výsledky: V letech 2010 a 2011 bylo zadáno do registru IKTA celkem 15 880 pacientů z 13 center. Přítomnost rizikového faktoru (RF) se hodnotila podle anamnestických údajů nebo zjištěnou a opakovaně ověřenou laboratorní (i jinak měřitelnou) abnormalitou v průběhu hospitalizace na akutní CMP. Hodnotili jsme výskyt tří hlavních dobře definovatelných RF: hypertenze, dyslipidemie a diabetes mellitus (DM). Arteriální hypertenzi jsme v hodnoceném souboru zjistili v průměru v 86,2 %, následovala dyslipidemie (58,2 %). DM byl přítomen u 34,9 % pacientů. Tři a více RF mělo 80,7 % pacientů po CMP, nejčastější byla kombinace čtyř RF (20,5 %). Závěr: Procentuální výskyt RF u pacientů po ischemické CMP je v naší práci významně vyšší, než se uvádí v literatuře, a tento nepříznivý rizikový profil může být hlavní příčinou vyššího počtu recidiv CMP i vyšší incidence.

Introduction: Cardiovascular disease is the main cause of death in the Czech Republic. From 1958, we observe a decrease in mortality from cardiovascular disease as well as reduced incidence, including the incidence of stroke. Analysis of combined incidence of ischemic stroke in our country showed higher proportion of recurrence than in other western European countries. The incidence is affected by a post‐stroke patient risk profile. The aim of this research was to determine a proportion of patients with major risk of stroke (risk profile) in the Czech Republic. High incidence of risk factors might significantly contribute to high recurrence of stroke in our country. Methods and results: Total of 15,880 patients from 13 centers were entered into the IKTA register between 2010 and 2011. Risk factors (RF) were identified from anamnestic data, or based on abnormality detected and repeatedly verified with laboratory (or other) tests during hospitalization for acute stroke. We evaluated occurrence of three major well‐definable RFs: hypertension, dyslipidemia and diabetes mellitus (DM). Arterial hypertension was identified in 86.2% of patients and was followed by dyslipidemia (58.2%). DM was present in 34.9% of patients. Three or more RFs were found in 80.7% of post‐stroke patients, the most common was a combination of four RFs (20.5%). Conclusion: The incidence of RFs in patients after ischemic stroke in our study is significantly higher than that stated in the literature and this unfavorable risk profile may be the main cause of the high incidence of stroke and its recurrence.

• MeSH
• cévní mozková příhoda * komplikace   MeSH
• diabetes mellitus MeSH
• fibrilace síní MeSH
• hypercholesterolemie MeSH
• hypertenze MeSH
• kardiovaskulární nemoci MeSH
• kouření MeSH
• lidé MeSH
• recidiva MeSH
• registrace * MeSH
• rizikové faktory * MeSH
• statistika jako téma MeSH
• věkové faktory MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH