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MeSH: kyselina citronová-aplikace a dávkování

10 záznamů v Medvik Filtry

Článek

Efficacy and safety of an adsorbent and anti-oxidative vaginal gel on CIN1 and 2, on high-risk HPV, and on p16/Ki-67: a randomized controlled trial

Major, Attila Louis
Autor Major, Attila Louis Femina Gynecology Center, Rue Emile-Yung 1, 1205, Geneva, Switzerland. majorattila@outlook.fr Department of Obstetrics and Gynecology, Cantonal Hospital, University of Fribourg, Fribourg, Switzerland. majorattila@outlook.fr
Dvořák, Vladimír, 1961-
Autor Autorita Centrum ambulantní Gynekologie a primární péče, s.r.o., Brno, Czech Republic
Schwarzová, Jana
Autor Schwarzová, Jana Smetanova 388, 252 64 Velké Prilepy, Prague-West, Czech Republic
Skřivánek, Aleš
Autor Skřivánek, Aleš G-CENTRUM Olomouc, s.r.o., Olomouc, Czech Republic
Malík, Tomáš
Autor Malík, Tomáš Gyneko spol. s.r.o., Vsetin, Czech Republic
Pluta, Marek
Autor Pluta, Marek Fakultní Nemocnice v Motole (University Hospital Motol), Onkogynekologická a kolposkopická Ambulance, Praha, Czech Republic
Mayboroda, Ivanna
Autor Mayboroda, Ivanna Department of Obstetrics and Gynecology, University Hospital of Geneva, Geneva, Switzerland
Grandjean, Etienne Marc
Autor Grandjean, Etienne Marc Phidalsa Pharma-Consultants, Petit-Lancy/Geneva, Switzerland Camara-Partners, Consultant, Nyon, Switzerland

Archives of gynecology and obstetrics. 2021 ; 303 (2) : 501-511. [pub] 20201120

Arch Gynecol Obstet
ISSN 1432-0711
Medvik
Zdroj

PURPOSE: The effect of SAM vaginal gel, a medical device containing adsorptive silicon dioxide and antioxidative sodium selenite and citric acid, on histologically-proven cervical intraepithelial neoplasia type 2 (CIN2) as well as p16 positive CIN1, and on the presence of the onco-marker p16 was investigated. METHODS: 216 women aged 25-60 years were randomized to either receive an intravaginal daily dose of SAM gel for three 28-day periods, or be followed-up without intervention. The primary endpoint was efficacy, defined as a combined histological and cytological regression. At baseline and after 3 months participants had: a guided biopsy including p16 immunohistochemical (IHC) staining, only if a lesion was visible at colposcopy; a cervical smear for cytology, high-risk human papillomavirus (hr-HPV) and a p16/Ki-67 test. At 6 months a further cytology and p16/Ki-67 test was performed. RESULTS: Regression of CIN lesions was observed in 78 out of 108 patients (72.2%) in the SAM gel arm and in 27 out of 108 patients (25.0%) in the control arm. Similarly, the change in the p16/Ki-67 cytological test status was significantly in favor of the treatment arm. The prevalence of hr-HPV decreased significantly (p < 0.001) in the treatment arm, from 87.0% to 39.8%, while it slightly increased in the control arm, from 78.7% to 83.3%. At 6 months the cytological regression in the treatment group and the highly significant effect on p16/Ki-67 was still present. CONCLUSION: SAM vaginal gel enhances the regression of cervical lesions and clears hr-HPV and p16/Ki-67 in smears significantly, thus offering an active non-destructive management to prevent cervical cancer. TRIAL REGISTRATION NUMBER: ISRCTN11009040, date of registration: 10/12/2019; https://doi.org/10.1186/ISRCTN11009040 ; retrospectively registered.

Článek

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

International journal of colorectal disease. 2017 ; 32 (12) : 1763-1766. [pub] 20170924

Int J Colorectal Dis
ISSN 1432-1262
Medvik
Zdroj

PURPOSE: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. METHODS: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. RESULTS: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). CONCLUSIONS: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.

Článek

Changes of serum calcium, magnesium and parathyroid hormone induced by hemodialysis with citrate-enriched dialysis solution

Kidney & blood pressure research. 2015 ; 40 (1) : 13-21. [pub] 20150131

Kidney Blood Press Res
ISSN 1423-0143
Medvik
Zdroj

BACKGROUND/AIMS: In recent years, one of technical attempts to improve biocompatibility and tolerability of the hemodialysis procedure is the substitution of acetate in dialysis solution with citrate. The aim of our study was to compare two dialysis solutions: traditional bicarbonate dialysis solution containing acetate (3 mmol/L) (solution A); and (solution C) commercially produced citrate-enriched bicarbonate dialysis solution (0.8 mmol/L citrate). METHODS: Patients from a single hemodialysis center (N=126) were included in the study. Both conventional low-flux hemodialysis and on-line hemodiafiltration procedures were studied. Both dialysis solutions contained identical calcium (1.5 mmol/L) and magnesium (0.5 mmol/L) concentrations. RESULTS: Parathyroid hormone (iPTH) concentration decreased during procedures with solution A by 64%. On the contrary, when solution C was used, iPTH concentration increased insignificantly by 4%. For solution A, serum calcium and magnesium increased during procedures in patients with predialysis concentrations lower than 2.33 and 0.76 mmol/L, respectively. In procedures with dialysis solution C these concentrations were significantly lower: 2.19 mmol/L for Ca and 0.68 mmol/L for Mg. CONCLUSION: Our study clearly shows that the substitution of part of acetate with citrate in dialysis solution significantly influences changes of serum calcium, magnesium and parathyroid hormone concentrations during hemodialysis and hemodiafiltration procedures.

MeSH
biologické markery krev MeSH
dialýza ledvin trendy MeSH
dialyzační roztoky aplikace a dávkování MeSH
hořčík krev MeSH
kohortové studie MeSH
kyselina citronová aplikace a dávkování MeSH
lidé středního věku MeSH
lidé MeSH
parathormon krev MeSH
prospektivní studie MeSH
senioři MeSH
vápník krev MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH

Článek

A single or split dose picosulphate/magnesium citrate before colonoscopy: comparison regarding tolerance and efficacy with polyethylene glycol. A randomized trial

Journal of gastrointestinal and liver diseases. 2014 ; 23 (2) : 141-6.

J Gastrointestin Liver Dis
ISSN 1842-1121
Medvik
Zdroj

BACKGROUND & AIMS: To compare the efficacy and tolerance of sodium picosulphate/magnesium citrate (PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation. METHODS: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy. Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure. The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale. RESULTS: A total of 600 patients were enrolled, 88.2% were included in the analysis. Satisfactory bowel cleansing (Aronchick score 1 and 2) was significantly more frequent when a split dose was used irrespective of the solution type (81.6% PMC2/2, 87.3% PEG3/1 vs. 73.0% PEG4/0, p = 0.024). In single dose regimens, PMC performed better than PEG (82.6% vs. 73.0%). Single or split dose PMC preparations were comparable. A PMC based solution was generally better tolerated than PEG regardless of the regimen used (p < 0.001). Nausea was reported mostly after the 4L PEG (32.8%, p < 0.001), incontinence after a split PMC dose (34.4%, p = 0.002), and bloating after the 4L PEG (38.0%, p < 0.001). There was no significant difference in the prevalence of vomiting. CONCLUSION: Colonic preparation with PMC yields similar results as a split PEG dose, regardless of whether PMC is administered in single or separate doses. PMC is better tolerated than any PEG-based preparation. A single 4L PEG the day before the colonoscopy is less appropriate for bowel cleansing.

Článek

Volba koncentrace vápníku v dialyzačním roztoku - literární přehled a kazuistická sdělení
[Calcium concentration in dialysis solution – review of the literature and case reports]

Aktuality v nefrologii. 2011 ; 17 (3) : 113-123.

Medvik
Zdroj

Koncentrace vápníku v dialyzačním roztoku je jedna ze složek, které vytváří celkovou bilanci vápníku v organismu. Nesprávná bilance vápníku může být spoluzodpovědná za zvýšenou morbiditu a mortalitu dialyzovaných pacientů. Volba správné koncentrace vápníku pro dialyzační roztok přitom není jednoduchá - je potřeba ji individualizovat dle stavu a potřeb jednotlivých pacientů se zohledněním užívané terapie a dalších faktorů.

Hemodialysis is an important component of whole-body calcium balance. Inappropriate selection of calcium concentration for dial ysis solution may be responsible for increased morbidity and mortality of hemodialysis patients. Choice of adequate calcium concentr ation is complicated, have to be individualized, and must take into account number of factors including clinical status of the patien t and concomitant medication.

Klíčová slova
bilance vápníku, kalcifikace, CKD-MBD, hemodialýza,
MeSH
chronické selhání ledvin metabolismus terapie MeSH
dialýza ledvin metody MeSH
dospělí MeSH
financování organizované MeSH
hemodialyzační roztoky chemie MeSH
kalcifylaxe diagnóza etiologie MeSH
kyselina citronová aplikace a dávkování metabolismus MeSH
lidé MeSH
parathormon metabolismus MeSH
sekundární hyperparatyreóza diagnóza etiologie terapie MeSH
vápník aplikace a dávkování krev metabolismus MeSH
Check Tag
dospělí MeSH
lidé MeSH
ženské pohlaví MeSH
Publikační typ
kazuistiky MeSH
přehledy MeSH

Článek

Prostacyclin versus citrate in continuous haemodiafiltration: an observational study in patients with high risk of bleeding

Blood purification. 2005 ; 23 (4) : 325-329.

ISSN 0253-5068
Medvik
Zdroj

BACKGROUND: The efficacy and safety of prostacyclin (PGI2) and citrate (ACD) anticoagulation were observed and compared during continuous haemodiafiltration. METHODS: Mechanically ventilated patients received either the PGI2 analogue epoprostenol (group A, n = 17) in escalating doses of 4.5-10.0 ng.kg(-1).min(-1) in combination with heparin (6 IU.kg(-1).h(-1)) or 2.2% ACD (group B, n = 15). Blood flow was set to match the circuit-filling volume per unit time equal to the intravascular half-life of PGI2. RESULTS: Median filter lifetimes were 26 h (interquartile range 16-37) in group A (39 filters) and 36.5 h (interquartile range 23-50) in group B (56 filters; p < 0.01). In group A, 4 patients (23.5%, p < 0.05) had the dose reduced due to hypotension. The final mean dose of PGI2 was 8.7 +/- 2.4 ng.kg(-1).min(-1). Four patients in group A (23.5%, p < 0.05) were switched to ACD due to a decrease in platelet count. No bleeding episodes, decrease in platelet count or adverse haemodynamic effects were encountered in group B. The cost of epoprostenol plus low dose heparin (EUR 204.73 +/- 53.04) was significantly higher than the cost of ACD-based anticoagulation (EUR 93.92 +/- 45.2, p < 0.05). CONCLUSION: ACD offers longer filter survival, has no impact on platelet count and is less expensive. Increasing the dose of PGI2 up to the average of 8.7 ng.kg(-1).min(-1) did not increase the haemodynamic side effects. (c) 2005 S. Karger AG, Basel

MeSH
antikoagulancia aplikace a dávkování ekonomika MeSH
epoprostenol aplikace a dávkování ekonomika MeSH
glukosa analogy a deriváty aplikace a dávkování MeSH
hemodiafiltrace metody normy MeSH
heparin aplikace a dávkování MeSH
krvácení prevence a kontrola MeSH
kyselina citronová aplikace a dávkování MeSH
lidé středního věku MeSH
lidé MeSH
riziko MeSH
senioři MeSH
trombocyty účinky léků MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
srovnávací studie MeSH

Článek

Comparison of different protocols for 13C-urea breath test for the diagnosis of Helicobacter pylori infection in healthy volunteers

Scandinavian journal of clinical & laboratory investigation. 2005 ; 65 (6) : 491-498.

ISSN 0036-5513
Medvik
Zdroj

OBJECTIVE: The (13)C-urea breath test ((13)C-UBT) is the most accurate non-invasive method for diagnosis of Helicobacter pylori infection. However, several methodological issues have not been resolved yet. The aim of this study was to test different protocols of (13)C-UBT to find the optimal test drink and sampling interval. MATERIAL AND METHODS: (13)C-UBT was performed at 3-day intervals in 27 healthy volunteers using citric acid (test A), orange juice (B) and still water (C) as test drinks. Breath samples were collected from time 5 to 60 min. A total number of 2106 breath samples were analysed by isotope ratio mass spectrometry (cut-off value 3.5). RESULTS: Differences in delta values were greater than would be expected by chance (A versus B and A versus C at times 20, 25, 30, 35 and 40 min, p<0.05, Dunnett's method). There were no grey zone- or false-negative results among H. pylori-positive persons in test A at any time, but some were found in tests B and C. Optimal intervals for breath sampling are at times 20 or 25 min after (13)C-urea ingestion. CONCLUSIONS: Citric acid solution as a test drink and 20- or 25-min breath sampling intervals are optimal for the (13)C-UBT in healthy volunteers.