BACKGROUND: The post-activation performance enhancement (PAPE) effect has been widely studied; however, its repeatability across training sessions during the competitive season in team sports has not yet been verified. Therefore, this study investigates whether PAPE effect, as measured by the countermovement jump (CMJ) without arm swing, induced by an maximum voluntary isometric squat as a conditioning activity (ICA) three days after the match, could be replicated over a 4-week training period throughout the season. The study also explores whether the magnitude of acute PAPE responses correlates with match running variables, as monitored by global positioning system (GPS) data. METHODS: Fifteen national level soccer players participated in the study (mean age: 26.9 ± 4.2 years, body mass: 79.2 ± 6.5 kg, height: 182.1 ± 6.5 cm, experience in soccer training: 11.2 ± 4.2 years, experience in strength training: 10.5 ± 4.6 years, relative maximal strength in squat: 1.84 kg/body mass). Each participant performed 1 repetition of the CMJ approximately 120 s before (pre-ICA) and approximately 60 s after (as post-ICA) 1 set of maximum voluntary isometric squat using a Smith machine as the ICA lasting 5 s. The measurements were repeated across 4 testing sessions performed week apart and each time 3 days after the soccer match. Moreover, running performance variables during matches including total distance, high-speed running distance, sprint distance, player load, total number of accelerations, total number of decelerations were collected via GPS system. RESULTS: A two-way repeated-measures ANOVA showed a significant main effect of time, indicating an increase in CMJ height (mean difference = 1.05 ± 0.3 cm; Cohen's d = 0.222; p = 0.005) post-ICA compared to pre-ICA. The one-way ANOVA did not reveal significant differences between sessions, which may indicate repeatable acute PAPE responses (F = 0.093, p = 0.963, η2p = 0.006). Additionally, the one-way ANOVAs did not reveal significant differences in all GPS data between particular soccer matches (p > 0.145; for all). The interclass correlation coefficient for the PAPE response was poor to moderate (interclass correlation coefficient = 0.56, 95% confidence interval: 0.06-0.83). The Cochran's Q test indicated that PAPE response distributions varied across sessions (p = 0.018). However, pairwise McNemar tests did not reveal significant differences (p = 0.549-1.000), suggesting that while response distribution fluctuated, no specific session-to-session differences were detected. Moreover, Pearson's product-moment correlation coefficient, did not show significant correlation between the percentage PAPE responses and all of match GPS data variables (p > 0.074; for all). CONCLUSIONS: The findings suggest that ICA can consistently elicit a PAPE response of small magnitude in national-level soccer players with a short 60-s rest interval. However, the variability in individual responsiveness and the lack of a relationship with running variables monitored via GPS during soccer matches indicate that other physiological and neuromuscular factors may influence the magnitude of PAPE responses. Given this variability, individually monitoring PAPE responsiveness may be beneficial for optimizing its application.

• Publication type
• Journal Article MeSH

INTRODUCTION: Resistance exercises are effective for maintaining health and activating stabilizing muscles, as they trigger abdominal wall tension responses. This study compared the effects of multi-joint and single-joint, upper-body and lower-body exercises (Lat pulldown, Rows, Peck deck, Chest press, Biceps curls, Triceps extensions, French-Press, Step up, Hip abduction/adduction, Squat, Leg press, Romanian deadlift, Hamstring curls) performed at maximal and submaximal intensities. METHODS: This cross-sectional study included 12 men and 18 women (age:47.8 ± 5.9 years, height:174.8 ± 10.2 cm, weight: 77.7 ± 15.4 kg, BMI:25.3 ± 3.6), who wore a noninvasive sensor Ohmbelt to measure abdominal wall tension performing exercises at 15 repetition maximum (RM), 10RM, 5RM, and 1RM. Differences across exercises and sex were compared by Friedman test with Durbin-Conover post-hoc, and intensities were analyzed by Wilcoxon test. RESULTS: The study found significant differences (p < 0.05) in abdominal wall tension changes based on the type of exercise and training intensity. Multi-joint lower-body exercises, such as the Romanian deadlift, dumbbell front squat, and leg press, led to the greatest increases in abdominal tension in both sexes in comparison to single-joint upper-body exercises. Males had higher abdominal wall tension changes than females (p < 0.05) at 1RM, 5RM, and 10RM. However, no significant difference was found at 15RM, indicating that lower intensities produce similar abdominal wall tension changes in both sexes. CONCLUSIONS: This study showed that multi-joint lower-body exercises were found to produce greatest abdominal wall tension increases, especially compared to single-joint upper-body exercises. The abdominal wall tension was higher in males than females due to higher loads, emphasizing the need for exercise-specific approaches.

• Publication type
• Journal Article MeSH

Escherichia coli (E. coli) is a rod-shaped gram-negative bacterium that includes the diarrheagenic strains, an identical group of intestinal pathogens.E. coli diarrhea is transmitted through the feco-oral route, through contaminated food and water. Enteropathogenic E. coli (EPEC) is one of the leading causes of diarrhea in the pediatric age group in developing and developed countries. Depending on the absence or presence of E. coli adherence factor plasmids, they are classified as typical or atypical isolates. The distinguishing feature of EPEC's pathology is the attaching and effacing lesions, which facilitate localized damage by tightly adhering to intestinal epithelial cells, disarranging their surfaces, and effacing microvilli. Typical EPEC possess the locus of enterocyte effacement (LEE), a pathogenicity island, encoding adherence factors, including the Type III Secretion System (T3SS), a needle-like structure injecting effector proteins into host cells. EPEC also have other effector genes like cif or nleC encoded by non-LEE pathogenicity islands, which enable destruction of tight junctions in the host cell. Another key virulence factor is bundle-forming pili (BFP), which aids in the first attachment to enterocytes. Methods like quantitative PCR exist to diagnose EPEC accurately. As of today, no licensed vaccine exists to prevent EPEC infections. Virulence factors for attachment, such as bfpA and intimin, and immunogenic carriers can be potential candidates for vaccine development. Moreover, studies are required to better understand the interaction of EPECwith the intestinal microbiome and immune evasion strategies. This article is aimed at providing a comprehensive review of the epidemiology, transmission, virulence factors, challenges in studying EPEC virulence factors, pathogenesis, host-pathogen interaction, mechanism of intestinal injury, diagnosis, treatment, antibiotic resistance, and vaccination strategy for EPEC, and future research implications. We conducted a comprehensive literature search using credible sources such as PubMed, Google Scholar, and Scopus. We refined our keywords, applied database filters, and assessed citations in the included studies. No meta-analysis, statistical aggregation, or formal evaluation of risk bias was carried out as this review consolidates the literature narratively. High-quality English articles published in reputable peer-reviewed journals from 2010 to 2025 were analyzed, and their findings have been summarized in this comprehensive review.

• Publication type
• Journal Article MeSH
• Review MeSH

Publikace obsahuje rozhovor s českým plastickým chirurgem Ondřejem Měšťákem o jeho profesním i osobním životě.; Lze krásu vyjádřit matematickým vzorcem? Dají se prsa zvětšit vlastním tukem? S čím nejčastěji chodí na plastiky muži? Na tyto a mnoho dalších otázek odpovídá renomovaný plastický chirurg Ondřej Měšťák, mimo jiné specialista na rekonstrukce prsů a operace nosů, vědec a v neposlední řadě syn legendárního plastického chirurga Jana Měšťáka. V knižním rozhovoru se čtenář dozví, jak těžké je stát se plastickým chirurgem, jak si správně plastického chirurga vybrat a které úkony hradí zdravotní pojišťovna. Projdeme různé druhy plastických operací na jednotlivých částech těla. Zabrousíme i do vážnějších témat, jako jsou mikrochirurgické operace onkologických pacientek nebo operace rozestupu břišních svalů po těhotenství. Prostor ale dostanou i odlehčenější dotazy, jako například zda Ondřej dostává nevyžádané zprávy od žen, zda si bere svou práci domů nebo odkud čerpá energii. Společně s autorem knihy Pavlem Hénikem si také zafilozofují o kráse.

• MeSH
• Surgeons MeSH
• History, 20th Century MeSH
• History, 21st Century MeSH
• Surgery, Plastic MeSH
• Check Tag
• History, 20th Century MeSH
• History, 21st Century MeSH
• Publication type
• Interview MeSH
• Geographicals
• Czech Republic MeSH

• Conspectus
• Ortopedie. Chirurgie. Oftalmologie
• Biografie
• NML Fields
• plastická chirurgie

• About
• Měšťák, Ondřej Authority

Brožura obsahuje práce přednesené na kongresu, který se zaměřil na farmakoterapii idiopatických střevních zánětů, zejména pomocí léku mirikizumab. Určeno odborné veřejnosti.

• Keywords
• mirikizumab,
• MeSH
• Antibodies, Monoclonal, Humanized MeSH
• Inflammatory Bowel Diseases drug therapy   MeSH
• Janus Kinase Inhibitors MeSH
• Publication type
• Congress MeSH
• News MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• gastroenterologie
• farmakoterapie
• NML Publication type
• brožury

Brožura je sborníkem prací, které se zaměřily na harm reduction prevenci nádorových nemocí. Určeno odborné veřejnosti.

• MeSH
• Neoplasms prevention & control   MeSH
• Primary Prevention MeSH
• Secondary Prevention MeSH
• Harm Reduction MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• onkologie
• preventivní medicína
• NML Publication type
• brožury

Příručka, která se zaměřuje na metody diagnostiky a terapie arteriální hypertenze. Určeno odborné veřejnosti.; S problematikou arteriální hypertenze se setkávají nejen internisté a praktičtí lékaři, ale i specialisté napříč klinickými obory. Ambicí kolektivu autorů této knihy není shrnout veškerou dostupnou evidenci, ale spíše přinést praktické informace pro každodenní kontakt s pacienty diagnostikovanými a léčenými pro arteriální hypertenzi. Výběr kapitol vychází nejen z klinické praxe hypertenzních ambulancí v České republice, ale také z dlouholeté lektorské praxe autorů, monitorace zájmu o jednotlivá témata a nejčastějších dotazů z auditorií. Informace reflektující nejnovější evidenci jsou podány co nejpřehlednějším a zároveň co nejkonkrétnějším způsobem umožňujícím rychlou orientaci a pomoc při rozhodování v klinických situacích souvisejících s diagnózou arteriální hypertenze.

• MeSH
• Antihypertensive Agents MeSH
• Drug Therapy MeSH
• Hypertension diagnosis   therapy   MeSH
• Publication type
• Handbook MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• angiologie
• NML Publication type
• kolektivní monografie

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• MeSH
• Esophageal and Gastric Varices diagnostic imaging   diagnosis   nursing   therapy   MeSH
• Endoscopy, Gastrointestinal MeSH
• Liver Cirrhosis surgery   diagnosis   etiology   complications   physiopathology   therapy   MeSH
• Emergency Medicine MeSH

• MeSH
• Vascular Access Devices trends   MeSH
• Hospitals, Teaching MeSH
• Catheterization, Peripheral methods   standards   nursing   trends   MeSH
• Patient Care Team MeSH
• Catheters, Indwelling standards   trends   MeSH

• MeSH
• Continuity of Patient Care legislation & jurisprudence   MeSH
• Patient Handoff legislation & jurisprudence   MeSH
• Patient Discharge legislation & jurisprudence   MeSH