1. elektronické vydání 1 online zdroj (192 stran)
V přípravě pedagogů, psychologů a dalších oborů má interakční psychologický výcvik nezastupitelné místo. Kniha přináší konkrétní hry a postupy pro práci se skupinou. Vedoucím i členům skupiny umožňuje porozumět základním pravidlům a zákonitostem, kterými se práce s výcvikovou skupinou řídí.
elektronický časopis
- Conspectus
- Psychologie
- NML Fields
- psychologie, klinická psychologie
- NML Publication type
- elektronické časopisy
elektronický časopis
- Conspectus
- Psychologie
- NML Fields
- psychologie, klinická psychologie
- NML Publication type
- elektronické časopisy
BACKGROUND AND PURPOSE: Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1 receptors. SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and CB1 receptors co-localize in axons and presynaptic boutons. SGIP1 interferes with the internalization of activated CB1 receptors in transfected heterologous cells. Consequently, the transient association of CB1 receptors with β-arrestin2 is enhanced and prolonged, and CB1 receptor-mediated ERK1/2 signalling is decreased. Because of these actions, SGIP1 may modulate affect, anxiety, pain processing, and other physiological processes controlled by the endocannabinoid system (ECS). EXPERIMENTAL APPROACH: Using a battery of behavioural tests, we investigated the consequences of SGIP1 deletion in tasks regulated by the ECS in SGIP1 constitutive knockout (SGIP1-/- ) mice. KEY RESULTS: In SGIP1-/- mice, sensorimotor gating, exploratory levels, and working memory are unaltered. SGIP1-/- mice have decreased anxiety-like behaviours. Fear extinction to tone is facilitated in SGIP1-/- females. Several cannabinoid tetrad behaviours are altered in the absence of SGIP1. SGIP1-/- males exhibit abnormal behaviours on Δ9 -tetrahydrocannabinol withdrawal. SGIP1 deletion also reduces acute nociception, and SGIP1-/- mice are more sensitive to analgesics. CONCLUSION AND IMPLICATIONS: SGIP1 was detected as a novel protein associated with CB1 receptors, and profoundly modified CB1 receptor signalling. Genetic deletion of SGIP1 particularly affected behavioural tests of mood-related assessment and the cannabinoid tetrad. SGIP1-/- mice exhibit decreased nociception and augmented responses to CB1 receptor agonists and morphine. These in vivo findings suggest that SGIP1 is a novel modulator of CB1 receptor-mediated behaviour.
- MeSH
- Adaptor Proteins, Signal Transducing physiology MeSH
- Affect MeSH
- Emotions MeSH
- Extinction, Psychological MeSH
- Cannabinoids MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Nociception * MeSH
- Receptor, Cannabinoid, CB1 * genetics MeSH
- Receptors, Cannabinoid MeSH
- Fear MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
elektronický časopis
- Conspectus
- Psychologie
- NML Fields
- psychologie, klinická psychologie
- sociologie
- NML Publication type
- elektronické časopisy
- MeSH
- Adult MeSH
- Extraversion, Psychological MeSH
- Humans MeSH
- Narcissism MeSH
- Personality Disorders * diagnosis psychology therapy MeSH
- Psychoanalytic Theory MeSH
- Psychoanalytic Therapy * MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH