- MeSH
- Mental Health MeSH
- Psychological Well-Being MeSH
- Psychosomatic Medicine MeSH
- Publication type
- Interview MeSH
- MeSH
- Hospice and Palliative Care Nursing * MeSH
- Death MeSH
- Terminally Ill MeSH
- Publication type
- Interview MeSH
V kazuistike analyzujeme príčinu nízkeho time in range u 66-ročného, pravidelne športujúceho pacienta s diabetes mellitus 1. typu v trvaní 17 rokov a anamnézou chronického srdcového zlyhávania používajúceho kontinuálny monitoring glykémií.
In the case report, we analyse the cause of a low time in range in a 66-year-old regularly exercising patient with type 1 diabetes mellitus lasting for 17 years and a history of chronic heart failure, and using continuous blood glucose monitoring.
INTRODUCTION: Postoperative constipation (PC) in patients with imperforate anus and perineal fistula (PF) has been reported in up to 60%. Histological studies of PF revealed innervation anomalies which seem to be one of the reasons for PC. Perioperative histologically controlled fistula resection (PHCFR) allows appropriate resection of PF and pull-down normoganglionic rectum at the time of posterior sagittal anorectoplasty (PSARP). MATERIALS AND METHODS: A total of 665 patients with anorectal malformations underwent surgery between 1991 and 2021. Of these, 364 presented PF; 92 out of them (41 F) were studied. Patients with sacral and spinal cord anomalies, neurological disorders, and cut-back anoplasty were excluded. PSARP was done on all patients. Hematoxylin-eosin staining and NADH Tetrazolium-reductase histochemical method were used. Four and more ganglion cells in the myenteric plexus represented a sufficient length of the resection. The continence was scored according to the modified Krickenbeck scoring system. Final scores ranged from 1 to 7 points. Values are given as median. RESULTS: A total of 65 (70.7%) patients presented an aganglionic segment in PF, and 27 patients presented hypoganglionosis. The median length of the resected fistula was 25 mm (interquartile range [IQR]: 20-30). The median total continence score was 7 (IQR: 6-7). Post-op constipation was observed in 6/92 (6.5%) patients. CONCLUSION: PHCFR diminished PC to 6.5% of patients.
- MeSH
- Anus, Imperforate * surgery MeSH
- Child MeSH
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Perineum surgery MeSH
- Postoperative Complications etiology MeSH
- Child, Preschool MeSH
- Rectal Fistula * surgery MeSH
- Rectum surgery abnormalities MeSH
- Retrospective Studies MeSH
- Treatment Outcome MeSH
- Constipation etiology surgery MeSH
- Plastic Surgery Procedures methods MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review insulin, which has at least one plausible mechanism for slowing ALS progression. However, pre-clinical studies are limited and there have been no trials in PALS yet. Insulin use in patients without a metabolic need may cause very serious and potentially lethal side effects. While further studies to evaluate potential benefits may be warranted, at this time we cannot endorse insulin treatment to slow ALS progression.
- MeSH
- Amyotrophic Lateral Sclerosis * drug therapy MeSH
- Insulin adverse effects MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- MeSH
- Complementary Therapies MeSH
- Humans MeSH
- Labyrinth Diseases pathology MeSH
- Tinnitus * etiology therapy MeSH
- Check Tag
- Humans MeSH
