Mobilní a nositelná elektronika nabízí pacientům s diabetes mellitus nové možnosti sběru dat a jejich efektivnější analýzu. Aplikace pro chytré telefony Diabetesdagboka a webový portál Diani umožňují shromažďování a analýzu hodnot glykemie, dávek sacharidů a inzulinu a míry pohybové aktivity. Hodnoty jsou dostupné v příslušném mobilním telefonu, ale jsou též automatizovaně přenášeny do internetového portálu, kde mohou být doplněny o záznam z elektronického krokoměru a kontinuálního monitoru glykemie. Lze je též zobrazit v různých typech grafických výstupů a jsou dostupné nejenom pacientovi, ale i jeho lékaři. Kazuistika pacienta, který systém téměř 2 roky využíval, prokazuje významné zlepšení metabolické kompenzace (pokles průměrné hodnoty HbA1c o 18,6 mmol/mol v porovnání s předchozím obdobím).

Mobile and wearable technologies offer patients with diabetes mellitus new possibilities for data collection and their more effective analysis. The Diabesdagboga smartphone application and the Diani web portal enable to collect and analyze glycaemia values, carbohydrates intake, insulin doses and the level of physical activity. The data are not only accessible in the corresponding smartphone but also automatically transferred to an Internet portal, where they may be completed by the records from an electronic pedometer and continuous glucose monitor. All these data may then be displayed in various types of graphical outputs and are available to both the patient and the physician. The case report of a patient who has used the system for almost two years shows a significant improvement in metabolic compensation (a decrease in the mean HbA1c value by 18.6 mmol/mol as compared with the previous period).

• Klíčová slova
• diabetický deník, telemonitoring, webová aplikace, webový portál,
• MeSH
• deníky jako téma MeSH
• diabetes mellitus 1. typu * diagnóza   terapie   MeSH
• diabetes mellitus diagnóza   terapie   MeSH
• dospělí MeSH
• glykovaný hemoglobin analýza   MeSH
• hypoglykemie prevence a kontrola   MeSH
• lidé MeSH
• mobilní aplikace MeSH
• selfmonitoring glykemie metody   MeSH
• telemedicína metody   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH
• práce podpořená grantem MeSH

• MeSH
• čas MeSH
• počítače MeSH
• software MeSH

Backgrounds and aims This study focuses on the role of time perspective (TP) in Internet gaming disorder (IGD). An inventory-based study on 377 massive multiplayer online role playing game players was conducted, followed by a 3-year-follow-up in which 48 active players from the original sample participated. We proposed that TP factors (negative TP and future positive TP) will influence either the current presence of IGD symptoms or the further development of IGD over time. In other words, the effect of TP is stable. Finally, game usage patterns were analyzed in the sense of changes in playing time and IGD symptoms in gamers after 3 years. Methods To access the variables, two scales were administered through online inventory, the Zimbardo Time Perspective Inventory-short, and Charlton and Danforths' Core Addiction Scale, both in 2012 (N = 377) and 2015 (N = 48). The amount of time that gamers usually spent playing were obtained through self-reports. Results The study's primary presumptions were confirmed. Both negative TP and future positive TP were confirmed as significant predictors of the presence of IGD symptoms, either immediately or in the following 3 years. Data on game usage showed a significant decrease in playing time and IGD symptoms between year 0 and year 3 of the study.

• MeSH
• dítě MeSH
• dospělí MeSH
• internet * MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• mladiství MeSH
• mladý dospělý MeSH
• následné studie MeSH
• návykové chování psychologie   MeSH
• senioři MeSH
• videohry * MeSH
• vnímání času * MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

EU project OLDES (Older People's e-services at home) aims at developing a very low cost and easy to use entertainment and health care platform designed to ease the life of older people in their homes. The platform is based on a PC corresponding to Negroponte's paradigm of a 100 $ device. OLDES combines user entertainment services (through easy-to-access thematic interactive channels and special interest forums supported by animators) and health care facilities. The pilot case study of diabetes type II compensation under the OLDES framework is presented. Apart from measurement of continuous glucose, blood pressure and weight, the user feeds into OLDES system food daily consumption using interactive food scales via user friendly software interface designed by user-centered design paradigm and obtains advice if necessary.

• MeSH
• algoritmy MeSH
• diabetes mellitus 2. typu farmakoterapie   MeSH
• dostupnost zdravotnických služeb MeSH
• financování organizované MeSH
• hypoglykemika terapeutické užití   MeSH
• internet MeSH
• inzulin terapeutické užití   MeSH
• krevní glukóza metabolismus   MeSH
• lidé MeSH
• monitorování fyziologických funkcí metody   MeSH
• péče o sebe MeSH
• pilotní projekty MeSH
• počítačové zpracování signálu MeSH
• software MeSH
• studie proveditelnosti MeSH
• telefon MeSH
• Check Tag
• lidé MeSH

We introduce a rapid deterministic algorithm for identification of the most critical links which are capable of causing network disruptions. The algorithm is based on searching for the shortest cycles in the network and provides a significant time improvement compared with a common brute-force algorithm which scans the entire network. We used a simple measure, based on standard deviation, as a vulnerability measure. It takes into account the importance of nodes in particular network components. We demonstrate this approach on a real network with 734 nodes and 990 links. We found the worst scenarios for the cases with and without people living in the nodes. The evaluation of all network breakups can provide transportation planners and administrators with plenty of data for further statistical analyses. The presented approach provides an alternative approach to the recent research assessing the impacts of simultaneous interruptions of multiple links.

• MeSH
• algoritmy * MeSH
• čas MeSH
• doprava * MeSH
• lidé MeSH
• sběr dat MeSH
• software MeSH
• záznamy jako téma MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH

BACKGROUND: Cognitive rehabilitation is a highly individualised, non-pharmacological intervention for people with mild cognitive impairment (MCI) and dementia, which in recent years has also been developed for various IT platforms. METHODS: In this study, we aim to evaluate the effectiveness of the cognitive rehabilitation software GRADIOR in a multi-centre, single-blinded randomised controlled trial with people with MCI and mild dementia. A total of 400 people with MCI and mild dementia will be randomly allocated to one of four groups. This trial will compare the cognitive rehabilitation treatment using the GRADIOR programme with a psychosocial stimulation intervention (PSS) using the ehcoBUTLER platform, with a combined treatment consisting of GRADIOR and ehcoBUTLER, and with a group receiving treatment as usual during a period of 1 year. DISCUSSION: The outcomes of this clinical trial will be to determine any relevant changes in cognition, mood, quality of life, activities of daily living and quality of patient-carer relationship after 4 months and 1 year of intervention in a cross-sectional group comparison. Participants will be followed-up for 1 year to investigate potential long-term effects of the conducted treatments. TRIAL REGISTRATION: Current Controlled Trials ISRCTN, ID: 15742788 . Registered on 12 June 2017.

• MeSH
• afekt MeSH
• časové faktory MeSH
• činnosti denního života MeSH
• demence diagnóza   psychologie   rehabilitace   MeSH
• jednoduchá slepá metoda MeSH
• kognice * MeSH
• kognitivní dysfunkce diagnóza   psychologie   rehabilitace   MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• multicentrické studie jako téma MeSH
• počítačem asistovaná terapie metody   MeSH
• psychoterapie metody   MeSH
• randomizované kontrolované studie jako téma MeSH
• senioři MeSH
• software * MeSH
• stupeň závažnosti nemoci MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• protokol klinické studie MeSH
• Geografické názvy
• Španělsko MeSH

BACKGROUND: The glycemic index (GI) is routinely measured 120 minutes after food intake (GI120). The purpose of this prospective open label study was to assess (1) the dynamics of glycemia over the 210 minutes following food consumption and (2) the evolution of GIs based on 120-, 150-, 180-, and 210-minute glycemic profiles. METHOD: Twenty healthy subjects (mean +/- SE; 21.9 +/- 1.39 years of age; body mass index 23.6 +/- 0.63 kg/m(2); 7 men and 13 women) completed the study. Each subject consumed 10 different foods with known GI120 on three separate occasions at four different times of day according to a defined meal plan over a 9-day period; 32 meals were evaluated. The GIs for intervals of 120, 150, 180 and 210 minutes after food consumption were determined using a continuous glucose monitoring system (CGMS) to measure glycemia. The Wilcoxon signed-rank test was applied to compare the GIs. RESULTS: Glycemia returned to baseline within 120 minutes for honey and tomato soup; within 210 minutes for white bread, choco-rice cookies, fish and potatoes, wafers, and meat ravioli with cheese; and later for dark chocolate, apricot dumplings, and choco-wheat cookies. The extended GIs were higher than the respective GI120s in eight of the foods. CONCLUSIONS: The 120-minute glycemic index fails to fully account for changes in glycemia after ingestion of a mixed meal because glycemia remains above baseline for a longer period. The CGMS is a convenient method to determine the glucose response/GIs over intervals extended up to 210 minutes, which is adequate time for the absorption of most foods.

• MeSH
• čas MeSH
• dospělí MeSH
• glykemický index fyziologie   MeSH
• krevní glukóza analýza   MeSH
• lidé MeSH
• potraviny MeSH
• přijímání potravy fyziologie   MeSH
• software MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• práce podpořená grantem MeSH

BACKGROUND AND AIMS: The question of when and how to treat truly asymptomatic patients with severe aortic stenosis (AS) and normal left ventricular (LV) systolic function is still subject to debate and ongoing research. Here, the results of extended follow-up of the AVATAR trial are reported (NCT02436655, ClinicalTrials.gov). METHODS: The AVATAR trial randomly assigned patients with severe, asymptomatic AS and LV ejection fraction ≥ 50% to undergo either early surgical aortic valve replacement (AVR) or conservative treatment with watchful waiting strategy. All patients had negative exercise stress testing. The primary hypothesis was that early AVR will reduce a primary composite endpoint comprising all-cause death, acute myocardial infarction, stroke, or unplanned hospitalization for heart failure (HF), as compared with conservative treatment strategy. RESULTS: A total of 157 low-risk patients (mean age 67 years, 57% men, mean Society of Thoracic Surgeons score 1.7%) were randomly allocated to either the early AVR group (n = 78) or the conservative treatment group (n = 79). In an intention-to-treat analysis, after a median follow-up of 63 months, the primary composite endpoint outcome event occurred in 18/78 patients (23.1%) in the early surgery group and in 37/79 patients (46.8%) in the conservative treatment group [hazard ratio (HR) early surgery vs. conservative treatment 0.42; 95% confidence interval (CI) 0.24-0.73, P = .002]. The Kaplan-Meier estimates for individual endpoints of all-cause death and HF hospitalization were significantly lower in the early surgery compared with the conservative group (HR 0.44; 95% CI 0.23-0.85, P = .012, for all-cause death and HR 0.21; 95% CI 0.06-0.73, P = .007, for HF hospitalizations). CONCLUSIONS: The extended follow-up of the AVATAR trial demonstrates better clinical outcomes with early surgical AVR in truly asymptomatic patients with severe AS and normal LV ejection fraction compared with patients treated with conservative management on watchful waiting.

• MeSH
• aortální chlopeň chirurgie   MeSH
• aortální stenóza * chirurgie   mortalita   terapie   MeSH
• asymptomatické nemoci terapie   MeSH
• avatar MeSH
• cévní mozková příhoda MeSH
• chirurgická náhrada chlopně * metody   MeSH
• hospitalizace statistika a číselné údaje   MeSH
• konzervativní terapie * metody   MeSH
• lidé středního věku MeSH
• lidé MeSH
• následné studie MeSH
• pozorné vyčkávání MeSH
• senioři MeSH
• tepový objem fyziologie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• randomizované kontrolované studie MeSH
• srovnávací studie MeSH

• MeSH
• aktivace makrofágů * imunologie   MeSH
• bakteriální infekce MeSH
• čas MeSH
• cytokiny MeSH
• ELISA MeSH
• Francisella tularensis MeSH
• geny MeSH
• glukany MeSH
• imunitní systém - jevy * MeSH
• imunomodulace * MeSH
• interferon gama MeSH
• kadmium MeSH
• kathepsin B MeSH
• kultivované buňky MeSH
• lidé MeSH
• lipopolysacharidy MeSH
• myši MeSH
• olovo MeSH
• proliferace buněk MeSH
• proteiny analýza   MeSH
• software MeSH
• těžké kovy MeSH
• Th1 buňky MeSH
• Th2 buňky MeSH
• výzkum MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• Publikační typ
• práce podpořená grantem MeSH

ELIXIR is a pan-European intergovernmental organisation for life science that aims to coordinate bioinformatics resources in a single infrastructure across Europe; bioinformatics training is central to its strategy, which aims to develop a training community that spans all ELIXIR member states. In an evidence-based approach for strengthening bioinformatics training programmes across Europe, the ELIXIR Training Platform, led by the ELIXIR EXCELERATE Quality and Impact Assessment Subtask in collaboration with the ELIXIR Training Coordinators Group, has implemented an assessment strategy to measure quality and impact of its entire training portfolio. Here, we present ELIXIR's framework for assessing training quality and impact, which includes the following: specifying assessment aims, determining what data to collect in order to address these aims, and our strategy for centralised data collection to allow for ELIXIR-wide analyses. In addition, we present an overview of the ELIXIR training data collected over the past 4 years. We highlight the importance of a coordinated and consistent data collection approach and the relevance of defining specific metrics and answer scales for consortium-wide analyses as well as for comparison of data across iterations of the same course.

• MeSH
• algoritmy MeSH
• biomedicínský výzkum MeSH
• databáze faktografické MeSH
• hodnocení programu MeSH
• kontinuální vzdělávání MeSH
• kurikulum MeSH
• reprodukovatelnost výsledků MeSH
• řízení kvality * MeSH
• sběr dat MeSH
• software MeSH
• uživatelské rozhraní počítače MeSH
• výpočetní biologie výchova   normy   MeSH
• výzkumní pracovníci MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Evropa MeSH