The cavernous hemangiomas of the liver are usually small sized and asymptomatic. Most of them are incidentally diagnosed and a very small portion requires therapy. Giant hemangioma can be symptomatic, and this condition is the indication for treatment. The striking complication of surgical treatment of cavernous hemangiomas is intra-operative bleeding. In this case, we aimed to demonstrate that the risk of intraoperative bleeding can be eliminated with the preoperative percutaneous trans-catheter arterial embolization technique.
- MeSH
- Digestive System Surgical Procedures methods utilization MeSH
- Angiography, Digital Subtraction methods utilization MeSH
- Adult MeSH
- Catheterization methods utilization MeSH
- Hemangioma, Cavernous diagnosis therapy MeSH
- Blood Loss, Surgical prevention & control MeSH
- Humans MeSH
- Liver Neoplasms diagnosis surgery MeSH
- Tomography, X-Ray Computed methods utilization MeSH
- Preoperative Care methods utilization MeSH
- Embolization, Therapeutic methods utilization MeSH
- Ultrasonography MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
BACKGROUND AND PURPOSE: Motor speech alterations are a prominent feature of clinically manifest Huntington's disease (HD). Objective acoustic analysis of speech can quantify speech alterations. It is currently unknown, however, at what stage of HD speech alterations can be reliably detected. We aimed to explore the patterns and extent of speech alterations using objective acoustic analysis in HD and to assess correlations with both rater-assessed phenotypical features and biological determinants of HD. METHODS: Speech samples were acquired from 44 premanifest (29 pre-symptomatic and 15 prodromal) and 25 manifest HD gene expansion carriers, and 25 matched healthy controls. A quantitative automated acoustic analysis of 10 speech dimensions was performed. RESULTS: Automated speech analysis allowed us to differentiate between participants with HD and controls, with areas under the curve of 0.74 for pre-symptomatic, 0.92 for prodromal, and 0.97 for manifest stages. In addition to irregular alternating motion rates and prolonged pauses seen only in manifest HD, both prodromal and manifest HD displayed slowed articulation rate, slowed alternating motion rates, increased loudness variability, and unstable steady-state position of articulators. In participants with premanifest HD, speech alteration severity was associated with cognitive slowing (r = -0.52, p < 0.001) and the extent of bradykinesia (r = 0.43, p = 0.004). Speech alterations correlated with a measure of exposure to mutant gene products (CAG-age-product score; r = 0.60, p < 0.001). CONCLUSION: Speech abnormalities in HD are associated with other motor and cognitive deficits and are measurable already in premanifest stages of HD. Therefore, automated speech analysis might represent a quantitative HD biomarker with potential for assessing disease progression.
- MeSH
- Adrenalectomy statistics & numerical data adverse effects MeSH
- Adrenal Insufficiency epidemiology etiology MeSH
- Asymptomatic Diseases MeSH
- Cushing Syndrome epidemiology surgery physiopathology MeSH
- Humans MeSH
- Adrenal Glands physiology surgery MeSH
- Postoperative Complications epidemiology MeSH
- Prevalence MeSH
- Check Tag
- Humans MeSH
- Publication type
- Overall MeSH
- MeSH
- Asymptomatic Diseases MeSH
- Humans MeSH
- Adolescent MeSH
- Myocarditis * diagnosis therapy MeSH
- Sports MeSH
- Troponin analysis blood MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Publication type
- Clinical Study MeSH
Význam subklinických tyreopatií je v současné době předmětem diskusí. Jde o laboratorně definovanou jednotku, u které je při normální hladině tyroxinu (T4) změněna hodnota tyreotropního hormonu hypofýzy (thyroid-stimulating hormone – TSH). Při jeho snížení jde o subklinickou hypertyreózu/tyreotoxikózu (STx), při zvýšení o subklinickou hypotyreózu (SH). Tyto stavy jsou 2–3krát častější než klinicky manifestní formy. Představují nesporně 2–3krát zvýšené riziko vzniku klinicky manifestních onemocnění. Méně shody je v tom, jak závažná je z klinického hlediska samotná přítomnost subklinických tyreopatií. SH vede k poruchám lipidového metabolizmu, ke změnám elasticity cévní stěny a funkce endotelu. Důsledkem je zvýšené riziko aterosklerózy. STx vyvolává elektrickou instabilitu myokardu s následným rizikem arytmií, poruchy kostního metabolizmu s následnou osteoporózou a další dosud ne zcela jednoznačně hodnocené změny. Největší význam mají subklinické tyreopatie v kardiologii, v reprodukční medicíně a gynekologii a v porodnictví.
Importance of subclinical thyroid disease (STh) is now a matter of discussion. Definition of this unit is laboratory: in presence of normal level of thyroxine (T4) TSH value is changed: in lower TSH level the subclinical hyperthyroidism (STx) in increase TSH levels subclinical hypothyroidism (SH) is present. Risk of clinical manifestation is twoo three times highter in comparison with persons with normal TSH level. Clinical importance STh is still not evaluated definitively. SH caused disturbance of lipid metabolism, elasticity of vessels and endothelial function and therefore increases risk of atherosclerosis. STx causes electrical instability of myocardium with increased risk of arythmias, increases risk of osteoporosis and other changes. Most important are effects of STh in cardiology, reproductive medicine and gynecology. Clinical significance of these effects is not definitively evaluated.
- MeSH
- Asymptomatic Diseases * MeSH
- Atherosclerosis etiology complications MeSH
- Hyperthyroidism * diagnosis etiology therapy MeSH
- Hypothyroidism * diagnosis etiology therapy MeSH
- Humans MeSH
- Thyrotropin blood MeSH
- Thyrotoxicosis * diagnosis etiology therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Asymptomatic Diseases MeSH
- Diagnosis, Differential MeSH
- Incidence MeSH
- Humans MeSH
- Tuberculosis, Pulmonary diagnosis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Case Reports MeSH
Urachus je zakrnělá tubulární struktura, která na počátku embryonálního vývoje spojuje močový měchýř s extraembryonálním alantois. Urachální cysta (UC) je vzácná vrozená anomálie způsobená neúplnou regresí zbytků urachu během vývoje, při kterém jsou oba konce kanálu uzavřeny, ale přetrvává jeho centrální část plnící se tekutinou. UC je jen zřídka příčinou klinických příznaků, pokud nedojde k její sekundární inflamaci. Obvykle se dostane do klinické pozornosti jako náhodný nález při ultrazvukovém vyšetření. Referujeme kazuistiku 4,5letého chlapce s poruchou vyprazdňování stolice, u kterého byla diagnóza UC potvrzena při vyšetření břicha ultrazvukem.
The urachus is a stunted tubular structure that connects the bladder with the extraembryonic allantois at the beginning of embryonic development. Urachal cyst (UC) is a rare congenital anomaly caused by incomplete regression of urachal remnants during development, in which both ends of the canal are closed but its central fluid-filling portion persists. UC is rarely the cause of clinical symptoms unless secondary inflammation occurs. They usually come to clinical attention as random findings on ultrasound. We report a case report of a 4.5-year-old boy with a stool emptying disorder in whom the diagnosis of UC was confirmed by ultrasound examination of the abdomen.
