AIMS: Ossifying fibromyxoid tumour is a rare mesenchymal neoplasm predominantly affecting adults characterised by a multinodular growth pattern and the presence of a fibrous pseudocapsule with areas of ossification. Prompted by the recognition of a non-ossifying ossifying fibromyxoid tumour with lipomatous differentiation which caused diagnostic difficulty, we sought to further explore cases of ossifying fibromyxoid tumour with non-osseous heterologous elements. METHODS AND RESULTS: A search of our institutional and consultation archives revealed three additional cases that demonstrated lipomatous components and two cases with cartilaginous differentiation. RNA-sequencing revealed fusions involving PHF1 (n = 4) or EPC1 (n = 1) in all (five of five) cases tested, including EPC1::PHC1 and JAZF1::PHF1 fusions, which have not been reported before in ossifying fibromyxoid tumour. CONCLUSION: These six cases expand the histomorphological spectrum of ossifying fibromyxoid tumour, introducing lipomatous differentiation as a hitherto undocumented feature. Awareness of these rare variants will ensure appropriate diagnosis and clinical management.

• MeSH
• Cell Differentiation MeSH
• Cartilage pathology   MeSH
• Diagnosis, Differential MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Lipoma * pathology   diagnosis   genetics   MeSH
• Soft Tissue Neoplasms * pathology   diagnosis   genetics   MeSH
• Fibroma, Ossifying * pathology   diagnosis   genetics   MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Case Reports MeSH

The sacroiliac joint (SIJ) exhibits significant variation in auricular surface morphology. This variation influences the mechanics of the SIJ, a central node for transmitting mechanical energy from upper body to lower limbs and vice versa. The impact of the auricular surface morphology on stress and deformation in the SIJ remains poorly understood to date. Computed tomography scans obtained from 281 individuals were included to extract the geometry of the pelvic ring. Then, the auricular surface area, SIJ cartilage thickness, and total SIJ cartilage volume were identified. Based on these reconstructions, 281 finite element models were created to simulate SIJ mechanical loading. It was found that SIJ cartilage thickness only weakly depended on age or laterality, while being strongly sex sensitive. Auricular surface area and SIJ cartilage volume depended weakly and non-linearly on age, peaking around menopause in females, but without significant laterality effect. Larger SIJs, characterized by greater auricular area and cartilage volume, exhibited reduced stress and deformation under loading. These findings highlight the significant role of SIJ morphology in its biomechanical response, suggesting a potential link between morphological variations and the risk of SIJ dysfunction. Understanding this relationship could improve diagnosis and targeted treatment strategies for SIJ-related conditions.

• MeSH
• Finite Element Analysis MeSH
• Biomechanical Phenomena physiology   MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Stress, Mechanical MeSH
• Adolescent MeSH
• Young Adult MeSH
• Tomography, X-Ray Computed * MeSH
• Sacroiliac Joint * anatomy & histology   physiology   diagnostic imaging   MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

The alveolar-capillary interface is the key functional element of gas exchange in the human lung, and disruptions to this interface can lead to significant medical complications. However, it is currently challenging to adequately model this interface in vitro, as it requires not only the co-culture of human alveolar epithelial and endothelial cells but mainly the preparation of a biocompatible scaffold that mimics the basement membrane. This scaffold should support cell seeding from both sides, and maintain optimal cell adhesion, growth, and differentiation conditions. Our study investigates the use of polycaprolactone (PCL) nanofibers as a versatile substrate for such cell cultures, aiming to model the alveolar-capillary interface more accurately. We optimized nanofiber production parameters, utilized polyamide mesh UHELON as a mechanical support for scaffold handling, and created 3D-printed inserts for specialized co-cultures. Our findings confirm that PCL nanofibrous scaffolds are manageable and support the co-culture of diverse cell types, effectively enabling cell attachment, proliferation, and differentiation. Our research establishes a proof-of-concept model for the alveolar-capillary interface, offering significant potential for enhancing cell-based testing and advancing tissue-engineering applications that require specific nanofibrous matrices.

• MeSH
• Basement Membrane MeSH
• Humans MeSH
• Nanofibers * chemistry   MeSH
• Proof of Concept Study MeSH
• Pulmonary Alveoli * chemistry   cytology   MeSH
• Polyesters * chemistry   MeSH
• Tissue Engineering * methods   MeSH
• Tissue Scaffolds * MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH

OBJECTIVES: Nonpharmacologic interventions (NPIs) constitute an important part of treatment for older adults, cover a broad and diverse range of interventions, and have advantages over pharmacologic interventions (eg, limited adverse side effects). However, an unambiguous definition of NPIs is still lacking. Defining NPIs may facilitate research on this topic and enhance comparability of results between studies, and might help to face the challenges of recognition, acceptation, funding, and implementation. Therefore, the aim of this review was to provide an overview and comparison of the definitions of NPIs used in the current literature on older adults. DESIGN: A systematic review was performed to provide an overview of the definitions of NPIs that are used in the current literature on older populations and to organize the characteristics involved in the definitions. SETTING AND PARTICIPANTS: People ≥60 years of age were included, not limited to a specific setting. METHODS: A systematic search was performed in the following 5 databases: PubMed, Embase, Clarivate Analytics/Web of Science Core Collection, Cumulative Index to Nursing and Allied Health Literature, and Wiley/Cochrane Library. The time frame within the databases was from inception to December 4, 2023. Review articles, editorials and consensus papers were included. RESULTS: We included 28 articles. We organized the definitions of NPI according to 4 different aspects: types of interventions involved, target population, goals the interventions addressed, and requirements of the interventions. Definitions in the current literature can generally be divided into 2 groups: NPIs described as not involving medication, and more elaborated multidomain definitions. Based on the results, we formulated criteria for types of interventions that can be considered an NPI. CONCLUSIONS AND IMPLICATIONS: Using current descriptions and characteristics, elements for a new definition for NPIs were proposed. To improve research in this field, consensus needs to be reached regarding elements covered by a definition of NPIs.

• MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Therapeutics * methods   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Systematic Review MeSH

High soil pH and excess CaCO3 are major contributors to calcareous soil limitations on crops' access to essential nutrients, especially phosphorus (P) and micronutrients, which in turn impact pulses yields and growth. The purpose of this study was to determine the effect of bio sulfur granules (BSG) on the growth of black gram and the availability of nutrients in calcareous vertisols deficient in sulfur. BSG was developed by using sulfur-oxidizing bacteria (SOB) and elemental sulfur (ES) through an incubation study. Developed BSG was tested in a pot and field conditions to evaluate their effectiveness on black gram growth and yield. In the incubation study, soil treated with Methylobacterium thiocyanatum VRI7-A4 and ES (40 kg S/ha) significantly decreased pH and increased available S (SO42-) in calcareous soils. After 40 days of incubation, the solubility of P, Fe, and Zn was greatly increased by the addition of ES @ 40 kg S/ ha in combination with M. thiocyanatum VRI7-A4 or Pandoraea thiooxydans ATSB16. Black gram in S-deficient calcareous soil was improved by the application of BSG (ES @ 40 kg S/ ha with M. thiocyanatum VRI7-A7) in terms of root and shoot lengths, nodule number, plant biomass, pod yield, and biological yield as compared to control. The same treatment greatly increased plant nutrient intake as well as the concentrations of P, Fe, and Zn in the soil. The results showed that the addition of BSG granules (ES @ 40 kg S/ha + M. thiocyanatum VRI7-A4) to calcareous vertisol deficient in S enhanced the nutrient solubility through S oxidation. The developed bio sulfur granules may be added to the fertilizer schedule of the pulses growers to get improved crop growth and yield of black gram in calcareous soil.

• MeSH
• Phosphorus analysis   metabolism   MeSH
• Hydrogen-Ion Concentration MeSH
• Methylobacterium * metabolism   MeSH
• Soil * chemistry   MeSH
• Soil Microbiology MeSH
• Sulfur * metabolism   MeSH
• Publication type
• Journal Article MeSH

Cíl: Tato studie se zaměřila na posouzení spolehlivosti a vzdělávací hodnoty videí o hysterektomii pomocí transluminální endoskopické operace s přirozeným vaginálním vstupem (vNOTES – vaginal natural orifice transluminal endoscopic surgery) na YouTube a jejich vhodnosti pro školení chirurgů. Materiál a metody: Dne 12. června 2024 byl YouTube prohledáván pomocí klíčových slov „vNOTES hysterektomie“, „TVNOTES hysterektomie“, „transvaginální transluminální endoskopická hysterektomie s přirozeným otvorem“, „vNOTES“ a „vaginální hysterektomie“. Kritéria pro zařazení splnilo celkem 73 videí. Byly zaznamenány metriky zapojení diváků, jako je doba od nahrání, počet zhlédnutí, hodnocení Líbí se mi, Nelíbí se mi, komentáře a délka videa. Byly vypočteny poměry, jako je poměr zobrazení, podobný poměr a index výkonu videa (VPI – video power index). Videa byla kategorizována pomocí modifikované globální škály kvality (GQS – global quality scale) a hodnocena na základě bodovacího systému odvozeného ze standardizovaného 10krokového postupu hysterektomie vNOTES se skóre v rozmezí 0–15. Výsledky: Ze 73 videí bylo 40 (53,8 %) označeno jako nekvalitní, 13 (17,8 %) jako středně kvalitní a 20 (27,4 %) jako dobré. Mezi skupinami nebyly nalezeny žádné významné rozdíly, pokud jde o dobu od nahrání, počet zhlédnutí, hodnocení Nelíbí se mi, komentářů nebo poměru Líbí se mi. Videa ve skupině dobré kvality však měla výrazně vyšší počet lajků a skóre VPI. Kritické prvky, jako je příprava a polohování pacientky, nastavení operačního sálu, obřízka děložního čípku a uzávěr klenby, byly ve videích nižší kvality nedostatečně řešeny. Videa s didaktickým hlasem měla výrazně více zhlédnutí, lajků a komentářů než videa s hudbou nebo bez zvuku. Mezi délkou videa a metrikami zapojení nebyly nalezeny žádné významné korelace. Závěr: Většina videí o hysterektomii vNOTES (53,8 %) na YouTube postrádá komplexní vzdělávací obsah, přičemž pouze malá část je považována za vhodnou pro chirurgický výcvik. Hodnocení zájmu diváků nemusí souviset s mírou užitečnosti videí. Chirurgové a organizace by se měli zaměřit na produkci vysoce kvalitních instruktážních recenzovaných videí, aby zlepšili vzdělávací hodnotu YouTube jako zdroje informací.

Objective: This study aimed to assess the reliability and educational value of vaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy videos on YouTube and their suitability for training surgeons. Materials and methods: On June 12, 2024, YouTube was searched using the keywords “vNOTES hysterectomy,” “TVNOTES hysterectomy,” “transvaginal natural orifice transluminal endoscopic hysterectomy,” “vNOTES,” and “vaginal notes hysterectomy.” A total of 73 videos met the inclusion criteria. Viewer engagement metrics, such as time since upload, number of views, likes, dislikes, comments, and video duration were recorded. Ratios such as a view ratio, a like ratio, and Video Power Index (VPI) were calculated. The videos were categorized by the modified Global Quality Scale (GQS) and evaluated based on a scoring system derived from a standardized 10-step vNOTES hysterectomy procedure, with scores ranging from 0 to 15. Results: Out of 73 videos, 40 (53.8%) were categorized as poor quality, 13 (17.8%) as moderate, and 20 (27.4%) as good. No significant differences were found between groups in terms of time since upload, views, dislikes, comments, or a like ratio. However, videos in the good-quality group had a significantly higher number of likes and VPI scores. Critical elements such as patient preparation and positioning, setup of the operation room, circumcision of the cervix, and vault closure were inadequately addressed in lower-quality videos. Videos with a didactic voice had significantly more views, likes, and comments than those with music or no sound. No significant correlations were found between video length and engagement metrics. Conclusion: The majority of vNOTES hysterectomy videos (53.8%) on YouTube lack comprehensive educational content, with only a small fraction deemed appropriate for surgical training. The interest rates of the viewers may not be correlated with the usefulness rates of the videos. Surgeons and organizations should focus on producing high-quality, peer-reviewed instructional videos to improve the educational value of YouTube as a resource.

Neural networks are responsible for processing sensory stimuli and driving the synaptic activity required for brain function and behavior. This computational capacity is expensive and requires a steady supply of energy and building blocks to operate. Importantly, the neural networks are composed of different cell populations, whose metabolic profiles differ between each other, thus endowing them with different metabolic capacities, such as, for example, the ability to synthesize specific metabolic precursors or variable proficiency to manage their metabolic waste. These marked differences likely prompted the emergence of diverse intercellular metabolic interactions, in which the shuttling and cycling of specific metabolites between brain cells allows the separation of workload and efficient control of energy demand and supply within the central nervous system. Nevertheless, our knowledge about brain bioenergetics and the specific metabolic adaptations of neural cells still warrants further studies. In this review, originated from the Fourth International Society for Neurochemistry (ISN) and Journal of Neurochemistry (JNC) Flagship School held in Schmerlenbach, Germany (2022), we describe and discuss the specific metabolic profiles of brain cells, the intercellular metabolic exchanges between these cells, and how these bioenergetic activities shape synaptic function and behavior. Furthermore, we discuss the potential role of faulty brain metabolic activity in the etiology and progression of Alzheimer's disease, Parkinson disease, and Amyotrophic lateral sclerosis. We foresee that a deeper understanding of neural networks metabolism will provide crucial insights into how higher-order brain functions emerge and reveal the roots of neuropathological conditions whose hallmarks include impaired brain metabolic function.

• MeSH
• Energy Metabolism * physiology   MeSH
• Humans MeSH
• Metabolic Networks and Pathways * physiology   MeSH
• Brain * metabolism   MeSH
• Nerve Net * metabolism   MeSH
• Neurons * metabolism   MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

Úvod: Badmintonová zranění jsou i přes celosvětovou oblibu tohoto sportu relativně opomíjenou problematikou. Metodika vyhledávání studií: Tento přehledový článek se zaměřuje na literaturu a výzkum zranění v badmintonu a na možnosti konzervativní léčby společně s rehabilitací těchto zranění. Jedním z cílů bylo shrnout poznatky z dostupných vědeckých studií publikovaných do roku 2023. Vyhledávání relevantní literatury bylo realizováno v databázích PubMed a Web of Science pomocí anglických ekvivalentů klíčových slov: badminton, zranění, etiologie, prevence, fyzioterapie. Výsledky: Celkem bylo pro tvorbu článku nalezeno a využito 51 studií, které se zabývají rizikovými faktory badmintonových zranění, jejich konkrétním typem a incidencí (zejména incidencí a rizikovými faktory), fyziologickými nároky badmintonu a možnostmi léčby daných poranění s důrazem na sportovní fyzioterapii. Studie zabývající se specificky možnostmi rehabilitace a jiných konzervativních postupů pro hráče badmintonu nebyly nalezeny. Možnosti rehabilitace vycházejí z aktuálních poznatků vztahující se obecně zejména k akutním a chronickým zraněním ve sportu. Diskuze: Ze současné evidence se jako efektivní přístup ke zraněním z přetížení jeví progresivní zatížení prvky silového tréninku s cílem navození pozitivních adaptačních změn v postižené tkáni. Ve sportovní fyzioterapii bývá hojně užíváno např. prvků kryoterapie, která ovšem pro podporu hojení a regenerace úponových bolestí nemá dostatečnou evidenci. Zranění, která vznikají akutním nedostatkem kapacity tkáně snášet nadměrnou zátěž, by měla být léčena primárně pohybovou terapií s konkrétně nastavenými parametry. Konkrétní rehabilitační postupy pozdní fáze návratu do hry jsou podmíněny specifikami sportu, jeho biomechanikou a konkrétním typem zranění. Závěr: I když je k většině zranění v badmintonu přistoupeno konzervativní metodou léčby, neexistuje dostatečná evidence vztahující se k rehabilitaci zranění specificky u badmintonistů. Cílem léčby badmintonových zranění je snížení bolestivosti, zvýšení kapacity, zlepšení koordinace a balance. Z východisek práce vyplývají následně i možnosti prevence zranění a konzervativních léčebných postupů zranění s akcentem na sportovní fyzioterapii.

Introduction: Badminton injuries are a relatively neglected issue despite the worldwide popularity of the sport. Methodology of the study search: This review article focuses on the literature and research on badminton injuries and conservative treatment options along with rehabilitation of these injuries. One of the objectives was to summarize the findings from available scientific studies published up until 2023. The search for relevant literature was performed in PubMed and Web of Science databases using the English equivalents of the keywords: badminton, injury, etiology, prevention, and physiotherapy. Results: A total of 51 studies were identified and used for the development of the article, which dealt with the risk factors of badminton injuries, their specific type and incidence (especially incidence and risk factors), the physiological demands of badminton, and treatment options for the injuries in question, with an emphasis on sports physiotherapy. Studies specifically addressing rehabilitation options and other conservative treatments for badminton players were not found. Rehabilitation options are based on current knowledge related to acute and chronic injuries in the sport in general. Discussion: From current evidence, progressive loading with elements of strength training to induce positive adaptive changes in the affected tissue appears to be an effective approach to overuse injuries. For example, elements of cryotherapy are widely used in sports physiotherapy, but there is insufficient evidence to support healing and regeneration of tendon pain. Injuries that result from an acute lack of tissue capacity to tolerate excessive load should be treated primarily with movement therapy with specific parameters. Specific rehabilitation procedures of the late phase of return to play are conditioned by the specifics of the sport, its biomechanics, and the particular type of injury. Conclusion: Although most injuries in badminton are treated conservatively, there is insufficient evidence relating to injury rehabilitation specifically for badminton players. The goal of treatment for badminton injuries is to reduce soreness, increase capacity, and improve coordination and balance. The premise of this article subsequently suggests options for injury prevention and conservative injury treatments with an emphasis on sports physiotherapy.

• MeSH
• Humans MeSH
• Racquet Sports MeSH
• Athletic Injuries * etiology   prevention & control   rehabilitation   MeSH
• Physical Therapy Modalities MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

BACKGROUND: The education of healthcare professionals, including nurses, represents a critical intersection with health systems science (HSS), which is often considered the third pillar of healthcare education alongside basic and clinical sciences. Despite the amount of research on nursing education during the COVID-19 pandemic, there remains a gap in analysis from an HSS perspective. METHODS: A Comparative Education Approach involving undergraduate nursing programs (UNPs) across Europe, with longitudinal data collection from 2002 to 2023. The aim of the study was threefold: (a) to summarize the overall changes in UNPs during the COVID-19 pandemic; (b) to identify the changes retained in the post-pandemic era; and (c) to identify the impact of the pandemic on nursing education as perceived by nurse educators across nine European countries. RESULTS: This study compares the changes in nursing education in European countries during and after the COVID-19 pandemic using a qualitative approach with data from nine universities. The COVID-19 pandemic had a significant impact on education provision. During the first wave, government restrictions forced a complete shift to online learning for theory classes, clinical training and laboratories. In subsequent waves, a hybrid format was chosen that combined online and face-to-face sessions. A major challenge was the placement of nursing students alongside general university students. This approach neglected their need for practical clinical training, which is crucial for their future careers. To compensate for the lack of clinical hours, various alternative teaching methods were introduced. Students were also offered the opportunity to volunteer in large-scale public health initiatives such as vaccination and testing campaigns, although bedside care for COVID-19 patients remained limited. The pandemic has also left its mark in the post-pandemic period. Some UNPs have retained elements of online education, notably lectures, research seminars, meetings, consultations and even online exams. Interestingly, an initial increase in applicant numbers was observed at six of the nine participating UNPs. CONCLUSIONS: The COVID-19 pandemic has widened the gap between university-educated nurses and the clinical setting, i.e. between theory and practise, underlining the importance of HSS in nursing education. Rebuilding strong partnerships is crucial, but simply returning to the pre-pandemic model is not enough. To ensure uninterrupted education during future crises, proactive planning, including the creation of predefined protocols for collaboration, is essential. The pandemic underscores the need for closer alignment between the two sectors, which would better equip future nurses with the skills they need to thrive in the nursing workforce and ensure they are prepared for the challenges of the 21st century.

• MeSH
• COVID-19 * epidemiology   MeSH
• Education, Distance trends   MeSH
• Curriculum MeSH
• Humans MeSH
• Longitudinal Studies MeSH
• Pandemics MeSH
• SARS-CoV-2 MeSH
• Education, Nursing, Baccalaureate * trends   organization & administration   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Geographicals
• Europe MeSH

OBJECTIVES: This study aimed to investigate the impact of bleaching agents based on carbamide or hydrogen peroxide on dental ceramics in vitro, utilizing scanning electron microscopy (SEM) and elemental analysis via inductively coupled plasma optical emission spectroscopy (ICP-OES). METHODS: CAD/CAM ceramics (IPS e.max®CAD, IPS Empress®CAD, Vitablocs® Mark II, Celtra Duo, and inCoris TZI) were treated with bleaching agents using either 10%, 20%, 30% carbamide peroxide or with 35%, and 40% hydrogen peroxide. RESULTS: Surface elemental release was not significantly affected by the type or concentration of bleaching agent (p>0.05). Ion release in feldspathic ceramics was significantly higher than in other ceramic materials (p⟨0.0001). Microstructural surface changes were observed in all materials except for lithium disilicate and zirconia-reinforced lithium silicate ceramics. CONCLUSIONS: All bleaching agents tested in this study showed a similar impact within each material type tested regarding total mass loss, elemental composition, or surface structure. CLINICAL RELEVANCE: Lithium disilicate and zirconia-reinforced lithium silicate ceramics were the most resistant to bleaching agents. In contrast, feldspathic ceramic showed the highest ion release and surface deterioration when exposed to all bleaching agents tested.

• MeSH
• Computer-Aided Design * MeSH
• Carbamide Peroxide * chemistry   MeSH
• Ceramics * chemistry   MeSH
• Tooth Bleaching Agents * chemistry   MeSH
• Microscopy, Electron, Scanning MeSH
• Hydrogen Peroxide * chemistry   MeSH
• Surface Properties MeSH
• Materials Testing MeSH
• Zirconium chemistry   MeSH
• Dental Porcelain * chemistry   MeSH
• Publication type
• Journal Article MeSH