BACKGROUND: Treadmill exercise nitrogen-13 ((13)N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients. METHODS AND RESULTS: Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m(2) (range 19.5-63.5 kg/m(2)). Feasibility of treadmill (13)N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score. CONCLUSIONS: Treadmill (13)N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.

• MeSH
• Ammonia MeSH
• Middle Aged MeSH
• Humans MeSH
• Coronary Artery Disease complications   MeSH
• Obesity complications   MeSH
• Positron-Emission Tomography methods   MeSH
• Radiopharmaceuticals MeSH
• Nitrogen Radioisotopes * MeSH
• Reproducibility of Results MeSH
• Aged MeSH
• Sensitivity and Specificity MeSH
• Feasibility Studies MeSH
• Exercise Test MeSH
• Myocardial Perfusion Imaging methods   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, N.I.H., Extramural MeSH

Hypertensive intracerebral hematoma is one of the most severe forms of cerebrovascular pathology, characterized by high lethality and disability. One of the objectives in providing assistance remains the development of new minimally invasive methods for the removal of hematomas. We have analyzed the results of surgical treatment of 176 patients with intracerebral hematoma. Patients from the 1st group were done open craniotomy. Patients from the 2nd group were performed the external ventricular drainage, also needle aspiration with fibrinolysis. Patients from the 3rd group were performed minimally invasive removal using the original device. Results of treatment were evaluated using Glasgow outcome scale. Lethality was observed in 1st group in 47.8% of cases, in 2nd group in 31.8%, in 3rd group in 29.7%. Minimally invasive technique reduced the postoperative mortality and improved treatment outcomes of patients with intracerebral hematoma.

• MeSH
• Drainage methods   utilization   MeSH
• Endoscopy MeSH
• Fibrinolysis MeSH
• Glasgow Outcome Scale MeSH
• Hematoma therapy   MeSH
• Hypertension * complications   MeSH
• Intracranial Hemorrhages * diagnosis   etiology   mortality   physiopathology   therapy   MeSH
• Needles utilization   MeSH
• Blood Sedimentation MeSH
• Middle Aged MeSH
• Humans MeSH
• Minimally Invasive Surgical Procedures MeSH
• Cerebrovascular Circulation MeSH
• Punctures methods   utilization   MeSH
• Aged MeSH
• Severity of Illness Index MeSH
• Outcome and Process Assessment, Health Care MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH

BACKGROUND: Patients with transposition of the great arteries (TGA) and systemic right ventricle often confront significant adverse cardiac events. The prognostic significance of invasive hemodynamic parameters in this context remains uncertain. Our hypothesis is that the aortic pulsatility index and hemodynamic profiling utilizing invasive measures provide prognostic insights for patients with TGA and a systemic right ventricle. METHODS: This retrospective multicenter cohort study encompasses adults with TGA and a systemic right ventricle who underwent cardiac catheterization. Data collection, spanning from 1994 to 2020, encompasses clinical and hemodynamic parameters, including measured and calculated values such as pulmonary capillary wedge pressure, aortic pulsatility index, and cardiac index. Pulmonary capillary wedge pressure and cardiac index values were used to establish 4 distinct hemodynamic profiles. A pulmonary capillary wedge pressure of ≥15 mm Hg indicated congestion, termed wet, while a cardiac index <2.2 L/min per m2 signified inadequate perfusion, labeled cold. The primary outcome comprised a composite of all-cause death, heart transplantation, or the requirement for mechanical circulatory support. RESULTS: Of 1721 patients with TGA, 242 individuals with available invasive hemodynamic data were included. The median follow-up duration after cardiac catheterization was 11.4 (interquartile range, 7.5-15.9) years, with a mean age of 38.5±10.8 years at the time of cardiac catheterization. Among hemodynamic parameters, an aortic pulsatility index <1.5 emerged as a robust predictor of the primary outcome, with adjusted hazard ratios of 5.90 (95% CI, 3.01-11.62; P<0.001). Among the identified 4 hemodynamic profiles, the cold/wet profile was associated with the highest risk for the primary outcome, with an adjusted hazard ratio of 3.83 (95% CI, 1.63-9.02; P<0.001). CONCLUSIONS: A low aortic pulsatility index (<1.5) and the cold/wet hemodynamic profile are linked with an elevated risk of adverse long-term cardiac outcomes in patients with TGA and systemic right ventricle.

• MeSH
• Adult MeSH
• Ventricular Function, Right physiology   MeSH
• Hemodynamics * physiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Pulmonary Wedge Pressure physiology   MeSH
• Prognosis MeSH
• Retrospective Studies MeSH
• Cardiac Catheterization * MeSH
• Heart Ventricles * physiopathology   diagnostic imaging   MeSH
• Transposition of Great Vessels * physiopathology   surgery   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH

It should be expected that the hepatic blood flow increase in the cases with liver metastasis. We aimed to find out if there is a correlation between Doppler parameters and hepatic metabolic activity in oncology patients. 35 patients with hepatic metastases who were identified by 18F-fluorodeoxyglucose positron emission tomography scan and assessed with Doppler ultrasound were included in this prospective study. Patients with hepatic disease, cardiac dysfunction, dehydration, history of alcoholism, intake of antihypertensive or vasoactive medication were excluded. Volume flow of the proper hepatic artery and the portal vein were measured in the hepatoduodenal ligament by Doppler sonography. Doppler perfusion index (the ratio of the hepatic artery flow to the total liver blood flow) and flow volumes of 31 age matched subjects were compared. Both flow of the proper hepatic artery and portal vein were found to be significantly higher in patients with liver metastasis. The mean Doppler perfusion index value was 0.2 ± 0.13 in hepatic metastases whereas 0.13 ± 0.05 in control group. Doppler perfusion index was significantly higher in liver metastases (p=0.008). A positive correlation was found between the maximum standardized uptake value of the liver and flow volume of the proper hepatic artery (r=0.774, p=0). Blood flow of the proper hepatic artery and Doppler perfusion index correlates with hepatic standardized uptake value. Flow measurements of the liver may become an important parameter for selecting patients for further positron emission tomography scan and following-up the response after systemic and local therapeutic procedures.

• MeSH
• Adult MeSH
• Hemodynamics * MeSH
• Middle Aged MeSH
• Humans MeSH
• Liver Neoplasms blood supply   metabolism   secondary   ultrasonography   MeSH
• Prospective Studies MeSH
• Regional Blood Flow * MeSH
• Aged MeSH
• Ultrasonography, Doppler * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

Rapid reperfusion of the entire territory distal to vascular occlusions is the aim of stroke interventions. Recent studies defined successful reperfusion as establishing some perfusion with distal branch filling of <50% of territory visualized (Thrombolysis In Cerebral Infarction "TICI" 2a) or more. We investigate the importance of the quality of final reperfusion and whether a revision of the successful reperfusion definition is warranted. We retrospectively evaluated a prospective database of anterior circulation strokes treated using stentrievers to assess the quality of final reperfusion using two scores: the traditional TICI score and a modified TICI score. The modified TICI score includes an additional category (TICI 2c): near complete perfusion except for slow flow or distal emboli in a few distal cortical vessels. We compared different cut-off definitions of reperfusion (TICI 2a - 3 vs. TICI-2b-3 vs. TICI 2c-3) using the area under the curve to identify their correlation with a favorable 90-day outcome (mRS≤2). In our cohort of 110 patients, 90% achieved TICI 2a-3 reperfusion with 80% achieving TICI 2b-3 and 55.5% achieving TICI 2c-3. The proportion of patients with a favorable 90-day outcome was higher in the TICI 2c (62.5%) compared to TICI 2b (44.4%) or TICI 2a (45.5%) but similar to the TICI 3 group (75.9%). A TICI 2c-3 reperfusion had a better predictive value than TICI 2b-3 for 90-day mRS 0-1. Defining successful reperfusion as TICI 2c/3 has merits. In this cohort, there was evidence toward faster recovery and better outcomes in patients with the TICI 2c vs. the traditional TICI 2b grade.

• MeSH
• Stroke epidemiology   radiography   surgery   MeSH
• Databases, Factual MeSH
• Outcome Assessment, Health Care methods   statistics & numerical data   MeSH
• Humans MeSH
• Mechanical Thrombolysis statistics & numerical data   MeSH
• Cerebral Angiography statistics & numerical data   MeSH
• Observer Variation MeSH
• Prevalence MeSH
• Reproducibility of Results MeSH
• Retrospective Studies MeSH
• Risk Factors MeSH
• Aged MeSH
• Sensitivity and Specificity MeSH
• Severity of Illness Index * MeSH
• Treatment Outcome MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Evaluation Study MeSH
• Validation Study MeSH
• Geographicals
• Alberta MeSH

• MeSH
• Physiology MeSH
• Gastroenterology MeSH
• Gastrointestinal Tract physiology   MeSH
• Digestive System MeSH

• Conspectus
• Fyziologie člověka a srovnávací fyziologie
• NML Fields
• gastroenterologie
• fyziologie

• MeSH
• Cardiology MeSH
• Publication type
• Periodical MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• kardiologie
• angiologie

• MeSH
• Diagnosis, Differential MeSH
• Molecular Biology MeSH
• Skin Neoplasms diagnosis   therapy   MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• dermatovenerologie
• onkologie
• NML Publication type
• kolektivní monografie

74 patients with broncho-pulmonary paecilomycosis were observed for the indexes of pulmonoscintigraphy. According to the clinical manifestations of the disease all investigated patients were divided into two groups: 1st group - 25 people with predominance of the clinical signs of bronchial asthma (5 people with chronic obstructive bronchitis, 20 people with bronchial asthma) and 2nd group - 54 people with predominance of the clinical signs of inflammation process of the lungs' parenchyma and interstitial tissue (38 patients with pneumonia, 16 patients with exogenous-allergic alveolitis). The results of radionuclide investigation showed that scintigraphic pictures of the investigated people of the 1st and 2nd groups were significantly differed from the lungs' picture of the patients from the control group. During visual evaluation of the scintigrams the areas of disorders of pulmonary circulation were presented by defects of different degree. Also, they had uneven decreasing of the distribution of the radiopharmaceutical drug in the injured areas, most often in the middle and lower areas of the lungs, sometimes along the whole lung areas. Density of radiopharmaceutical distribution in these areas was decreased in comparison with the adjoining lung tissue. The functional area of parenchyma and the form of the organ were not changed.

• Keywords
• capillary blood circulation,
• MeSH
• Asthma etiology   MeSH
• Bronchitis, Chronic etiology   MeSH
• Adult MeSH
• Alveolitis, Extrinsic Allergic etiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Statistics, Nonparametric MeSH
• Paecilomyces * MeSH
• Perfusion Imaging * methods   statistics & numerical data   MeSH
• Lung blood supply   MeSH
• Lung Diseases, Fungal * diagnosis   MeSH
• Pneumonia etiology   MeSH
• Radiopharmaceuticals diagnostic use   MeSH
• Technetium Tc 99m Aggregated Albumin diagnostic use   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH

• MeSH
• Pulsatile Flow MeSH
• Risk Factors MeSH
• Blood Flow Velocity MeSH
• Vascular Stiffness MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• angiologie
• kardiologie