Publikace obsahuje úplné znění aktuálních českých zákonů a vyhlášek, které se týkají sociálního zabezpečení. Určeno odborné veřejnosti.

• MeSH
• sociální péče zákonodárství a právo   MeSH
• sociální práce zákonodárství a právo   MeSH
• sociální zabezpečení zákonodárství a právo   MeSH
• Geografické názvy
• Česká republika MeSH
• Ukrajina MeSH

• Konspekt
• Sociální problémy vyžadující podporu a pomoc. Sociální zabezpečení
• NLK Obory
• právo, zákonodárství
• sociologie
• ekonomie, ekonomika, ekonomika zdravotnictví
• NLK Publikační typ
• zákony
• právní předpisy

• Klíčová slova
• peer konzultant,
• MeSH
• duševně nemocní MeSH
• duševní zdraví MeSH
• služby péče o duševní zdraví MeSH
• zotavení z duševní nemoci MeSH

• MeSH
• dětská psychologie MeSH
• dítě MeSH
• mladiství MeSH
• psychický stres MeSH
• šikana psychologie   MeSH
• vývoj dítěte MeSH
• Check Tag
• dítě MeSH
• mladiství MeSH

• MeSH
• dezinfekce rukou MeSH
• hygiena rukou metody   trendy   MeSH
• infekce spojené se zdravotní péčí prevence a kontrola   MeSH
• kontrola infekčních nemocí metody   MeSH

• MeSH
• duševně nemocní MeSH
• fyzické omezení metody   zákonodárství a právo   MeSH
• ochrana zájmů pacientů MeSH
• práva pacientů MeSH
• ústavy pro duševně nemocné MeSH
• zákonodárství lékařské MeSH

• Klíčová slova
• dvanáctikrokové programy,
• MeSH
• alkoholici psychologie   výchova   MeSH
• Anonymní alkoholici MeSH
• pití alkoholu terapie   MeSH
• svépomocné skupiny MeSH

• Klíčová slova
• Johanka Hrebendová Bóriková,
• MeSH
• dějiny 19. století MeSH
• dějiny ošetřovatelství MeSH
• významné osobnosti MeSH
• Check Tag
• dějiny 19. století MeSH
• Publikační typ
• biografie MeSH
• Geografické názvy
• Slovenská republika MeSH

BACKGROUND: Newborn screening (NBS) programs for severe combined immunodeficiency facilitate early diagnosis of severe combined immunodeficiency and promote early treatment with hematopoietic stem cell transplantation, resulting in improved clinical outcomes. Infants with congenital athymia are also identified through NBS because of severe T-cell lymphopenia. With the expanding introduction of NBS programs, referrals of athymic patients for treatment with thymus transplantation have recently increased at Great Ormond Street Hospital (GOSH) (London, United Kingdom). OBJECTIVE: We studied the impact of NBS on timely diagnosis and treatment of athymic infants with thymus transplantation at GOSH. METHODS: We compared age at referral and complications between athymic infants diagnosed after clinical presentation (n = 25) and infants identified through NBS (n = 19) who were referred for thymus transplantation at GOSH between October 2019 and February 2023. We assessed whether age at time of treatment influences thymic output at 6 and 12 months after transplantation. RESULTS: The infants referred after identification through NBS were significantly younger and had fewer complications, in particular fewer infections. All deaths occurred in the group of those who did not undergo NBS, including 6 patients before and 2 after thymus transplantation because of preexisting infections. In the absence of significant comorbidities or diagnostic uncertainties, timely treatment was achieved more frequently after NBS. Treatment when younger than age 4 months was associated with higher thymic output at 6 and 12 months after transplantation. CONCLUSION: NBS contributes to earlier recognition of congenital athymia, promoting referral of athymic patients for thymus transplantation before they acquire infections or other complications and facilitating treatment at a younger age, thus playing an important role in improving their outcomes.

• MeSH
• kojenec MeSH
• lidé MeSH
• novorozenec MeSH
• novorozenecký screening MeSH
• syndromy imunologické nedostatečnosti * MeSH
• těžká kombinovaná imunodeficience * diagnóza   terapie   MeSH
• thymus MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• novorozenec MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

High resistance to environmental factors as well as the ability to form biofilms allow Listeria monocytogenes to persist for a long time in difficult-to-reach places in food-producing plants. L. monocytogenes enters final products from contaminated surfaces in different areas of plants and poses a health risk to consumer. Modified surfaces are already used in the food industry to prevent cross-contamination. In this study, stainless-steel surfaces were coated with nanoscale silicon dioxide and the effects on attachment, bacterial growth and detachment of L. monocytogenes were evaluated. Attachment was considered for three different ways of application to simulate different scenarios of contamination. Bacterial growth of L. monocytogenes on the surface was recorded over a period of up to 8 h. Detachment was tested after cleaning inoculated stainless-steel surfaces with heated distilled water or detergent. Coating stainless-steel surfaces with nanoscale silica tends to reduce adherence and increased detachment and does not influence the bacterial growth of L. monocytogenes. Further modifications of the coating are necessary for a targeted use in the reduction of L. monocytogenes in food-processing plants.

• MeSH
• bakteriální adheze MeSH
• biofilmy MeSH
• kontaminace potravin * analýza   MeSH
• Listeria monocytogenes * MeSH
• nerezavějící ocel analýza   MeSH
• počet mikrobiálních kolonií MeSH
• potravinářská mikrobiologie MeSH
• Publikační typ
• časopisecké články MeSH

Persons living in industrial environments are exposed to levels of air pollution that can affect their health and fertility. The Czech capital city, Prague, and the Ostrava industrial agglomeration differ in their major sources of air pollution. In Prague, heavy traffic produces high levels of nitrogen oxides throughout the year. In the Ostrava region, an iron industry and local heating are sources of particulate matter (PM) and benzo[a]pyrene (B[a]P), especially in the winter. We evaluated the effects of air pollution on human sperm mitochondrial DNA (mtDNA). Using real-time PCR, we analysed sperm mtDNA copy number and deletion rate in Prague city policemen in two seasons (spring and autumn) and compared the results with those from Ostrava. In Prague, the sperm mtDNA deletion rate was significantly higher in autumn than in spring, which is the opposite of the results from Ostrava. The sperm mtDNA copy number did not show any seasonal differences in either of the cities; it was correlated negatively with sperm concentration, motility, and viability, and with sperm chromatin integrity (assessed with the Sperm Chromatin Structure Assay). The comparison between the two cities showed that the sperm mtDNA deletion rate in spring and the sperm mtDNA copy number in autumn were significantly lower in Prague vs. Ostrava. Our study supports the hypothesis that sperm mtDNA deletion rate is affected by the composition of air pollution. Sperm mtDNA abundance is closely associated with chromatin damage and standard semen characteristics.

• MeSH
• dospělí MeSH
• látky znečišťující vzduch toxicita   škodlivé účinky   MeSH
• lidé MeSH
• mitochondriální DNA * genetika   MeSH
• motilita spermií účinky léků   MeSH
• pevné částice toxicita   škodlivé účinky   MeSH
• policie MeSH
• roční období MeSH
• spermie * účinky léků   MeSH
• variabilita počtu kopií segmentů DNA * MeSH
• znečištění ovzduší * škodlivé účinky   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Česká republika MeSH