ARTERIOSCLEROSIS/blood Dotaz Zobrazit nápovědu
- MeSH
- arterioskleróza terapie MeSH
- fibrinolýza MeSH
- lidé MeSH
- lipidy krev MeSH
- minerální vody MeSH
- sulfidy MeSH
- trombocyty MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Polsko MeSH
Advances in experimental medicine and biology ; 104
1st ed. 16, 546 s.
Workshop sponsored by the Councils on Thrombosis and Arteriosclerosis of the American Heart Association and by the Divisions of Heart and Vascular Diseases and Blood Diseases and Resources of the National Heart, Lung, and Blood Institute.
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- angiologie
- kardiologie
The traditional non-invasive method for the early detection of arteriosclerosis is the brachial-ankle pulse wave velocity (PWV); however, this method is significantly influenced by blood pressure (BP) changes. Recently, a new non-invasive method for the arterial stiffness assessment was developed – the cardio-ankle vascular index (CAVI). This method has been shown to be unaffected by BP variations and thus it could be recommended for wide clinical use, including large population studies. The aim of this paper was to evaluate the CAVI in a sample of Czech adult population. A group of 121 healthy subjects (aged from 20 to >70 years) was examined using the newest type of non-invasive monitoring system VaSera® 1500 (Fukuda Denshi Co., Tokyo, Japan). This control group was then compared with 3 groups of patients with selected lifestyle-related diseases: coronary artery disease (CAD; n = 74), diabetes mellitus (DM; n = 36), and hypertension (HT; n = 58). The statistical analysis showed a significant difference in the CAVI parameter between healthy subjects and patients with coronary artery disease, diabetes, and hypertension; the mean CAVI value in the control group (6.9) was significantly lower compared to the patients with CAD (CAVI = 9.2; P < 0.001 vs. control group), diabetes (CAVI = 8.5; P < 0.001 vs. control group), and hypertension (CAVI = 8.9; P < 0.001 vs. control group). These results demonstrate that CAVI should be considered as an important clinical parameter independent of blood pressure changes, and should be recommended as a valuable indicator of the preventive evaluation of the arteriosclerotic risk in healthy subjects and patients with life-style related diseases.
- MeSH
- arteria brachialis fyziologie MeSH
- arteriae carotides fyziologie MeSH
- arterioskleróza diagnóza MeSH
- diabetes mellitus prevence a kontrola MeSH
- diagnostické techniky kardiovaskulární přístrojové vybavení trendy MeSH
- diagnostické vybavení trendy MeSH
- dospělí MeSH
- financování organizované MeSH
- hypertenze komplikace prevence a kontrola MeSH
- kardiovaskulární nemoci diagnóza MeSH
- kotník krevní zásobení MeSH
- krevní tlak fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měření krevního tlaku mortalita přístrojové vybavení trendy MeSH
- nemoci koronárních tepen diagnóza prevence a kontrola MeSH
- neparametrická statistika MeSH
- oscilometrie přístrojové vybavení využití MeSH
- pulzatilní průtok MeSH
- reprodukovatelnost výsledků MeSH
- rychlost toku krve fyziologie MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- MeSH
- antihypertenziva MeSH
- arterioskleróza diagnóza MeSH
- farmakologie metody MeSH
- hypertenze krev MeSH
- intrakraniální arterioskleróza diagnóza MeSH
- krevní tlak fyziologie MeSH
- metabolismus MeSH
- mozek anatomie a histologie krevní zásobení růst a vývoj MeSH
- mozkový krevní oběh MeSH
- neurotické poruchy diagnóza MeSH
- roztroušená skleróza diagnóza MeSH
Atherosclerosis, ISSN 0021-9150 Supplement Vol. 118
S149 s. : il. ; 28 cm
- MeSH
- arterioskleróza patofyziologie etiologie MeSH
- cévy patologie patofyziologie MeSH
- lipoproteiny fyziologie MeSH
- výzkum MeSH
- Publikační typ
- kongresy MeSH
- sborníky MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- kardiologie
- vnitřní lékařství
- angiologie
The most frequent cause of ischaemic heart disease is coronary arteriosclerosis. This study was aimed at assessing gene expression of TNFA and its two receptors (TNFR1, TNFR2), as well as determining coronary artery calcium score (CACS) in the context of occurrence of classical risk factors in patients with subclinical atherosclerosis of coronary vessels. The study involved 47 subjects with complaints of chest pain and suspicion of acute coronary syndrome or stable coronary disease. Additionally, CACS was assessed by 64-slice computerized tomography. QRT-PCR molecular studies were performed using RNA isolated from peripheral blood mononuclear cells. Preliminary results of molecular studies on patients with subclinical coronary atherosclerosis revealed a significantly lower numbers of TNFR1 and TNFR2 gene copies as compared with healthy subjects. In addition, it can be demonstrated that among classical risk factors hypertension is of substantial importance in the progression of coronary arteries' calcification, and that in the examined group CACS increases together with the rising number of classical risk factors involved. No correlation was observed, however, between expression of TNFA, TNFR1 and TNFR2 genes and the value of CACS. Conclusions: 1. The occurrence of hypertension facilitates initiation and progression of arteriosclerotic lesions in blood vessels including the coronary ones; the raised number of circulatory disease classical risk factors involved correlates with elevated calcification of coronary arteries as shown by 64-slice computerized tomography scans. 2. Significantly decreased numbers of TNFR1 and TNFR2 gene copies observed in the investigated group may play a significant role in initiation and progression of arteriosclerosis.
- MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- genetická transkripce * MeSH
- koronární cévy metabolismus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen genetika MeSH
- receptory TNF - typ I genetika metabolismus MeSH
- receptory TNF - typ II genetika metabolismus MeSH
- regulace genové exprese MeSH
- rizikové faktory MeSH
- senioři MeSH
- TNF-alfa genetika MeSH
- vápník metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
