Finnish method
Dotaz
Zobrazit nápovědu
Acta oto-laryngologica, ISSN 0365-5237 suppl. 210, 1965
86 s. : tab., grafy ; 26 cm
Background and Purpose: Currently, there is no available Finnish version of the Genomic Nursing Concept Inventory tool (GNCI). This study tested the validity, reliability, and clinical usability of a Finnish translation. Methods: A decision tree algorithm was used to guide the translation, as per International Society for Pharmacoeconomics and Outcomes Research guidelines. Item-Content Validity Index (I-CVI), modified kappa (k*) statistics, and Cronbach's alpha were calculated. Results: The I-CVI and k* values were "good" to "excellent" (I-CVI = 0.63-1.00, k* = 0.52-1.00), and Cronbach's alpha value was "good" (α = 0.816; 95% confidence interval: 0.567-0.956). Conclusion: The Mandysova's decision tree algorithm provided clear and rigorous direction for the translation and validity of the Finnish GNCI.
- MeSH
- genomika * MeSH
- lidé MeSH
- lingvistika * MeSH
- průzkumy a dotazníky MeSH
- reprodukovatelnost výsledků MeSH
- rozhodovací stromy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Finsko MeSH
Short-QT syndrome is an inherited disorder characterized by a short QT interval and an increased risk of sudden cardiac death. The clinical significance of a short QT interval observed in a randomly recorded ECG is not known. Therefore, we assessed the prevalence and prognostic significance of a short QT interval in a general population. METHODS AND RESULTS: QT intervals were measured from the 12-lead ECGs of 10 822 randomly selected middle-aged subjects (5658 males, mean age 44+/-8.4 years) enrolled in a population study and followed up for 29+/-10 years. The end points were all-cause and cardiovascular mortality. In addition to Bazett's method (corrected QT interval, or QTc), the Fridericia (QTfc) and nomogram (QTnc) methods were used to correct the QT interval for heart rate. The cutoff values for short QT intervals were defined as 320 ms (very short) and 340 ms (short). The prevalence of QT interval <320 ms based on QTc, QTfc, and QTnc was 0.10%, 0.08%, and 0.06%, and the prevalence of QT interval <340 ms was 0.4%, 0.3%, and 0.3%, respectively. The majority of subjects with short QT intervals were males. All-cause or cardiovascular mortality did not differ between subjects with a very short or short QT interval and those with normal QT intervals (360 to 450 ms). There were no sudden cardiac deaths, aborted sudden cardiac deaths, or documented ventricular tachyarrhythmias among subjects with a QTfc <340 ms. CONCLUSIONS: A short QT interval does not appear to indicate an increased risk for all-cause or cardiovascular mortality in middle-aged nonreferral, community-based individuals.
- MeSH
- dospělí MeSH
- elektrokardiografie MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- prevalence MeSH
- prognóza MeSH
- srdeční arytmie diagnóza epidemiologie mortalita MeSH
- syndrom MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Finsko MeSH
Autoři přinášejí první informaci o zavedení nové rehabilitační a lázeňské metody v České republice. Celotělová chladová terapie (ceiotěiová kryoterapie) byla poprvé do běžné praxe zavedena v Japonsku v 70. letech minulého století, v Evropě se objevila v roce 1985. V naší republice tuto novou metodu jako první začalo nabízet pacientům - klientům beskydské Rehabilitační centrum Čeladná od srpna 2004. Autoři vyjmenovávají hlavní indikace pro použití nové metody, popisují průběh procedury, bezpečnostní opatření, hodnotí relativní a absolutní kontraindikace a nežádoucí účinky. V závěru sdělení informují o zahájení longitudinální studie, která bude mít za úkol zhodnotit účinnost nové metody vzhledem k jednotlivým diagnózám a stavům, pro které pacienti absolvovali celotělovou chladovou terapii.
The authors present the first information on the introduction of new rehabilitation and health resort methods in the Czech Repubiic. The whole-body cold therapy (whole-body cryotherapy) was introduced for the first time in Japan in the seventies of the last century and appeared in Europe in 1985. In the Czech Republic the therapy was offered to patients - clients of the Beskydy Rehabilitation Cancer in Čeladná for the first time in August 2004. The authors name the main indications for application of the new method, describe the course of the procedure, safety measures, and evaluate relative and absolute contraindications and untoward effects. In conclusion, the authors inform about the beginning of a longitudinal study, which will be aimed to evaluating efficiency of the method in view of individual diagnoses and conditions, established as indications for the whole-body cold therapy.
- MeSH
- autoimunitní nemoci terapie MeSH
- balneologie MeSH
- bolest patofyziologie MeSH
- endorfiny sekrece MeSH
- hyperemie MeSH
- kryoterapie kontraindikace metody využití MeSH
- lidé MeSH
- management bolesti MeSH
- parní lázeň MeSH
- revmatické nemoci imunologie terapie MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Česká republika MeSH
PURPOSE: To characterise and compare twenty-eight Finnish Clostridium difficile RT027-like isolates, selected based on the presence of 18 bp deletion in the tcdC gene and toxin gene profile (A, B, binary), with eleven RT027 isolates from different Finnish geographical areas and time periods. METHODS: Twenty-eight C. difficile RT027-like isolates and 11 RT027 comparative strains were characterised by capillary-electrophoresis (CE) ribotyping, multi-locus variable tandem-repeats analysis (MLVA), multi-locus sequence typing (MLST), and sequencing of tcdC and gyrA gene fragments. Susceptibility to moxifloxacin was determined by E-test. RESULTS: Of 28 RT027-like isolates, seven RTs (016, 034, 075, 080, 153, 176 and 328), three WEBRIBO types (411, 475, AI-78) and three new profiles (F1-F3) were identified. MLVA revealed six clonal complexes (RTs 016, 027, 176 and F3). MLST showed eleven sequence types (1, 41, 47, 67, 95, 191,192, 223, 229, 264 and new ST). Twenty-two isolates (RTs 016, 080, 176, 328, F1, F2, F3 and WRTAI-78) carried Δ117 in the tcdC gene. Isolates of RTs 016, 027 and 176 were moxifloxacin resistant and harboured Thr82Ile in the GyrA. CONCLUSION: Our results show a high diversity within 28 Finnish RT027-like C. difficile isolates, with twelve CE-ribotyping profiles and eleven STs. MLVA revealed the regional spread of RTs 016, 027, 176 and F3. The presence of Δ117 in the tcdC gene in eight non-027 RTs highlights the importance of careful interpretation of the results from molecular systems targeting this site in the genome of C. difficile and the need of strain typing for epidemiological purposes.
- MeSH
- ADP-ribosatransferasy genetika MeSH
- antibakteriální látky farmakologie MeSH
- bakteriální léková rezistence MeSH
- bakteriální proteiny genetika MeSH
- bakteriální toxiny analýza genetika MeSH
- Clostridioides difficile klasifikace účinky léků genetika izolace a purifikace MeSH
- DNA bakterií analýza MeSH
- DNA gyráza genetika MeSH
- dospělí MeSH
- enterotoxiny genetika MeSH
- fluorochinolony farmakologie MeSH
- genotyp MeSH
- klostridiové infekce epidemiologie mikrobiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- minisatelitní repetice genetika MeSH
- mladý dospělý MeSH
- molekulární epidemiologie MeSH
- moxifloxacin MeSH
- multilokusová sekvenční typizace metody MeSH
- polymerázová řetězová reakce metody MeSH
- represorové proteiny genetika MeSH
- ribotypizace metody MeSH
- sekvence nukleotidů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- techniky typizace bakterií * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Finsko MeSH
OBJECTIVE: The study aimed to explore changes in the prevalence of psychological distress and co-occurring psychological symptoms among 19-34 years old Finnish university students between the years 2000 and 2012. METHODS: The prevalence of perceived frequent psychological symptoms was compared in four nationwide cross-sectional student health surveys with random samples (N=11,502) in the following years: 2000 (N=3,174), 2004 (N=3,153), 2008 (N=2,750), and 2012 (N=2,425). RESULTS: In the time phase from 2000 to 2012, the overall psychological distress (12-item General Health Questionnaire, GHQ-12) increased from 22% to 28%, while there was also an increase in the frequently experienced psychological symptoms (depressiveness from 13% to 15%, anxiety from 8% to 13%, concentration problems from 12% to 18%, and psychological tension from 13% to 18% with a peak prevalence observed in 2008). The co-occurrence of different psychological symptoms increased as well. Psychological distress was more common in females and in older students. CONCLUSIONS: The findings suggest an increasing trend of frequent psychological distress among Finnish university students over the years from 2000 to 2012, with the peak prevalence occurring in 2008, which may reflect the growing multifaceted environmental demands.
- MeSH
- deprese epidemiologie MeSH
- dospělí MeSH
- lidé MeSH
- průřezové studie MeSH
- psychiatrické posuzovací škály MeSH
- psychický stres epidemiologie MeSH
- studenti psychologie MeSH
- univerzity * MeSH
- úzkost epidemiologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Finsko epidemiologie MeSH
OBJECTIVES: In the present study, we examine whether the labour market status is a significant factor in explaining the association between self-rated health and subjective well-being. THEORETICAL BASE: We test whether social support reduces the negative effects of impaired health on well-being. Hence, we analysed whether the groups of employed and unemployed are different in terms of how they each benefit from receiving social support. METHODS: The study is based on a survey conducted in 2016. The data consist of 841 respondents from which 732 had the labour market status of employed people and 109 had the labour market status of unemployed people. OUTCOMES: Labour market status is a significant factor in explaining the association between self-rated health and subjective well-being. Unemployed people with a low health status had a much lower rating with respect to subjective well-being compared to employed people with a similar low-rated health situation. There is a greater reduction in the impact of negative factors on subjective well-being via social support in the group of employed people. SOCIAL WORK IMPLICATIONS: The findings suggest that disadvantaged people should have been offered intensified services. From a policy perspective, the findings suggest a need for close cooperation between health, labour and social services.
BACKGROUND: We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS: Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimmunity (median age 17.4 months) followed by type 1 diabetes, and 18 tightly matched controls from the Finnish Diabetes Prediction and Prevention (DIPP) cohort. Three stool samples were analyzed, taken 3, 6, and 9 months before the first detection of serum autoantibodies in the case child. The risk of islet autoimmunity was evaluated in relation to the composition of the bacteriome 16S rDNA profiles assessed by mass sequencing, and to the composition of DNA and RNA viromes. RESULTS: Four operational taxonomic units were significantly less abundant in children who later on developed islet autoimmunity as compared to controls-most markedly the species of Bacteroides vulgatus and Bifidobacterium bifidum. The alpha or beta diversity, or the taxonomic levels of bacterial phyla, classes or genera, showed no differences between cases and controls. A correlation analysis suggested a possible relation between CrAssphage signals and quantities of Bacteroides dorei. No apparent associations were seen between development of islet autoimmunity and sequences of yet unknown origin. CONCLUSIONS: The results confirm previous findings that an imbalance within the prevalent Bacteroides genus is associated with islet autoimmunity. The detected quantitative relation of the novel "orphan" bacteriophage CrAssphage with a prevalent species of the Bacteroides genus may exemplify possible modifiers of the bacteriome.
- MeSH
- autoimunita * MeSH
- autoimunitní nemoci krev epidemiologie etiologie imunologie MeSH
- Bacteroides klasifikace imunologie izolace a purifikace virologie MeSH
- bakteriální RNA chemie metabolismus MeSH
- bakteriofágy klasifikace imunologie izolace a purifikace MeSH
- diabetes mellitus 1. typu krev epidemiologie etiologie imunologie MeSH
- dítě MeSH
- dysbióza imunologie mikrobiologie patofyziologie virologie MeSH
- feces mikrobiologie virologie MeSH
- fylogeneze MeSH
- kohortové studie MeSH
- Langerhansovy ostrůvky imunologie MeSH
- lidé MeSH
- longitudinální studie MeSH
- molekulární typizace MeSH
- nemocnice univerzitní MeSH
- prospektivní studie MeSH
- riziko MeSH
- RNA ribozomální 16S chemie metabolismus MeSH
- RNA virová chemie metabolismus MeSH
- střevní mikroflóra imunologie MeSH
- studie případů a kontrol MeSH
- výpočetní biologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Finsko epidemiologie MeSH
