elektronický časopis
- Conspectus
- Fyzioterapie. Psychoterapie. Alternativní lékařství
- NML Fields
- psychologie, klinická psychologie
- psychoterapie
- NML Publication type
- elektronické časopisy
V současné době neexistuje v České republice ucelený zdroj informací o možnostech užívání léčiv v době těhotenství, bezpečnosti a rizicích plynoucích z jejich podávání těhotným ženám. Uvedená práce prezentuje vznik nového webového informačního serveru, který se věnuje problematice farmakoterapie v období těhotenství. Cílem práce je vytvoření webových stránek, které podávají co nejucelenější přehled o bezpečnosti, teratogenitě a rizicích plynoucích z podávání léčiv v průběhu těhotenství.
There are no integrated data sources having to do with taking drugs during pregnancy, benefits and risks resulting from drug administration to pregnant women in the Czech republic. This article describes the new information server, which presents informations about pharmacotherapy in pregnancy. The main aim of this work is to create the web pages giving compacted overview about safety, teratogens and risk factors resulting from drugs administration in pregnancy.
- MeSH
- Safety MeSH
- Drug Therapy contraindications methods MeSH
- Internet utilization MeSH
- Drug Monitoring MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Pregnancy drug effects MeSH
- Teratogens analysis pharmacology MeSH
- Check Tag
- Pregnancy drug effects MeSH
- Female MeSH
- Publication type
- Review MeSH
Electronic Health Record (EHR) systems currently in use are not designed for widely interoperable longitudinal health data. Therefore, EHR data cannot be properly shared, managed and analyzed. In this article, we propose two approaches to making EHR data more comprehensive and FAIR (Findable, Accessible, Interoperable, and Reusable) and thus more useful for diagnosis and clinical research. Firstly, the data modeling based on the LinkML framework makes the data interoperability more realistic in diverse environments with various experts involved. We show the first results of how diverse health data can be integrated based on an easy-to-understand data model and without loss of available clinical knowledge. Secondly, decentralizing EHRs contributes to the higher availability of comprehensive and consistent EHR data. We propose a technology stack for decentralized EHRs and the reasons behind this proposal. Moreover, the two proposed approaches empower patients because their EHR data can become more available, understandable, and usable for them, and they can share their data according to their needs and preferences. Finally, we explore how the users of the proposed solution could be involved in the process of its validation and adoption.
- MeSH
- Data Management MeSH
- Electronic Health Records * MeSH
- Humans MeSH
- Semantic Web * MeSH
- Software MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
R-loops are common non-B nucleic acid structures formed by a three-stranded nucleic acid composed of an RNA-DNA hybrid and a displaced single-stranded DNA (ssDNA) loop. Because the aberrant R-loop formation leads to increased mutagenesis, hyper-recombination, rearrangements, and transcription-replication collisions, it is regarded as important in human diseases. Therefore, its prevalence and distribution in genomes are studied intensively. However, in silico tools for R-loop prediction are limited, and therefore, we have developed the R-loop tracker tool, which was implemented as a part of the DNA Analyser web server. This new tool is focused upon (1) prediction of R-loops in genomic DNA without length and sequence limitations; (2) integration of R-loop tracker results with other tools for nucleic acids analyses, including Genome Browser; (3) internal cross-evaluation of in silico results with experimental data, where available; (4) easy export and correlation analyses with other genome features and markers; and (5) enhanced visualization outputs. Our new R-loop tracker tool is freely accessible on the web pages of DNA Analyser tools, and its implementation on the web-based server allows effective analyses not only for DNA segments but also for full chromosomes and genomes.
- MeSH
- Algorithms * MeSH
- DNA chemistry genetics MeSH
- Genomics methods MeSH
- Internet statistics & numerical data MeSH
- Humans MeSH
- Genomic Instability * MeSH
- R-Loop Structures * MeSH
- Software MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
With biodiversity research activities being increasingly shifted to the web, the need for a system of persistent and stable identifiers for physical collection objects becomes increasingly pressing. The Consortium of European Taxonomic Facilities agreed on a common system of HTTP-URI-based stable identifiers which is now rolled out to its member organizations. The system follows Linked Open Data principles and implements redirection mechanisms to human-readable and machine-readable representations of specimens facilitating seamless integration into the growing semantic web. The implementation of stable identifiers across collection organizations is supported with open source provider software scripts, best practices documentations and recommendations for RDF metadata elements facilitating harmonized access to collection information in web portals. Database URL: : http://cetaf.org/cetaf-stable-identifiers.
- MeSH
- Biodiversity * MeSH
- Databases, Factual * MeSH
- Semantic Web * MeSH
- Software * MeSH
- Natural Language Processing * MeSH
- Publication type
- Journal Article MeSH
Objectives: A significant portion of care related to cardiorespiratory diseases is provided at home, usually but not exclusively, after the discharge of a patient from hospital. It is the purpose of the present study to present the technical means which we have developed, in order to support the adaptation of the continuity of care of cardiorespiratory diseases at home. Methods: We have developed an integrated system that includes: first, a prototype laptop-based portable monitoring system that comprises low-cost commercially available components, which enable the periodical or continuous monitoring of vital signs at home; second, software supporting medical decision-making related to tachycardia and ventricular fibrillation, as well as fuzzy-rules-based software supporting home-ventilation optimization; third, a typical continuity of care record (CCR) adapted to support also the creation of a homecare plan; and finally, a prototype ontology, based upon the HL7 clinical document architecture (CDA), serving as basis for the development of semantically annotated web services that allow for the exchange and retrieval of homecare information. Results: The flexible design and the adaptable data-exchange mechanism of the developed system result in a useful and standard-compliant tool, for cardiorespiratory disease-related homecare. Conclusions: The ongoing laboratory testing of the system shows that it is able to contribute to an effective and low-cost package solution, supporting patient supervision and treatment. Furthermore, semantic web technologies prove to be the perfect solution for both the conceptualization of a continuity of care data exchange procedure and for the integration of the structured medical data.
- MeSH
- Information Systems standards MeSH
- Internet MeSH
- Cardiovascular Diseases MeSH
- Continuity of Patient Care MeSH
- Humans MeSH
- Semantics MeSH
- Home Care Services MeSH
- Systems Integration MeSH
- Telemetry methods instrumentation MeSH
- Information Storage and Retrieval methods MeSH
- Quality Assurance, Health Care methods MeSH
- Check Tag
- Humans MeSH
In this paper, a new web solution for administering allergies, asthma and rhinitis in a pan-European level is described. The proposed system was designed to provide: professionals with easy workload and access educational and informational material; sufferers with personalised management tools and educational sources; and citizens with rich informational material. The IREMMA system architecture embeds the existing information networks and data sources on allergy by offering high data integration and multi-modal access to its users, through a multi-service tool and high-distributed architecture. Hence, IREMMA sets the ground for establishing a wide integrated network for environmental monitoring and diffusion of health information. User feedback was collected through extensive pilot trials with real users and the results were used to improve the IREMMA services and the designing and the content specification.
- Keywords
- IREMMA,
- MeSH
- Allergens immunology classification adverse effects MeSH
- Hypersensitivity diagnosis prevention & control MeSH
- Asthma diagnosis prevention & control MeSH
- Databases as Topic standards MeSH
- Epidemiologic Factors MeSH
- Financing, Organized MeSH
- Internet trends MeSH
- Humans MeSH
- Environmental Monitoring standards MeSH
- Online Systems standards MeSH
- Pollen immunology classification adverse effects MeSH
- Rhinitis diagnosis prevention & control MeSH
- Systems Integration MeSH
- Medical Order Entry Systems utilization MeSH
- Information Storage and Retrieval methods utilization MeSH
- User-Computer Interface MeSH
- Geography MeSH
- Check Tag
- Humans MeSH
- Geographicals
- Greece MeSH
- Spain MeSH
elektronický časopis
Human genome sequencing efforts have greatly expanded, and a plethora of missense variants identified both in patients and in the general population is now publicly accessible. Interpretation of the molecular-level effect of missense variants, however, remains challenging and requires a particular investigation of amino acid substitutions in the context of protein structure and function. Answers to questions like 'Is a variant perturbing a site involved in key macromolecular interactions and/or cellular signaling?', or 'Is a variant changing an amino acid located at the protein core or part of a cluster of known pathogenic mutations in 3D?' are crucial. Motivated by these needs, we developed MISCAST (missense variant to protein structure analysis web suite; http://miscast.broadinstitute.org/). MISCAST is an interactive and user-friendly web server to visualize and analyze missense variants in protein sequence and structure space. Additionally, a comprehensive set of protein structural and functional features have been aggregated in MISCAST from multiple databases, and displayed on structures alongside the variants to provide users with the biological context of the variant location in an integrated platform. We further made the annotated data and protein structures readily downloadable from MISCAST to foster advanced offline analysis of missense variants by a wide biological community.
- MeSH
- Internet MeSH
- Protein Conformation * MeSH
- Humans MeSH
- Mutation, Missense * MeSH
- Proteins chemistry genetics MeSH
- Software * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
HotSpot Wizard is a web server for automatic identification of 'hot spots' for engineering of substrate specificity, activity or enantioselectivity of enzymes and for annotation of protein structures. The web server implements the protein engineering protocol, which targets evolutionarily variable amino acid positions located in the active site or lining the access tunnels. The 'hot spots' for mutagenesis are selected through the integration of structural, functional and evolutionary information obtained from: (i) the databases RCSB PDB, UniProt, PDBSWS, Catalytic Site Atlas and nr NCBI and (ii) the tools CASTp, CAVER, BLAST, CD-HIT, MUSCLE and Rate4Site. The protein structure and e-mail address are the only obligatory inputs for the calculation. In the output, HotSpot Wizard lists annotated residues ordered by estimated mutability. The results of the analysis are mapped on the enzyme structure and visualized in the web browser using Jmol. The HotSpot Wizard server should be useful for protein engineers interested in exploring the structure of their favourite protein and for the design of mutations in site-directed mutagenesis and focused directed evolution experiments. HotSpot Wizard is available at http://loschmidt.chemi.muni.cz/hotspotwizard/.
- MeSH
- beta-Lactamases chemistry MeSH
- Glycoside Hydrolases chemistry MeSH
- Phosphoric Triester Hydrolases chemistry MeSH
- Hydrolases chemistry MeSH
- Internet MeSH
- Protein Engineering MeSH
- Reproducibility of Results MeSH
- Software MeSH
- User-Computer Interface MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
